Effect of indomethacin on papillary solute concentration in the potassium-deficient rat

1986 ◽  
Vol 250 (1) ◽  
pp. F97-F102
Author(s):  
Y. Takamitsu ◽  
R. T. Kunau
Keyword(s):  
Solute Transport ◽  
Plasma Flow ◽  
Solute Concentration ◽  
Potassium Deficiency ◽  
Base Line ◽  
Experimental Setting ◽  
Solute Addition ◽  
Multiple Factors

Administration of indomethacin or meclofenamate to normal rats increases renal papillary solute concentration primarily by enhancing solute addition. A reduction in papillary solute concentration is characteristic of potassium deficiency. Of the multiple factors probably responsible for this reduction, several can be influenced by indomethacin or meclofenamate. The present study examined the effect of indomethacin on papillary solute concentration in the potassium-deficient rat. Indomethacin increased papillary solute concentration in normal but not potassium-deficient rats when studied in the conscious hydropenic state. Since indomethacin could increase papillary plasma flow in the potassium-deficient rat, potentially negating any enhancement of solute transport into the papilla, papillary plasma flow and papillary Cl concentration were determined in anesthetized surgically manipulated rats. Base-line papillary Cl concentrations were reduced in this setting. Indomethacin increased papillary plasma flow only in potassium-deficient rats but increased papillary Cl concentration equivalently in normal and potassium-deficient rats. The ability of indomethacin to increase papillary solute concentration in the potassium-deficient rat seemingly depends upon the experimental setting.

scholarly journals Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device

Micromachines ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 839
Author(s):  
Michael Miles ◽  
Biddut Bhattacharjee ◽  
Nakul Sridhar ◽  
Apresio Kefin Fajrial ◽  
Kerri Ball ◽  
...  
Keyword(s):  
Solute Transport ◽  
Concentration Profile ◽  
Microfluidic Channel ◽  
Region Of Interest ◽  
Solute Concentration ◽  
Cross Sectional ◽  
Driven Systems ◽  
Solute Profile ◽  
Dynamics Simulations ◽  
Pressure Driven

In recent years, microfluidic devices have become an important tool for use in lab-on-a-chip processes, including drug screening and delivery, bio-chemical reactions, sample preparation and analysis, chemotaxis, and separations. In many such processes, a flat cross-sectional concentration profile with uniform flow velocity across the channel is desired to achieve controlled and precise solute transport. This is often accommodated by the use of electroosmotic flow, however, it is not an ideal for many applications, particularly biomicrofluidics. Meanwhile, pressure-driven systems generally exhibit a parabolic cross-sectional concentration profile through a channel. We draw inspiration from finite element fluid dynamics simulations to design and fabricate a practical solution to achieving a flat solute concentration profile in a two-dimensional (2D) microfluidic channel. The channel possesses geometric features to passively flatten the solute profile before entering the defined region of interest in the microfluidic channel. An obviously flat solute profile across the channel is demonstrated in both simulation and experiment. This technology readily lends itself to many microfluidic applications which require controlled solute transport in pressure driven systems.

scholarly journals Direct characterization of solute transport in unsaturated porous media using fast X-ray synchrotron microtomography

2020 ◽  
Vol 117 (38) ◽  
pp. 23443-23449 ◽  
Author(s):  
Sharul Hasan ◽  
Vahid Niasar ◽  
Nikolaos K. Karadimitriou ◽  
Jose R. A. Godinho ◽  
Nghia T. Vo ◽  
...  
Keyword(s):  
Solute Transport ◽  
High Speed ◽  
Three Dimensional ◽  
Concentration Field ◽  
Solute Concentration ◽  
Breakthrough Curves ◽  
Pore Scale ◽  
X Ray ◽  
Long Tails ◽  
Computed Microtomography

Solute transport in unsaturated porous materials is a complex process, which exhibits some distinct features differentiating it from transport under saturated conditions. These features emerge mostly due to the different transport time scales at different regions of the flow network, which can be classified into flowing and stagnant regions, predominantly controlled by advection and diffusion, respectively. Under unsaturated conditions, the solute breakthrough curves show early arrivals and very long tails, and this type of transport is usually referred to as non-Fickian. This study directly characterizes transport through an unsaturated porous medium in three spatial dimensions at the resolution of 3.25 μm and the time resolution of 6 s. Using advanced high-speed, high-spatial resolution, synchrotron-based X-ray computed microtomography (sCT) we obtained detailed information on solute transport through a glass bead packing at different saturations. A large experimental dataset (>50 TB) was produced, while imaging the evolution of the solute concentration with time at any given point within the field of view. We show that the fluids’ topology has a critical signature on the non-Fickian transport, which yet needs to be included in the Darcy-scale solute transport models. The three-dimensional (3D) results show that the fully mixing assumption at the pore scale is not valid, and even after injection of several pore volumes the concentration field at the pore scale is not uniform. Additionally, results demonstrate that dispersivity is changing with saturation, being twofold larger at the saturation of 0.52 compared to that at the fully saturated domain.

