scholarly journals Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Isabel Pérez-Flores ◽  
Jose Luis Santiago ◽  
Natividad Calvo-Romero ◽  
Alberto Barrientos-Guzmán ◽  
Ana Isabel Sánchez-Fructuoso
Keyword(s):  
Graft Survival ◽  
Negative Impact ◽  
First Year ◽  
Hla Antibodies ◽  
Positive Predicted Value ◽  
Antigen Assay ◽  
Single Antigen ◽  
One Year ◽  
The One ◽  
Cellular Rejection

It is well know that anti-HLA antibodies are an important obstacle in kidney transplantation. Our aim was to study the clinical impact of pretransplant donor specific anti-HLA antibodies (HLA-DSA), in highly sensitized (HS) patients. We analyzed retrospectively the day-of-transplant sera by Luminex Single Antigen Assay (LSA) in HS patients, and the results were correlated with episodes of humoral and cellular rejection as well as with graft and patient survival. All HS subjects received the same induction therapy and rejection episodes were biopsy proven. Thirteen patients (56.5%) preformed HLA-DSA, and we observed higher incidence of acute rejection in aforementioned patients than in the pre-transplant negatives DSA recipients (77% versus 30%, ). The one-year graft survival was significantly reduced in positive pre-transplant HLA-DSA patients (60% versus 100%, Breslow). The positive predicted value of HLA-DSA in relation to rejection reached 100% if patients lost their previous graft in the first year after transplant. Among anti-HLA antibodies present in patients before transplant, HLA-DSA were significantly associated with high risk of acute humoral and cellular rejection and reduced graft survival in posttransplant outcome. The negative impact of these antibodies was even higher when patients suffered an early loss of the previous transplant.

Renal Transplantation—A Tale of Two Cities

1980 ◽  
Vol 25 (4) ◽  
pp. 269-274
Author(s):  
R. F. M. Wood ◽  
P. R. F. Bell ◽  
J. Walls ◽  
J. R. Nash ◽  
D. S. MacPherson ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Survival Rate ◽  
Graft Survival ◽  
Initial Experience ◽  
Tissue Typing ◽  
Two Cities ◽  
Transplant Team ◽  
The Difference ◽  
One Year ◽  
The One

In 1974 three members of the transplant team from the Western Infirmary in Glasgow moved to the new medical school in Leicester. The initial experience with 33 patients transplanted in Glasgow was published in 1972 and this paper compares the results of that series with the first 21 patients grafted in Leicester. Despite improvements in tissue typing, better quality donor kidneys and fewer complications, there has been a failure to improve on the levels of graft survival. The overall one year graft survival rate in the Glasgow series was 79 per cent compared to 52 per cent in Leicester. In these two series the difference in results appears to be explained by blood transfusion. All the Glasgow patients had been poly-transfused but of the Leicester patients the 10 transfused pre-transplant had a one year graft survival of 90 per cent while in the 11 non-transfused patients the one year graft survival was only 18 per cent.

scholarly journals The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Cristina Ribeiro de Castro ◽  
Erick A. Barbosa ◽  
Renata P. Souza ◽  
Fabiana Agena ◽  
Patrícia S. de Souza ◽  
...  
Keyword(s):  
Acute Rejection ◽  
De Novo ◽  
First Year ◽  
Sharp Drop ◽  
Hla Antibodies ◽  
Single Antigen ◽  
The Impact ◽  
Kinetics Of ◽  
Time Point ◽  
Rejection Rates

