Some physiological changes accompanying tetany induced by exposure to hot, wet conditions

1961 ◽  
Vol 16 (3) ◽  
pp. 409-412 ◽  
Author(s):  
P. F. Iampietro ◽  
M. Mager ◽  
E. B. Green

Twenty-seven men were exposed to various hot, wet conditions for a total of 87 experiments. Determinations were made of rectal temperature, heart rate, blood pH, and the concentrations of CO2, calcium, inorganic phosphorus, and protein in plasma. Symptoms ranging from tingling of extremities to carpopedal spasms were observed. The frequency and severity of symptoms were apparently not related to the absolute change in any of the blood constituents but rather to the rate of change. Submitted on October 31, 1960

1967 ◽  
Vol 45 (1) ◽  
pp. 1-12 ◽  
Author(s):  
E. Arnold Higgins ◽  
P. F. Iampietro

Forty-five dogs were exposed to nine different environmental conditions (five dogs per condition) consisting of three ambient temperatures (100 °F, 110 °F, and 120 °F) and relative humidities (30%, 60%, and 90%). After an initial control period of 30 minutes (ambient 21–24 °C) the animals were exposed to one of the experimental conditions for [Formula: see text] hours or until rectal temperature reached 42.0 °C. Under combined conditions of high temperature and humidity the non-biothermally involved consequences of panting became evidenced by an increase in blood pH, a decrease in blood CO2 (as a result of the thermally forced hyperventilation), and an increase in blood O2. The more severe the heat load (combined temperature and humidity) the greater was the rate of elevation of rectal temperature over control levels. It was evident that both relative humidity and ambient temperature were drives for increasing respiratory rate. It was also evident that increased humidity as well as increased temperature facilitated the rate of change of rectal temperature, blood pH, and blood CO2 and O2 concentrations. It appears possible that only under heat loads in which rectal temperature can be maintained at control levels by panting can the shift in acid–base balance be avoided.


Author(s):  
G. Kumar Roonwal ◽  
B. P. Shukla ◽  
S. Shukla ◽  
R. Jain

A study was planned to evaluate the efficacy of Levobupivacaine as an epidural analgesia, with and without Fentanyl Citrate and to evaluate the clinico-physiological changes. The study was conducted on 12 healthy cow calves, weighing between 50 to 70 kg. The animals were divided into two groups of six animals each. The animals of group 1 received Levobupivacaine (@ 0.8 mg/kg body wt.) in sacrococcygeal space, while animals of group 2 received Levobupivacaine (@ 0.8 mg/ kg. body wt.) and Fentanyl Citrate (@ 2 μg/kg body wt.) simultaneously in the sacrococcygeal space. The clinico-physiological changes were recorded at different time intervals in both treatments. The animals of treatment II showed longer duration and good depth as compared to animals of treatment I. The recovery was smooth in both groups. Rectal temperature, respiration rate and heart rate showed non-significant decrease in their values in both the groups.


Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Juan M. Vázquez-García ◽  
Gregorio Álvarez-Fuentes ◽  
Héctor O. Orozco-Gregorio ◽  
Juan C. García-López ◽  
Milagros González-Hernández ◽  
...  

We tested whether maternal energy supplementation during the last third of gestation improves birth weight, neonatal wellbeing, and mother–young bonding. Thirty-six pregnant French Alpine goats were randomly allocated among three nutritional treatments for the last third of pregnancy: (i) Control, fed alfalfa (T-0; n = 12); (ii) alfalfa + 150 g/head daily energy concentrate (T-150; n = 12); (iii) alfalfa + 300 g/head daily energy concentrate (T-300; n = 12). At birth, we collected progeny data on birth weight, birth type, sex, rectal temperature, heart rate, respiratory rate, time to standing, time to udder connection, and time to first feeding. For the dams, we collected data on the duration of labor, time to clean the progeny, and time to allow first suckling. At birth, body weight, rectal temperature, heart rate, and the respiratory rate did not differ among treatments (p > 0.05). In the dams, labor duration was not affected by the treatments (p > 0.05). The T-150 dams were faster to clean the newborn and allow first suckling (p < 0.05). The T-150 progeny were faster to stand and the T-300 progeny were faster to connect to the udder (p < 0.05). We conclude that energy supplementation of the dam during the last third of gestation does not affect the birth weight of the progeny, but enhances the mother–young bonding.