Changes in relaxation rate with diaphragmatic fatigue in humans

1983 ◽  
Vol 54 (5) ◽  
pp. 1353-1360 ◽  
Author(s):  
S. A. Esau ◽  
F. Bellemare ◽  
A. Grassino ◽  
S. Permutt ◽  
C. Roussos ◽  
...  
Keyword(s):  
Relaxation Rate ◽  
Time Course ◽  
Low Frequency ◽  
Base Line ◽  
Experimental Setting ◽  
Inspiratory Time ◽  
Transdiaphragmatic Pressure ◽  
Diaphragmatic Fatigue ◽  
Tension Time ◽  
Male Subjects

Maximum relaxation rate (MRR) and the time constant of relaxation (tau) of transdiaphragmatic pressure (Pdi) was measured in four male subjects and compared with the high-to-low frequency ratio (H/L) of the diaphragmatic electromyogram (EMG) as a predictor of diaphragmatic fatigue. Pdi and inspiratory time-to-total breath duration ratios (TI/TT) were varied, and TT and tidal volume were held constant; inspiratory resistances were used to increase Pdi. Studies were performed at various tension-time indices (TTdi = Pdi/Pdimax X TI/TT). Base-line MRR/Pdi was 0.0100 +/- 0.0004 (SE) ms-1, and baseline tau was 53.2 +/- 3.2 ms. At TTdi greater than 0.20, MRR and H/L decreased and tau increased, with maximum changes at the highest TTdi. At TTdi less than 0.20, there was no change in H/L, MRR, or tau. The time course of changes in H/L correlated with those of MRR and tau under fatiguing conditions. In this experimental setting, change in relaxation rate was as useful a predictor of diaphragmatic fatigue as fall in H/L of the diaphragmatic EMG.

scholarly journals Solute transport by suspended buoyant particles

2021 ◽  
Vol 249 ◽  
pp. 09002
Author(s):  
Iván Colecchio ◽  
Natalia Arze ◽  
Georgina Flores ◽  
Ana Quijandria ◽  
Alejandro Boschan
Keyword(s):  
Solute Transport ◽  
Solid Fraction ◽  
Light Transmission ◽  
Solute Concentration ◽  
Suspended Particles ◽  
Sharp Interface ◽  
Transmission Technique ◽  
Fingering Instability ◽  
Mass Discharge ◽  
Hele Shaw Cell

The transport of a colouring solute, driven by the buoyant displacement of microscopic suspended particles, and in the absence of net flow, is studied experimentally in a Hele Shaw cell. Initially, a sharp interface between a transparent fluid without particles and an underlying coloured suspension is obtained. From this situation, the suspended particles rise, carrying the solute in the form of a fingering instability across the interface, where a light transmission technique is used to measure the local solute concentration. This one attains an asymptotic value that increases with the solid fraction ϕ of suspended particles, and decreases with the distance to the interface. The solute mass discharge also increases with ϕ, always being relatively small (< 3%). The onset and development of the instability as the mechanism driving the transport of the solute is discussed.

scholarly journals Solute Transport in the Element of Fractured Porous Medium with an Inhomogeneous Porous Block

Symmetry ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1028
Author(s):  
Bakhtiyor Khuzhayorov ◽  
Jabbor Mustofoqulov ◽  
Gafurjan Ibragimov ◽  
Fadzilah Md Ali ◽  
Bekzodjon Fayziev
Keyword(s):  
Porous Medium ◽  
Solute Transport ◽  
Solute Concentration ◽  
Graphical Form ◽  
Asymmetric Distribution ◽  
Nonlinear Kinetics ◽  
Kinetics Of Adsorption ◽  
Fractured Porous Medium ◽  
Slowing Down ◽  
Porous Block

In this paper, the problem of solute transport in a fractured-porous medium taking into account the non-equilibrium adsorption kinetic is studied. The solute transport in fractured-porous medium consisting of two fractures and a porous block between them located in a symmetric form is considered. The problem is then solved numerically by using the finite difference method. Based on the numerical results, the solute concentration and adsorption fields in the fractures and porous blocks are shown in graphical form. The effect of adsorption on the solute transport in a fractured-porous medium is then analyzed. In the case of different parameters in two zones, asymmetric distribution of the solute concentration and adsorption is obtained. The nonlinear kinetics of adsorption leads to an increase in the adsorption effects, conversely slowing down the rate of the distribution of concentration of the solute in the fluid.

