scholarly journals Effect of Experimental Infection withHaemonchus contortuson Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
J. C. Bambou ◽  
T. Larcher ◽  
W. Ceï ◽  
P. J. Dumoulin ◽  
N. Mandonnet
Keyword(s):  
Experimental Infection ◽  
Inflammatory Cell ◽  
Average Daily Gain ◽  
Cellular Responses ◽  
Cell Infiltration ◽  
Mononuclear Cell Infiltration ◽  
Blood Eosinophilia ◽  
Fecal Egg Count ◽  
Genetic Status ◽  
Daily Gain

This study was carried out to evaluate the relationships of cellular changes in the abomasal mucosa and parasitological parameters, by comparing resistant and susceptible young Creole goats (kids) after experimental infection withHaemonchus contortus. The kids were infected over 2 periods (challenges 1 and 2) of 7 and 6 weeks, respectively. Fecal egg count (FEC), blood eosinophilia, packed cell volume (PCV), and body weight were weekly monitored. At the end of both challenges a subgroup of kids was slaughtered for nematode burden measurements and analysis of inflammatory cell infiltration in the abomasal mucosa. The average daily gain was higher in resistant kids after both challenges. Blood eosinophilia and FEC were higher in susceptible kids after both challenges. The number of immature worms and the means of female length were lower after challenge 2 whatever the genetic status. No differences were observed in the eosinophil and mononuclear cell infiltration between challenges 1 and 2 and resistant and susceptible kids. Globule leukocyte infiltration was found higher after the challenge 1 in resistant kids. This effect of the genetic status on globule leukocytes counts but not on the other inflammatory cell highlights the need for further study on the functional activity of these cell populations.

scholarly journals Chemokine Expression Precedes Inflammatory Cell Infiltration and Chemokine Receptor and Cytokine Expression during the Initiation of Murine Lupus Nephritis

2001 ◽  
Vol 12 (7) ◽  
pp. 1369-1382 ◽  
Author(s):  
GUILLERMO PÉREZ DE LEMA ◽  
HOLGER MAIER ◽  
ELENA NIETO ◽  
VOLKER VIELHAUER ◽  
BRUNO LUCKOW ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Proinflammatory Cytokines ◽  
Chemokine Receptor ◽  
Chemokine Receptors ◽  
Renal Damage ◽  
Inflammatory Cell ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Mononuclear Cell Infiltration ◽  
Monocyte Chemoattractant Protein 1

Abstract. Lupus nephritis is characterized by immune complex deposition and inflammatory cell infiltration. Therefore, the initiation and progression of lupus nephritis in MRL/MpJ Faslpr/lpr(MRL/lpr) mice were investigated, with a focus on the expression of several chemokines and chemokine receptors. Mice were monitored for proteinuria from 6 to 20 wk of age, and kidneys were examined every 2 wk by light microscopy, electron microscopy, and immunohistologic analyses. Furthermore, the expression of chemokines, chemokine receptors, and proinflammatory cytokines was analyzed in ribonuclease protection assays. MRL/lpr mice demonstrated increased expression of monocyte chemoattractant protein-1, regulated upon activation, normal T cell-expressed and -secreted protein, inducible protein of 10 kD, and macrophage inflammatory protein-1β at week 8. At that time point, levels of circulating and glomerular immune complexes were increased, and no proteinuria or histopathologic signs of renal damage could be observed. As assessed in immunohistochemical andin situhybridization analyses, monocyte chemoattractant protein-1 and regulated upon activation, normal T cell-expressed and -secreted protein expression was preferentially located in the glomeruli and interstitium. Mononuclear cell infiltration of the kidney was observed by weeks 10 to 12. At week 12, the renal expression of chemokine receptor 1 (CCR1), CCR2, and CCR5 was increased, mice became proteinuric, and renal damage was histologically evident. Finally, the expression of proinflammatory cytokines was detected (weeks 12 to 14). In summary, (1) chemokines are upregulated before inflammatory cell infiltration, proteinuria, and kidney damage are observed; (2) chemokine generation is restricted to sites of subsequent inflammatory cell infiltration,i.e., glomeruli and interstitium; (3) chemokine receptor expression parallels mononuclear cell infiltration; and (4) proinflammatory cytokines are upregulated later, in parallel with inflammatory cell infiltration and the onset of proteinuria. These results support the hypothesis that chemokines initiate leukocyte infiltration and precede proteinuria and renal damage in MRL/lpr mice.

