Synthesis, Characterization and Biological Activity of Mn2+, Co2+, Ni2+and Cu2+Complexes of Benzoic Acid Ligand

T. Arunachalam; R. Bhakyaraj; A. K. Sasi

doi:10.1155/2009/780192

Synthesis, Characterization and Biological Activity of Mn2+, Co2+, Ni2+and Cu2+Complexes of Benzoic Acid Ligand

E-Journal of Chemistry ◽

10.1155/2009/780192 ◽

2009 ◽

Vol 6 (3) ◽

pp. 743-746 ◽

Cited By ~ 3

Author(s):

T. Arunachalam ◽

R. Bhakyaraj ◽

A. K. Sasi

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Magnetic Susceptibility ◽

Biological Activity ◽

Benzoic Acid ◽

Conductivity Measurements ◽

Octahedral Structure ◽

E Coli ◽

Acid Ligand

Metal complex of Mn(II), Co(II), Ni(II) and Cu(II) with benzoic acid have been prepared and characterized by physiochemical methods. On the basis of electronic spectra and magnetic susceptibility measurement in conjunction with infrared spectra, six coordinated octahedral structure have been proposed to all the complexes. The benzoic acid and their complexes have been tested for their antibacterial activity against the bacteriaE. coli,Bacillus subtilis,Pseudomonas aeruginosaandStaphylococcus aureus. Further, the non electrolytic nature of all the synthesized complexes was identified from conductivity measurements.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

Revista de Chimie ◽

10.37358/rc.19.10.7605 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3603-3610

Author(s):

Madalina Mihalache ◽

Cornelia Guran ◽

Aurelia Meghea ◽

Vasile Bercu ◽

Ludmila Motelica ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antimicrobial Activity ◽

Antibacterial Activity ◽

Biological Activity ◽

Candida Albicans ◽

Antifungal Activity ◽

Copper Complexes ◽

Substrate Adhesion ◽

Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

Characterization and Antimicrobial Activity of Erbium(III) Complexes of C-3 Substituted 2-hydroxy-1,4-naphthalenedione-1-oxime Derivatives

Metal-Based Drugs ◽

10.1155/mbd.2001.159 ◽

2001 ◽

Vol 8 (3) ◽

pp. 159-164 ◽

Cited By ~ 4

Author(s):

S. B. Jagtap ◽

N. N. Patil ◽

B. P. Kapadnis ◽

B. A. Kulkarni

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antimicrobial Activity ◽

Antibacterial Activity ◽

Magnetic Susceptibility ◽

Candida Albicans ◽

Xanthomonas Campestris ◽

Antimicrobial Activities ◽

Diffusion Method ◽

Oxime Derivatives

Erbium(III) complexes of 2-hydroxy-l,4-naphthalenedione-1-oxime and its C-3 substituted derivatives are synthesized and characterized by elemental analysis, thermogravimetric analysis, infrared spectroscopy, magnetic susceptibility measurements 2-hydroxy-1,4-naphthalenedione-1-oxime derivatives are analysed using H1 and C13 NMR spectroscopy. The molecular composition of the synthesized complexes is found to be [ML3(H2O)2]. The antimicrobial activity of these complexes is determined by well diffusion method against the target microorganisms- Staphylococcus aureus, Xanthomonas campestris, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antimicrobial activities of 2- hydroxy-1,4-naphthalenedione-1-oximes and their complexes are compared. It is observed that 2-hydroxy-1,4-naphthalenedione-l-oximes exhibit higher antifungal activity as compared to antibacterial activity. These activities are reduced upon complexation of these oximes with Erbium.

