scholarly journals Microbiota modulation by eating patterns and diet composition: impact on food intake

2018 ◽  
Vol 315 (6) ◽  
pp. R1254-R1260 ◽  
Author(s):  
Elizabeth Klingbeil ◽  
Claire B. de La Serre
Keyword(s):  
Diet Composition ◽  
Food Composition ◽  
Eating Patterns ◽  
Microbiota Composition ◽  
Gi Tract ◽  
Nucleus Of Solitary Tract ◽  
And Behavior ◽  
The Brain ◽  
Lps Treatment

There is accumulating evidence that the gut microbiota and its composition dynamics play a crucial role in regulating the host physiological functions and behavior. Diet composition is the primary modulator of bacterial richness and abundance in the gastrointestinal (GI) tract. Macronutrient (fat, sugar, and protein) and fiber contents are especially important in determining microbiota composition and its effect on health outcomes and behavior. In addition to food composition, time of intake and eating patterns have recently been shown to significantly affect gut bacterial makeup. Diet-driven unfavorable microbiota composition, or dysbiosis, can lead to an increased production of proinflammatory by-products such as lipopolysaccharide (LPS). Increased inflammatory potential is associated with alteration in gut permeability, resulting in elevated levels of LPS in the bloodstream, or metabolic endotoxemia. We have found that a chronic increase in circulating LPS is sufficient to induce hyperphagia in rodents. Chronic LPS treatment appears to specifically impair the gut-brain axis and vagally mediated satiety signaling. The vagus nerve relays information on the quantity and quality of nutrients in the GI tract to the nucleus of solitary tract in the brain stem. There is evidence that microbiota dysbiosis is associated with remodeling of the vagal afferent pathway and that normalizing the microbiota composition in rats fed a high-fat diet is sufficient to prevent vagal remodeling. Taken together, these data support a role for the microbiota in regulating gut-brain communication and eating behavior. Bacteria-originating inflammation may play a key role in impairment of diet-driven satiety and the development of hyperphagia.

scholarly journals Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

2018 ◽  
Vol 115 (17) ◽  
pp. E4091-E4100 ◽  
Author(s):  
K. Kalafatakis ◽  
G. M. Russell ◽  
C. J. Harmer ◽  
M. R. Munafo ◽  
N. Marchant ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Memory Performance ◽  
Synaptic Activity ◽  
Human Cognition ◽  
Cognitive Responses ◽  
Hormone Pulses ◽  
And Behavior ◽  
Ultradian Rhythmicity ◽  
The Brain

Glucocorticoids (GCs) are secreted in an ultradian, pulsatile pattern that emerges from delays in the feedforward-feedback interaction between the anterior pituitary and adrenal glands. Dynamic oscillations of GCs are critical for normal cognitive and metabolic function in the rat and have been shown to modulate the pattern of GC-sensitive gene expression, modify synaptic activity, and maintain stress responsiveness. In man, current cortisol replacement therapy does not reproduce physiological hormone pulses and is associated with psychopathological symptoms, especially apathy and attenuated motivation in engaging with daily activities. In this work, we tested the hypothesis that the pattern of GC dynamics in the brain is of crucial importance for regulating cognitive and behavioral processes. We provide evidence that exactly the same dose of cortisol administered in different patterns alters the neural processing underlying the response to emotional stimulation, the accuracy in recognition and attentional bias toward/away from emotional faces, the quality of sleep, and the working memory performance of healthy male volunteers. These data indicate that the pattern of the GC rhythm differentially impacts human cognition and behavior under physiological, nonstressful conditions and has major implications for the improvement of cortisol replacement therapy.

Introduction

2019 ◽  
pp. xx-8
Author(s):  
Giovanni Stanghellini ◽  
Matthew Broome ◽  
Anthony Vincent Fernandez ◽  
Paolo Fusar-Poli ◽  
Andrea Raballo ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Subjective Experiences ◽  
Primary Focus ◽  
And Behavior ◽  
The Relationship ◽  
The Brain ◽  
Psychiatric Study ◽  
Phenomenological Psychopathology

This introductory chapter discusses the primary focus of psychiatry and how phenomenological psychopathology in particular serves as the basis for psychiatry. It argues that psychiatry is not only a biological discipline. It must maintain an intense concern with the quality of patients’ experiences by focusing on the “psyche” and not just the brain, which is of interest to psychiatry only insofar as it helps one better understand the relevant psychic phenomena. Thus, one must investigate the relationship between these subjective experiences, the brain, and the way we classify psychiatric disorders. In this light, phenomenological psychopathology becomes increasingly central to these discussions. At present, the psychiatric study of psyche and subjectivity is defined mainly by changes in experience and behavior. Therefore, psychopathology, the discipline that assesses and makes sense of the suffering psyche, is at the heart of psychiatry.

