scholarly journals Active Smoking Increases Microsomal PGE2-Synthase-1/PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jaime-Félix Dilmé ◽  
David Solà-Villà ◽  
Sergi Bellmunt ◽  
José-María Romero ◽  
José-Román Escudero ◽  
...  
Keyword(s):  
Risk Factors ◽  
Association Studies ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Aortic Aneurysms ◽  
Cell Type ◽  
Current Smoking ◽  
Abdominal Aortic ◽  
Local Levels ◽  
Insight Into

Background. The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of thePGE2pathway in human AAA.Methods. Aortic(n=89)and plasma(n=79)samples from patients who underwent AAA repair were collected. Patients were grouped according to risk factors. COX-isoenzymes, mPGES-1, EPs,α-actin, and CD45 and CD68 transcripts levels were quantified by QRT-PCR and plasmaPGE2metabolites by EIA.Results. Current smoking (CS) patients compared to no-CS had significantly higher local levels of mPGES-1(P=0.009), EP-4(P=0.007), andPGE2metabolites plasma levels(P=0.008). In the multiple linear regression analysis, these parameters remained significantly enhanced in CS after adding confounding factors. Results from association studies with cell type markers suggested that the increased mPGES-1/EP-4 levels were mainly associated with microvascular endothelial cells.Conclusions. This study shows that elements of thePGE2pathway, which play an important role in AAA development, are increased in CS. These results provide insight into the relevance of tobacco smoking in AAA development and reinforce the potential of mPGES-1 and EP-4 as targets for therapy in AAA patients.

scholarly journals Risk Factor Assessment in a Greek Cohort of Patients With Large Abdominal Aortic Aneurysms

Angiology ◽  
2018 ◽  
Vol 70 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Georgios Makrygiannis ◽  
Evanthia Mourmoura ◽  
Konstantinos Spanos ◽  
Nikolaos Roussas ◽  
Helena Kuivaniemi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Screening Program ◽  
Multiple Logistic Regression Analysis ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Aortic Dilatation ◽  
Nucleotide Polymorphisms ◽  
Current Smoking ◽  
Abdominal Aortic

Environmental and genetic risk factors contribute to the etiology of abdominal aortic aneurysms (AAAs). Matrix metalloproteinases (MMPs) have been associated with the pathophysiology of AAAs. A prospective, nonrandomized case–control study was undertaken to investigate the risk factors for large AAAs (≥5.5 cm) among 175 male Greek AAA patients and to compare the results with a cohort of 166 male controls free from any aortic dilatation, as confirmed by ultrasonography from an existing AAA screening program in the same region. We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (−1561C/T; rs3918242) and MMP13 (−77A/G; rs2252070), and the presence of large AAAs. Multiple logistic regression analysis revealed AAA family history ( P = .028), hypercholesterolemia ( P < .001), and current smoking ( P < .001) as AAA risk factors. Statistical difference was reached in genotype ( P = .047) and allele ( P = .037) frequencies for rs2252070, but the results did not remain significant after correction for multiple testing. No significant differences in genotype or allele frequencies for rs3918242 were detected. In summary, AAA family history, hypercholesterolemia, and current smoking were found to be risk factors for large AAAs.

scholarly journals Comparative Study of Chemical Compositions and Antioxidant Capacities of Oils Obtained from 15 Macadamia (Macadamia integrifolia) Cultivars in China

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1031
Author(s):  
Xixiang Shuai ◽  
Taotao Dai ◽  
Mingshun Chen ◽  
Ruihong Liang ◽  
Liqing Du ◽  
...  
Keyword(s):  
Palmitoleic Acid ◽  
Linear Regression Analysis ◽  
Monounsaturated Fatty Acids ◽  
Multiple Linear Regression Analysis ◽  
Chemical Compositions ◽  
Macadamia Integrifolia ◽  
Antioxidant Capacities ◽  
Squalene Content ◽  
First Time ◽  
Insight Into

The planting area of macadamia in China accounted for more than one third of the world’s planted area. The lipid compositions, minor components, and antioxidant capacities of fifteen varieties of macadamia oil (MO) in China were comparatively investigated. All varieties of MO were rich in monounsaturated fatty acids, mainly including oleic acid (61.74–66.47%) and palmitoleic acid (13.22–17.63%). The main triacylglycerols of MO were first time reported, including 19.2–26.1% of triolein, 16.4–18.2% of 1-palmitoyl-2,3-dioleoyl-glycerol, and 11.9–13.7% of 1-palmitoleoyl-2-oleoyl-3-stearoyl-glycerol, etc. The polyphenol, α-tocotrienol and squalene content varied among the cultivars, while Fuji (791) contained the highest polyphenols and squalene content. Multiple linear regression analysis indicated the polyphenols and squalene content positively correlated with the antioxidant capacity. This study can provide a crucial directive for the breeding of macadamia and offer an insight into industrial application of MO in China.

