scholarly journals Comparing the Effects of Dietary Flaxseed and Omega-3 Fatty Acids Supplement on Cyclical Mastalgia in Iranian Women: A Randomized Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Farideh Vaziri ◽  
Mansooreh Zamani Lari ◽  
Alamtaj Samsami Dehaghani ◽  
Mousa Salehi ◽  
Hossein Sadeghpour ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Repeated Measures ◽  
Treatment Strategies ◽  
Analysis Of Covariance ◽  
Wheat Bread ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Significant Difference ◽  
Negative Side Effects ◽  
Cyclical Mastalgia

Considering the negative side effects of chemical drugs, there is a great need for effective alternative treatment strategies to manage cyclical mastalgia. Therefore, this study aimed at comparing the effects of flaxseed diet and omega-3 fatty acids supplement on treatment of cyclical mastalgia. In this study, 61, 60, and 60 women, respectively, received flaxseed as bread, omega-3 fatty acids as pearl, and wheat bread as their diet for two menstrual cycles. At the baseline cycle and end of both interventional cycles, intensity of mastalgia was measured using visual analogue scale. Analysis of covariance showed a significant difference among the three groups regarding the mean intensity of cyclical mastalgia in the first and second cycles of the interventions (P<0.001). Also, repeated measures analysis of covariance with adjustment of two variables of age and mastalgia intensity of the baseline cycle demonstrated that flaxseed bread was more effective compared to omega-3 and wheat bread (P<0.001). The results of this study demonstrated that flaxseed bread diet was an effective approach in decreasing cyclical mastalgia and could be prescribed to women as a simple treatment with few complications.

A pilot randomized, placebo-controlled, double-blind study of omega-3 fatty acids to prevent paclitaxel-associated acute pain syndrome.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24115-e24115
Author(s):  
Zoneddy R. Dayao ◽  
Ursa Abigail Brown-Glaberman ◽  
V. Shane Pankratz ◽  
Lu Chen ◽  
Jacqueline M. Lafky ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pain Score ◽  
Acute Pain ◽  
Pain Syndrome ◽  
Double Blind Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Significant Difference ◽  
Maximum Pain ◽  
To Receive

e24115 Background: Paclitaxel, a widely used chemotherapeutic agent, is associated with an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is no standard of care for P-APS. Commonly used analgesics, including NSAIDs and narcotics, have considerable toxicity profiles. Omega-3 fatty acids, a common dietary supplement, have well established anti-inflammatory and neuroprotective properties. The primary aim of the study was to assess if omega 3 fatty acids could prevent P-APS. Methods: Patients scheduled to receive weekly paclitaxel (70-90mg/m2) were randomized to receive 4 g of omega-3 acid ethyl esters (Lovaza) or placebo, beginning 1 week prior to starting paclitaxel and continued until paclitaxel was discontinued. Patients completed acute pain questionnaires at baseline, Days 2-7, prior to each subsequent treatment and one month after completion of therapy. The EORTC- QLQ CIPN 20 questionnaire was completed prior to each dose of paclitaxel and 1 month after completion. The primary objective was to compare the effect of omega 3 fatty acids, versus placebo, on the maximum pain score for the week following the 1st treatment and each subsequent paclitaxel treatment, and to compare pain medication use between the 2 arms. The secondary objective was to compare the effect of the intervention on the severity of CIPN. Results: 49 patients were randomized to treatment versus placebo. Linear mixed effects models were applied with the addition of a bootstrap approach to overcome limitations in the distributional assumptions to compare outcomes between treatment groups. Placebo results were similar to the reported natural history of P-APS. There was no significant difference in trends over time between the 2 groups in the maximum pain score at week 1 (p = .14) and over 12 weeks (p = .21). There was also no difference noted in the rates of use of over the counter analgesics (p = .39) and narcotics (p = .46). CIPN results did not differ between the 2 groups (p = .08). Conclusions: The results of this pilot study do not support the use of omega-3 fatty acids for the prevention of paclitaxel-associated pain syndrome. Clinical trial information: NCT01821833 .

scholarly journals The Effect of Administration of Omega-3 and Vitamin E on the Levels of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) in Preeclampsia White Rats (Rattus Norvegicus)

2021 ◽  
Vol 8 (12) ◽  
pp. 7-15
Author(s):  
Dina Taufia ◽  
Syamel Muhammad ◽  
Arni Amir
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Vitamin E ◽  
Control Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pregnant Rats ◽  
White Rats ◽  
Significant Difference ◽  
One Way Anova

