Renal Transplantation—A Tale of Two Cities

In 1974 three members of the transplant team from the Western Infirmary in Glasgow moved to the new medical school in Leicester. The initial experience with 33 patients transplanted in Glasgow was published in 1972 and this paper compares the results of that series with the first 21 patients grafted in Leicester. Despite improvements in tissue typing, better quality donor kidneys and fewer complications, there has been a failure to improve on the levels of graft survival. The overall one year graft survival rate in the Glasgow series was 79 per cent compared to 52 per cent in Leicester. In these two series the difference in results appears to be explained by blood transfusion. All the Glasgow patients had been poly-transfused but of the Leicester patients the 10 transfused pre-transplant had a one year graft survival of 90 per cent while in the 11 non-transfused patients the one year graft survival was only 18 per cent.

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Flat Glass or Crystal Dome Aperture? A Year-Long Comparative Analysis of the Performance of Light Pipes in Real Residential Settings and Climatic Conditions

Sustainability ◽

10.3390/su12093858 ◽

2020 ◽

Vol 12 (9) ◽

pp. 3858 ◽

Cited By ~ 1

Author(s):

Magda Sibley ◽

Antonio Peña-García

Keyword(s):

Comparative Analysis ◽

Flat Glass ◽

Climatic Conditions ◽

Long Term Effect ◽

Different Types ◽

The Difference ◽

The Aesthetic ◽

One Year ◽

The One

This paper presents the first comparative study of its type of the performance of light pipes with different types of apertures: a flat glass versus a bohemian crystal dome. Measurements were taken at 20-minute intervals over a period of one year in the bathrooms of two newly built identical houses of the same orientation located in Manchester, UK. The comparative analysis of the data collected for both light pipes types reveals that the crystal domed aperture consistently outperforms the flat glass one. Furthermore, the difference in the recorded horizontal illuminance is most marked during the winter months and at the end of the one-year experiment, indicating that the crystal dome has better performance for low incident winter light and higher resistance for the long term effect of weathering and pollution. This study provides strong evidence based on long term real measurements. Such evidence informs architects’ decisions when weighing up the aesthetic considerations of a flat glass aperture versus the higher illumination levels afforded by a crystal dome aperture with higher resistance to weathering and pollution.

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Gemcitabine, oxaliplatin and weekly high-dose 5-FU as a 24-hr-infusion in chemonaive patients with advanced or metastatic carcinoma of the gallbladder: Preliminary results of a multicenter phase II-study

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.4129 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 4129-4129 ◽

Cited By ~ 2

Author(s):

A. D. Wagner ◽

P. Buechner-Steudel ◽

H. Schmalenberg ◽

M. Moehler ◽

O. Kuss ◽

...

Keyword(s):

