Cellular and molecular neuroscience of alcoholism

1997 ◽  
Vol 77 (1) ◽  
pp. 1-20 ◽  
Author(s):  
I. Diamond ◽  
A. S. Gordon
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Molecular Level ◽  
Cellular Functions ◽  
Short Term ◽  
Medical Disorders ◽  
Molecular Neuroscience ◽  
Long Term Changes ◽  
The Brain

Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.

An Inventory of Short Term and Long Term Changes in Gene Expression Under Interferon β Treatment of Relapsing Remitting MS Patients

2012 ◽  
Vol 18 (29) ◽  
pp. 4475-4484 ◽  
Author(s):  
Brigitte K. Paap ◽  
Alexander Hundeshagen ◽  
Michael Hecker ◽  
Uwe K. Zettl
Keyword(s):  
Gene Expression ◽  
Interferon Β ◽  
Short Term ◽  
Relapsing Remitting ◽  
Long Term Changes

Short-Term and Long-Term Changes of Left Ventricular Volumes During Rate-Adaptive and Single-Rate Pacing

1989 ◽  
Vol 12 (12) ◽  
pp. 1863-1868 ◽  
Author(s):  
MEREDITH I. SEDNEY ◽  
ERIC WEIJERS ◽  
ERNST E. WALL ◽  
JEEEREY D. ADIPRANOTO ◽  
JAN CAMPS ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Volumes ◽  
Short Term ◽  
Ventricular Volumes ◽  
Long Term Changes ◽  
Rate Adaptive

scholarly journals On the peculiarities in the spin-down of isolated radio pulsars

2012 ◽  
Vol 8 (S291) ◽  
pp. 208-208
Author(s):  
Augustine Chukwude
Keyword(s):  
Radio Astronomy ◽  
Time Resolution ◽  
Local Phase ◽  
Astronomy Observatory ◽  
Radio Pulsars ◽  
Short Term ◽  
Radio Astronomy Observatory ◽  
Long Term Changes ◽  
Timing Data

AbstractWe investigate the spin-down behaviour of a sample of 25 radio pulsars on decadal timescales (~ 18 years) using a continuous timing data obtained over a period of at Hartebeesthoek Radio Astronomy Observatory (HartRAO). Particular attention is placed on achieving a better time resolution of both the short-term and long-term changes in pulsar spin-down using local phase-coherent measurements of the spin-down rates (). We demonstrate that the spin-down of radio pulsars is generally complicated by a superposition of processes that may or may not be related. Specifically, our results show that (i) for 7 pulsars, the observed spin-down variation is largely stochastic, characterized by random and sustained jumps in of varying amplitudes, (ii) for 9 objects, the spin-down evolution shows dominant monotonic variations in superimposed on short-term stochastic jumps in the parameter, and (iii) for the remaining 9 pulsars, the long-term spin-down evolution is non-monotonic, dominated by some systematic excursion in the measured spin-down rates.

Signaling in new directions

1995 ◽  
Vol 73 (3-4) ◽  
pp. 133-136 ◽  
Author(s):  
Haleh Vahidi Samiei
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Tyrosine Kinase ◽  
Map Kinase ◽  
Receptor Tyrosine Kinase ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Molecular Level ◽  
Clear Cut ◽  
New Directions

Many laboratories, using a variety of organisms, have contributed to deciphering the identity and the order of the components leading from ligand-bound receptor tyrosine kinases to various intracellular events, including changes in gene expression. The gaps have only been filled recently. This minireview summarizes the findings and points out the degree of conservation of the same pathway in distant organisms, both at the molecular level and in terms of the consecutive steps. The review also looks at points at which this pathway might be diverging and points onto which other pathways might be converging. These interactions are not always clear cut, and understanding them will be the challenge for the future.Key words: signal transduction, receptor tyrosine kinase, RAS, RAF, MAP kinase.

scholarly journals Long- and Short-Term Changes of the Structure of Macrophytes in Lake Piaseczno in Relation to Land Use in the Łęczna-Włodawa Lakeland (Poland)

2013 ◽  
Vol 15 (2) ◽  
pp. 101-110
Author(s):  
Joana Sender ◽  
Weronika Maślanko
Keyword(s):  
Land Use ◽  
Aquatic Plants ◽  
Short Term ◽  
Main Interest ◽  
Central European ◽  
Macrophyte Communities ◽  
Long Term Changes ◽  
Very High ◽  
Macrophyte Structure

ABSTRACT The Łęczna-Włodawa Plain, known also as the Łęczna-Wlodawa Lakeland, lies within the territory of the largest subregion of the Polesie region, covering over 1,300 km2. The main interest of the Łęczna-Włodawa Lakeland is that it is the oldest in the Central European Lowlands group of about 68 lakes. Among such a large number of lakes there exist all trophic types. However, since the late 1950’s, enormous dynamics of change associated with the disappearance of oligo- and mesotrophic lakes and their transformation into eutrophic, even hypertrophic, lakes have been observed. One of the biocenotic elements of the lakes, which are indicators of these changes, is aquatic plants. The aim of this study was to determine the macrophyte structure of Piaseczno Lake and changes of land use in its surroundings. Piaseczno Lake still represents very high natural values. A reduction in the number of macrophyte communities, which occurred especially in 2008, was a consequence of the fast-growing recreation infrastructure. From 1976 until 2010 an area of recreation infrastructure in the studied area increased more than 3.5 times, and in the built-up area more than five times, as well as a doubling of the total length of the roads. Meanwhile the surface area of wetlands and peatbogs significantly decreased - more than 11 times. Long-term changes in the structure of the macrophyte communities show that the number of communities has varied in each year, probably as a consequence of changes in landuse. Analysis showed changes to the surfaces inhabited by macrophytes, which have decreased significantly over only four years, by more than 25%. However, the proportion of rush communities has increased.

