scholarly journals Longstanding Eosinophilic Gastroenteritis of More Than 20 Years

2009 ◽  
Vol 23 (9) ◽  
pp. 632-634 ◽  
Author(s):  
Hugh J Freeman
Keyword(s):  
Inflammatory Process ◽  
Biological Effects ◽  
Eosinophilic Gastroenteritis ◽  
Gastric Body ◽  
Clinical Relapse ◽  
Long Term Effects ◽  
Mucosal Folds ◽  
Erosive Change ◽  
Symptomatic Benefit

Eosinophilic gastroenteritis (EGE) is an eosinophil-predominant inflammatory process that may be detected in endoscopic gastric or intestinal biopsies. The long-term natural history and effects of EGE treatment are not known. A 44-year-old man with abdominal pain was treated with oral ketotifen and followed for more than 20 years. Ketotifen provided symptomatic benefit, with prompt clinical relapse if the drug was discontinued. However, despite the use of ketotifen, the endoscopic abnormalities persisted and appeared to progress. Gastric body and antral mucosal folds appeared thickened, erythematous and friable, with minimal erosive change. Later, even during long asymptomatic periods suggesting clinical ‘remission’, inflammatory polypoid change, previously described in children with EGE, developed with mucosal ‘pock-marking’ and apparent scarring. Ketotifen treatment does not appear to prohibit or reverse the inflammatory process in the gastric mucosa in EGE, although long-term effects of steroids may be avoided. In the future, treatment of EGE may involve monoclonal antibody agents that target the specific biological effects of the eosino-phil, apparently central to this unusual inflammatory process.

BIOLOGICAL EFFECTS OF 131I AND 125I ISOTOPES OF IODINE IN THE RAT

1976 ◽  
Vol 71 (1) ◽  
pp. 109-114 ◽  
Author(s):  
I. DONIACH ◽  
D. J. SHALE
Keyword(s):  
Thyroid Function ◽  
Biological Effects ◽  
Female Rats ◽  
Long Term Effects ◽  
Significant Elevation ◽  
Radioiodine Uptake ◽  
Male And Female ◽  
Male And Female Rats ◽  
Serum Tsh

SUMMARY From the differences in radiation profiles between 131I and 125I isotopes of iodine it would be expected that they would show different effects on thyroid function. The differences should lead to lower rates of thyroid gland destruction with 125I and hence less post-irradiation hypothyroidism. This difference in biological effect has been demonstrated in rats by indirect assessment of thyroid function. In this report the long-term effects of a range of similar doses of 131I and 125I were compared, in male and female rats, by direct assessment of thyroid function. Seventeen months after receiving 25 and 125 μCi of 131I, male and female rats showed significant elevation of serum TSH concentration and a reduction in 3 h radioiodine uptake. Rats receiving 1 and 5 μCi of 131I and all doses of 125I showed no significant changes in thyroid function. These findings confirm the previously reported differences in effect between the 131I and 125I isotopes of iodine in the rat.

scholarly journals Histological long-term effects in relevant tissues after 131I contamination of two Wistar rat models

2019 ◽  
Vol 14 ◽  
pp. 05009
Author(s):  
Meriem Mezaguer-Lekouaghet ◽  
Abdelwahab Badreddine ◽  
Saadia Mameri ◽  
Maamar Souidi ◽  
Ahcène Baz ◽  
...  
Keyword(s):  
Biological Effects ◽  
Thyroid Tissue ◽  
Absorbed Dose ◽  
Wistar Rat ◽  
Tissue Analysis ◽  
Long Term Effects ◽  
Target Organs ◽  
Thyroid Mass ◽  
Iodine 131

Procedures using iodine-131 (131I) represent about 90% of all therapies in nuclear medicine [1, 2]. It is important to evaluate the long-term biological effects of 131I treatment on non-target organs in order to improve the patient radioprotection. The aim of this work is to use an experimental animal model to contribute to the understanding of some biological effects induced by 131I contamination, and especially histological effects. Two models of Wistar rats with (Tr+) and without thyroid (Tr-) were orally contaminated with iodine and after 8 months they were sacrificed and the histological effects on some relevant tissues such as thyroid, testes, liver and kidneys were been studied. Thyroid tissue analysis revealed that in the case of the Tr+ model compared to their control (Tr+ uncontaminated), 50% of the slides examined had remodeled the thyroid tissue with rare follicles choked by fibrosis and with epithelial changes. However, for Tr- compared to their control, the examined slides reveal the presence of a small, completely atrophied thyroid mass associated with vesicular fibrosis and with detachment of the colloid. For the renal organ, disturbances are observed: inflammation of the presence of tissue fibrosis and glomerular necrosis. For the liver, there is an appearance of inflammatory focus in different degrees around the portals. However, the results of the testes of both models compared to their controls revealed no histological abnormalities. The observed histological effects are correlated with the corresponding absorbed dose received by each organ and calculated using the RODES software [3, 4].