Survival Rate ◽

Median Survival ◽

Phase Ii ◽

Tumor Response ◽

Phase Ii Study ◽

Metastatic Carcinoma ◽

Phase Iii ◽

Carcinoma Of The Gallbladder ◽

One Year ◽

The One

4129 Background: Combinations of gemcitabine (GEM)/5-FU, GEM/oxaliplatin (LOHP) or 5-FU/LOHP work synergistically in pancreatic and/or colorectal malignancies, and have non-overlapping safety profiles. This phase II-study was designed to evaluate the efficacy and safety of the triple combination GEM/LOHP/5-FU in patients (pts) with advanced or metastatic carcinoma of the gallbladder. Methods: One-stage, multicentre phase II study. Eligibility criteria: chemonaive pts with histologically proven advanced, recurrent or metastatic gallbladder carcinoma (ECOG 0–1; expected survival >3 months; measurable disease; adequate renal, hepatic and bone marrow function). According to the results of our previous phase I-study (Proc ASCO 2003, # 1298), pts were treated with GEM 900mg/m2 as a 30-min infusion, followed by LOHP 65 mg/m2 (2-hr infusion) after a 30 min rest and 5-FU 1500 mg/m2 (24-hr-infusion) on d 1, 8, every 3 weeks. Planned sample size: 35 response evaluable patients. The primary endpoint was tumor response, secondary endpoints were toxicity, median survival, the one-year-survival rate, clinical benefit and quality of life. Results: At time of abstract submission, median follow-up of 35 enrolled pts is 9.8 months. Pt. characteristics: m/f: 11/24, median age 61 (range 42–81), ECOG 0/1: 24/11 (69/31%) pts, locally advanced/metastatic disease 1/32 (3/91%) pts. Analysis of tumor response is still pending. Grade III/IV (NCI-CTC) toxicities occurred in 36/3% of 191 cycles and were: leucopenia 3/1%, neutropenia 4/1%, thrombocytopenia 4/1%, anemia 2/0%, nausea 1/0%, sensory neuropathy 4/0%, asthenia 1/0%, elevated bilirubin 2/0%, AP 4/0%, or elevated SGOT/SGPT 1/0%, edema 1/0%, infection 1/0%, dyspnoe 1/1%. Median survival of all pts is 9.9 months (95% CI: 7.5–11.5), the one-year-survival-rate is 30 % (95% CI: 16–47). Conclusions: GEM/LOHP/5-FU combination therapy is tolerated well in patients with gallbladder cancer. The promising survival data has to be confirmed in a phase III study. (Supported by grants from Eli Lilly and Company, Indianapolis, IN, USA and Sanofi-Synthelabo, Paris, France). [Table: see text]

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Percutaneous insertion of peritoneal dialysis catheter is a safe and effective technique irrespective of BMI

10.21203/rs.2.10345/v2 ◽

2020 ◽

Author(s):

Dayang Xie ◽

Jianhui Zhou ◽

Xueying Cao ◽

Qingtao Zhang ◽

Yanli Sun ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Catheter Insertion ◽

Percutaneous Technique ◽

Peritoneal Dialysis Catheter ◽

Dialysis Catheter ◽

Peritoneal Catheter ◽

Catheter Survival ◽

The Difference ◽

One Year ◽

The One

Abstract Background. A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion , although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large BMI can also choose the percutaneous technique for peritoneal dialysis catheter insertion. Methods. 187 consecutive patients underwent peritoneal catheter insertions in the Chinese PLA General Hospital between January 1, 2015 and December 31, 2016, with 178 eligible cases being included in the analysis. Two groups were created based on the catheter insertion techniques, the percutaneous group (group P) and the surgical group (group S). Subgroups were created according to BMI>28 or≤28. The outcomes included catheter related complications and catheter survival. Results. Total infectious complication rates were significantly lower in group P than in group S. The late peritonitis rates tended to be lower in group P than in group S, although the difference was not significant. There were no significant differences in all other measured complications between the two groups. Though the one-year infection-free catheter survival in group P was 7.5% higher than group S, the difference was not significant. The one-year dysfunction-free catheter survival, one-year dysfunction-and-infection-free catheter survival, and overall catheter survival were similar between the two groups. Subgroup analyses showed a superior one-year infection-free catheter survival of percutaneous technique in patients with BMI>28, which was confirmed by Kaplan-Meier analysis. Conclusions. Despite the challenges that may be encountered with patients who have a large BMI, the percutaneous technique is a safe and effective approach to placing a peritoneal dialysis catheter.

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The results of reconstructive penetrating keratoplasty in the children

Russian Pediatric Ophthalmology ◽

10.18821/1993-1859-2016-11-4-192-195 ◽

2016 ◽

Vol 11 (4) ◽

pp. 192-195

Author(s):

Alla Vyacheslavovna Pleskova ◽

E. V Mazanova

Keyword(s):