Background: Preeclampsia is a disease with a variety of theories that describe the uncertainty of the pathophysiology. According to the oxidative stress theory, preeclampsia originates from the failure of trophoblast invasion during the implantation process, causing ischemia and placental hypoxia, which in turn causes cell damage, including placental endothelial cell dysfunction. Omega-3 fatty acids and vitamin E have an important role in preventing preeclampsia. Omega-3 fatty acids play an important role in maintaining cell membranes and anti-inflammatory processes. At the same time, vitamin E acts as a fat-soluble antioxidant that can prevent oxidative stress, inhibit proinflammatory cytokines, and protect fatty acids from oxidation. Aim: The purpose of this study was to determine the effect of omega-3 and vitamin E on the level of ROS and NO in pregnant rats with preeclampsia models. Method & Material: This type of research is experimental with Post-Test Only Control Group Design. The sample consisted of 35 pregnant rats, which were divided into five groups. On the 19th day, blood serum was taken to check the levels of ROS and NO. The measuring instrument used is a spectrophotometer with the ELISA method. Data were analyzed using the Shapiro Wilks normality test. After the parametric test was completed, the hypothesis was tested using one-way ANOVA. Results: The average levels of ROS in each group were K- : 121,684 ng/L, K+ : 143,885 ng/L, P1 : 136,250 ng/L, P2 : 132.433 ng/L, and P3 : 122,993 ng/L. The average levels of NO obtained were K-: 29,502 ng/L, K+: 26,053 ng/L, P1: 27,250 ng/L, P2: 27,555 ng/L, and P3: 32,278 ng/L. The results of one-way ANOVA analysis showed that the administration of omega-3 and vitamin E had a significant difference between the control and treatment groups, both at levels of ROS (p=0.001) and levels of NO (p=0.001). Conclusion: The administration of omega-3, vitamin E, and omega-3 plus vitamin E can reduce ROS levels in pregnant rats with preeclampsia models. There is an increase of NO levels only in the administration of omega-3 plus vitamin E. Keywords: [Omega-3, Vitamin E, Oxidative stress, ROS, NO, Preeclampsia].

scholarly journals Most Effective Combination of Nutraceuticals for Improved Memory and Cognitive Performance in the House Cricket, Acheta domesticus

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 362
Author(s):  
Samskruthi Madireddy ◽  
Sahithi Madireddy
Keyword(s):  
Fatty Acids ◽  
Recognition Memory ◽  
Spatial Memory ◽  
Cognitive Performance ◽  
Acheta Domesticus ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
House Cricket ◽  
Effective Combination ◽  
Significant Difference

Background: Dietary intake of multivitamins, zinc, polyphenols, omega fatty acids, and probiotics have all shown benefits in learning, spatial memory, and cognitive function. It is important to determine the most effective combination of antioxidants and/or probiotics because regular ingestion of all nutraceuticals may not be practical. This study examined various combinations of nutrients to determine which may best enhance spatial memory and cognitive performance in the house cricket (Acheta domesticus (L.)). Methods: Based on the 31 possible combinations of multivitamins, zinc, polyphenols, omega-3 polyunsaturated fatty acids (PUFAs), and probiotics, 128 house crickets were divided into one control group and 31 experimental groups with four house crickets in each group. Over eight weeks, crickets were fed their respective nutrients, and an Alternation Test and Recognition Memory Test were conducted every week using a Y-maze to test spatial working memory. Results: The highest-scoring diets shared by both tests were the combination of multivitamins, zinc, and omega-3 fatty acids (VitZncPuf; Alternation: slope = 0.07226, Recognition Memory: slope = 0.07001), the combination of probiotics, polyphenols, multivitamins, zinc, and omega-3 PUFAs (ProPolVitZncPuf; Alternation: slope = 0.07182, Recognition Memory: slope = 0.07001), the combination of probiotics, multivitamins, zinc, and omega-3 PUFAs (ProVitZncPuf; Alternation: slope = 0.06999, Recognition Memory: slope = 0.07001), and the combination of polyphenols, multivitamins, zinc, and omega-3 PUFAs (PolVitZncPuf; Alternation: slope = 0.06873, Recognition Memory: slope = 0.06956). Conclusion: All of the nutrient combinations demonstrated a benefit over the control diet, but the most significant improvement compared to the control was found in the VitZncPuf, ProVitZncPuf, PolVitZncPuf, and ProPolVitZncPuf. Since this study found no significant difference between the performance and improvement of subjects within these four groups, the combination of multivitamins, zinc, and omega-3 fatty acids (VitZncPuf) was concluded to be the most effective option for improving memory and cognitive performance.

