scholarly journals Metabolic Phenotype and Adipose Tissue Inflammation in Patients with Chronic Obstructive Pulmonary Disease

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Peter Skyba ◽  
Jozef Ukropec ◽  
Pavol Pobeha ◽  
Barbara Ukropcova ◽  
Pavol Joppa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Pulmonary Disease ◽  
Normal Weight ◽  
Cell Surface Receptor ◽  
Metabolic Phenotype ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α

Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age62.3±7.2years). With increasing body mass index, increases in AT expressions of IL-6, TNF-α, and CD68 were observed (P<.001;P=.005;P<.001, resp.), in association with reduced insulin sensitivity (P<.001). No differences were observed between cachectic and normal-weight patients in AT expressions of inflammatory or proapoptotic markers. Adipose tissue CD68 and TNF-α expressions predicted insulin sensitivity independently of known confounders (P=.005;P=.025;R2=0.840). Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. Cachectic patients remain insulin sensitive, with no AT upregulation of inflammatory or proapoptotic markers.

scholarly journals Low-grade adipose tissue inflammation in patients with mild-to-moderate chronic obstructive pulmonary disease

2011 ◽  
Vol 94 (6) ◽  
pp. 1504-1512 ◽  
Author(s):  
Bram van den Borst ◽  
Harry R. Gosker ◽  
Geertjan Wesseling ◽  
Wilco de Jager ◽  
Valéry ACV Hellwig ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Adipose Tissue ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Low Grade ◽  
Adipose Tissue Inflammation ◽  
Obstructive Pulmonary Disease ◽  
Tissue Inflammation

scholarly journals Epicardial Adipose Tissue in Patients with Chronic Obstructive Pulmonary Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65593 ◽  
Author(s):  
Jorge Zagaceta ◽  
Javier J. Zulueta ◽  
Gorka Bastarrika ◽  
Inmaculada Colina ◽  
Ana B. Alcaide ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Adipose Tissue ◽  
Pulmonary Disease ◽  
Epicardial Adipose Tissue ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals The influence of various regimens of treatment on the level of proinflammatory cytokine TNF-alpha in induced sputum in case of an exacerbation of chronic obstructive pulmonary disease (copd) in persons, who suffered from pulmonary tuberculosis

2013 ◽  
Vol 17 (1 (65)) ◽  
pp. 38-40
Author(s):  
Ya. V. Ivanova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Disease ◽  
Proinflammatory Cytokine ◽  
Combined Treatment ◽  
Induced Sputum ◽  
Tnf Alpha ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α

The influence of various regimens of treatment of the regional (in induced sputum) level of proinflammatory cytokine TNF-α in patients with chronic obstructive pulmonary disease (COPD), who have suffered from pulmonary tuberculosis (PT), has been studied. An advantage of using a combined treatment of COPD exacerbation by means of β2agonist and an anticholinergic preparation (berodual), and also doxofillin (aerofillin) for the purpose of correcting regional (endobronchial) imbalance of cytokine homeostasis is proved.

scholarly journals Circulatory and Adipose Tissue Leptin and Adiponectin in Relationship to Resting Energy Expenditure in Patients With Chronic Obstructive Pulmonary Disease

2012 ◽  
pp. 469-480 ◽  
Author(s):  
M. BRÚSIK ◽  
J. UKROPEC ◽  
P. JOPPA ◽  
B. UKROPCOVÁ ◽  
P. SKYBA ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Serum Levels ◽  
Tissue Expression ◽  
Normal Weight ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Increases in resting energy expenditure (REE) likely contribute to weight loss in various chronic diseases. In chronic obstructive pulmonary disease (COPD), relationships between the ventilatory impairment and increased REE, and between disturbances in adipokines and weight loss were previously described. Therefore, we investigated serum levels and adipose tissue expression of leptin and adiponectin, and their relationships to REE in patients with COPD. In 44 patients with stable COPD (38 male; age 62.3±7.2 years), REE was assessed using indirect calorimetry. Subcutaneous adipose tissue samples were analyzed using real-time PCR. From underweight [n=9; body mass index (BMI) <20.0 kg.m−2], to normal weight-overweight (n=24, BMI=20.0-29.9 kg.m−2) and obese patients (n=11; BMI≥30 kg.m−2), REE adjusted for body weight decreased (32.9±6.1 vs. 26.2±5.8 vs. 23.9±6.6 kcal.kg−1.24 h−1, p=0.006), serum levels and adipose tissue expression of leptin increased (p<0.001 for both), and serum and adipose tissue adiponectin decreased (p<0.001; p=0.004, respectively). REE was inversely related to serum and adipose tissue leptin (R=−0.547, p<0.001; R=−0.458, p=0.002), and directly to serum adiponectin (R=0.316, p=0.039). Underweight patients had increased REE compared to normal weight-overweight patients, in association with reductions in serum and adipose tissue leptin, and increased serum adiponectin, suggesting a role of adipokines in energy imbalance in COPD-related cachexia.

scholarly journals Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1029
Author(s):  
Iva Hlapčić ◽  
Daniela Belamarić ◽  
Martina Bosnar ◽  
Domagoj Kifer ◽  
Andrea Vukić Dugac ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Extracellular Adenosine ◽  
Reactive Protein ◽  
Copd Patients ◽  
Tnf Α ◽  
Necrosis Factor

Interleukin (IL)-1α, IL-1β, IL-6, IL-8 and tumor necrosis factor (TNF)α contribute to inflammation in chronic obstructive pulmonary disease (COPD). We wanted to investigate their interrelations and association with disease severity, as well as to combine them with other inflammation-associated biomarkers and evaluate their predictive value and potential in identifying various patterns of systemic inflammation. One hundred and nine patients with stable COPD and 95 age- and sex-matched controls were enrolled in the study. Cytokines’ concentrations were determined in plasma samples by antibody-based multiplex immunosorbent assay kits. Investigated cytokines were increased in COPD patients but were not associated with disease or symptoms severity. IL-1β, IL-6 and TNFα showed the best discriminative values regarding ongoing inflammation in COPD. Inflammatory patterns were observed in COPD patients when cytokines, C-reactive protein (CRP), fibrinogen (Fbg), extracellular adenosine triphosphate (eATP), extracellular heat shock protein 70 (eHsp70) and clinical data were included in cluster analysis. IL-1β, eATP and eHsp70 combined correctly classified 91% of cases. Therefore, due to the heterogeneity of COPD, its assessment could be improved by combination of biomarkers. Models including IL-1β, eATP and eHsp70 might identify COPD patients, while IL-1β, IL-6 and TNFα combined with CRP, Fbg, eATP and eHsp70 might be informative regarding various COPD clinical subgroups.

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