Graft Survival ◽

Postoperative Period ◽

Penetrating Keratoplasty ◽

Functional Results ◽

Early Postoperative Period ◽

Corneal Transplant ◽

Fold Reduction ◽

Corneal Opacities ◽

The Difference ◽

One Year

Objective. To evaluate the immediate and long-term biological and functional results of reconstructive penetrating keratoplasty (RPKP) in the children. Materials and methods. We undertook a comparative analysis of the outcomes of 86 cases of the surgical intervention on 74 children presenting with corneal opacities of different etiology who had been treated with the application of reconstructive penetrating keratoplasty based at the Department of Eye Pathology in Children, The Helmholtz Moscow Research Institute of Eye Diseases. All operations were made by the same surgeon during the period from 2008 to 2014. The results of reconstructive penetrating keratoplasty were compared with the outcomes of conventional penetrating keratoplasty. The biological results were evaluated in terms of the graft survival (Kaplan-Meir’s) model. The duration of the postoperative follow-up period ranged from 5 months to 8 years and averaged 20,8 ± 9,7 months in the children treated with the use of reconstructive penetrating keratoplasty and to 3,0 ± 15,4 months in the patients treated by means of conventional penetrating keratoplasty. Results. During the early postoperative period (within 1 and 6 months after surgery), the difference in the graft survival rate between the two groups was practically non-existent. After 1 month, the transparency of the transplanted cornea was fairly well preserved in the children of both groups, but persisted for 6 months only in 72% and 95% of the patients treated by reconstructive and conventional penetrating keratoplasty respectively. One year after surgery, the graft survival in the children treated with the use of reconstructive penetrating keratoplasty was documented in 54% of the cases in comparison with 78% in the patients treated by means of conventional penetrating keratoplasty. The difference between the two groups was statistically significant (p < 0,05). Two and three years after surgery, the transparency of the transplanted cornea in the children treated with the use of reconstructive penetrating keratoplasty fell down to 50% and 20% respectively. During the same periods, the transparency of the transplanted cornea in the children treated by means of conventional penetrating keratoplasty remained as high as 76% and 62% respectively. Conclusion. Although the combination of penetrating keratoplasty with other surgical modalities results in the almost three-fold reduction of the probability of engraftment of the transparent corneal transplant in the remote postoperative period in comparison with the standard implantation of the donor cornea transplant, this operation provides the only possibility for the restoration of vision in the children suffering from severe corneal pathology.

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Molecular tissue typing in renal transplantation: Initial experience from a tertiary care Naval Hospital

Indian Journal of Human Genetics ◽

10.4103/0971-6866.29854 ◽

2006 ◽

Vol 12 (3) ◽

pp. 120

Author(s):

MahendraN Mishra ◽

Haresh Mani ◽

VinodK Saxena ◽

MahendraK Gupta

Keyword(s):

Renal Transplantation ◽

Tertiary Care ◽

Initial Experience ◽

Tissue Typing ◽

Naval Hospital

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Analysis of Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection and Its Effect on the Outcome of Early Infection After Kidney Transplantation

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.726282 ◽

2021 ◽

Vol 11 ◽

Author(s):

Fei Zhang ◽

Jinbiao Zhong ◽

Handong Ding ◽

Jiashan Pan ◽

Jing Yang ◽

...

Keyword(s):

Risk Factors ◽

Survival Rate ◽

Klebsiella Pneumoniae ◽

Postoperative Mortality ◽

Effective Prevention ◽

Carbapenem Resistant ◽

Kaplan Meier ◽

Total Prevalence ◽

One Year ◽

The One

BackgroundInfections remain a major cause of morbidity and mortality in kidney transplant (KT) recipients. This study was performed to identify the overall prevalence of early infections, prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection after KT, one-year postoperative mortality in patients with early infections and risk factors for CRKP infections.MethodsWe conducted a retrospective study of all patients who received KT in our hospital between January 2017 and December 2019. We evaluated the demographic, clinical, infection characteristics and the one-year postoperative outcomes.ResultsAmong the 419 patients who received KT between January 2017 and December 2019, 150 patients had at least one infection within 90 days after KT. The total prevalence of early infections was 36.1% (150/415), the prevalence of early CRKP infections was 10.4% (43/415), and the one-year postoperative mortality was 15.3% (23/150) in patients with early infections. The risk factors independently related to one-year postoperative mortality were mechanical ventilation (MV) > 48 h (Odds ratio (OR)= 13.879, 95%Confidence interval (CI): 2.265~85.035; P=0.004) and CRKP infection (OR=6.751, 95% CI: 1.051~43.369; P =0.044). MV> 48 h was independently related to CRKP infection (OR=3.719, 95% CI: 1.024~13.504; P=0.046). Kaplan-Meier survival curves showed that the one-year survival rate of patients infected with CRKP in the early postoperative stage was significantly lower than that of uninfected patients.ConclusionsIn general, the prevalence of early infections after KT is high, and CRKP infection is closely correlated with poor prognosis. The effective prevention and treatment of CRKP infection is an important way to improve the one-year survival rate after KT.