2021 ◽  
Vol 121 (4) ◽  
pp. 1207-1218
Author(s):  
Josh T. Arnold ◽  
Stephen J. Bailey ◽  
Simon G. Hodder ◽  
Naoto Fujii ◽  
Alex B. Lloyd

Abstract Purpose This study assessed the impact of normobaric hypoxia and acute nitrate ingestion on shivering thermogenesis, cutaneous vascular control, and thermometrics in response to cold stress. Method Eleven male volunteers underwent passive cooling at 10 °C air temperature across four conditions: (1) normoxia with placebo ingestion, (2) hypoxia (0.130 FiO2) with placebo ingestion, (3) normoxia with 13 mmol nitrate ingestion, and (4) hypoxia with nitrate ingestion. Physiological metrics were assessed as a rate of change over 45 min to determine heat loss, and at the point of shivering onset to determine the thermogenic thermoeffector threshold. Result Independently, hypoxia expedited shivering onset time (p = 0.05) due to a faster cooling rate as opposed to a change in central thermoeffector thresholds. Specifically, compared to normoxia, hypoxia increased skin blood flow (p = 0.02), leading to an increased core-cooling rate (p = 0.04) and delta change in rectal temperature (p = 0.03) over 45 min, yet the same rectal temperature at shivering onset (p = 0.9). Independently, nitrate ingestion delayed shivering onset time (p = 0.01), mediated by a change in central thermoeffector thresholds, independent of changes in peripheral heat exchange. Specifically, compared to placebo ingestion, no difference was observed in skin blood flow (p = 0.5), core-cooling rate (p = 0.5), or delta change in rectal temperature (p = 0.7) over 45 min, while nitrate reduced rectal temperature at shivering onset (p = 0.04). No interaction was observed between hypoxia and nitrate ingestion. Conclusion These data improve our understanding of how hypoxia and nitric oxide modulate cold thermoregulation.


2016 ◽  
Vol 45 ◽  
pp. 39-45 ◽  
Author(s):  
Maria Soroko ◽  
Kevin Howell ◽  
Anna Zwyrzykowska ◽  
Krzysztof Dudek ◽  
Paulina Zielińska ◽  
...  

Author(s):  
G. Piccione ◽  
S. Casella ◽  
P. Pennisi ◽  
C. Giannetto ◽  
A. Costa ◽  
...  

Rectal temperature, heart and respiratory rates, and the course of some blood parameters were monitored in calves during perinatal and neonatal periods. The study was carried out on eight Limousine calves. From all subjects, rectal temperature, heart rate, and respiratory rate were measured. Blood samples were taken at the same hour (9am) from the external jugular vein, and then centrifuged and stored until analyses. By means of an UV spectrophotometer, the following blood parameters were assessed for each subject: total protein, total cholesterol, triglycerides, glucose, non-esterified fatty acids (NEFA), urea, creatinine, cholinesterase, lactate dehydrogenase (LDH), hydroxybutirate, glutamate pyruvate transaminases (GPT), glutamate oxalacetate transaminases (GOT), direct and total bilirubin, magnesium, iron, potassium, phosphorus, chloride and sodium. The results showed a significant effect of days of life (P<0.05) only on total cholesterol, creatinine and GOT during the first week of life and a significant effect of days of life on rectal temperature, heart rate, respiratory rate, total cholesterol, NEFA, creatinina, and GOT during the first month of life. A correlation among individual values for postnatal age (days of life) and heart rate in calves during the first month of life was observed. In conclusion, modifications of studied parameters could be attributed to functional development of calves in neonatal period and contribute to the knowledge of adaptation processes in calf during the first week and the first month of life resulting useful for the diagnosis and treatment of any neonatal diseases.


1959 ◽  
Vol 52 (3) ◽  
pp. 296-304 ◽  
Author(s):  
W. Bianca

1. Three calves were individually exposed in a climatic room to an environment of 45° C. dry-bulb and 28° C. wet-bulb temperature for 21 successive days up to 5 hr. each day.2. In the 21-day period, mostly during the first half of it, the following changes in the physiological reactions of the animals were observed: progressive reductions in rectal temperature, in heart rate and in respiratory rate with a change of breathing from a laboured to a less laboured type.3. It was suggested that a decrease in metabolic heat production might play a part in the observed acclimatization.


