PPAR-δin Vascular Pathophysiology
Keyword(s):
Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α,β/δ, andγ. PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-δis implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-δon cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-δmay have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.
2021 ◽
2015 ◽
Vol 123
(08)
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pp. 492-499
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1999 ◽
Vol 70
(4)
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pp. 566-571
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1996 ◽
Vol 12
(1)
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pp. 335-363
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2012 ◽
Vol 33
(4)
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pp. 491-505
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2019 ◽
Vol 12
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pp. 1-11