A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat

2000 ◽  
Vol 4 (1) ◽  
pp. 93-100 ◽  
Author(s):  
MADHU DHAR ◽  
LISA S. WEBB ◽  
LAUREL SMITH ◽  
LOREN HAUSER ◽  
DABNEY JOHNSON ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Body Fat ◽  
The Body ◽  
Chromosome 7 ◽  
Mouse Tissues ◽  
Body Fat Content ◽  
P Type ◽  
Or Genes ◽  
Minimal Region ◽  
P Locus

A region of mouse chromosome 7, just distal to the pink-eyed ( p) dilution locus, contains a gene or genes, which we have named p-locus-associated obesity ( plo1), affecting body fat. Mice heterozygous for the most distally extending chromosomal deletions of this region have nearly double the body fat of mice when the deletion is inherited maternally as when it is inherited paternally. We have physically mapped the 1-Mb critical region, which lies between the Gabrb3 and Ube3a/ Ipw genes, and DNA sequencing has localized a new member of the third subfamily of P-type ATPases to the minimal region specifying the trait. This gene, which we have called p-locus fat-associated ATPase ( pfatp) is differentially expressed in human and mouse tissues with predominant expression in the testis and lower levels of expression in adipose tissue and other organs. We propose this ATPase as the prime candidate for the gene at the plo1 locus modulating body fat content in the mouse. The unusual inheritance pattern of this phenotype suggests either genomic imprinting, known to occur in other local genes ( Ube3a, Ipw), or an effect of maternal haploinsufficiency during pregnancy or lactation on body fat in the progeny.

scholarly journals Seasonal change in body fat of the Hyrax Procavia capensis (Pallas, 1766) using a body fat ranking index

Koedoe ◽  
1985 ◽  
Vol 28 (1) ◽  
Author(s):  
L.J. Fourie ◽  
M.R. Perrin
Keyword(s):  
Seasonal Change ◽  
Body Fat ◽  
Seasonal Variations ◽  
Physiological Condition ◽  
The Body ◽  
Body Fat Content ◽  
Total Body Fat ◽  
Procavia Capensis ◽  
Total Body ◽  
Ranking Index

Changes in the body fat content of the hyrax Procavia capensis were used as an indicator of physiological condition. Body fat rankings for the different sexes showed seasonal variations related to physiologically stressful periods (rutting, gestation and lactation). The subjective body fat rankings were correlated significantly with total body fat.

Seasonal Changes of Fat Content in the Yellow Perch (Perca flavescens) of Two Laurentian Lakes

1975 ◽  
Vol 32 (11) ◽  
pp. 2214-2221 ◽  
Author(s):  
George E. Newsome ◽  
Gérard Leduc
Keyword(s):  
Body Fat ◽  
Yellow Perch ◽  
Perca Flavescens ◽  
Fat Content ◽  
The Body ◽  
Differential Mortality ◽  
Fat Reserves ◽  
Body Fat Content ◽  
Fat Level ◽  
Males And Females

Different body fat reserves in male and female yellow perch (Perca flavescens) may determine a marked differential mortality during the winter. This was revealed by a study in two Laurentian lakes of the Province of Quebec harboring stunted yellow perch with a marked predominance of males. The proportion of females in each year-class is markedly smaller, thus suggesting a higher mortality among immature and mature females than among males.In an attempt to explain the differential mortality, the seasonal variation of body fat content in males and females was measured; also the fat level at time of death caused by starvation under laboratory conditions was determined. The results showed that in the females the body fat content falls to a critical level of about 2% at least 4 mo before spawning, whereas the males maintain a fat level of almost 5% throughout winter.

scholarly journals Effect of Eight-Week Training Programme on V02 Max and Body Composition

2005 ◽  
Vol 11 (2) ◽  
pp. 31-34
Author(s):  
Kim Geok SOH ◽  
Ruby HUSAIN
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Maximal Oxygen Consumption ◽  
Training Programme ◽  
Fat Content ◽  
The Body ◽  
Test Results ◽  
Body Fat Content ◽  
Post Test ◽  
The Impact

LANGUAGE NOTE | Document text in English; abstract also in Chinese.The purpose of the study was to determine the maximal oxygen consumption (V02 max) and the body fat content in Malaysian national junior netball players and the impact of an eight-week aerobic and strength-training programme on these two variables. A total of 21 netball players (mean age of 16.12±1.55 years old) from Bukit Jalil Sports School were the subjects used. The 12-minute Run was used to determine the V02 max while the body composition was calculated using the skinfold method. Pre-test and post-test results showed significant improvement in the V02 max and body fat content among the netball players. The Z value for the V02 max test was -3.25 (p