PSXIV-18 Genetic improvement for resistance to gastrointestinal parasitism in growing meat goats and hair sheep through a centralized performance test in the southcentral USA

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 493-493
Author(s):  
Arthur L Goetsch ◽  
Yoko Tsukahara ◽  
Terry A Gipson ◽  
Steven P Hart ◽  
Lionel J Dawson ◽  
...  
Keyword(s):  
Performance Test ◽  
Average Daily Gain ◽  
Artificial Infection ◽  
Hair Sheep ◽  
Fecal Egg Count ◽  
Meat Goats ◽  
Moderately Resistant ◽  
On Farm ◽  
Daily Gain ◽  
Selection Of

Abstract Progress from selecting meat goats and hair sheep from different farms in the southcentral United States for resistance to internal parasitism during three consecutive central performance tests was evaluated. Tests entailed 7–10 wk of data collection after artificial infection of growing males with Haemonchus contortus larvae. There were 44, 50, and 50 Boer, Kiko, and Spanish goats and 54, 55, 34, and 47 Dorper, Katahdin-farm-A, Katahdin-farm-B, and St. Croix sheep, respectively. In year 1, males were randomly selected and in years 2 and 3 were progeny of sires and females classified as highly and moderately resistant. Criteria for males was average daily gain and residual feed intake during the performance test and means of fecal egg count (FEC) and packed cell volume after artificial infection and for females was FEC and FAMACHA on-farm. There were interactions in FEC of breed×year (P < 0.001) for both species (1,046; 1,134; and 2,630 for Boer; 3,781; 1,239; and 1,216 for Kiko; 1,303; 1,357; and 1,464 for Spanish; 3,288; 1,956; and 1,315 for Dorper; 1,528; 1,759; and 2,241 for Katahdin-A, 2,414; 3,874; and 1,793 for Katahdin-B; and 1,371; 1,160; and 1,175 eggs/g for St. Croix in years 1, 2, and 3, respectively) and year×resistance group (RG; P = 0.005) for goats (1,359; 610, and 552 for high; 1,951; 1,268; and 1,440 for moderate; 2,821; 1,852; and 3,118 eggs/g for low RG in years 1, 2, and 3, respectively) but not for sheep (P = 0.639). In conclusion, resistance appeared greatest for Spanish and St. Croix within species and was increased by selection of Kiko and Dorper. For highly resistant goats, lower FEC in year 2 and 3 vs. 1, compared with no year differences for moderate and low RG, indicates selection progress, and the lack of similar differences for sheep may reflect their relatively greater resistance.

86 Anthelmintic Resistance in Angus Bulls Participating in Regional Performance Tests

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 47-47
Author(s):  
Roger T Rohrbaugh ◽  
Scott P Greiner ◽  
Scott A Bowdridge
Keyword(s):  
Negative Correlation ◽  
Transition Period ◽  
Anthelmintic Resistance ◽  
Average Daily Gain ◽  
Parasite Infection ◽  
Performance Tests ◽  
Fecal Egg Count ◽  
Regional Performance ◽  
Daily Gain

Abstract Resistance to anthelmintics, more commonly referred to as “de-wormers,” has been on the rise in parasites that affect cattle. Parasite infection can have severe impacts on calf productivity resulting in reduced profitability. Therefore, we sought to better understand anthelmintic resistance in Appalachia by surveying Angus bulls entering performance tests in VA and WV. During a four-year period, over 1050 Angus bulls were tested at bull development facilities in Wardensville, WV, Culpeper, VA, and Wytheville, VA. Fecal samples were collected at arrival and 14 days later for determination of fecal egg count (FEC) reduction. Upon arrival, all bulls received either fenbendazole (Wardensville, WV) or moxidectin (both VA tests). In Wardensville, treatment with albendazole had a 96.7% FEC reduction, whereas, treatment with moxidectin at Culpeper and Wytheville stations resulted in FEC reduction of 29% and 34.9%, respectively. Gain during these 14 days was significantly lower for bulls from Wytheville (0.87 kg/d) than those of Culpeper and Wardensville (1.87 and 2.1 kg/d; respectively). These data can be partially explained by higher bull FEC after treatment in Wytheville (101 eggs/g) compared to bulls in Wardensville and Culpeper (3.4 and 46.4 eggs/g respectively). Additionally, there was a negative correlation between delivery FEC and average daily gain. Taken together these data demonstrate resistance to moxidectin in bulls from the Appalachian region, and that elevated parasite infection may have contributed to reduced gain during the transition period.

