scholarly journals HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications

2009 ◽  
Vol 31 (3) ◽  
pp. 227-233
Author(s):  
Emilia Fransvea ◽  
Angelo Paradiso ◽  
Salvatore Antonaci ◽  
Gianluigi Giannelli
Keyword(s):  
Growth Factors ◽  
Clinical Outcome ◽  
Kinase Inhibitor ◽  
Clinical Aspects ◽  
Clinical Implications ◽  
New Approach ◽  
Tissue Microenvironment ◽  
Novel Approach ◽  
History Of ◽  
Extreme Variability

Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributable to several different biological pathways. A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects.Design: Herein, the relevance of these molecular differences in combination with the biological and molecular pathways regulating the clinical outcome will be discussed. Use of a mechanistic and pathogenic approach to clarify the natural history of HCC is not just an academic speculation but should help to develop new therapies and to tailor these therapies to each individual patient.Conclusion: New biological therapies targeting components of the tumoral or peritumoral microenvironment are crucial to the fight against HCC. However, biological redundancies and the presence of several growth factors, hormones, cytokines, etc., potentially involved in HCC tumor progression make it difficult to assess the best target. Sorafenib, a multi-tyrosine kinase inhibitor, blocks the functions of different growth factors present in the tissue microenvironment. The use of Sorafenib in patients with HCC offers a new approach to the therapy of this disease, stimulating research focusing on the development of drugs based on new molecular and pathogenic insights.

scholarly journals A Hybrid Method of Hiding The Text Information Using Stegnography

2013 ◽  
pp. 21-25
Author(s):  
M.Grace Vennice ◽  
M. Swapna ◽  
MD.Ahmad Ali ◽  
T.Dharma Reddy
Keyword(s):  
Hybrid Method ◽  
Information Hiding ◽  
Secret Message ◽  
Privacy And Security ◽  
New Approach ◽  
Novel Approach ◽  
Text Steganography ◽  
Suitable Amount ◽  
History Of ◽  
Text Information

The Often Distribution of encrypted messages will depict the concentration of third parties. The attempts can be made to break and expose the actual messages by the hackers and cracker crackers. To conceal the subsistence of message steganography is introduced by hiding a secret message inside another credulous message.Steganography along with cryptograph y is used and offers suitable amount of privacy and security over the communication cha channel. nnel. In this paper along with various existing text text-based steganography techniques, an overview of text steganography and a concise history of steganography can be presented. The problems present in the text steganography and issues with existing solution solutionss are highlighted. In information hiding, a novel approach is proposed by using inter-word word spacing and inter inter-paragraph paragraph spacing as a hybrid method. Based on the length of the secret message, the proposed method provides dynamic generated stego stego-text with six ix options of maximum capacity. The considerable drawbacks of every existing method and how our new approach might be recommended as a solution can be analyzed in this paper.

Novel approach for pericapsular radiofrequency ablation of sacrococcygeal junction for patients with coccydynia

2022 ◽  
pp. rapm-2021-103183
Author(s):  
Guy Feigin ◽  
Ning Nan Wang ◽  
Vitaliano Di Grazia ◽  
Philip Peng
Keyword(s):  
Conservative Therapy ◽  
Case Series ◽  
Rf Ablation ◽  
New Approach ◽  
Novel Approach ◽  
Different Types ◽  
History Of ◽  
Sacrococcygeal Joint ◽  
Fluoroscopy Guidance ◽  
Large Case

IntroductionCoccydynia is a multifactorial complex clinical challenge. A multimodal approach with both conservative measures and procedural interventions is often recommended. We described a novel approach of radiofrequency (RF) ablation for the management of coccydynia.MethodsThree patients with known history of coccydynia refractory to conservative therapy were referred to our clinic. All received different types of RF ablation before: one with anterior bipolar lesion with no analgesia benefit, one with posterior stripped lesion with good benefit but only after 8 weeks of pain flare and one received anterior monopolar lesion with 50% pain reduction for 2–3 months. All subjects underwent a novel RF ablation to the anterior surface of the sacrococcygeal and intercoccygeal joints with two bipolar lesions using multi-tined needles under fluoroscopy guidance. One bipolar lesion was between two needles: one in the sacrococcygeal and another in the intercoccygeal (between first and second coccyx) joints. Another bipolar lesion was between needles on both side of the sacrococcygeal joint.ResultsAll experienced at least 65% pain relief for 6 months. The sitting endurance increased from less than 5 min to an average of 70 min. No adverse effect was observed in two and in the patient who used to have pain flare after lesioning, the pain flare lasted only for 2 weeks.DiscussionThe configuration of the two bipolar lesions with multi-tined needles in this case series stimulates the thinking of new approach for the ablation technique for pain from coccyx. Further prospective large case cohort study is needed.

