scholarly journals Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ranjan Ku. Sahoo ◽  
Nikhil Biswas ◽  
Arijit Guha ◽  
Nityananda Sahoo ◽  
Ketousetuo Kuotsu
Keyword(s):  
Drug Delivery ◽  
Nonionic Surfactant ◽  
Delivery System ◽  
Physical Stability ◽  
Cost Effective ◽  
Water Soluble ◽  
Ocular Delivery ◽  
Surfactant Vesicles ◽  
Nonionic Surfactant Vesicles ◽  
Water Soluble Drugs

With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs.

scholarly journals FUSOGENIC LIPOSOME FOR THE TREATMENT OF FUNGAL MENINGITIS: AN OVERVIEW

2018 ◽  
Vol 11 (12) ◽  
pp. 95
Author(s):  
Irene Susan Alex ◽  
Jeneetta Jose ◽  
Rahul R ◽  
Anju Gopal ◽  
Anu Priya
Keyword(s):  
Drug Delivery ◽  
Amphotericin B ◽  
Cost Effective ◽  
Water Soluble ◽  
Drug Bioavailability ◽  
Medication Therapy ◽  
The People ◽  
Fungal Meningitis ◽  
Water Soluble Drugs ◽  
Molecular Nanotechnology

Fungal meningitis is an infection which is caused by fungus which spreads through the blood to the spinal cord. People with weakened immunity get this disease easily like persons with AIDs, etc. To make sure the disease is fungal meningitis, a sample is taken from the cerebrospinal fluid and it is sent to the laboratory. Usually, fungal meningitis is not mediated from person to person, but it is caused when a fungi are inhaled from the surrounding and spread into the blood to the central nervous system. Normally medications such as vaccines, IV, and oral suspensions are given to the people for curing fungal meningitis. Commonly used drugs are Amphotericin B and fluconazole oral suspension. Amphotericin B is an antifungal, antiprotozoal, and hydrophobic drug. However, these drugs cannot give a directly as medication therapy for the patients, because it offers toxic effect and side effects, absorption rate is slower, and crossing the blood–brain barrier (BBB) is getting difficult. Adverse effects can be minimized with the application of nanotechnology. Therefore, in human medical services, the availability of molecular nanotechnology will provide rapid progress. Nanoparticle (NP) systems help to improve the solubility of poorly water-soluble drugs which has been explained using Noyes–Whitney equations. Nanoparticles offers several advantages as a drug delivery system, such as better drug bioavailability, reduction of dosing frequency enables them for the betterment of diseases, can cross the BBB, and it is very cost-effective. Types of NP include polymeric NP, carbon nanotubes, metallic structures, nanocrystals, and fusogenic liposomes. Fusogenic liposomes are a peculiar class of phospholipid vesicles. The fusogenic liposomes can deliver encapsulated NP into the targeted sites and also can cross the BBB. On comparing with cationic liposomes, fusogenic liposomes are more effective as well as rapid in the drug delivery.

scholarly journals Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure / Razvoj samoemulzifirajućeg sustava za isporuku albendazola (SEDDS) s pojačanom sistemskom apsorpcijom

2012 ◽  
Vol 62 (4) ◽  
pp. 563-580 ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Exposure ◽  
Tween 80 ◽  
Water Soluble ◽  
Formulation Development ◽  
Suspension Formulation ◽  
Water Soluble Drugs

The aim of the study was to develop and evaluate a self- -emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary phase diagrams were plotted to identify the microemulsification existence area. SEDDS formulation of ABZ was prepared using oil (Labrafac Lipopfile WL1349) and a surfactant/ co-surfactant (Tween 80/PEG 400) mixture and was characterized by appropriate studies, viz., microemulsifying properties, droplet size measurement, in vitro dissolution, etc. Finally, PK of the ABZ SEDDS formulation was performed on rats in parallel with suspension formulation. It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ.

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System of Naproxen

2015 ◽  
Vol 8 (1) ◽  
pp. 2715-2722
Author(s):  
Saritha D ◽  
Penjuri Subhash Chandra Bose ◽  
Nagaraju Ravoru
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Size Analysis ◽  
Albino Rats ◽  
Significant Activity ◽  
Water Soluble Drugs

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nanoemulsions containing the solubilized drug. The objective of the present work was to formulate a self nanoemulsifying drug delivery system (SNEDDS) for naproxen. Naproxen SNEDDS were formulated using Labrafac PG (Oil), Span 80 (Surfactant) and propylene glycol (Co surfactant). The developed SNEDDS were evaluated for turbidimetry, droplet size analysis, zeta potential, refractive index, viscosity, drug content and in vitro diffusion profiles. All formulations of naproxen SNEDDS showed globule size in nanometric range, good stability with no phase separation and rapidly formed clear emulsion. All formulations showed more than 95% of drug release at the end of 60 min. The SEDDS showed improved dissolution rate compared to pure naproxen. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SNEDDS showed more significant activity than the pure drug. The study illustrated the potential of naproxen SNEDDS for oral administration and its biopharmaceutical performance.

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