The impact of the kinetics of the anti-HLA antibodies after KTx on the occurrence of acute rejection as well as the better time-point to monitor anti-HLA Abs after transplantation is not completely defined. This prospective study followed 150 patients over 12 months after transplantation. Serum IgG anti-HLA Abs were detected by single antigen beads after typing donors and recipients for loci A, B, C, DR, and DQ. Before KTx, 89 patients did not present anti-HLA Abs and 2% developed “de novo” Abs during the 1st year, 39 patients were sensitized without DSAs, and 13% developed DSA after surgery; all of them presented ABMR. Sensitized patients presented higher acute rejection rates (36.4% versus 13.5%, p<0.001), although 60% of the patients did not present ABMR. Patients, in whom DSA-MFI decreased during the first two weeks after surgery, did not develop ABMR. Those who sustained their levels presented a rate of 22% of ABMR. 85% of patients developed ABMR when MFIs increased early after transplantation (which occurred in 30% of the DSA positive patients). In the ABMR group, we observed an iDSA-MFI sharp drop on the fourth day and then an increase between the 7th and 14th POD, which suggests DSA should be monitored at this moment in sensitized patients for better ABMR prediction.

scholarly journals Incidence of surgical procedures for gastrointestinal complications after abdominal wall closure in patients with gastroschisis and omphalocele

2021 ◽  
Author(s):  
M. Haghshenas ◽  
U. Rolle ◽  
M. Hutter ◽  
T. M. Theilen
Keyword(s):  
Abdominal Wall ◽  
Surgical Procedures ◽  
Retrospective Chart Review ◽  
First Year ◽  
Special Focus ◽  
Abdominal Wall Closure ◽  
Gastrointestinal Complications ◽  
Secondary Operations ◽  
One Year ◽  
The One

Abstract Purpose This study aims to define the extent of additional surgical procedures after abdominal wall closure (AWC) in patients with gastroschisis (GS) and omphalocele (OC) with special focus on gastrointestinal related operations. Methods A retrospective chart review was performed including all operations in GS and OC patients in the first year after AWC (2010–2019). The risk for surgery was calculated using the one-year cumulative incidence (CI). Results 33 GS patients (18 simple GS, 15 complex) and 24 OC patients (12 without (= OCL), 12 OC patients with liver protrusion (= OCL +)) were eligible for analysis. 43 secondary operations (23 in GS, 20 in OC patients) occurred after a median time of 84 days (16–824) in GS and 114.5 days (12–4368) in OC. Patients with complex versus simple GS had a significantly higher risk of undergoing a secondary operation (one-year CI 64.3% vs. 24.4%; p = 0.05). 86.5% of surgical procedures in complex GS and 36.3% in OCL + were related to gastrointestinal complications. Complex GS had a significantly higher risk for GI-related surgery than simple GS. Bowel obstruction was a risk factor for surgery in complex GS (one-year CI 35.7%). Conclusion Complex GS and OCL + patients had the highest risk of undergoing secondary operations, especially those with gastrointestinal complications.

scholarly journals Risk factors associated with the development of death events during the first year of follow-up after pulmonary thromboembolism

2019 ◽  
pp. 80-85
Author(s):  
S. A. Berns ◽  
E. A. Schmidt ◽  
A. G. Neeshpapa ◽  
A. A. Potapenko ◽  
K. V. Smirnov ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
High Risk ◽  
Anticoagulant Therapy ◽  
Severe Heart Failure ◽  
First Year ◽  
Factors Associated ◽  
Risk Of Death ◽  
One Year ◽  
The One

