scholarly journals Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Nunzia Giordano ◽  
Valérie Tikhonoff ◽  
Paolo Palatini ◽  
Anna Bascelli ◽  
Giovanni Boschetti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Neuropsychological Tests ◽  
Cognitive Reserve ◽  
Mini Mental State Examination ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
State Examination

In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 sec (MI-10) (−33%,P=0.03), clock drawing test (CLOX) (−28%,P<0.01), and mini-mental state examination (MMSE) (−6%,P=0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (odds ratio, OR, 0.97,P=0.02; OR 0.98,P<0.005; OR 0.95,P<0.001) and higher pulse blood pressure (BP) (OR 0.97,P=0.02; OR 0.97,P<0.01; and 0.95,P<0.0001). The cognitive reserve index (CRI) was 6% lower in the HT (P=0.03) and was predicted by higher pulse BP (OR 0.82,P<0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. The label of hypertension and higher values of systolic or pulse BP are associated to worse memory and executive functions. Higher diastolic BP, although insufficient to impair cognition, strengthens this association. CRI is predicted by higher systolic BP associated to lower diastolic BP.

scholarly journals GAMBARAN FUNGSI KOGNITIF PADA PASIEN RAWAT JALAN DENGAN RIWAYAT STROKE DI POLIKLINIK SARAF RSUP PROF. DR. R.D. KANDOU MANADO

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Tirzha N. Paparang ◽  
Corry N. Mahama ◽  
Denny J. Ngantung
Keyword(s):  
Cognitive Function ◽  
Mini Mental State Examination ◽  
Trail Making Test ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
Trail Making ◽  
Cross Sectional Design ◽  
State Examination

Abstract: Stroke is a major cause of cognitive dysfunction. The incidences of cognitive dysfunction increase three-fold after strokes, usually involving impairement of abilities in visuo-spacial, memory, orientation, speech, attention, and performance functions. The rapid, practical, and approved examinations used to evaluate and confirm the decline in cognitive functions are the Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT), and the Trail Making Test (TMT). This study aimed to reveal the cognitive functions of outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado by using the above mentioned examinations. This was a descriptive study with a cross-sectional design conducted in November 2012. The results showed that there were 51 respondents who fulfilled the inclusion criteria consisting of 32 males and 19 females. The highest decline of cognitive function by age, the educational level, and employment was 60-79 years, more than 9 years of education, and retired workers, respectively. The results of the MMSE, CDT, and TMT examinations for cognitive impairment evaluation were as follow: MMSE 62.75%, CDT 56.86%, TMT A 96.08%, and TMT B 84.31%. Conclusion: Most of the outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado showed cognitive impairments. Keywords: CDT, cognitive function, MMSE, stroke, TMT-A and B.   Abstrak: Stroke merupakan penyebab utama gangguan fungsi kognitif. Insiden gangguan kognitif meningkat tiga kali lipat setelah stroke, dan biasanya melibatkan kemampuan visuospasial, memori, orientasi, bahasa, perhatian dan fungsi eksekutif. Pemeriksaan yang digunakan untuk mengevaluasi dan mengonfirmasi penurunan  fungsi kognitif yang cepat dan praktis namun bernilai tinggi ialah Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), dan Trail Making Test (TMT). Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado. Penelitian ini bersifat deskriptif dengan cross-sectional design dan dilaksanakan selama bulan November 2012. Hasil penelitian memperlihatkan bahwa 51 responden memenuhi kriteria inklusi, terdiri dari 32 laki-laki dan 19 perempuan. Berdasarkan usia, tingkat pendidikan, dan pekerjaan, penurunan fungsi kognitif terbanyak pada usia 60-79 tahun, tingkat pendidikan terakhir >9 tahun, dan pekerjaan pensiunan. Hasil pemeriksaan MMSE, CDT, dan TMT terhadap fungsi kognitif responden ialah: MMSE 62,75%, CDT 56,86%, TMT A 96,08%, dan TMT B 84,31%. Simpulan: Sebagian besar pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado telah memperlihatkan gagguan fungsi kognitif.Kata kunci: stroke, fungsi kognitif, MMSE, CDT, TMT-A dan B.