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Establishment of white poplar clonal plantations by stools

Topola ◽

10.5937/topola2101011k ◽

2021 ◽

pp. 11-20

Author(s):

Branislav Kovačević ◽

Duško Bastajić ◽

Slađana Dabić ◽

Zoran Novčić ◽

Zoran Galić ◽

...

Keyword(s):

Survival Rate ◽

Deep Level ◽

Underground Water ◽

High Survival ◽

White Poplar ◽

Rooted Cuttings ◽

Clonal Plantation ◽

Poplar Plantations ◽

One Year ◽

The One

The results of white poplar clonal plantation establishment by stools are presented. The trials were established at three sites, characterized by favorable water regime for growth and development of poplars. Also, the effect of different factors on survival rate, diameter at breast height and plants' height was analyzed. Results suggest that similar high survival rate (90-100%) was achieved by planting of stools on depth of 2.5 m (deep planting), as it was achieved by planting of rooted cuttings at the depth of 0.8 m, which is a comon practise in the establishment of white poplar plantations. The survival rate of planted stools did not decrease signifficantly between the end of the first and second growing season. Selected clones achieved survival rate of Villafranca clone with both methods of planting. Two-year old rootless shoots (2/0 type of plantings) achieved higher survival rate than the one-year old ones (1/0 type) and two-year old rooted cuttings (2/2 type). Survival rate of one-year old rootless shoots (1/0 type) planted at the depth of 0.8 m was not significantly lower than of those planted at the depth of 2.5 m, but it was notably lower than survival rate of rooted cuttings (1/1 type). Establishment of white poplar clones by stools could significantly improve white poplar wood production, considering the benefits of plants production in stool beds. The potential for improvement of the establishment of white poplar plantations on sandy soils with relatively deep level of underground water, and the potential for successful planting of difficult-to-root white poplar genotypes, should be the subject of further studies.

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Properties and cleanability of new and traditional surface materials in cattle barns - a field study

Agricultural and Food Science ◽

10.2137/145960608786118839 ◽

2008 ◽

Vol 17 (3) ◽

pp. 227 ◽

Cited By ~ 4

Author(s):

R. KUISMA ◽

H-R. KYMÄLÄINEN ◽

M. HELLSTEDT

Keyword(s):

Field Study ◽

Laboratory Experiments ◽

Laboratory Studies ◽

Surface Materials ◽

Colour Changes ◽

The Difference ◽

Coated Surfaces ◽

One Year ◽

The One

In this study surface properties and cleanability of new and traditional surface materials in cattle barns were examined in a field test. The concrete and plastic-coated samples were placed on a walking path on the floor and on a feeding table in a cattle barn. The surfaces were characterized using colorimetric and gloss measurements and determination of topography. In most cases, the colour of the surfaces placed on the floor darkened during the one year study period, whereas the colour changes of the samples placed on the feeding table did not show a similar trend. However, in both locations the plastic-coated surfaces were generally the easiest to clean, and the highest colour changes indicating soil residues were detected on the uncoated and silane-impregnated concrete surfaces. The difference between the locations was also seen in the gloss values, which increased in the samples placed on the floor during the one-year test period but varied considerably between the different materials on the surfaces placed on the feeding table. This field study confirmed the observation from earlier laboratory studies that plastic coatings improved the cleanability of concrete cattle barn surfaces. Silane impregnation was not functionally competitive with the plastic coatings. In general, the cleanability results were in accordance with the results of previous laboratory experiments but the field study provided practical information about the behaviour of the surface materials examined.;

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A multicenter phase II study of S-1 plus ramucirumab as first-line treatment in elderly patients with advanced/recurrent gastric cancer (KSCC1701).

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.4043 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 4043-4043

Author(s):

Hiroo Katsuya ◽

Koichi Suyama ◽

Kazuma Kobayashi ◽

Naoki Izawa ◽

Yoshikazu Uenosono ◽

...