scholarly journals Groundwater Solute Transport Modeling:Effects of Transport and Fate

2019 ◽  
Vol 8 (2) ◽  
pp. 3541-3544
Keyword(s):  
Analytical Solution ◽  
Solute Transport ◽  
Test Problem ◽  
Transport Model ◽  
Sorption Process ◽  
Solute Concentration ◽  
Matlab Software ◽  
Advection Dispersion ◽  
Saturated Media ◽  
Fate And Transport Modeling

In this paper, the solution of the advection-dispersion equation with different sorption values is used for the prediction of solute concentration in groundwater. Sorption process in the groundwater is complex, due to increasing the groundwater pollution the effect of different chemical transport plotted. The fate and sorption process of different chemical different degradation constant. We used the analytical solution to evaluate the transport phenomenon and analysis of the chemical dissolved in groundwater. The solute transport model simulated with the analytical solution and final result obtained using MATLAB software. The solution of a test problem based on the sequential degradation of the different chemical in the groundwater. This solution of equilibrium and rate of sorption dynamics of processes is imperative for accurate fate and transport modeling. The present study shows the effects of advection, dispersion/diffusion, and sorption equation on the saturated media of soil. MATLAB software used for analyzing the solution of groundwater and showing the different case taking care of saturated aquifer and with different void ratio of soil its shows that the soil parameter is also impotent parameter and its effect can see in plot between concertation vs time. The solute transport model simulated with the analytical solution and final result obtained using MATLAB software. The solution of a test problem based on the sequential degradation of the different chemical in the groundwater. This study compares the solute concentration with respect to distance and its different hydraulics conductivity of dense sad and lose.

scholarly journals Solute Transport Measurements in Different Soil Types using Time Domain Reflectometry

2001 ◽  
Vol 32 (2) ◽  
pp. 99-114 ◽  
Author(s):  
Magnus Persson
Keyword(s):  
Solute Transport ◽  
Time Domain ◽  
Calibration Method ◽  
Calibration Procedure ◽  
Solute Concentration ◽  
Time Domain Reflectometry ◽  
Soil Types ◽  
Undisturbed Soil ◽  
Transport Measurements ◽  
Calibration Methods

During recent years, time domain reflectometry (TDR) has proved to be a valuable tool for both water content (θ) and bulk electrical conductivity (σa) measurements. To allow resident solute concentration (Cr) measurements, a calibration procedure is necessary for the relationship between σa and Cr. Two main calibration approaches exist. Direct calibration allows for Cr measurements with varying θ, while the indirect calibration method is used for conditions with constant θ. In this paper, three methods of achieving direct calibration parameters are presented and evaluated in three different soil types. Calibrations are made in both disturbed and undisturbed soil columns as well as in the field. It was shown that there were only small differences between calibration methods in homogeneous sand. In other soils, choosing the correct calibration is important. In clay soils solute transport measurements are difficult to take under conditions with varying θ, therefore it is suggested that only the indirect calibration approach should be used. When using TDR it is important to be aware of the accuracy of the TDR system in order to interpret data correctly. Some error sources are thus also briefly discussed.

scholarly journals On the Efficacy of Water Transport in Leaves. A Coupled Xylem-Phloem Model of Water and Solute Transport

2021 ◽  
Vol 12 ◽  
Author(s):  
Gen Sakurai ◽  
Stanley J. Miklavcic
Keyword(s):  
Solute Transport ◽  
Water Transport ◽  
Vascular System ◽  
Leaf Shape ◽  
Solute Concentration ◽  
Second Order ◽  
Hydraulic Pressure ◽  
Sucrose Transport ◽  
Main Vein ◽  
Water And Solute Transport

In this paper, we present and use a coupled xylem/phloem mathematical model of passive water and solute transport through a reticulated vascular system of an angiosperm leaf. We evaluate the effect of leaf width-to-length proportion and orientation of second-order veins on the indexes of water transport into the leaves and sucrose transport from the leaves. We found that the most important factor affecting the steady-state pattern of hydraulic pressure distribution in the xylem and solute concentration in the phloem was leaf shape: narrower/longer leaves are less efficient in convecting xylem water and phloem solutes than wider/shorter leaves under all conditions studied. The degree of efficiency of transport is greatly influenced by the orientation of second-order veins relative to the main vein for all leaf proportions considered; the dependence is non-monotonic with efficiency maximized when the angle is approximately 45° to the main vein, although the angle of peak efficiency depends on other conditions. The sensitivity of transport efficiency to vein orientation increases with increasing vein conductivity. The vein angle at which efficiency is maximum tended to be smaller (relative to the main vein direction) in narrower leaves. The results may help to explain, or at least contribute to our understanding of, the evolution of parallel vein systems in monocot leaves.

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