Physical Characteristics of Malaysian Netball Players in Relation to Playing Skill

2007 ◽  
Vol 13 (1) ◽  
pp. 54-57
Author(s):  
Kim Geok SOH ◽  
Ruby HUSAIN ◽  
Kim Lam SOH
Keyword(s):  
Body Mass ◽  
Body Fat ◽  
Fat Content ◽  
Physical Characteristics ◽  
The Body ◽  
English Abstract ◽  
Body Fat Content

LANGUAGE NOTE | Document text in English; abstract also in Chinese. This study sought to document the physical characteristics of top Malaysian netball players by their playing skill. The variables measured were age, height, body mass, body fat and somototype. Thirty-two national players (mean age 18.19 ± 3.86 years) were assessed, divided into three groups by their playing skill (senior/elite, junior and reserve). The body fat content was determined by the skinfold method and their somatotype using the Heath Carter Somatotyping method. There were no significant differences in the physical characteristics between the players by playing skill. The players were predominantly ecto-endomorphic with a mean somatotype of 6.12±1.42 - 2.38±1.05 - 2.71±1.38. Their height and body mass were 170.80±4.61 cm and 64.44±7.46 kg, respectively. Female national Australian and English netball players had a body fat of 28.90±3.50% (Wither & Roberts, 1981) and 24.50±3.90% (Bale & Hunt, 1986) respectively, while the Malaysian players in this study 24.50 ± 5.13%. 本文旨在探討馬來西亞女子投球選手的身體特徵與技術，並與同類研究進行比較及分析。

Mice with experimental colitis show an altered metabolism with decreased metabolic rate

2007 ◽  
Vol 292 (1) ◽  
pp. G165-G172 ◽  
Author(s):  
Silvia Melgar ◽  
Mikael Bjursell ◽  
Anna-Karin Gerdin ◽  
Lennart Svensson ◽  
Erik Michaëlsson ◽  
...  
Keyword(s):  
Body Weight ◽  
Metabolic Rate ◽  
Chronic Inflammation ◽  
Body Fat ◽  
Experimental Colitis ◽  
Fat Content ◽  
The Body ◽  
Mineral Density ◽  
Metabolic Alterations ◽  
Body Fat Content

Patients with inflammatory bowel disease (IBD) suffer from body weight loss, malnutrition, and several other metabolic alterations affecting their quality of life. The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. Clinical symptoms and inflammatory markers revealed the presence of an ongoing inflammatory response in the DSS-treated mice. Mice with acute inflammation had decreased body weight, respiratory exchange ratios (RER), food intake, and body fat content. Mice with chronic inflammation had decreased nutrient uptake, body fat content, locomotor activity, metabolic rates, and bone mineral density. Despite this, the body weight, food and water intake, lean mass, and RER of these mice returned to values similar to those in healthy controls. Thus, murine experimental colitis is associated with significant metabolic alterations similar to IBD patients. Our data show that the metabolic responses during acute and chronic inflammation are different, although the metabolic rate is reduced in both phases. These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology.

scholarly journals Anthropometric studies on African athletes who participated in the 1st African University Games

1977 ◽  
Vol 38 (3) ◽  
pp. 353-360 ◽  
Author(s):  
J. D. Watson ◽  
D. Y. Dako
Keyword(s):  
Body Fat ◽  
Subcutaneous Fat ◽  
Skinfold Thickness ◽  
Fat Content ◽  
The Body ◽  
International Standards ◽  
Body Build ◽  
Body Fat Content ◽  
Index Weight ◽  
Triceps Skinfold Thickness

1. Height, weight, skinfold thicknesses and mid-arm circumference were measured in 540 males and 117 females aged 20-24 years who took part in the 1st African University Games, held at the University of Ghana, Legon. Body fat content, Quetelet's index (weight ÷ height × 100; Khosla & Lowe (1967)) and mid-arm muscle circumference were derived from the measurements taken.2. The physique or body-build of the subjects as assessed by Quetelet's index showed that both male and female subjects from the various countries were of medium body-build. The body fat content for males was between 10 and 12% with the exception of the Egyptians (12.8%) while that of females was between 23-24%.3. Body measurements of the subjects compared favourably with that of international standards (WHO, 1966) with the exception of the triceps skinfold thickness which was only approximately 60% of the standard value.4. The low values for triceps skinfold thickness are probably due to differences in the distribution of subcutaneous fat at different sites in the body as found between caucasian and non-caucasian population groups. The results are discussed in relation to the findings of other workers on ethnic differences in skinfold thickness.

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