scholarly journals Report of a Case of Radiation-Induced New-Onset Vitiligo with Collective Review of Cases in the Literature of Radiation-Related Vitiligo

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Keechilat Pavithran ◽  
Shripad Brahmanand Pande ◽  
Makuny Dinesh
Keyword(s):  
Family History ◽  
Case Reports ◽  
Radiation Delivery ◽  
History Of ◽  
Radiation Induced ◽  
New Onset

Radiation-induced hypopigmentation consistent vitiligo has been reported in a few case reports. We report herewith a case of vitiligo at the site of radiation delivery after a lag of several months in a patient with preexisting hypothyroidism without a previous or family history of vitiligo, and review the cases reported in the literature collectively.

scholarly journals Clozapine-induced stuttering in the absence of known risk factors: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Florence Jaguga
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Side Effect ◽  
Case Reports ◽  
Extrapyramidal Symptoms ◽  
Prior History ◽  
Case Presentation ◽  
Rare Side Effect ◽  
History Of ◽  
Electrophysiological Findings

Abstract Background Stuttering is a rare side effect of clozapine. It has been shown to occur in the presence of one or more factors such as abnormal electrophysiological findings and seizures, extrapyramidal symptoms, brain pathology, and a family history of stuttering. Few case reports have documented the occurrence of clozapine-induced stuttering in the absence of these risk factors. Case presentation A 29-year-old African male on clozapine for treatment-resistant schizophrenia presented with stuttering at a dosage of 400 mg/day that resolved with dose reduction. Electroencephalogram findings were normal, and there was no clinical evidence of seizures. The patient had no prior history or family history of stuttering, had a normal neurological examination, and showed no signs of extrapyramidal symptoms. Conclusion Clinicians ought to be aware of stuttering as a side effect of clozapine, even in the absence of known risk factors. Further research should investigate the pathophysiology of clozapine-induced stuttering.

scholarly journals New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

2018 ◽  
Vol 2 (1) ◽  
pp. 35-40
Author(s):  
Sakthirajan R ◽  
Dhanapriya J ◽  
Dineshkumar T ◽  
Balasubramaniyan T ◽  
Gopalakrishnan N ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Family History ◽  
Fasting Blood Glucose ◽  
Hcv Infection ◽  
Clinical Profile ◽  
Family History Of Diabetes ◽  
Onset Diabetes ◽  
History Of ◽  
New Onset

Background: New onset diabetes after transplant (NODAT) remains one among the significant threats to both renal allograft and patient survival. The aim of this study was to analyse the clinical profile and risk factors for NODAT.Methods: This prospective observational study involved patients who underwent renal transplantation in our centre between 2010 and 2015.Results: During the mean follow up period of 18 ± 6 months, incidence of NODAT was 26.6% and the cumulativeincidence was highest in the first year after transplant. Recipient age, pre transplant impaired fasting glucose, Hepatitis C virus (HCV) infection, family history of diabetes, tacrolimus, post transplant hypertriglyceridemia and metabolic syndrome were found to be statistically significant risk factors for NODAT. In Cox multivariate regression analysis, age and family history of diabetes were found to be independent risk factors for NODAT. Fasting C-peptide level underlines insulin resistance as predominant mechanism for NODAT in two third of patients. There were higher incidence of urinary tract infection in the NODAT patients. NODAT was found to be an independent risk factor for fungal infection and 10 year cardiovascular risk in the renal recipients. There was no significant impact of NODAT on short term graft and patient survival.Conclusion: Age, pre-transplant fasting blood glucose, family history of diabetes, HCV infection and tacrolimus were found to be the important risk factors, with insulin resistance as the predominant mechanism for NODAT.

scholarly journals Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies

2017 ◽  
Vol 7 (4) ◽  
pp. 141-157 ◽  
Author(s):  
Rafael G. dos Santos ◽  
José Carlos Bouso ◽  
Jaime E. C. Hallak
Keyword(s):  
Systematic Review ◽  
Family History ◽  
Adverse Reactions ◽  
Population Studies ◽  
Case Reports ◽  
Case Series ◽  
Lysergic Acid ◽  
Psychotic Illness ◽  
History Of ◽  
Low Incidence