scholarly journals Food and the gut: relevance to some of the autisms

2017 ◽  
Vol 76 (4) ◽  
pp. 478-483
Author(s):  
Paul Whiteley
Keyword(s):  
Quality Of Life ◽  
Autistic Traits ◽  
Autism Spectrum ◽  
Gi Tract ◽  
Social Communication Skills ◽  
Bidirectional Associations ◽  
Core Symptoms ◽  
The Brain

Complex, diverse and rarely appearing without comorbidity, the autism spectrum disorders continue to be a source of research interest. With core symptoms variably impacting on social communication skills, the traditional focus of many research efforts has centred on the brain and how genetic and environmental processes impact on brain structure, function and/or connectivity to account for various behavioural presentations. Alongside emerging ideas on autistic traits being present in various clinical states, the autisms, and the overrepresentation of several comorbid conditions impacting on quality of life, other research avenues have opened up. The central role of the brain in relation to autism may be at least partially influenced by the functions of other organs. The gastrointestinal (GI) tract represents an important biological system pertinent to at least some autism. The notion of a gut–brain–behaviour axis has garnered support from various findings: an overrepresentation of functional and pathological bowel states, bowel and behavioural findings showing bidirectional associations, a possible relationship between diet, GI function and autism and recently, greater focus on aspects of the GI tract such as the collected gut microbiota in relation to autism. Gaps remain in our knowledge of the functions of the GI tract linked to autism, specifically regarding mechanisms of action onward to behavioural presentation. Set however within the context of diversity in the presentation of autism, science appears to be moving towards defining important GI-related autism phenotypes with the possibility of promising dietary and other related intervention options onward to improving quality of life.

scholarly journals Molecular Mechanisms of Cancer-Induced Sleep Disruption

2019 ◽  
Author(s):  
William H. Walker II ◽  
Jeremy C. Borniger
Keyword(s):  
Molecular Mechanisms ◽  
Systemic Disease ◽  
Sleep Disruption ◽  
Poor Sleep ◽  
Therapeutic Approaches ◽  
Treatment Regimens ◽  
Patients With Cancer ◽  
And Behavior ◽  
The Brain

Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of systemic disease, including depression, metabolic syndrome, and cognitive impairments. Further evidence has accumulated suggesting a role for sleep in cancer initiation and progression (primarily breast cancer). Indeed, patients with cancer and cancer survivors frequently experience poor sleep, manifested as insomnia, circadian misalignment, hypersomnia, somnolence syndrome, hot flushes, and nightmares. These problems are associated with a reduction in patients’ quality of life and increased mortality. Due to the heterogeneity among cancers, treatment regimens, patient populations, and lifestyle factors, the etiology of cancer-induced sleep disruption is largely unknown. Here, we discuss recent advances in understanding the pathways linking cancer and the brain and how this leads to altered sleep patterns. We describe a conceptual framework where tumors disrupt normal homeostatic processes, resulting in aberrant changes in physiology and behavior that are detrimental to health. Finally, we discuss how this knowledge can be leveraged to develop novel therapeutic approaches for cancer-associated sleep disruption, with special emphasis on host-tumor interactions.

Review of Self-regulation of the Brain and Behavior.

1985 ◽  
Vol 30 (12) ◽  
pp. 999-999
Author(s):  
Gerald S. Wasserman
Keyword(s):  
Self Regulation ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain

Classification of methods for generating pseudo-CT from MRI images for MRI-alone RT

2017 ◽  
Vol 1 (3) ◽  
pp. 54
Author(s):  
BOUKELLOUZ Wafa ◽  
MOUSSAOUI Abdelouahab
Keyword(s):  
Performance Metrics ◽  
Radiation Treatment ◽  
Hybrid Methods ◽  
Dose Calculation ◽  
Absolute Error ◽  
Ct Images ◽  
General Technique ◽  
Therapy Field ◽  
The Brain

Background: Since the last decades, research have been oriented towards an MRI-alone radiation treatment planning (RTP), where MRI is used as the primary modality for imaging, delineation and dose calculation by assigning to it the needed electron density (ED) information. The idea is to create a computed tomography (CT) image or so-called pseudo-CT from MRI data. In this paper, we review and classify methods for creating pseudo-CT images from MRI data. Each class of methods is explained and a group of works in the literature is presented in detail with statistical performance. We discuss the advantages, drawbacks and limitations of each class of methods. Methods: We classified most recent works in deriving a pseudo-CT from MR images into four classes: segmentation-based, intensity-based, atlas-based and hybrid methods. We based the classification on the general technique applied in the approach. Results: Most of research focused on the brain and the pelvis regions. The mean absolute error (MAE) ranged from 80 HU to 137 HU and from 36.4 HU to 74 HU for the brain and pelvis, respectively. In addition, an interest in the Dixon MR sequence is increasing since it has the advantage of producing multiple contrast images with a single acquisition. Conclusion: Radiation therapy field is emerging towards the generalization of MRI-only RT thanks to the advances in techniques for generation of pseudo-CT images. However, a benchmark is needed to set in common performance metrics to assess the quality of the generated pseudo-CT and judge on the efficiency of a certain method.