Antibacterial Activity of Cu Nanoparticles against E. coli, Staphylococcus aureus and Pseudomonas aeruginosa

Nano Biomedicine and Engineering ◽

10.5101/nbe.v9i1.p9-14 ◽

2017 ◽

Vol 9 (1) ◽

Cited By ~ 15

Author(s):

Lalit Yadav ◽

Ravi Mani Tripathi ◽

Ram Prasad ◽

Ramesh Namdeo Pudake ◽

Jagjiwan Mittal

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Cu Nanoparticles ◽

E Coli

Uji Aktivitas Antibakteri Ekstrak Sarang Lebah Hutan (Apis Dorsata) Terhadap Pertumbuhan Staphylococcus aureus, Escherichia coli Dan Pseudomonas aeruginosa

ALCHEMY Jurnal Penelitian Kimia ◽

10.20961/alchemy.14.1.13028.179-194 ◽

2018 ◽

Vol 14 (1) ◽

pp. 179

Author(s):

Ika Prestianti ◽

Maswati Baharuddin ◽

Sappewali Sappewali

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Apis Dorsata ◽

Soaking Time ◽

E Coli ◽

Extract Concentration ◽

X 24 ◽

Paper Disc

Penyakit infeksi akibat bakteri merupakan masalah serius dalam kesehatan. Antibakteri alami yang dapat digunakan untuk menghambat pertumbuhan bakteri yaitu sarang lebah hutan (Apis dorsata) (propolis, kantong madu, kantong telur dan kantong pollen) yang mengandung senyawa metabolit sekunder seperti flavonoid, tanin dan asam fenolat.Tujuan dari penelitian ini adalah megetahui aktivitas antibakteri ekstrak sarang lebah hutan dari setiap pelarut yang digunakan dan untuk mengetahui pengaruh konsentrasi ekstrak sarang lebah hutan terhadap pertumbuhan bakteri Staphylococcus aureus, Escherichia coli dan Pseudomonas aeruginosa. Pengujian antibakteri dilakukan dengan metode difusi kertas cakram dengan lama perendaman 1 jam kemudian diinkubasi selama 3 x 24 jam. Hasil penelitian menunjukkan bahwa aktivitas antibakteri ekstrak metanol sarang lebah memiliki aktivitas tertinggi pada bakteri E. coli yaitu 3,8 mm pada konsentrasi 8%, ekstrak etil asetat sarang lebah pada bakteri S. a ureus yaitu 3,72 mm pada konsentrasi 8% dan ekstrak n-heksan sarang lebah pada bakteri E. coli yaitu 16,1 mm pada konsentrasi 8%. Pengaruh konsentrasi ekstrak yaitu semakin tinggi konsentrasi ekstrak maka semakin besar pula daya hambat ekstrak terhadap pertumbuhan bakteri S. aureus, E. coli dan P. aeruginosa.Antibacterial Evaluation of Extract Beehive (Apis dorsata) on Growth Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Bacterial infectious diseases are serious health problems. One of natural antibacterial that can be used to inhibit bacterial growth is honeycomb (propolis, honey bag, egg bag and pollen bag) containing secondary metabolite compounds such as flavonoids, tannins and phenolic acids. The purpose of this research is to know the antibacterial activity of honeycomb extract from each solvent used and to know the effect of honeycomb extract concentration on the growth of S. aureus, E. coli and P. aeruginosa bacteria. Antibacterial testing was performed by the method of paper disc diffusion with soaking time 1 hour then incubated for 3 x 24 hours. The results showed that antibacterial activity of methanol honeycomb extract had the highest activity in E. coli bacteria i.e., 3.8 mm at 8% concentration, ethyl acetate honey extract on S. aureus bacteria ie 3.72 mm at 8% concentration and n extract n-hexan honeycomb in E. coli bacteria that is 16,1 mm at 8% concentration. The higher extract concentration the greater the inhibitory activity of extract on the growth of S. aureus, E. coli and P. aeruginosa bacteria.