scholarly journals Biological effects of fulvestrant on estrogen receptor positive human breast cancer: short, medium and long‐term effects based on sequential biopsies

2015 ◽  
Vol 138 (1) ◽  
pp. 146-159 ◽  
Author(s):  
Amit Agrawal ◽  
John F.R. Robertson ◽  
Kwok L. Cheung ◽  
Eleanor Gutteridge ◽  
Ian O. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Human Breast Cancer ◽  
Biological Effects ◽  
Human Breast ◽  
Long Term Effects ◽  
Estrogen Receptor Positive

scholarly journals Glucosamine for Osteoarthritis: Biological Effects, Clinical Efficacy, and Safety on Glucose Metabolism

Arthritis ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Juan Salazar ◽  
Luis Bello ◽  
Mervin Chávez ◽  
Roberto Añez ◽  
Joselyn Rojas ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Biological Effects ◽  
The Elderly ◽  
Long Term Effects ◽  
Management Schemes ◽  
Mechanical Factors ◽  
The Subject ◽  
Degenerative Disorder ◽  
Methodological Aspects

Osteoarthritis is a chronic degenerative disorder that currently represents one of the main causes of disability within the elderly population and an important presenting complaint overall. The pathophysiologic basis of osteoarthritis entails a complex group of interactions among biochemical and mechanical factors that have been better characterized in light of a recent spike in research on the subject. This has led to an ongoing search for ideal therapeutic management schemes for these patients, where glucosamine is one of the most frequently used alternatives worldwide due to their chondroprotective properties and their long-term effects. Its use in the treatment of osteoarthritis is well established; yet despite being considered effective by many research groups, controversy surrounds their true effectiveness. This situation stems from several methodological aspects which hinder appropriate data analysis and comparison in this context, particularly regarding objectives and target variables. Similar difficulties surround the assessment of the potential ability of glucosamine formulations to alter glucose metabolism. Nevertheless, evidence supporting diabetogenesis by glucosamine remains scarce in humans, and to date, this association should be considered only a theoretical possibility.

Biological effects of stevia, sucralose and sucrose in a citrus-maqui juice in overweight subjets

2021 ◽  
Author(s):  
Pilar Zafrilla ◽  
Hedyeh Masoodi ◽  
Cerdá Begoña ◽  
C. Garcia-Viguera ◽  
Débora Villaño Valencia
Keyword(s):  
Biological Effects ◽  
Long Term Effects ◽  
Added Sugars

Background: In the last few years, there has been emerging interest in substituting added sugars from juices by other sweeteners to make them healthier. But their long-term effects have been...

Biological Effects of Environmental Electromagnetic Fields

2011 ◽  
Vol 183-185 ◽  
pp. 532-536 ◽  
Author(s):  
Gun Li ◽  
Xiao Feng Pang
Keyword(s):  
Electromagnetic Field ◽  
Electromagnetic Fields ◽  
Human Body ◽  
Geomagnetic Field ◽  
Biological Effects ◽  
Long Term Effects ◽  
Negative Effects ◽  
The Past ◽  
Theoretical Results

Each of us are exposed to the environmental electromagnetic fields, such as the geomagnetic field, electromagnetic field from power line, and antenna radiation etc. all the time, when the biological tissue exposure in the electromagnetic fields may lead some certain effects, and many effects are studied during the past few years, most of these studies concentrated on negative effects of electromagnetic fields. It is necessary to explore effects of these environmental electromagnetic fields on human body comprehensively, some effects of environmental electromagnetic fields are studied theoretically in the following paper, and attenuate characteristics of several environmental electromagnetic fields propagate in human body is discussed. The theoretical results expressed the penetration depth of several environmental electromagnetic fields, and the possible effects of long term effects are analyzed.