scholarly journals Turkish Version of the Test Your Memory (TYM-TR) as a Screening Tool in Memory Clinics

2021 ◽  
Vol 36 ◽  
pp. 153331752098220
Author(s):  
Reza Naghdi Sadeh ◽  
Sara Farhang ◽  
Serhat Özkan ◽  
Hossein Jabbari Khamnei ◽  
Çınar Yenilmez ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Mini Mental State Examination ◽  
Neurocognitive Disorder ◽  
Turkish Version ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
Memory Clinics ◽  
Cross Sectional Design ◽  
State Examination

Introduction: This study compared the Turkish version of Test Your Memory (TYM) MMSE (Mini-Mental State Examination) and CDT (Clock Drawing Test) in patients with neurocognitive disorder. Methods: After a thorough medical workup, patients with a diagnosis of neurocognitive disorder were enrolled. A cross-sectional design was used to compare the TYM results with those of MMSE and CDT. Results: This study was conducted on 100 patients, including 46 males and 54 females, aged 52 to 86. The majority of patients were diagnosed with vascular neurocognitive disorder. The z-score of TYM-TR was significantly lower in the domains of registration, recall, visuospatial, and total score. The same results were achieved when CDT was added to MMSE. The same pattern was observed separately for those who were diagnosed with a mild or major neurocognitive disorder. Conclusion: Patients’ cognitive deficits might be more evident when measured by the TYM-TR compared to the MMSE.

scholarly journals COGNITIVE FUNCTIONS CONDITION OF POST-STROKE PATIENTS

2019 ◽  
pp. 16-21
Author(s):  
V. R. Gerasymchuk ◽  
I. F. Uwa-Agbonikhena ◽  
L. T. Maksymchuk ◽  
M. Yu. Kupnovytska-Sabadosh ◽  
T. I. Nehrych ◽  
...  
Keyword(s):  
Executive Functions ◽  
Mini Mental State Examination ◽  
Cognitive Status ◽  
Control Group ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
Status Assessment ◽  
Trail Making ◽  
State Examination ◽  
Moca Score

60 patients after a hemispheric ischemic stroke (IS) were examined. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Trail Making Test A and B (TMT), and the Clock Drawing Test (CDT) were used for the cognitive status assessment. A decrease in the MMSE, FAB and MoCA score compared to the control group (CG) (p<0.05) was observed, with probable differences mainly in the domains of attention (p<0.05) and executive functions (p<0.05). An increase in the time of task execution by 45.5% was detected for TMT A (p <0.05) and 61.9% for TMT B (p <0.01), and violation of CDT performance compared to the CG (p<0.05). Thus, the study of cognitive status using TMT and CDT may be recommended for timely detection of the initial executive functions impairment.

Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Mohan Thanikachalam ◽  
Shasha Bai ◽  
Vijayakumar Harivanzan ◽  
Ragavendra R Baliga ◽  
William T Abraham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Arterial Stiffness ◽  
Multivariate Regression ◽  
Independent Predictor ◽  
Density Lipoprotein ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

scholarly journals A Novel Exercise for Enhancing Visuospatial Ability in Older Adults with Frailty: Development, Feasibility, and Effectiveness

Geriatrics ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 29
Author(s):  
Miyuki Nemoto ◽  
Hiroyuki Sasai ◽  
Noriko Yabushita ◽  
Keito Tsuchiya ◽  
Kazushi Hotta ◽  
...  
Keyword(s):  
Older Adults ◽  
Mini Mental State Examination ◽  
Exercise Program ◽  
Exercise Group ◽  
Visuospatial Ability ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
Before And After ◽  
Global Cognition ◽  
State Examination