Ayahuasca is a hallucinogen brew traditionally used for ritual and therapeutic purposes in Northwestern Amazon. It is rich in the tryptamine hallucinogens dimethyltryptamine (DMT), which acts as a serotonin 5-HT2A agonist. This mechanism of action is similar to other compounds such as lysergic acid diethylamide (LSD) and psilocybin. The controlled use of LSD and psilocybin in experimental settings is associated with a low incidence of psychotic episodes, and population studies corroborate these findings. Both the controlled use of DMT in experimental settings and the use of ayahuasca in experimental and ritual settings are not usually associated with psychotic episodes, but little is known regarding ayahuasca or DMT use outside these controlled contexts. Thus, we performed a systematic review of the published case reports describing psychotic episodes associated with ayahuasca and DMT intake. We found three case series and two case reports describing psychotic episodes associated with ayahuasca intake, and three case reports describing psychotic episodes associated with DMT. Several reports describe subjects with a personal and possibly a family history of psychosis (including schizophrenia, schizophreniform disorders, psychotic mania, psychotic depression), nonpsychotic mania, or concomitant use of other drugs. However, some cases also described psychotic episodes in subjects without these previous characteristics. Overall, the incidence of such episodes appears to be rare in both the ritual and the recreational/noncontrolled settings. Performance of a psychiatric screening before administration of these drugs, and other hallucinogens, in controlled settings seems to significantly reduce the possibility of adverse reactions with psychotic symptomatology. Individuals with a personal or family history of any psychotic illness or nonpsychotic mania should avoid hallucinogen intake.

scholarly journals COVID-19-associated brief psychotic disorder

2020 ◽  
Vol 13 (8) ◽  
pp. e236940 ◽  
Author(s):  
Colin M Smith ◽  
Jonathan R Komisar ◽  
Ahmad Mourad ◽  
Brian R Kincaid
Keyword(s):  
Mental Illness ◽  
Family History ◽  
Psychotic Disorder ◽  
Neuropsychiatric Symptoms ◽  
Healthy Woman ◽  
Psychotic Symptoms ◽  
First Case ◽  
Brief Psychotic Disorder ◽  
History Of ◽  
New Onset

A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

scholarly journals Studying the Association Between Breast Cancer and Renal Cell Carcinoma

2021 ◽  
Author(s):  
Khalid A Jazieh ◽  
Firas Baidoun ◽  
Nataly Torrejon ◽  
Zahi Merjaneh ◽  
Anas Saad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Renal Cell Carcinoma ◽  
Genetic Testing ◽  
Family History ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Case Reports ◽  
Population Data ◽  
Seer Database ◽  
History Of

Abstract Purpose: There are case reports of patients with both primary breast cancer (BC) and renal cell carcinoma (RCC). We explore the association between these two malignancies using SEER population data and our institutional records.Methods: We studied the association between BC and RCC in the 2000-2016 Surveillance, Epidemiology and End Results (SEER) database. We then reviewed our hospital records of patients with both BC and RCC and collected information including personal and family history of cancers, genetic testing, and patient outcomes.Results: Of the 813,477 females diagnosed with BC in the SEER database, 1,914 later developed RCC. The risk of developing RCC was significantly increased within the first six months, 7-12 months, and 1-5 years following BC diagnosis with standardized incidence ratios (SIRs) of 5.08 (95% CI, 4.62- 5.57), 2.09 (95% CI, 1.8-2.42), and 1.15 (95% CI, 1.06-1.24), respectively. Of 56,200 females with RCC, 1,087 later developed BC. The risk of developing BC following RCC was elevated within the first six months (SIR of 1.45 [95% CI, 1.20-1.73]). For our hospital patients, 437 had both BC and RCC. 427 (97.71%) were female, and 358 (81.92%) were white, and breast cancer was diagnosed before RCC in 246 (61.5%) patients. There were 15 germline mutations in those with genetic testing. Conclusion:Our findings suggest that BC patients are at higher risk of developing RCC and vice versa. BC tended to precede RCC, and patients frequently had personal histories of other malignancies and a family history of cancer, particularly BC.

Schizophrenics with a family history of bipolar disorder. Possible involvement of obstetric complications

1993 ◽  
Vol 8 (4) ◽  
pp. 223-226
Author(s):  
H Verdoux ◽  
M Bourgeois
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Case Reports ◽  
Obstetric Complications ◽  
Schizophrenic Patients ◽  
History Of ◽  
The Continuum

SummaryThe case reports of two DSM III-R schizophrenic patients with a family history of bipolar disorder are presented. The two patients had a history of severe obstetric complications (OCs). These cases are discussed in the light of neurodevelopmental theories of schizophrenia and in the continuum view of psychosis.