Antibacterial Activity of Pakistani Honey

Biological Sciences - PJSIR ◽

10.52763/pjsir.biol.sci.62.2.2019.97.100 ◽

2019 ◽

Vol 62 (2) ◽

pp. 97-100

Author(s):

Taif Shah ◽

Niyaz Ali ◽

Zahir Shah ◽

Azam Hayat

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Apis Mellifera ◽

Bacterial Species ◽

Salmonella Typhi ◽

Stingless Bee ◽

E Coli ◽

Zones Of Inhibition ◽

Khyber Pakhtunkhwa Province

The current study was conducted to determine the antibacterial activity of 50 crude and processed honey samples produced by Apis mellifera and stingless bee. All the honey samples were collected from different places of Districts Dir, Swat and Oghi of Khyber Pakhtunkhwa Province, Pakistan and were tested against the six ATCC bacterial species including E. coli ATCC number 25922, Pseudomonas aeruginosa ATCC number 27853, Staphylococcus aureus ATCC number 6538, Enterococcus faecalis ATCC number 19433, Salmonella typhi ATCC number 19943 and Klebsiella pneumoniae ATCC number 27736. The honey samples showed variable zones of inhibition by using Agar well plate technique. E. coli showed 17-23 mm, S. typhi 31-37 mm, E. faecalis 28 mm, P. aeruginosa 14-15 mm, K. pneumoniae 20-24 mm and Staph. aureus 19-25 mm. Most of the honey samples used in this study showed broad spectrum antibacterial activity.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

Revista de Chimie ◽

10.37358/rc.19.10.3603 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3603-3610

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antimicrobial Activity ◽

Antibacterial Activity ◽

Biological Activity ◽

Candida Albicans ◽

Antifungal Activity ◽

Copper Complexes ◽

Substrate Adhesion ◽

Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: Cl (C1), •H2O (C2) and (NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications. Keywords: 1-(o-tolyl)biguanide, a-ketoglutaric acid, copper complexes, antibacterial activity, celule HeLa, antifungal activity

Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00831 ◽

2021 ◽

pp. 4777-4782

Author(s):

Anshul Kumar ◽

Rajnish Kumar ◽

Avijit Mazumdar

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Shigella Flexneri ◽

Literature Survey ◽

Klebsiella Pneumonia ◽

Standard Drug ◽

E Coli ◽

Maximum Inhibition ◽

Hypertensive Drug

Terazosin hydrochloride is an anti-hypertensive drug which is used to treat the diseases of hypertension. The literature survey shows the proposed synthesis of Terazosin hydrochloride derived from the starting material of 2-chloro-6, 7-dimethoxy–quinazoline-4-amine in the presence of 2-methoxy ethanol with n- benzyl piperazine to form the product. The Terazosin derivatives were prepared with the help of literature survey were 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1, 4-bis-(tertrahydrofuran-2-yl) carbonyl piperazine, and 1-(4-amino-6, 7-dimethoxy- quinazoline-2-yl)- 4-formyl- piperazine were prepared by maintaining environmental condition. The characterization done for prepared derivative was done through 1H-NMR, MASS and IR Spectroscopy. The antibacterial activity of prepared derivatives was performed on the various bacteria like E. coli, Pseudomonas aeruginosa, Shigella sonneii, Klebsiella pneumonia, Staphylococcus aureus, Shigella flexneri, Vibrio cholera, Bacillus subtilis, Pseudomonas fluorescens, Pseudomonas aeruginosa, Staphylococcus aureus. The desired derivatives shown maximum zone of inhibition using concentration prepared 100µg and 200µg using standard drug. The derivatives that shows maximum inhibition 6, 7-dimethoxy-2-piperazine-1-yl-quinazoline -4-amine and minimum was shown by 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1,4-bis-(tertrahydrofuran- 2-yl) carbonyl piperazine. The result should that prepared Terazosin derivatives shows potent actively when compared with standard ciprofloxacin.