We aimed to develop a novel exercise to improve visuospatial ability and evaluate its feasibility and effectiveness in older adults with frailty. A non-randomized preliminary trial was conducted between June 2014 and March 2015. We recruited 35 adults with frailty (24 women), aged 66–92 years. Participants were assigned to either locomotive- or visuospatial-exercise groups. All participants exercised under the supervision of physiotherapists for 90 min/week for 12 weeks. The visuospatial exercise participants used cubes with six colored patterns and were instructed to “reproduce the same colored pattern as shown in the photo”, using the cubes. In the locomotive exercise group, lower extremity functional training was provided. Rates of retention and attendance measured feasibility. Most participants completed the intervention (77.3%, locomotive; 84.6%, visuospatial) and had good attendance (83.8%, locomotive; 90.7%, visuospatial). Mini-mental state examination (MMSE), clock drawing test (CDT), and seven physical performance tests were conducted before and after interventions. The improvement in the MMSE score, qualitative analysis of CDT, grip strength, and sit and reach assessments were significantly greater in the visuospatial exercise group than in the locomotive exercise group. The cube exercise might be a feasible exercise program to potentially improve visuospatial ability and global cognition in older adults with frailty.

scholarly journals Is the Mini-Mental State Examination the best cognitive screening test for less educated people?

2019 ◽  
Vol 77 (5) ◽  
pp. 330-334 ◽  
Author(s):  
Luis Felipe Scarabelot ◽  
Mariane de Moraes Monteiro ◽  
Mauren Carneiro da Silva Rubert ◽  
Viviane de Hiroki Flumignan Zetola
Keyword(s):  
Verbal Fluency ◽  
Mini Mental State Examination ◽  
Recall Test ◽  
Cognitive Screening ◽  
Delayed Recall ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
State Examination ◽  
Fluency Test

ABSTRACT Mini-Mental State Examination (MMSE) results are strongly influenced by educational level. The Brief Cognitive Screening Battery (BCSB) is an alternative assessment tool that provides more accurate results in individuals with less education. Objective: Our aim was to compare the MMSE and BCSB as screening tests. Methods: The MMSE and BCSB were assessed in 112 participants by two evaluators blind to the other test's result. Participants were classified according to their level of education. The influence of education level was analyzed using the Kruskal-Wallis and multiple comparison tests. Results: Scores of the MMSE (p < 0.0001) and the clock-drawing test (p < 0.0001) were influenced by education level but the delayed recall test score was not (p = 0.0804). The verbal fluency test (p = 0.00035) was influenced only by higher educational levels. It took three minutes less to apply the MMSE than to apply the BCSB (p < 0.0001). Conclusions: These findings suggest that the delayed recall test and the verbal fluency test of the BCSB are better than the MMSE and clock-drawing test as tools for evaluating cognition in people with limited education.

scholarly journals Assessment for apraxia in Mild Cognitive Impairment and Alzheimer's disease

2015 ◽  
Vol 9 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Mirela Ward ◽  
Juliana F. Cecato ◽  
Ivan Aprahamian ◽  
José Eduardo Martinelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mini Mental State Examination ◽  
Average Score ◽  
Clock Drawing Test ◽  
Healthy Elderly ◽  
Drawing Test ◽  
State Examination

OBJECTIVE: To evaluate apraxia in healthy elderly and in patients diagnosed with Alzheimer's disease (AD) and Mild cognitive impairment (MCI). METHODS: We evaluated 136 subjects with an average age of 75.74 years (minimum 60 years old, maximum 92 years old) and average schooling of 9 years (minimum of 7 and a maximum of 12 years), using the Mini-Mental State examination (MMSE), Cambridge Cognitive Examination (CAMCOG) and the Clock Drawing Test. For the analysis of the presence of apraxia, eight subitems from the CAMCOG were selected: the drawings of the pentagon, spiral, house, clock; and the tasks of putting a piece of paper in an envelope; the correct one hand waiving "Goodbye" movements; paper cutting using scissors; and brushing teeth. RESULTS: Elder controls had an average score of 11.51, compared to MCI (11.13), and AD patients, whose average apraxia test scores were the lowest (10.23). Apraxia scores proved able to differentiate the three groups studied (p=0.001). In addition, a negative correlation was observed between apraxia and MMSE scores. CONCLUSION: We conclude that testing for the presence of apraxia is important in the evaluation of patients with cognitive impairments and may help to differentiate elderly controls, MCI and AD.

scholarly journals PENERAPAN ART THERAPY MEMBATIK COLET SEBAGAI UPAYA MEMELIHARA FUNGSI KOGNITIF LANSIA DI POSYANDU BAROKAH, KELURAHAN KLAMPIS NGASEM, KECAMATAN SUKOLILO, KOTA SURABAYA, PROVINSI JAWA TIMUR