Mania and Down's Syndrome

1993 ◽  
Vol 162 (6) ◽  
pp. 739-743 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Richard A. Collacott
Keyword(s):  
Learning Disabilities ◽  
Family History ◽  
Affective Disorder ◽  
Clinical Features ◽  
Case Reports ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Atypical Presentation ◽  
Rapid Cycling ◽  
History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

Abstract P455: Obesity Types (Body Mass Index vs. Waist Circumference) Affect on Development of Major Cardiovascular Risks: Data From Korean National Health Insurance Service - National Sample Cohort (NHIS-NSC)

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Eun Joo Cho ◽  
Sungha Park ◽  
Hae Young Lee ◽  
Ki Chul Sung ◽  
Wook Bum Pyun ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Health Insurance ◽  
Family History ◽  
Waist Circumference ◽  
Independent Predictor ◽  
National Sample ◽  
History Of ◽  
Korean National Health Insurance ◽  
Cv Disease ◽  
New Onset

Background: Population based study demonstrated that obesity (defined as increased body mass index, BMI) is important predictor for developing hypertension and diabetes mellitus (DM), which have been well known major cardiovascular (CV) risk factors. Increased waist circumference (WC) representative of central obesity is focused as main factor for developing CV disease and its major risks. This study was to evaluate obesity as a predictor for new onset of hypertension and DM within 1-year in previously normotensives or normoglycemic subjects. Methods: The Korean National Health Insurance Service - National Sample Cohort (NHIS-NSC) established data about BMI and WC with medical, social and familial histories in 2009 and have been followed up for 1 years. Among total 349257 subjects with age more than 20 year-old, 95124 (normotensive group: 75.2% of population were 25-55 year-old, 54121(56.9%) male) of normotensives for evaluate new hypertension and 120501 (normoglycemic group: 83.6% of population were 25-65 year-old, 67183 (55.8%) male) normoglycemic subjects for evaluate new DM were analyzed. Results: During 1-year follow-up period, 3773 (3.97%) new hypertension in normotensive group and 1594 (1.32%) new DM in normoglycemic group were developed. Binary logistic regression analysis revealed that BMI was the predictor (Exp(B)=1.18, Sig<0.001) for new onset hypertension with age (Exp(B)=1.31, Sig<0.001), sex (Exp(B)=0.664, Sig<0.001), dyslipidemia and family history of hypertension. For new onset DM, WC (Exp(B)=1.04, Sig<0.001), age (Exp(B)=1.26, Sig<0.001), sex Exp(B)=0.664, Sig<0.001) and family history of DM (Exp(B)=1.76, Sig<0.001) were the independent predictors. Conclusion: Increase of BMI is independent predictor for new onset hypertension and increase of WC is independent predictor for new onset DM within 1-year. Obesity type might affects development of different major CV risks and hence, obesity itself is the important risk factor for CV disease.

Somnambulism Induced by Quetiapine: Two Case Reports and a Review of the Literature

CNS Spectrums ◽  
2007 ◽  
Vol 12 (12) ◽  
pp. 910-912 ◽  
Author(s):  
Zeba Hasan Hafeez ◽  
Constance M. Kalinowski
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Family History ◽  
Attention Deficit ◽  
Slow Wave Sleep ◽  
Case Reports ◽  
Sleep Stages ◽  
Review Of The Literature ◽  
Motor Behaviors ◽  
Hyperactivity Disorder ◽  
History Of

ABSTRACTSomnambulism, a previously unreported side effect of quetiapine, is described in two cases. Both cases involved individuals who had no prior or family history of somnambulism and had attention-deficit/hyperactivity disorder. The possible significance of this will also be discussed. Somnambulism is a common parasomnia that reflects an impairment in the normal mechanisms of arousal from sleep in which motor behaviors are activated without full consciousness. Motor behaviors are initiated during deep non-rapid eye movement or slow-wave sleep (stages 3-4), and may be limited to relatively simple manifestations, such as sitting up, fumbling with objects or bedclothes, or mumbling.

scholarly journals Reversible Severe Rhabdomyolysis Associated with Thyrotoxic Hypokalemic Periodic Paralysis

2021 ◽  
pp. 394-397
Author(s):  
Praewchompoo Sathirapanya ◽  
Komsai Suwanno ◽  
Pornchai Sathirapanya
Keyword(s):  
Creatine Kinase ◽  
Family History ◽  
Case Reports ◽  
Specific Treatment ◽  
Periodic Paralysis ◽  
Hypokalemic Periodic Paralysis ◽  
Gated Channel ◽  
History Of ◽  
Symptoms And Signs ◽  
Thyrotoxic Hypokalemic Periodic Paralysis

We report a case of reversible symptomatic rhabdomyolysis associated with thyrotoxic hypokalemic periodic paralysis. The patient had neither past medical nor family history of either disorder. The presenting neurological symptoms and signs, serum potassium, and creatine kinase levels returned to normal without specific treatment. Based on previous case reports, we attributed the combination of the disorders to a mutation of the calcium-gated channel (CACN) gene and its related encoded proteins.

Sign in / Sign up

Export Citation Format

Share Document