scholarly journals Guidelines for Developing Yoga Interventions for Randomized Trials

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Karen J. Sherman
Keyword(s):  
Randomized Trials ◽  
Systematic Approach ◽  
Total Duration ◽  
Treatment Protocols ◽  
Breathing Exercises ◽  
Protocol Development ◽  
Specific Protocol ◽  
Key Issues ◽  
Selection Of ◽  
Made In

Little guidance is available to assist researchers in developing treatment protocols for research on yoga for health concerns. Because yoga is a complex multifactorial mind-body discipline historically developed for nonmedical purposes, numerous decisions must be made in order to thoughtfully develop such protocols. In this paper, a systematic approach is proposed to assist researchers in selecting an intervention that is appropriate for the condition under consideration and explicitly developed. Researchers need to consider the type or “style” of yoga, the components to include (e.g., breathing exercises, postures) as well as the specific protocol for each component, the dose to be delivered (frequency, duration of practice, and the total duration of practice), and issues related to selection of instructors and monitoring the fidelity to the intervention. Each of these domains and the key issues for the development of protocols is discussed. Finally, some areas for further research related to protocol development are recommended.

scholarly journals A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bruce Schultz ◽  
Andrea Zaliani ◽  
Christian Ebeling ◽  
Jeanette Reinshagen ◽  
Denisa Bojkova ◽  
...  
Keyword(s):  
Drug Target ◽  
Systematic Approach ◽  
Drug Repurposing ◽  
Global Scale ◽  
Rational Selection ◽  
Related Information ◽  
Singular Source ◽  
Therapeutic Compounds ◽  
Selection Of ◽  
Made In

AbstractThe SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community’s massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field of drug repurposing. However, many of the proposed therapeutic compounds obtained from SARS-CoV-2 specific assays are not in agreement and thus demonstrate the need for a singular source of COVID-19 related information from which a rational selection of drug repurposing candidates can be made. In this paper, we present the COVID-19 PHARMACOME, a comprehensive drug-target-mechanism graph generated from a compilation of 10 separate disease maps and sources of experimental data focused on SARS-CoV-2/COVID-19 pathophysiology. By applying our systematic approach, we were able to predict the synergistic effect of specific drug pairs, such as Remdesivir and Thioguanosine or Nelfinavir and Raloxifene, on SARS-CoV-2 infection. Experimental validation of our results demonstrate that our graph can be used to not only explore the involved mechanistic pathways, but also to identify novel combinations of drug repurposing candidates.

scholarly journals The COVID-19 PHARMACOME: Rational Selection of Drug Repurposing Candidates from Multimodal Knowledge Harmonization

2020 ◽  
Author(s):  
Bruce Schultz ◽  
Andrea Zaliani ◽  
Christian Ebeling ◽  
Jeanette Reinshagen ◽  
Denisa Bojkova ◽  
...  
Keyword(s):  
Drug Target ◽  
Systematic Approach ◽  
Drug Repurposing ◽  
Global Scale ◽  
Rational Selection ◽  
Related Information ◽  
Singular Source ◽  
Therapeutic Compounds ◽  
Selection Of ◽  
Made In

AbstractThe SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community’s massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field drug repurposing. However, many of the proposed therapeutic compounds obtained from SARS-CoV-2 specific assays are not in agreement and thus demonstrate the need for a singular source of COVID-19 related information from which a rational selection of drug repurposing candidates can be made. In this paper, we present the COVID-19 PHARMACOME, a comprehensive drug-target-mechanism graph generated from a compilation of several disease maps and experimental data focused on SARS-CoV-2 / COVID-19 pathophysiology. By applying a systematic approach, we were able to predict the effect of drug pairs on SARS-CoV-2 infection. Experimental validation of our results demonstrate that our graph can be used to not only explore the involved mechanistic pathways, but also to identify novel combinations of drug repurposing candidates.