scholarly journals Short-term and long-term international scientific mobility of Italian PhDs: An analysis by gender

2021 ◽  
pp. 35-40
Author(s):  
Valentina Tocchioni ◽  
Alessandra Petrucci ◽  
Alessandra Minello
Keyword(s):  
Multinomial Logistic Regression ◽  
Early Career ◽  
International Mobility ◽  
Short Term ◽  
Host Countries ◽  
Academic Mobility ◽  
Positive Effects ◽  
Long Run ◽  
The Brain

In the last years, there has been a large increase in high-educated and high-skilled people’s mobility as a consequence of the internationalization and globalization, the weakening of research and university systems of sending countries (the “brain drain” process), the increase in skilled demand and improvements in higher education of host countries (the “brain gain” process). At the micro-level, academic mobility has positive consequences on occupational prospects and careers of researchers, both in the short- and long- run. Nevertheless, numerous research studies have demonstrated the challenges of engaging in international academic mobility for people with caring responsibilities, particularly women. Using Italian data on occupational conditions of PhDs collected in 2018 by Istat and modelling multinomial logistic regression analyses, we intend to verify if female researchers are associated with a lower international mobility irrespective their field of study, and the extent to which gender interacts differently in the various fields of study in affecting the probability of moving abroad after PhD qualification. Also, the distinction between long-term and short-term mobility, which has been mainly neglected in the literature concentrating on longer stays, has taken into account. In this respect, short-term mobility is a potentially high-value investment that may be pursued also by those researchers and scientists who cannot move for longer periods, such as women with caring responsibilities. In the literature, it is acknowledged that an experience abroad during early career may have positive effects on future occupational prospects. With our work, we intend to shed light on potential disparities on moving abroad that may exist among researchers in their early career by gender, and which could contribute to leave behind women in academia.

scholarly journals Functional Connectivity within Brain Networks of Long Term and Short term Meditators

2019 ◽  
Vol 9 (2S) ◽  
pp. 29-34
Keyword(s):  
Functional Connectivity ◽  
Temporal Correlation ◽  
Brain Regions ◽  
Invasive Technique ◽  
Long Term Effects ◽  
Short Term ◽  
Statistical Concept ◽  
The Brain ◽  
Meditative Practices

Meditation refers to a state of mind of relaxation and concentration, where generally the mind and body is at rest. The process of meditation reflects the state of the brain which is distinct from sleep or typical wakeful states of consciousness. Meditative practices usually involve regulation of emotions and monitoring of attention. Over the past decade there has been a tremendous increase in an interest to study the neural mechanisms involved in meditative practices. It could also be beneficial to explore if the effect of meditation is altered by the number of years of meditation practice. Functional Magnetic Resonance Imaging (fMRI) is a very useful imaging technique which can be used to perform this analysis due to its inherent benefits, mainly it being a non-invasive technique. Functional activation and connectivity analysis can be performed on the fMRI data to find the active regions and the connectivity in the brain regions. Functional connectivity is defined as a simple temporal correlation between anatomically separate, active neural regions. Functional connectivity gives the statistical dependencies between regional time series. It is a statistical concept and is quantified using metrics like Correlation. In this study, a comparison is made between functional connectivity in the brain regions of long term meditation practitioners (LTP) and short-term meditation practitioners (STP) to see the differences and similarities in the connectivity patterns. From the analysis, it is evident that in fact there is a difference in connectivity between long term and short term practitioners and hence continuous practice of meditation can have long term effects.

scholarly journals Mechanisms of short-term and long-term adaptation

2020 ◽  
pp. 77-86
Author(s):  
Н.Б. Панкова
Keyword(s):  
Gene Expression ◽  
Epigenetic Regulation ◽  
Adaptive Response ◽  
Educational Environment ◽  
Stress Factors ◽  
Short Term ◽  
Functional Reserve ◽  
Short Term Adaptation ◽  
Expression Program

В лекции рассмотрены общие представления об адаптации, основанные на классических работах Г. Селье, Ф.З. Меерсона, Н.А. Агаджаняна, а также особенности адаптивного ответа развивающегося организма. Рассмотрены механизмы срочной адаптации как мобилизации функциональных резервов организма. В качестве одного из механизмов долговременной адаптации представлена эпигенетическая регуляция, которая позволяет выбрать и реализовать программу экспрессии генов - в соответствии с этапом онтогенетического развития, или средовым окружением. В качестве ещё одного механизма долговременной адаптации рассмотрено воздействие на генетический материал. Приведены примеры формирования адаптивного ответа организма на физико-химические и климатогеографические стрессорные факторы. Отдельно проанализированы механизмы адаптивного ответа организма детей на факторы образовательной среды. The lecture addresses general ideas about adaptation based on classic studies by H. Selye, F.Z. Meerson, and N.A. Agadzhanyan and features of the adaptive response in a developing body. Mobilization of the functional reserve is considered as a mechanism of short-term adaptation. Epigenetic regulation is presented as one of mechanisms for long-term adaptation, which allows selecting and implementing a gene expression program consistent with the stage of ontogenetic development or the environment. Another mechanism of long-term adaptation is influence on the genome. The lecture provides examples of adaptation to physicochemical and climatic geographical stress factors. Mechanisms of the adaptive response to factors of the educational environment in children are analyzed separately.

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