2016 ◽  
Vol 1 (1) ◽  
pp. 709-718
Author(s):  
Muhammad Junaidi ◽  
Cut Intan Novita ◽  
Dzarnisa Dzarnisa

Abstrak. Suatu penelitian telah dilaksanakan di desa Suka Mulya, Kecamatan Lembah Seulawah, Kabupaten Aceh Besar. Penelitian berlangsung dari bulan November sampai Desember 2016. Penelitian ini bertujuan untuk mengetahui kondisi faali sapi Peranakan Fries Holland (PFH) di peternakan rakyat desa Suka Mulya Kecamatan Lembah Seulawah Kabupaten Aceh Besar. Metode penelitian ini bersifat deskriptif analitis dengan mengunakan metode survei dan observasi langsung ke peternak dan sapi perah PFH. Lokasi penelitian ditentukan secara purposive sampling. Penetapan responden ditentukan mengunakan metode random sampling, jumlah responden sebanyak 10 peternak yang memelihara sapi perah. Materi yang digunakan dalam penelitian ini adalah 13 ekor sapi perah PFH. Parameter penelitian meliputi frekuensi pernafasan, denyut jantung dan suhu rektal. Data pendukung yang diperlukan dalam penelitian ini meliputi suhu dan kelembaban kandang, manajemen pemeliharaan sapi perah, kesehatan ternak, dan karakteristik peternak/responden. Hasil penelitian menunjukkan bahwa rataan frekuensi pernafasan sapi PFH adalah28,03 ± 0,63 kali/menit, frekuensi denyut jantung 68,92 ± 0,71  kali/menit dan suhu rektal 36,57 ± 0,55 °C. Dari hasil penelitian ini dapat disimpulkan bahwa kondisi faali/fisiologis ternak perah yang ada di peternakan Rakyat Desa Suka Mulya dalam keadaan baik/normal. Study on Condition of Dairy Cattle Breed Physiologic Fries Holland (PFH) Livestock in the Village People Prefer Mulya Seulawah Valley District District of Aceh Aceh Province Abstract. This study aimed to determine the effect of dairy cattle rearing system to physiological conditions in the district of Aceh Besar district seulawah Valley. The method used is descriptive analysis using the method of survey and direct observation to farmers and dairy cows PFH measurement of physiological conditions/physiological. This research by using two stages, the first stage is the observation field conditions and the second stage is the collection of data. Observation phase field conditions to determine the location of the study and the sample size, the data collection phase aims to obtain primary data and secondary data. The research location determined by purposive Desa Suka Mulya. Sampling of cattle that took cattle PFH to measure physiologic conditions/physiological. The number of samples taken in this study there are few dairy cows. The data collected from these samples include respiratory rate, heart rate, rectal temperature. Results of this study was the frequency of breathing 28,03 ± 0,63 times per minute, heart rate 68,92 ± 0,71 times per minute, a rectal temperature of 36,57 ± 0,55 times per minute. From the results of this research can be concluded that the physiologic conditions/physiological dairy cattle farm in the village of Suka Mulya People in a good state/normal


2020 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Eerdunbagena Ning ◽  
Zhijun Wang

Objective: To assess the safety, feasibility and eluting efficiency of intrahepatic arterial delivery of sorafenib on normal liver tissue of rabbit. Methods: 24 New Zealand rabbits were randomly divided into three groups: group Ⅰ (Lipiodol-sorafenid), group Ⅱ (Lipiodol) and group Ⅲ (Sorafenib). Group Ⅰ and Ⅱ were treated by transcatheter selective hepatic arterial embolization with emulsions of lipiodol and sorafenib or with only lipiodol, while group Ⅲ was given hepatic arterial infusion with sorafenib. Sorafenib concentration in plasma was determined by HPLC (high performance liquid chromatography) in 0 min, 20 min, 1h, 2h, 4h, 8h, 16h, 32h and 48h respectively. The breathing rate, heart rate, rectal temperature and body weight were measured, as well the blood routine test and the function of liver, kidney, and heart. Two animals of each group were respectively killed in the 3rd day, 1st, 3rd and 6th week after treatment. Histopathologic study was done to liver, heart, kinney, lung, brain, gall bladder and intestine. Result: ① The peak sorafenib concentration (Cmax)and AUC(Area under curve) in plasma in groupⅠwas 2.46±0.101μg/ml and 945.72 ± 52.3 μg/mL.min respectively, while in group Ⅲ which was 3.78±0.180 ug/ml and 546.98±21.1μg/mL.min. Compared with groupⅢ, the Cmax and AUC of groupⅠhad a significant statistics difference (p<0.05). ② The breathing rate, heart rate, rectal temperature and AST/ALT,WBC,NEU% of group Ⅰand groupⅢhas a significant statistics difference(p<0.05) in the 3rd day. ③CK ,CK-MB, DB, Cr,BUN,RBC,PLT in plasma did not change in all group.④Local necrosis was seen in group Ⅰand group Ⅱin the 3rd day and 1st week, but they did not seem to be different. Group Ⅲ showed no necrosis. Granulation tissue with bile duty, portal vein and microfossils hyperplasia were seen in local necrosis area in the 3rd week. No pathological changes were found in brain, heart, kidney, intestine and gallbladder. Conclusion: TAE with emulsions of lipiodol and sorafenib is feasible, safe and has some slow-release effect.


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