Basicity or Ionicity – A New Approach for Understanding Glass Properties

2008 ◽  
Vol 39-40 ◽  
pp. 129-134
Author(s):  
Adrian Volceanov
Keyword(s):  
Energy Levels ◽  
Electronic Energy ◽  
New Approach ◽  
Novel Approach ◽  
History Of ◽  
Chemical Character ◽  
Electronic Energy Levels ◽  
Major Adjustment ◽  
Global Mean ◽  
Glass Properties

Basicity of glass is still a challenge in spite of various attempts to measure or calculate it. The values assigned for basicity of glasses, either calculated or experimentally determined, are not always in full agreement with actual facts, and discrepancies among the theoretical ones are not unusual. For instance, SiO2 is described by a single basicity value even if the polymorphs of SiO2 are quite different. Only few attempts were made to face this challenge. Present paper deals with a novel approach on theoretical ionicity / basicity based on electronic energy levels or band structure of solids. Another major adjustment takes into account the possibility of decomposing ionicity of complex chemical bondings into a sum of binary bondings. Considering the distribution of the interbonding angles specific for vitreous systems, it is possible to estimate both a local ionicity (basicity) of bondings and a global (mean) basicity of glass. The variation of basicity (ionicity) with temperature is also presented, this finding being able to open a new view on thermal history of glass considered through chemical character of bondings.

Introduction

2020 ◽  
pp. 1-16
Author(s):  
David Faflik
Keyword(s):  
Urban Studies ◽  
Final Analysis ◽  
New Approach ◽  
Urban Forms ◽  
Modern City ◽  
Actual Existence ◽  
The Past ◽  
Novel Approach ◽  
History Of ◽  
The City

This book rests upon a pair of related propositions that have far-reaching consequences for the work of urban studies. The first is that the history of the modern city is a history of urban forms. The second is that the interpretive turn to formalism represents a wholly new approach to thinking about urbanism and historicism. In other words, this book argues that to conceive of the city “formally” is not only to revise our understanding of the city’s actual existence. It is to argue for an alternative way of apprehending the conditions through which knowledge of the city is even possible. Forms alter our sense of what the historical city was. Forms change how we perceive the very practice of urban perception, whether we’re talking about the perceptual habits of historical observers from the past or anyone who is mindful, today, of how forms function in the present century. In the final analysis, the twin claims on which this book depends suggest a different kind of urban being even as they propose a novel approach to city “reading.” In forms, we’ll never know the city the same way again.

A new approach to the logic of discovery

2007 ◽  
Vol 50 (1) ◽  
pp. 7-27
Author(s):  
Gerald Massey
Keyword(s):  
Modal Logic ◽  
Scientific Discovery ◽  
Traditional View ◽  
New Approach ◽  
Logic Of Discovery ◽  
Good Fortune ◽  
High Incidence ◽  
History Of ◽  
Deep Sense

Contending that the quest for a logic of scientific discovery was prematurely abandoned, the author lays down eight phenomena that such a logic or theory must explain: the banality of scientific discovery; the trainability of scientists; the high incidence of simultaneous discoveries; the ubiquity of relative novices; the fact of scientific genius; the barrenness of isolated workers; the incommensurability of concepts of successive theories; and the quasi-incorporation of old concepts, objects, and methods in successor theories, The author then presents a new theory or logic of discovery according to which discoveries are the termini of "tweak paths" generated when scientists "tinker" with the laws, concepts, methods, and instruments of a given theory. Tinkering and tweaking are illustrated by examples from many-valued and modal logic and from Darwinian biology. Through the history of planetary discovery, the accidental role played by luck or good fortune in some discoveries is explored, but the author emphasizes that in a deep sense serendipity is an in eliminable feature of all scientific discovery because scientists never know m advance whether their tweaks will lead to dead ends or to positive developments. The author's new theory of scientific discovery is shown to account for all eight explananda, ft also reveals science to be a more egalitarian enterprise than the traditional view of scientific discovery as ultimately inexplicable depicts it.

scholarly journals The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Karin Wildi ◽  
Samantha Livingstone ◽  
Chiara Palmieri ◽  
Gianluigi LiBassi ◽  
Jacky Suen ◽  
...  
Keyword(s):  
Age Groups ◽  
Geographical Location ◽  
High Morbidity ◽  
Shock State ◽  
Pharmacological Agents ◽  
New Approach ◽  
Novel Approach ◽  
Active Research ◽  
Targeted Medicine ◽  
Core Features