2020 ◽  
Vol 6 (1) ◽  
pp. 41-45
Author(s):  
Elida Ulfiana ◽  
Makhfudli ◽  
Kusnul Chotimah ◽  
Zenitha Rani
Keyword(s):  
Cognitive Function ◽  
Art Therapy ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Community Partnership ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
Dementia Prevention ◽  
State Examination ◽  
Partnership Program

Klampis Ngasem is one of the areas in East Surabaya, precisely in Sukolilo sub-district, Surabaya. The target group in the community partnership program (PKM) is the Elderly Posyandu "Barokah" in RW 3. Problems that occur in the Elderly Barokah Posyandu are less varied activities and innovation so that some elderly are less interested and bored to follow routinely as indicated by the presence of the elderly < 75%, the absence of efforts to prevent dementia that is carried out regularly and continue for the elderly, lack of elderly knowledge about changes in cognitive function and efforts to maintain cognitive function so as to prevent dementia, and the availability of leisure time for the elderly in addition to routine posyandu activities and those that have not been utilized to be useful and productive. The solution to overcome these problems is through the application of Art Therapy to make colet batik. The purpose of this community service is to help express themselves, maintain the cognitive function of the elderly and provide new skills in making batik as an activity in the Posyandu Elder Barokah Klampis Ngasem Village. The activities carried out are screening to see the cognitive function of the elderly using Mini mental state examination (MMSE) and clock drawing test (CDT), counseling about prevention of dementia which includes knowing dementia, prevention of dementia, and art therapy, batik colet training with demonstration methods, and simulation. The results of batik colet will be processed again with the help of cadres or the elderly who have sewing skills to be used as sofa pillowcases. From this process, a work or product will be produced from the batik colet method.

Ο επιπολασμός των γηριατρικών συνδρόμων στην πρωτοβάθμια φροντίδα υγείας ανάλογα με τη παρουσία σακχαρώδη διαβήτη τύπου 2

2019 ◽  
Author(s):  
Μαρίνα Κοτσάνη
Keyword(s):  
Mental State ◽  
Mini Mental State Examination ◽  
Timed Up And Go ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
State Examination