Additional nutritional considerations for preconditioning beef calves.

EDIS ◽  
2017 ◽  
Vol 2017 (4) ◽  
Author(s):  
Philipe Moriel
Keyword(s):  
Average Daily Gain ◽  
Beef Steers ◽  
Labor Costs ◽  
Vaccine Response ◽  
Negative Effects ◽  
Beef Calves ◽  
Supplemental Feed ◽  
Concentrate Supplementation ◽  
Protein Supply ◽  
Daily Gain

Calves can be preconditioned using a wide variety of supplemental feed ingredients. However, feed ingredient selection is not the only factor to consider during a preconditioning process. Increasing the protein supply to stressed, preconditioning beef steers led to greater growth performance, and increased immune response to vaccination during a 42-day preconditioning period. Producers should not reduce the frequency of concentrate supplementation during the entire preconditioning period as it might lead to poorer vaccine response and average daily gain (consequently, less calf value at sale). However, a gradual reduction of frequency of supplementation is a supplementation strategy that can overcome these negative effects on growth and immunity, and allows producers to save on feeding and labor costs without producing lighter calves that have weaker immune responses.  

A Case of Bullous Amyloidosis Associated with an Inflammatory Cell Infiltration and Prominent Pruritus

2008 ◽  
Vol 70 (3) ◽  
pp. 269-273
Author(s):  
Taisuke KAMIYAMA ◽  
Yoshihiro KAWAGUCHI ◽  
Masami SASAKI ◽  
Masamichi SATOU ◽  
Kumiko MIURA ◽  
...  
Keyword(s):  
Inflammatory Cell ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration

CHARACTERISTICS OF PRODUCTIVE QUALITIES OF FAMILIES OF RED WHITE BELTED PIGS IN SE «RF ZORYANE» BREEDING FARM

2016 ◽  
Vol 52 ◽  
pp. 58-63
Author(s):  
L. V. Onishchenko ◽  
M. I. Danilchuk
Keyword(s):  
High Performance ◽  
Average Daily Gain ◽  
Live Weight ◽  
Litter Weight ◽  
Complex Evaluation ◽  
Appraisal Index ◽  
Daily Gain ◽  
Compactness Index

The most perspective genotype in our region is Red White-belted breed, which has high performance both under pure breeding and under crossing with other breeds. The results of complex evaluation of Red White-belted swine of the herd bred in SE "RF Zoryane" breeding farm are presented. It was revealed that animals of the farm comply with elite class and the first class. The main breeding boars used at the farm belong to such genealogical lines: Deviz, Division, Dantist, Debut, and Dobryak. In the structure of the herd, the most numerous was Dobryak line, which part was 58.8%, Division, Debut, Devis lines – 11.8% per line, Dantist line – 5.8%. The herd sows belong to 7 families: Drabowka, Dekada, Dyktsiya, Doina, Dylema, Delta, Dogma. Average prolificacy of the sows was 10.0 piglets. Litter weight at 60 days’ age was 181.0 kg, and live weight of piglet – 19.0 kg. The performance of sows as prolificacy increased by 0.6 head on average. The complex appraisal index for the herd was 104.1 points. The average daily gain of the replacement pigs was 570 g. The highest daily gain was from five to six months – 611.2 g, and the figure of compactness index characterized a certain elongation of animals, increasing meat traits. Further work with Red White-belted breed aims at preserving and expanding the breeding base and genealogical structure, as well as increasing the reproductive, fattening and meat traits.

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