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

2020 ◽  
Author(s):  
Luke Adams ◽  
Lorna E. Wilkinson-White ◽  
Menachem J. Gunzburg ◽  
Stephen J. Headey ◽  
Martin J. Scanlon ◽  
...  
Keyword(s):  
Binding Site ◽  
Systematic Approach ◽  
Structural Information ◽  
Peptide Binding ◽  
Chemical Diversity ◽  
Chemical Probes ◽  
Protein Targets ◽  
Structure Activity ◽  
Peptide Binding Site ◽  
Selection Of

The development of low-affinity fragment hits into higher affinity leads is a major hurdle in fragment-based drug design. Here we demonstrate an approach for the Rapid Elaboration of Fragments into Leads (REFiL) applying an integrated workflow that provides a systematic approach to generate higher-affinity binders without the need for structural information. The workflow involves the selection of commercial analogues of fragment hits to generate preliminary structure-activity relationships. This is followed by parallel microscale chemistry using chemoinformatically designed reagent libraries to rapidly explore chemical diversity. Upon completion of a fragment screen against Bromodomain-3 extra terminal (BRD3-ET) domain we applied the REFiL workflow, which allowed us to develop a series of tetrahydrocarbazole ligands that bind to the peptide binding site of BRD3-ET. With REFiL we were able to rapidly improve binding affinity >30-fold. The REFiL workflow can be applied readily to a broad range of protein targets without the need of a structure, allowing the efficient evolution of low-affinity fragments into higher affinity leads and chemical probes.<br>

WINTER WHEAT DEVELOPED BY THE UDMURT RESEARCH INSTITUTE OF AGRICULTURE IN COMPETITIVE VARIETY TESTING

2020 ◽  
pp. 5-16
Author(s):  
I.V. TORBINA ◽  
◽  
I.R. FARDEYEVA ◽  
Keyword(s):  
Winter Wheat ◽  
Crop Rotation ◽  
Biological Characteristics ◽  
Commercial Use ◽  
Breeding Material ◽  
Rotation Pattern ◽  
Selection Of ◽  
Variety Testing ◽  
Made In ◽  
Research Institute

The paper assesses the promising varieties of winter wheat in a competitive variety test by the main economic and biological characteristics that determine the suitability of the variety for commercial use. The object of research was the authors’ own breeding material. The experiments on the selection of winter wheat were made in the experimental crop rotation pattern of the Institute.

Evidence-based Assessment

2010 ◽  
pp. 76-98
Author(s):  
John Hunsley ◽  
Eric J. Mash
Keyword(s):  
Decision Making ◽  
Clinical Assessment ◽  
Assessment Process ◽  
Evidence Based ◽  
The Past ◽  
Specific Assessment ◽  
The Many ◽  
Selection Of ◽  
Made In

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.

scholarly journals Biomarkers of Angiogenesis and Neuroplasticity as Promising Clinical Tools for Stroke Recovery Evaluation

2021 ◽  
Vol 22 (8) ◽  
pp. 3949
Author(s):  
Lidia Wlodarczyk ◽  
Rafal Szelenberger ◽  
Natalia Cichon ◽  
Joanna Saluk-Bijak ◽  
Michal Bijak ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Stroke Recovery ◽  
Clinical Scales ◽  
Recovery Processes ◽  
Recovery Potential ◽  
Current State ◽  
Standard Procedures ◽  
Key Issues ◽  
Clinical Tools ◽  
Selection Of

Several key issues impact the clinical practice of stroke rehabilitation including a patient’s medical history, stroke experience, the potential for recovery, and the selection of the most effective type of therapy. Until clinicians have answers to these concerns, the treatment and rehabilitation are rather intuitive, with standard procedures carried out based on subjective estimations using clinical scales. Therefore, there is a need to find biomarkers that could predict brain recovery potential in stroke patients. This review aims to present the current state-of-the-art stroke recovery biomarkers that could be used in clinical practice. The revision of biochemical biomarkers has been developed based on stroke recovery processes: angiogenesis and neuroplasticity. This paper provides an overview of the biomarkers that are considered to be ready-to-use in clinical practice and others, considered as future tools. Furthermore, this review shows the utility of biomarkers in the development of the concept of personalized medicine. Enhancing brain neuroplasticity and rehabilitation facilitation are crucial concerns not only after stroke, but in all central nervous system diseases.

scholarly journals A Clinical Study to Correlate the Facial Form and Maxillary Central Incisor Tooth Form in Males and Females of Davangere Population

2016 ◽  
Vol 04 (03) ◽  
pp. 156-164
Author(s):  
Deepak Bansal ◽  
Shruti Sharma ◽  
Manjit Kumar ◽  
Amrit Khosla
Keyword(s):  
Facial Appearance ◽  
Central Incisor ◽  
Incisor Tooth ◽  
Maxillary Central Incisor ◽  
Anterior Teeth ◽  
The Face ◽  
Tooth Form ◽  
Males And Females ◽  
Selection Of ◽  
Made In