Study time, glasses utilization and age affect quality of life among senior first-year Chinese myopia students

2021 ◽  
pp. 112067212098252
Author(s):  
Ziqian Zhu ◽  
Yan He ◽  
Jiezheng Yang ◽  
Qiaoli Li ◽  
HuanHuan Cheng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Study Time ◽  
First Year ◽  
Normal Vision ◽  
First Year Students

Purpose: To compare the quality of life of senior first-year students with normal vision and myopia, and to explore the risk factors related to quality of life in students with myopia. Methods: In this study, 1103 senior first-year students were enrolled in ten high schools. These students were divided according to the diopter degree, with 916 myopia students and 187 normal vision students. Visual function indexes, such as naked eye vision, were measured and recorded, and social demographic indexes and the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) was used. The differences in quality of life between the two groups were compared. Multiple linear regression analysis was used to explore the possible risk factors for quality of life in myopia students. Results: In the NEI VFQ-25, the total quality of life scores of myopia students (77.06 ± 15.66) were lower than those of normal vision students (85.49 ± 12.37). The difference was statistically significant ( p = 0.007). In the correlation analysis, the total scores of quality of life in myopia students were positively correlated with wearing glasses ( p = 0.049), and were negatively correlated with study time ( p = 0.029). Multiple linear regression analysis showed that study time, wearing glasses and age were risk factors affecting quality of life in myopia students. Conclusion: Our results show that senior first-year myopia students have lower quality of life scores than students with normal vision. Study time, wearing glasses and age are risk factors for quality of life in senior first-year myopia students.

Mortality rates and risk factors for emergent open repair of abdominal aortic aneurysms in the endovascular era

2017 ◽  
Vol 70 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Felice Pecoraro ◽  
Steffen Gloekler ◽  
Caecilia E. Mader ◽  
Malgorzata Roos ◽  
Lyubov Chaykovska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Open Repair ◽  
Abdominal Aortic Aneurysms ◽  
Mortality Rates ◽  
Aortic Aneurysms ◽  
Abdominal Aortic

scholarly journals Risk factors for Hyperhomocysteinemia for Specific MTHFR C677T Genotypes and Gender in Chinese Population.

2020 ◽  
Author(s):  
Hang Xiang ◽  
Tianyuan Xiang ◽  
Muyang Yan ◽  
Sheng Yu ◽  
Matthew John Horwedel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Linear Regression Analysis ◽  
Mthfr C677t ◽  
Multiple Linear Regression Analysis ◽  
Plasma Homocysteine ◽  
Independent Variables ◽  
Specific Risk ◽  
Physical Examinations ◽  
The Common ◽  
And Gender

Abstract Background­-- Our previous studies have identified that both gender and genotype of MTHFR C677T were independent variables for plasma homocysteine (Hcy) levels. Based on these results, we want to further explore their systemic information, in order to find specific risk factors for each genetic group, which might be used as predictors or targeting markers for lowering Hcy levels. Patients and Methods­--This cross section study was performed through November 2017 to July 2019. A total of 4534 adults aged 20-75y were selected for this study, and all of them underwent a physical examinations and MTHFR C677T genotyping. Results--The average of Hcy level was higher in TT genotype than CC and CT genotypes (P=0.000). Multiple linear regression analysis found that except the common protective factors (folate and Vit B12) and risk factor (Cr), each group has it specific risk factors for HHcy---female-CT (age, SBP and Hb), female-TT (SBP and AST); male-CC (age, AST and Hb), male-CT (age and AST) and male-TT (SBP, AST and Hb).Conclusion--The plasma Hcy level was influenced by different risk factors for specific gender and genotype. These risk factors might be useful for prediction or prevention of HHcy in the future.

RISK FACTORS FOR TYPE II ENDOLEAKS AFTER ENDOVASCULAR REPAIR OF ABDOMINAL AORTIC ANEURYSMS

2008 ◽  
Vol 78 (1-2) ◽  
pp. 61-63 ◽  
Author(s):  
Ranjana Warrier ◽  
Robert Miller ◽  
Rick Bond ◽  
Ian K. Robertson ◽  
Peter Hewitt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endovascular Repair ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Type Ii ◽  
Abdominal Aortic

The similarities and differences among patients with abdominal aortic aneurysms referred to a tertiary hospital and found at necropsy

Vascular ◽  
2014 ◽  
Vol 23 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Erasmo S da Silva ◽  
Vitor C Gornati ◽  
Ivan B Casella ◽  
Ricardo Aun ◽  
Andre EV Estenssoro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Protective Factor ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Maximum Diameter ◽  
Transverse Diameter ◽  
Abdominal Aortic ◽  
Tertiary Center

Objective To analyze the characteristics of patients with abdominal aortic aneurysms referred to a tertiary center and to compare with individuals with abdominal aortic aneurysm found at necropsy. Methods We have retrospectively analyzed the medical records of 556 patients with abdominal aortic aneurysm and 102 cases abdominal aortic aneurysm found at necropsy. Results At univariated analysis, hypertension, tobacco use and maximum diameter were significant risk factors for symptomatic aneurysm, while diabetes tended to be a protective factor for rupture. By logistic regression analysis, the largest transverse diameter was the only one significantly associated with abdominal aortic aneurysm rupture ( p < .0001, odds ratio 1.7, 95% confidence interval 1.481–1.951). Intact abdominal aortic aneurysm found at necropsy showed similarities with outpatients in relation to abdominal aortic aneurysm diameter and risk factors. Conclusion Intact abdominal aortic aneurysm at necropsy and at outpatients setting showed similarities that confirmed that abdominal aortic aneurysm repair is less offered to women, and they died more frequently with intact abdominal aortic aneurysm from other causes.

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