Antimicrobial Activity of Leaves Extracts of Tamarindus indica L. (Magyee)

Myanmar Health Sciences Research Journal ◽

10.34299/mhsrj.00935 ◽

2019 ◽

Vol 31 (2) ◽

pp. 125-130

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antimicrobial Activity ◽

Antibacterial Activity ◽

Petroleum Ether ◽

Aqueous Extracts ◽

Tamarindus Indica ◽

E Coli ◽

Ethanolic Extracts ◽

And Staphylococcus Aureus

This study aimed to determine antimicrobial activity of extracts of Tamarindus indica L. leaves (Magyee). It was the laboratory-based quasi experimental study design. Study sites were the University of Pharmacy (Mandalay and Yangon) and the Department of Medical Research (Yangon). The leaves of Tamarindus indica L. were extracted with petroleum ether, ethanol and distilled water by successive Soxhlet extraction method. Physicochemical and phytochemical studies were conducted according to reference analytical procedures. In vitro antimicrobial activity of three extracts of Tamarindus indica L. leaves were studied on control strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae) by agar disc diffusion method. Phytochemical analysis of Tamarindus indica L. leaves showed the presence of alkaloids, amino acids, carbohydrates, flavonoids, glycosides, polyphenol, starches, steroids/terpenoids, tannins, reducing sugars and anthroquinone. Ethanolic and aqueous extracts exhibited significant antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus. Both aqueous and ethanolic extracts possessed promising antibacterial activity on Pseudomonas aeruginosa and Staphylococcus aureus. This was an important finding upon pathogenic organisms causing food-borne diseases, skin and soft tissue infection. The petroleum ether extract did not show antibacterial activity against all tested organisms. With ethanolic extracts, the minimum inhibitory concentrations (MIC) results were 6.25 mg/ml for P. aeruginosa, S. aureus and 25 mg/ml for E. coli. For aqueous extracts, the MIC of P. aeruginosa and S. aureus were 12.5 mg/ml and K. pneumoniae was 25 mg/ml, respectively. Oral acute administration of 5000 mg/kg mice body weight of ethanolic and aqueous extracts of Tamarindus indica L. leaves resulted in no mortality. Therefore, the crude extracts from Tamarindus indica L. leaves had antimicrobial activity against K. pneumoniae, P. aeruginosa, S. aureus and E. coli.

Evaluation of Antibacterial Activity of Three Quaternary Ammonium Disinfectants on Different Germs Isolated from the Hospital Environment

BioMed Research International ◽

10.1155/2020/6509740 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Amal Ramzi ◽

Bouchra Oumokhtar ◽

Yassine Ez zoubi ◽

Touria Filali Mouatassem ◽

Moussa Benboubker ◽

...

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

Quaternary Ammonium ◽

Inhibitory Concentration ◽

Hospital Environment ◽

Gram Positive ◽

Gram Negative ◽

E Coli

Background. The microbiological risk of the hospital environment, including inert surfaces, medical devices, and equipment, represents a real problem. Objective. This study is aimed at demonstrating and assessing the antibacterial activity of three synthetic disinfectants classified as quaternary ammoniums on different bacterial strains (Gram-negative and Gram-positive like Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus) isolated from the hospital environment. The reference strains included Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, and Pseudomonas aeruginosa ATCC 27853 used as negative control strains. Method. Three quaternary ammonium disinfectants were tested: DDN9® (0.5%) which contains didecylmethylpolyoxyethylammonium propionate as an active substance, spray (0.4%) containing quaternary ammonium compounds, and Phagosurf ND® (0.4%) with didecyldimethylammonium chloride. Their effect was evaluated using the disk diffusion technique and the broth dilution methods, allowing the Minimum Inhibitory Concentration (MIC) and then the Minimum Bactericidal Concentration (MBC). Result. Only the growth of Gram-positive bacteria and some strains of Gram-negative bacteria were inhibited by the three synthetic disinfectants. NDD9® demonstrated an antibacterial effect only against the Gram-positive strains (S. aureus and S. aureus ATCC 29213) with a MIC of 0.25 mg/ml. The disinfectant spray showed effect against all four strains including E. coli (9), S. aureus, E. coli ATCC 25922, and P. aeruginosa ATCC 27853 with an inhibitory concentration of 4 mg/ml, while the growth of S. aureus ATCC 29213 was inhibited at 2 mg/ml. The third disinfectant, Phagosurf ND®, inhibited only the growth of S. aureus ATCC 29213 at a MIC of 4 mg/ml. Conclusion. This study is the first here in Morocco to evaluate the bacterial activity of products intended for the control of the healthcare environment. The results obtained on the three disinfectants tested reveal an ineffectiveness against some isolated strains from the hospital environment.