Purpose: to identify the factors associated with the development of death events during the year follow-up after hospitalization for pulmonary embolism (PE). Materials and methods: 93 patients with PE discharged to the outpatient stage of observation were studied. 45 (61,6%) patients were female with an average age of 66 years. The examination of patients at the stage of inclusion in the study consisted of standard methods of examination for this pathology. The diagnosis was confirmed by multislice computed tomography. Follow-up was 12 months. Statistical analysis was performed using the MedCalc Version 16.2.1. Results: during the one-year follow-up period 62 (66,7%) patients with PE were alive but 11 patients (11,8%) died, and no information was obtained about 20 patients. The causes of death were as follows: the development of recurrent PE – 4 (36,4%) patients, cancer – 3 patients (27,3%), stroke – 2 (18,1%), one patient (9,1%) died due to severe heart failure and one – myocardial infarction. A comparative analysis in the groups of alive patients (n = 62) and patients with a fatal events (n = 11) showed that the dead patients were older (78 (68; 81) vs. 65 (49; 75) years; p = 0,003), had a higher PESI score (119,0 (99,7; 137,2) vs. 88,0 (68,0; 108,0); p = 0,016) and were less compliant to prolonged anticoagulant therapy during the one year of observation (45,5% of patients (n = 5) vs. 82,3% ( = 51); p = 0,015). The ROC curve determined that a high risk of death during the one year after PE is associated with age over 70 years (p = 0,0001) and more than 95 points by PESI in the hospital period (p = 0,0001). Conclusion: The death events were developed in 11,8% of cases in patients with pulmonary embolism during the first year of follow-up. The death outcomes were significantly associated with elderly age, intermediate and high risk by PESI in the hospital period and low compliance to anticoagulant therapy extended during the year after pulmonary embolism.

scholarly journals The First Fifty ABO Blood Group Incompatible Kidney Transplantations: The Rotterdam Experience

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Madelon van Agteren ◽  
Willem Weimar ◽  
Annelies E. de Weerd ◽  
Peter A. W. te Boekhorst ◽  
Jan N. M. Ijzermans ◽  
...  
Keyword(s):  
Graft Survival ◽  
Intravenous Immunoglobulins ◽  
High Rate ◽  
Long Term Results ◽  
Control Group ◽  
First Year ◽  
Single Center Experience ◽  
Kidney Transplantations ◽  
One Year

This study describes the single center experience and long-term results of ABOi kidney transplantation using a pretransplantation protocol involving immunoadsorption combined with rituximab, intravenous immunoglobulins, and triple immune suppression. Fifty patients received an ABOi kidney transplant in the period from 2006 to 2012 with a follow-up of at least one year. Eleven antibody mediated rejections were noted of which 5 were mixed antibody and cellular mediated rejections. Nine cellular mediated rejections were recorded. Two grafts were lost due to rejection in the first year. One-year graft survival of the ABOi grafts was comparable to 100 matched ABO compatible renal grafts, 96% versus 99%. At 5-year follow-up, the graft survival was 90% in the ABOi versus 97% in the control group. Posttransplantation immunoadsorption was not an essential part of the protocol and no association was found between antibody titers and subsequent graft rejection. Steroids could be withdrawn safely 3 months after transplantation. Adverse events specifically related to the ABOi protocol were not observed. The currently used ABOi protocol shows good short and midterm results despite a high rate of antibody mediated rejections in the first years after the start of the program.

scholarly journals A Year of Phytobiomes

2018 ◽  
Vol 2 (2) ◽  
pp. 53-54 ◽  
Author(s):  
Carolyn A. Young ◽  
Linda L. Kinkel
Keyword(s):  
First Year ◽  
One Year ◽  
The One

It is hard to believe that we have just celebrated the one-year anniversary of our first issue of the Phytobiomes journal! As we celebrate our first year, and as the term ‘phytobiome’ becomes more deeply embedded in our science, it is worth pausing to reflect on the impetus and science behind the phytobiome concept, and on the next steps for our journal.

scholarly journals OUTCOMES OF COVID-19 INFECTIONS IN CHILDREN: A SINGLE-CENTER RETROSPECTIVE STUDY

2021 ◽  
Author(s):  
MUSTAFA GENÇELİ ◽  
Ozge Metin Akcan ◽  
Sevgi Pekcan ◽  
Fatih Akın ◽  
Mehmet Özdemir ◽  
...  
Keyword(s):  
Negative Impact ◽  
Severe Disease ◽  
Tertiary Care ◽  
Age Groups ◽  
Clinical Findings ◽  
First Year ◽  
Care Hospital ◽  
Mild Disease ◽  
Reactive Protein ◽  
One Year