Protective Effects of Omega-3 Fatty Acids on Energy Drink Induced Ovarian Cytotoxicity in Adult Female Albino Rats:

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Maria Ilyas ◽  
Masooma Ahmad ◽  
Huma Jawad ◽  
Nazia Siddique ◽  
Lubna Shahper ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adult Female ◽  
Energy Drinks ◽  
Energy Drink ◽  
Medical Institute ◽  
Albino Rats ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Significant Difference ◽  
Animal House

Background: Energy drinks (EDs) are commonly used to prevent fatigue, enhance physical, and cognitive performance. Its administration induces toxic effects in body. Omega-3 is an antioxidant and anti-inflammatory agent that helps in proper functioning of immune system. Objectives of this study were to evaluate the morphological effects of fish oil omega 3 fatty acids (Eicosapentaenoic acid / Docosahexaenoic acid) on energy drink induced ovarian cytotoxicity in adult female albino rats. Methods: The study was conducted at animal house, Anatomy department, Postgraduate Medical Institute, Lahore from January to march 2019. ARRIVE guidelines were followed for conduct of animal study. Ethical approval was obtained from PGMI, Lahore and Advanced Studies and Research Board of University of Health Sciences, Lahore. The study comprised 36 adult female albino rats divided into 3 groups i.e., control, energy drink and omega 3 treated. Rats were sacrificed, ovaries extracted, and sections were stained with H&E and PAS. SPSS version 21.0 were used. Results: Statistically significant difference was present in gross parameters between the control and experimental groups. Energy drink administration caused a decrease in diameter of mature graafian follicle and diameter of the oocyte. Disruption in basement membrane was more pronounced in Energy drink treated group. Conclusion: Energy drinks were found to cause cytotoxic effects on ovarian and oocyte morphology, ultimately leading to infertility. Omega 3 reduces the extent of damage caused by the intake of energy drinks.

scholarly journals Assessment of anti-depressant activity of omega 3 fatty acids in rodents

2018 ◽  
Vol 7 (12) ◽  
pp. 2353
Author(s):  
Arshaduddin Ahmed Syed ◽  
Kamathi Vipin Chandra
Keyword(s):  
Fatty Acids ◽  
Forced Swim Test ◽  
Antidepressant Effect ◽  
Control Group ◽  
Standard Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Swim Test ◽  
Forced Swim ◽  
Significant Difference

Background: Depression contributes to significant disease burden at national and global levels. At the personal and domestic level too, depression leads to poor quality of life, causing a huge socioeconomic impact. In the world, over 300 million people are estimated to have depression and the numbers of depressed persons are only projected to go up.Methods: The forced swim test (FST) is one of the most commonly used animal models for assessment of antidepressant effects in rodents. In the modified version of this test, the rats are forced to swim in a glass tank with no means of escape, inducing a behaviour of immobility, which resembles a state of despair, akin to depression in humans. The rats were divided into 6 groups: 1. control group: treated with distilled water; 2. standard group treated with fluoxetine Hcl (10mg/kg); 3.test-1 group treated with omega-3 FAs (300mg/kg); 4.test-2 group treated with a higher dose of omega-3 FAs (500 mg/kg); 5.test-3 group treated with omega-3 FAs (300mg/kg) and fluoxetine (10mg/kg); and 6.test-4 group treated with omega-3 FAs (500 mg/kg) and fluoxetine (10mg/kg).Results: The independent between-groups ANOVA yielded a statistically highly significant result, F (5, 30) = 9.47, P <0.001. Thus, the null hypothesis of no difference between the means was rejected. To further evaluate the nature of the differences between the means of the six groups, the statically significant ANOVA result was followed by Tukey's honest significant difference post-hoc tests.Conclusions: This study finds that omega 3 fatty acids have intrinsic antidepressant activity, and the combination of fluoxetine and omega 3 fatty acids has significantly more antidepressant effect than fluoxetine alone in the forced swim test done on Wistar rats.

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

Sign in / Sign up

Export Citation Format

Share Document