AbstractAn altered facial appearance is more difficult to face, than problems related to ill-fitting denture or eating. The selection of maxillary anterior teeth for complete denture has long posed problem in clinical practice and a controversy about the best method to employ still exists. An attempt is made in the present study to clinically correlate the face form with maxillary central incisor tooth form in males and females of Davangere population. In 1914, Leon William's projected the “the form method” where he classified facial forms as square, tapering, and ovoid. Maxillary central incisors were selected according to the facial forms.Of total 100 subjects four different tooth forms and face forms were evaluated. They are: square, ovoid, square-tapered, tapered. No significant correlation existed between face form in male and females. Females exhibited greater correlation between face forms and inverted tooth form but that correlation is not sufficient to serve as a guide for selection of anterior teeth.

New Development in High Efficiency Deep Grinding

2012 ◽  
Author(s):  
Andre D. L. Batako ◽  
Valery V. Kuzin ◽  
Brian Rowe
Keyword(s):  
Machine Tool ◽  
High Efficiency ◽  
Machining Process ◽  
Depth Of Cut ◽  
Removal Rates ◽  
Workpiece Surface ◽  
New Development ◽  
Cutting Processes ◽  
Selection Of ◽  
Made In

High Efficiency Deep Grinding (HEDG) has been known to secure high removal rates in grinding processes at high wheel speed, relatively large depth of cut and moderately high work speed. High removal rates in HEDG are associated with very efficient grinding and secure very low specific energy comparable to conventional cutting processes. Though there exist HEDG-enabled machine tools, the wide spread of HEDG has been very limited due to the requirement for the machine tool and process design to ensure workpiece surface integrity. HEDG is an aggressive machining process that requires an adequate selection of grinding parameters in order to be successful within a given machine tool and workpiece configuration. This paper presents progress made in the development of a specialised HEDG machine. Results of HEDG processes obtained from the designed machine tool are presented to illustrate achievable high specific removal rates. Specific grinding energies are shown alongside with measured contact arc temperatures. An enhanced single-pole thermocouple technique was used to measure the actual contact temperatures in deep cutting. The performance of conventional wheels is depicted together with the performance of a CBN wheel obtained from actual industrial tests.

scholarly journals Recent advances in the electrochemical construction of heterocycles

2014 ◽  
Vol 10 ◽  
pp. 2858-2873 ◽  
Author(s):  
Robert Francke
Keyword(s):  
Heterocyclic Compounds ◽  
Elevated Temperatures ◽  
Ring Formation ◽  
Environmentally Benign ◽  
Heterocyclic Chemistry ◽  
Ambient Conditions ◽  
Recent Developments ◽  
Strong Acids ◽  
Selection Of ◽  
Made In

Due to the fact that the major portion of pharmaceuticals and agrochemicals contains heterocyclic units and since the overall number of commercially used heterocyclic compounds is steadily growing, heterocyclic chemistry remains in the focus of the synthetic community. Enormous efforts have been made in the last decades in order to render the production of such compounds more selective and efficient. However, most of the conventional methods for the construction of heterocyclic cores still involve the use of strong acids or bases, the operation at elevated temperatures and/or the use of expensive catalysts and reagents. In this regard, electrosynthesis can provide a milder and more environmentally benign alternative. In fact, numerous examples for the electrochemical construction of heterocycles have been reported in recent years. These cases demonstrate that ring formation can be achieved efficiently under ambient conditions without the use of additional reagents. In order to account for the recent developments in this field, a selection of representative reactions is presented and discussed in this review.

Biomarkers of Radiographic Progression in Psoriatic Arthritis: A Report from the GRAPPA 2011 Annual Meeting

2012 ◽  
Vol 39 (11) ◽  
pp. 2189-2192 ◽  
Author(s):  
OLIVER FITZGERALD ◽  
CHRISTOPHER T. RITCHLIN ◽  
PHILIP J. MEASE
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Structural Damage ◽  
Radiographic Progression ◽  
Clinical Markers ◽  
Sample Collection ◽  
Critical Research ◽  
Specific Protocol ◽  
Radiographic Scoring Methods ◽  
Selection Of

Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.

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