AbstractThe acute respiratory distress syndrome (ARDS) is a severe lung disorder with a high morbidity and mortality which affects all age groups. Despite active research with intense, ongoing attempts in developing pharmacological agents to treat ARDS, its mortality rate remains unaltered high and treatment is still only supportive. Over the years, there have been many attempts to identify meaningful subgroups likely to react differently to treatment among the heterogenous ARDS population, most of them unsuccessful. Only recently, analysis of large ARDS cohorts from randomized controlled trials have identified the presence of distinct biological subphenotypes among ARDS patients: a hypoinflammatory (or uninflamed; named P1) and a hyperinflammatory (or reactive; named P2) subphenotype have been proposed and corroborated with existing retrospective data. The hyperinflammatory subphenotyope was clearly associated with shock state, metabolic acidosis, and worse clinical outcomes. Core features of the respective subphenotypes were identified consistently in all assessed cohorts, independently of the studied population, the geographical location, the study design, or the analysis method. Additionally and clinically even more relevant treatment efficacies, as assessed retrospectively, appeared to be highly dependent on the respective subphenotype. This discovery launches a promising new approach to targeted medicine in ARDS. Even though it is now widely accepted that each ARDS subphenotype has distinct functional, biological, and mechanistic differences, there are crucial gaps in our knowledge, hindering the translation to bedside application. First of all, the underlying driving biological factors are still largely unknown, and secondly, there is currently no option for fast and easy identification of ARDS subphenotypes. This narrative review aims to summarize the evidence in biological subphenotyping in ARDS and tries to point out the current issues that will need addressing before translation of biological subohenotypes into clinical practice will be possible.

scholarly journals Unimodular vs nilpotent superfield approach to pure dS supergravity

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Sukruti Bansal ◽  
Silvia Nagy ◽  
Antonio Padilla ◽  
Ivonne Zavala
Keyword(s):  
String Theory ◽  
General Framework ◽  
Recent Progress ◽  
High Energy ◽  
De Sitter Spacetime ◽  
De Sitter ◽  
New Approach ◽  
Sitter Spacetime ◽  
Novel Approach ◽  
De Sitter Vacua

Abstract Recent progress in understanding de Sitter spacetime in supergravity and string theory has led to the development of a four dimensional supergravity with spontaneously broken supersymmetry allowing for de Sitter vacua, also called de Sitter supergravity. One approach makes use of constrained (nilpotent) superfields, while an alternative one couples supergravity to a locally supersymmetric generalization of the Volkov-Akulov goldstino action. These two approaches have been shown to give rise to the same 4D action. A novel approach to de Sitter vacua in supergravity involves the generalisation of unimodular gravity to supergravity using a super-Stückelberg mechanism. In this paper, we make a connection between this new approach and the previous two which are in the context of nilpotent superfields and the goldstino brane. We show that upon appropriate field redefinitions, the 4D actions match up to the cubic order in the fields. This points at the possible existence of a more general framework to obtain de Sitter spacetimes from high-energy theories.

scholarly journals Compiling Life-Oriented Moral Education Textbooks for Elementary Schools in China: The Mimetic Approach in Morality and Law

2021 ◽  
pp. 209653112098296
Author(s):  
Yan Tang
Keyword(s):  
Elementary Schools ◽  
Moral Education ◽  
Life Events ◽  
Theoretical Perspective ◽  
Building Blocks ◽  
Learning Activities ◽  
Design Approach ◽  
New Approach ◽  
Novel Approach

Purpose: This study explores a novel approach to compiling life-oriented moral textbooks for elementary schools in China, specifically focusing on Morality and Law. Design/Approach/Methods: Adopting Aristotle’s Poetics as its theoretical perspective, this study illustrates and analyzes the mimetic approach used in compiling the life-oriented moral education textbook, Morality and Law. Findings: The mimetic approach involves imitating children's real activities, thoughts, and feelings in textbooks. The mimetic approach to compiling life-oriented moral textbooks comprises three strategies: constructing children's life events as building blocks for textbook compilation, designing an intricate textual device exposing the wholeness of children's life actions, and designing inward learning activities leading to children's inner worlds. Originality/Value: From the perspective of Aristotle's Poetics, the approach to compilation in Morality and Law can be defined as mimetic. And the compilation activity in the life-oriented moral education textbook also can be described as a processes of mimesis. So this article presents a new approach to compile moral education textbooks, and  an innovative way to understand the nature of one compiling activity.

scholarly journals Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient

2021 ◽  
pp. 190-194
Author(s):  
Sineida Berbert Ferreira ◽  
Rachel Berbert Ferreira ◽  
Afonso Cesar Neves Neto ◽  
Silvana Martins Caparroz Assef ◽  
Morton Scheinberg
Keyword(s):  
Case Report ◽  
Skin Disease ◽  
Kinase Inhibitor ◽  
Effective Therapy ◽  
Janus Kinase ◽  
Jak Inhibitor ◽  
Adolescent Patient ◽  
Jak Inhibitors ◽  
Janus Kinase Inhibitor ◽  
History Of

Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation.

Sign in / Sign up

Export Citation Format

Share Document