KHẢO SÁT ĐIỀU KIỆN NUÔI CẤY ĐỂ NÂNG CAO KHẢ NĂNG KHÁNG KHUẨN CỦA CÁC CHỦNG Streptomyces sp.

Tạp chí Khoa học và công nghệ nông nghiệp, Trường Đại học Nông Lâm Huế ◽

10.46826/huaf-jasat.v5n1y2021.459 ◽

2021 ◽

Vol 5 (1) ◽

pp. 2227-2236

Author(s):

Nguyễn Thị Thủy Tiên ◽

Lê Thị Thu Hiền ◽

Trần Thị Lệ Ngân ◽

Trần Văn Trung ◽

Nguyễn Thị Thúc ◽

...

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Antibacterial Activity ◽

16S Rrna ◽

Bacillus Cereus ◽

Salmonella Typhi ◽

Streptomyces Sp ◽

International Streptomyces Project ◽

E Coli

Streptomyces là những vi sinh vật có khả năng sinh tổng hợp các chất kháng sinh. Nghiên cứu này nhằm sàng lọc và chọn chủng có khả năng kháng khuẩn cao nhất từ 59 chủng Streptomyces có nguồn gốc từ đất đã được cung cấp dựa trên phương pháp cấy vạch vuông góc đối với 5 vi khuẩn gây bệnh chỉ thị, bao gồm Bacillus cereus, Escherichia coli, Salmonella typhi, Staphylococcus aureus và Pseudomonas aeruginosa. Mười lăm chủng thể hiện hoạt tính kháng khuẩn ở các mức độ khác nhau, các chủng còn lại không thể hiện khả năng kháng. Chủng có khả năng kháng khuẩn cao nhất là HĐM3.2, kháng 4/5 vi khuẩn chỉ thị đã sử dụng, gồm B. cerius, S. aureus, S. typhi và E. coli với kích thước vùng kháng đạt 9,5, 10,5, 16,5 và 14,5 mm. Chủng HĐM3.2 được xác định là chủng Streptomyces sp. dựa trên cây phát sinh loài đã xây dựng của trình tự gene 16S rRNA. Điều kiện nuôi cấy để chủng HĐM3.2 thể hiện hoạt tính kháng khuẩn cao nhất đã được khảo sát dựa trên phương pháp khuếch tán qua giếng thạch. Môi trường International Streptomyces Project 2 có pH 8, nhiệt độ nuôi cấy 28oC là điều kiện thích hợp để chủng Streptomyces sp. HĐM3.2 tạo ra vùng ức chế các loại vi khuẩn B. cereus, E. coli, S. typhi, S. aureus cao nhất. ABSTRACT Streptomyces is the microorganism that has capable of producing antibiotics. The current study aimed to screen and to select a strain that had the highest antibacterial activity from 59 available soil-derived Streptomyces strains based on the perpendicular culture method on 5 indicator pathogenic bacteria, including Bacillus cereus, Escherichia coli, Salmonella typhi, Staphylococcus aureus và Pseudomonas aeruginosa. Fourteen strains exhibited their antibacterial activity at various levels, the remaining did not have that activity. The strain that had the highest antibacterial ability was HĐM3.2 against 4/5 indicator microorganisms, including B. cerius, S. aureus, S. typhi and E. coli with inhibitory areas were 9.5, 10.5, 16.5, and 14.5 mm respectively. Strain HĐM3.2 was identified as strain Streptomyces sp. based on a phylogenetic tree built on the 16S rRNA gene sequences. Suitable conditions that made the strain HĐM3.2 showed the highest antibacterial activity were investigated based on agar well diffusion assay. The medium of International Streptomyces Project 2 with pH 8, the ambient temperature at 28oC were suitable conditions for Streptomyces sp. HĐM3.2 produced the highest inhibitory areas against B. cereus, E. coli, S. typhi, S. aureus.