Η διαχείριση του σακχαρώδη διαβήτη τύπου 2 (ΣΔ2) παρουσιάζει ιδιαίτερες προκλήσεις, ιδιαίτερα στους ηλικιωμένους. Σκοπός της μελέτης ήταν να συγκρίνει τον επιπολασμό ορισμένων γηριατρικών συνδρόμων, σε άτομα 65 ετών και άνω που ζουν στην κοινότητα, με ή χωρίς ΣΔ2. Διενεργήθηκε μία μελέτη χρονικής στιγμής, σε δομές πρωτοβάθμιας φροντίδας υγείας, με διαστρωματοποιημένη δειγματοληψία ως προς το ΣΔ2. Συνολικά 403 άτομα περιλήφθηκαν στην μελέτη, 198 με και 205 χωρίς ΣΔ2, στα οποία μελετήθηκαν, με τη βοήθεια δομημένης ατομικής κλινικής συνέντευξης και με τη χρήση ευρέως διαδεδομένων ανιχνευτικών κλιμάκων, οι εξής γηριατρικοί φαινότυποι: επηρεασμένη γνωστική λειτουργία, κατάθλιψη, περιορισμός στην κινητικότητα, λειτουργική έκπτωση και πτώσεις. Συλλέχθηκαν επίσης δεδομένα σχετικά με το ιατροκοινωνικό προφίλ. Τα άτομα με ή χωρίς διαβήτη δε διέφεραν ως προς το φύλο, την ηλικία, το βάρος και τον δείκτη μάζας σώματος. Τα άτομα με διαβήτη είχαν μεγαλύτερη περίμετρο μέσης και υψηλότερο επιπολασμό υπέρτασης, δυσλιπιδαιμίας και ιστορικού παροδικού ή εγκατεστημένου αγγειακού εγκεφαλικού επεισοδίου, ενώ έπαιρναν επίσης 2.3 περισσότερα φαρμακευτικά σκευάσματα σε σχέση με εκείνα χωρίς. Μεταξύ των εκτιμώμενων γηριατρικών συνδρόμων, η επηρεασμένη γνωστική λειτουργία ήταν σημαντικά συχνότερη στην ομάδα του ΣΔ2, όπως εκφραζόταν από το σκορ στην κλίμακα Mini Mental State Examination (MMSE), στην οποία τα άτομα με διαβήτη παρουσίασαν χαμηλότερη επίδοση κατά σχεδόν ένα πόντο σε σύγκριση με εκείνα χωρίς (μέση τιμή MMSE 26.8 έναντι 27.6, p=0.009), αλλά και από τη συχνότερη κατηγοριοποίηση στην ομάδα της επηρεασμένης γνωστικής λειτουργίας (36.4% έναντι 23.4%, p=0.004). Επίσης τα άτομα με διαβήτη παρουσίαζαν συχνότερα πιο αργή κινητική επίδοση, εκφραζόμενη με τη δοκιμασία Timed Up and Go (TUG), σε σχέση με εκείνα χωρίς διαβήτη (33.8% έναντι 24.9%, p=0.048). Πραγματοποιήθηκε επίσης ανάλυση ανά ηλικιακές υποομάδες, χωρίζοντας τον πληθυσμό της μελέτης μας σε νεότερους ηλικιωμένους 65-74 ετών και γηραιότερους ηλικιωμένους 75 ετών και άνω. Στην ηλικιακή υποομάδα των 75 ετών και άνω δεν βρέθηκαν διαφορές στον επιπολασμό των μελετώμενων γηριατρικών συνδρόμων μεταξύ των ατόμων με ή χωρίς διαβήτη. Αντίθετα, στην υποομάδα των νεότερων ηλικιωμένων 65-74 ετών, η μέση τιμή του σκορ MMSE διέφερε σημαντικά μεταξύ των ατόμων με ή χωρίς διαβήτη (27.3 έναντι 28.2, p=0.004), όπως και ο επιπολασμός της επηρεασμένης γνωστικής λειτουργίας (33.3 έναντι 15.4%, p=0.001), (OR: 2.8, 95%CI: 1.5-5.1, p=0.001). Επίσης το σκορ της γνωστικής δοκιμασίας Clock Drawing Test (CDT) διέφερε σημαντικά μεταξύ των ατόμων με ή χωρίς διαβήτη (9.1 έναντι 9.4, p=0.034) στη νεότερη ηλικιακή υποομάδα. Στην ίδια υποομάδα, η κινητικότητα, όπως εκτιμήθηκε από τη δοκιμασία TUG, φάνηκε πως διέφερε μεταξύ των ατόμων με ή χωρίς διαβήτη, τόσο όταν εκφραζόταν ως μέσος χρόνος εκτέλεσης της δοκιμασίας (10.9 έναντι 9.8 sec, p=0.017), όσο και όταν εκφραζόταν ως πιθανότητα για πιο αργή επίδοση (27.8 έναντι 12%, p=0.002) (OR: 2.8, 95%CI: 1.4-5.6, p=0.003). Τα αποτελέσματα διατηρήθηκαν και στα πολυπαραγοντικά λογαριθμικά μοντέλα, μετά από στάθμιση για πιθανούς συγχυτικούς παράγοντες. Δεν αναδείχθηκαν σημαντικές διαφορές στα υπόλοιπα μελετώμενα γηριατρικά σύνδρομα μεταξύ των ομάδων με ή χωρίς διαβήτη στο σύνολο του μελετώμενου πληθυσμού, ούτε στις επιμέρους ηλικιακές υποομάδες. Τα αποτελέσματα αποκάλυψαν ένα βαθμό γνωστικής και κινητικής ευπάθειας στα άτομα με διαβήτη. Επιπλέον, η ανάλυση ανά ηλικιακές υποομάδες ανέδειξε ένα συσχετισμό μεταξύ του ΣΔ2 και των γηριατρικών φαινοτύπων σε ηλικίες νεότερες από αυτές που κλασικά θεωρούνται πραγματικά γηριατρικές, υπονοώντας ένα είδος πρωιμότερης γήρανσης στα άτομα με ΣΔ2.

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