On the chemistry of EDC-tar and its biological significance in the sea

1975 ◽  
Vol 189 (1096) ◽  
pp. 333-346 ◽  
Keyword(s):  
Acute Toxicity ◽  
Vinyl Chloride ◽  
Biological Effects ◽  
Biological Significance ◽  
Long Term Effects ◽  
Marine Animals ◽  
Waste Products ◽  
Chlorinated Aliphatic Hydrocarbons ◽  
Medical Reports

The composition of EDC-tars originating as waste products in two different processes of vinyl chloride production has been studied. In total, 80 substances have been detected. Most of the chlorinated aliphatic hydrocarbons identified were found to contain one or two double bonds. 15 out of the 80 substances are aromatics, and most of these are chlorinated as well. Possible chemical or biological conversions of EDC-tar components in the marine environment are discussed. Data on acute toxicity of the EDC-tar to coastal water phytoplankton and some marine animals are given. It is shown that EDC-tar in concentrations as low as 10-100/10 9 may cause acute biological effects. In the light of the chemical data presented and recent medical reports on serious diseases in workers employed in vinyl chloride production plants, the possibility of similar long term effects in marine animals is briefly discussed.

Some conclusions regarding long -term biological effects of some major oil spills

1982 ◽  
Vol 297 (1087) ◽  
pp. 335-351 ◽  
Keyword(s):  
Oil Spills ◽  
Biological Effects ◽  
Biologically Active ◽  
Long Term Effects ◽  
Sediment Grain Size ◽  
Petroleum Fractions ◽  
Wide Range ◽  
Time Courses

Many of the world ’s major spills exhibit long-term consequences, associated mainly with lagoons, estuaries and marshes. This is due to the persistence of oil or petroleum fractions in these low-energy environments. The bioavailability of residual oil to infauna is influenced by several factors, such as solubility in water, feeding habit, weathering rate and sediment grain size. The time-courses for these long-term effects vary, but may run into decades for some community perturbations. The effects are at all levels of organization, including cellular, organismic and the community. Although the number of documented long-term effects is small, they involve a wide range of biological processes: development, genetic, growth, feeding and assimilation, photosynthesis, recruitment and fecundity, and community stability. It is important to note that the known effects are probably only representative of a much wider range of possible disorders that have occurred, but which have not been detected. This is due mainly to the selective nature of spill follow-up studies. Long-term spill consequences are generally local phenomena and so far no single spill has, to our limited knowledge, significantly altered entire ecosystems or materially affected fisheries. The combination of several spills can, however, place considerable stress on an environment. Also, so far there is no indication of an increasing mutagenic or carcinogenic load in the marine environment due to biologically active petroleum fractions or to carcinogenic or mutagenic metabolites. There is, however, the possibility of local build-up of these compounds, as in ‘hydrocarbon sink’ areas, where such a burden may become a local problem .

Long-Term Effects of Iron Particle (HZE) Irradiation on Mouse Spermatogonia

1985 ◽  
Vol 43 ◽  
pp. 652-653
Author(s):  
D. E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Cell Population ◽  
Radiation Effects ◽  
Biological Effects ◽  
Cosmic Ray ◽  
Iron Particle ◽  
Cell Loss ◽  
High Energy ◽  
Long Term Results ◽  
Long Term Effects

High-energy (HZE) cosmic ray particles in space present an environmental hazard, especially to long-duration high altitude space travel. The energy released when these particles slow down and stop in living tissue causes deleterious biological effects, including death of cells. In order to study and quantitate the effects of this radiation, a number of cell systems could be used. The spermatogonial cell population in mouse testes has a rapidly dividing cell population, can be examined three days after irradiation, and is one of the most sensitive tissues to radiation. Therefore, it is ideally suited for quantitative studies of radiation effects. Previous work has shown that the various types of spermatogonial cells differ in their radiation sensitivity and that this can be very easily evaluated with the light/electron microscope. Using the system of staging established by Oak-berg and Huckins, the mixed or single cell population can be evaluated. Our work, using this method, has revealed cell sensitivity at doses as low as one rad. In these experiments, the animals were sacrificed three days post-irradiation because this is the time when maximum cell loss can be viewed. However, we are now reporting long term results of HZE particles using iron irradiation.

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