Korelasi kreativitas dan motivasi kerja guru terhadap peningkatan mutu pembelajaran

2016 ◽  
Vol 1 (1) ◽  
pp. 51
Author(s):  
Muh Nashiruddin ◽  
Anharurrohman El Muhammadi
Keyword(s):  
Religious Education ◽  
Work Motivation ◽  
Sampling Technique ◽  
Islamic Education ◽  
Learning Improvement ◽  
Average Value ◽  
Teacher Creativity ◽  
Teacher Work ◽  
And Behavior

Penelitian ini bertujuan untuk mengetahui korelasi antara: 1) kreativitas guru PAI terhadap peningkatan mutu pembelajaran Pendidikan Agama dan Budi Pekerti , 2) motivasi kerja guru PAI terhadap peningkatan mutu pembelajaran Pendidikan Agama dan Budi Pekerti , dan 3) kreativitas dan motivasi kerja guru terhadap peningkatan mutu pembelajaran Pendidikan Agama dan Budi. Penelitian ini menggunakan metode deskripsi korelasional dengan melibatkan 33 orang sampel yang dipilih secara dengan metode sensus. Teknik pengumpulan data dilakukan dengan angket/kuesioner. Teknikanalisis data diawali dengan uji prasyarat yaitu uji normalitas dan linieritas. Uji hipotesis menggunakanuji regresi sederhana danuji regresi ganda. Hasil penelitian menunjukkan ; 1) Kreativitas guru berpengaruh terhadap peningkatan mutu pembelajaran Pendidikan Agama Islam dan Budi Pekerti. 2) motivasi kerja guru berpengaruh terhadap peningkatan mutu pembelajaran Pendidikan Agama Islam dan Budi Pekerti. 3) kreativitas guru dan motivasi kerja guru secara bersama-sama atau simultan berpengaruh terhadap mutu pembelajaran. Hasil analisis juga menunjukkan bahwa rata-rata nilai dari ketiga variabel tersebut hanya dapat dimasukkan dalam kategori sedang, sehingga untuk meningkatkan kinerja guru dalam mengajar perlu diperhatikan faktor-faktor lain seperti: gaji, jaminan kerja, jaminan hari tua, penghargaan atas prestasi kerja, dan sebagainya. Kata kunci: kreativitas, motivasi, mutupembelajaran Abstract [The Relationship Between Teachers’ Creativity and Motivation Toward Learning Improvement]. This research aim at determine the correlation between the creativity of teachers on the improvement of learning quality of religious education and behavior, the work motivation of teachers on the improvement of learning quality of religious education and behavior, and the creativity and the work motivation of eachers on the improvement of learning quality of religious education and behavior. This research employed a method of correlation description with 33 Islamic education teacher were selected as sample by means of census sampling. Technique of collecting data employed questionnaire. Technique of data analysis began with prerequisite of normality and linearity. Hypothesis used test of simple regression and double regression.The study revealed that teacher creativity affects on the improvement of learning quality of religious education and behavior, as well as teacher work motivation affects on the improvement of learning quality of religious education and behavior. Futhermore, analysis show that teacher creativity as well as teacher work motivation affects simultaneously on the learning quality of Islamic Education. In conclusion, the average value of those three variables may be only included into medium category. Thus, to increase teacher performance, it needs other factors, such as; salary, job guarantee, pension, appreciation of work achievement, etc. Keywords: Creativity, Motivation, Learning Quality

Neuro-Optometric Treatment of Complications from a Cerebellar Astrocytoma

2020 ◽  
pp. 304-312
Keyword(s):  
Visual System ◽  
Common Site ◽  
Us Army ◽  
Cranial Nerve Palsies ◽  
Pilocytic Astrocytomas ◽  
The Us ◽  
Extent Of Damage ◽  
Functional Components ◽  
The Brain

Background: Insult to the brain, whether from trauma or other etiologies, can have a devastating effect on an individual. Symptoms can be many and varied, depending on the location and extent of damage. This presentation can be a challenge to the optometrist charged with treating the sequelae of this event as multiple functional components of the visual system can be affected. Case Report: This paper describes the diagnosis and subsequent ophthalmic management of an acquired brain injury in a 22 year old male on active duty in the US Army. After developing acute neurological symptoms, the patient was diagnosed with a pilocytic astrocytoma of the cerebellum. Emergent neurosurgery to treat the neoplasm resulted in iatrogenic cranial nerve palsies and a hemispheric syndrome. Over the next 18 months, he was managed by a series of providers, including a strabismus surgeon, until presenting to our clinic. Lenses, prism, and in-office and out-of-office neurooptometric rehabilitation therapy were utilized to improve his functioning and make progress towards his goals. Conclusions: Pilocytic astrocytomas are the most common primary brain tumors, and the vast majority are benign with excellent surgical prognosis. Although the most common site is the cerebellum, the visual pathway is also frequently affected. If the eye or visual system is affected, optometrists have the ability to drastically improve quality of life with neuro-optometric rehabilitation.

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