Objective: The COVID-19 pandemic is an important cause of morbidity and mortality, which has had a negative impact worldwide. Our aim was to describe clinical findings and outcomes of SARS-CoV-2 viral infection and Covid-19 disease cared for at a large pediatric tertiary care hospital during the first year of the pandemic. Methods: Patients aged 1 month to 18 years who were diagnosed as having COVID-19 between March 2020 and April 2021 were included. The files of patients diagnosed with covid-19 were reviewed retrospectively. Results: 467 children were included in the study. There were 34 (7.3%) patients under one year of age, 111 (23.8%) between 1-5 years, 98 (30.4%) between 5-10 years, 142 (30.4%) between 11-15 years, and 82 (17.6%) age over 15 years. Fever (88.2%), vomiting (32.4%), and diarrhea (29.4%) in patients aged under 1 year, sore throat (36.6%) in patients aged 11-15 years, and dysgeusia (11%), anosmia (14.6%), headache (18.3%), malaise (40.8%), myalgia (28%), and dyspnea (17.1%) in those aged over 15 years of age were found significantly more common compared with the other age groups (p<0.05). Thirty-five (7.5%) patients were asymptomatic, 365 (78.1%) had mild disease, 35 (7.5%) were moderate, 27 (5.8%) were severe, and five (1.07%) were critical. Leukocyte count, erythrocyte sedimentation rate, ferritin, and C-reactive protein values were significantly higher in hospitalized patients. Four patients died during the study period (0.8%, 4/467). Conclusion: While SARS-CoV-2 infection may be asymptomatic and Covid-19 disease usually has a mild clinical course, some children have severe disease or mortality.

Donor-Directed HLA Antibodies Before and After Transplantectomy Detected by the Luminex Single Antigen Assay

2009 ◽  
Vol 87 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Evy V.A. Billen ◽  
Maarten H.L. Christiaans ◽  
JarHow Lee ◽  
Ella M. van den Berg-Loonen
Keyword(s):  
Hla Antibodies ◽  
Antigen Assay ◽  
Single Antigen ◽  
Before And After

scholarly journals Characterization of Wild Corsican Hops and Assessment of the Performances of German Hops in Corsican Environmental Conditions through a Multidisciplinary Approach

2021 ◽  
Vol 11 (9) ◽  
pp. 3756
Author(s):  
Axel Dabbous-Wach ◽  
Margherita Rodolfi ◽  
Julien Paolini ◽  
Jean Costa ◽  
Tommaso Ganino
Keyword(s):  
Essential Oils ◽  
Multidisciplinary Approach ◽  
Chemical Characterization ◽  
First Year ◽  
Morphological Comparison ◽  
Ssr Analysis ◽  
Chemical Profiles ◽  
One Year ◽  
The One

Hops (Humulus lupulus L.) is a species that grows spontaneously in Corsica, but the characterization of this species in this territory has not yet been investigated. The main objectives of this study are to explore the features of wild hops from Corsica and to determine the effect of the island terroir on some cultivars in the first year of growth. A multidisciplinary approach consisting of the genetic analysis, morphological comparison and chemical characterization of essential oils was carried out on four wild Corsican hops and three hop cultivars grown in Tettnang, Germany and Corsica, France. The morphological and GC-MS analysis of Corsican wild hops, set cluster coastal samples apart from the one far from the coast. This dissimilarity is supported by the SSR analysis by two of the three coastal accessions. The genetics demonstrate a proximity between the European noble cultivar Tettnanger and the mountain Corsican wild hop from Corte. The morphological comparison between German hops cultivated in Tettnang and in Corsican soil, and the GC-MS characterization of their essential oils’ chemical profiles, show different features between year 0 and year +1 for each sample. This multidisciplinary approach highlights an acclimatization of hop cultivars to the Corsican terroir one year after planting.

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