Keyword(s):

Gastric Cancer ◽

Survival Rate ◽

Elderly Patients ◽

Line Treatment ◽

Efficacy And Safety ◽

First Line ◽

Recurrent Gastric Cancer ◽

One Year ◽

The One ◽

First Line Treatment

4043 Background: Elderly patients are often intolerable in the combination with cytotoxic agents. Therapy with S-1 alone is a key option for initial chemotherapy for Japanese elderly patients with unresectable gastric cancer in clinical practice. However, there are some cases in which the antitumor effects with S-1 alone are insufficient. We aimed to investigate the efficacy and safety of S-1 plus ramucirumab therapy to elderly patients with advanced/recurrent gastric cancer. Methods: Patients aged 70 years and older with previously untreated unresectable or recurrent gastric cancer patients were included in Japan. They received S-1 therapy (40-60 mg twice daily for 28 days, every 6 weeks) plus ramucirumab therapy (8 mg/kg, every 2 weeks) until disease progression. The primary endpoint was the one-year survival rate and null hypothesis of one-year survival was set as 40%, which is the lower bound of the 95% confidence interval in previously reported studies on S-1 therapy. The secondary endpoints included progression-free survival (PFS), overall survival (OS), response rate (RR), and safety. Results: Between September 2017 and November 2019, 48 patients were enrolled in this study. The characteristics of patients were male/female: 34/14, median age: 77.5 years (range: 71-87), and PS (0/1): 20/28. The one-year survival rate was 65.2% (95% confidence interval 49.8-78.6%), which means this trial met the primary endpoint. The median OS and PFS were 16.4 months (95%CI:12.0–20.7) and 5.8 months (95%CI:4.0–7.2), respectively. The best RR (CR+PR) was 60.9%. The frequent grade 3 or grade 4 adverse events were neutropenia (27.7%), anorexia (23.4%), anemia (19.1%), hypertension (14.9%), leucopenia (12.8%) and hypoalbuminemia (12.8%). Conclusions: Based on the observed efficacy and safety, S-1 plus ramucirumab is an appropriate first-line treatment for elderly patients with advanced/recurrent gastric cancer. Clinical trial information: UMIN000028309.

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Different Impact of Pretransplant Anti-HLA Antibodies Detected by Luminex in Highly Sensitized Renal Transplanted Patients

BioMed Research International ◽

10.1155/2013/738404 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Isabel Pérez-Flores ◽

Jose Luis Santiago ◽

Natividad Calvo-Romero ◽

Alberto Barrientos-Guzmán ◽

Ana Isabel Sánchez-Fructuoso

Keyword(s):

Graft Survival ◽

Negative Impact ◽

First Year ◽

Hla Antibodies ◽

Positive Predicted Value ◽

Antigen Assay ◽

Single Antigen ◽

One Year ◽

The One ◽

Cellular Rejection

It is well know that anti-HLA antibodies are an important obstacle in kidney transplantation. Our aim was to study the clinical impact of pretransplant donor specific anti-HLA antibodies (HLA-DSA), in highly sensitized (HS) patients. We analyzed retrospectively the day-of-transplant sera by Luminex Single Antigen Assay (LSA) in HS patients, and the results were correlated with episodes of humoral and cellular rejection as well as with graft and patient survival. All HS subjects received the same induction therapy and rejection episodes were biopsy proven. Thirteen patients (56.5%) preformed HLA-DSA, and we observed higher incidence of acute rejection in aforementioned patients than in the pre-transplant negatives DSA recipients (77% versus 30%, ). The one-year graft survival was significantly reduced in positive pre-transplant HLA-DSA patients (60% versus 100%, Breslow). The positive predicted value of HLA-DSA in relation to rejection reached 100% if patients lost their previous graft in the first year after transplant. Among anti-HLA antibodies present in patients before transplant, HLA-DSA were significantly associated with high risk of acute humoral and cellular rejection and reduced graft survival in posttransplant outcome. The negative impact of these antibodies was even higher when patients suffered an early loss of the previous transplant.

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