scholarly journals Risk factors for Hyperhomocysteinemia for Specific MTHFR C677T Genotypes and Gender in Chinese Population.

2020 ◽  
Author(s):  
Hang Xiang ◽  
Tianyuan Xiang ◽  
Muyang Yan ◽  
Sheng Yu ◽  
Matthew John Horwedel ◽  
...  

Abstract Background­-- Our previous studies have identified that both gender and genotype of MTHFR C677T were independent variables for plasma homocysteine (Hcy) levels. Based on these results, we want to further explore their systemic information, in order to find specific risk factors for each genetic group, which might be used as predictors or targeting markers for lowering Hcy levels. Patients and Methods­--This cross section study was performed through November 2017 to July 2019. A total of 4534 adults aged 20-75y were selected for this study, and all of them underwent a physical examinations and MTHFR C677T genotyping. Results--The average of Hcy level was higher in TT genotype than CC and CT genotypes (P=0.000). Multiple linear regression analysis found that except the common protective factors (folate and Vit B12) and risk factor (Cr), each group has it specific risk factors for HHcy---female-CT (age, SBP and Hb), female-TT (SBP and AST); male-CC (age, AST and Hb), male-CT (age and AST) and male-TT (SBP, AST and Hb).Conclusion--The plasma Hcy level was influenced by different risk factors for specific gender and genotype. These risk factors might be useful for prediction or prevention of HHcy in the future.

2017 ◽  
Vol 24 (1) ◽  
pp. 35-53
Author(s):  
Sulastiningsih Sulastiningsih ◽  
Intan Ayu Candra

The purpose of this study is to prove: (1) Time pressure, locus of control, the action of supervision and materiality partially affect the premature termination of the audit procedures (2) Time pressure, locus of control, supervision and materiality simultaneously affect the premature termination on the audit procedures. This research was conducted in Public Accountant firm in Yogyakarta region of which total 12 samples of KAP, by distributing 105 questionnaires, and 57 questionnaires were returned (54%). 34 of the returned questionnaires can be processed (34%). The samples in this study were determined by using non-probability sampling, one of purposive sampling methods. Data analysis consisted of: (1) validity test, reliability test and classical assumption. The result showed that the instruments used are quite reliable and valid (2) multiple linear regression analysis. The results are (a) Some of independent variables partially affect premature termination of the audit procedure, while the action of supervision does not influence premature termination of audit procedures (b) All independent variables influence simultaneously to the premature termination of the audit procedures (c) All independent variables showed that as much as 55% it affects on premature termination of the audit procedures, the rest of it are influenced by other variables. (3) Friedman Test. The result shows that there are order of priority of audit procedures being terminated.


2021 ◽  
pp. 112067212098252
Author(s):  
Ziqian Zhu ◽  
Yan He ◽  
Jiezheng Yang ◽  
Qiaoli Li ◽  
HuanHuan Cheng ◽  
...  

Purpose: To compare the quality of life of senior first-year students with normal vision and myopia, and to explore the risk factors related to quality of life in students with myopia. Methods: In this study, 1103 senior first-year students were enrolled in ten high schools. These students were divided according to the diopter degree, with 916 myopia students and 187 normal vision students. Visual function indexes, such as naked eye vision, were measured and recorded, and social demographic indexes and the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) was used. The differences in quality of life between the two groups were compared. Multiple linear regression analysis was used to explore the possible risk factors for quality of life in myopia students. Results: In the NEI VFQ-25, the total quality of life scores of myopia students (77.06 ± 15.66) were lower than those of normal vision students (85.49 ± 12.37). The difference was statistically significant ( p = 0.007). In the correlation analysis, the total scores of quality of life in myopia students were positively correlated with wearing glasses ( p = 0.049), and were negatively correlated with study time ( p = 0.029). Multiple linear regression analysis showed that study time, wearing glasses and age were risk factors affecting quality of life in myopia students. Conclusion: Our results show that senior first-year myopia students have lower quality of life scores than students with normal vision. Study time, wearing glasses and age are risk factors for quality of life in senior first-year myopia students.


POINT ◽  
2021 ◽  
Vol 3 (2) ◽  
pp. 57-70
Author(s):  
Marina Malian

This study aims to analyze partially and simultaneously the influence of product quality, brand image and consumer trust on customer satisfaction. Including quantitative research using the results of questionnaire surveys filled by respondents. The sample used is 100 consumers of on line products in Palembang. The method of data analysis uses multiple linear regression analysis. To test the hypothesis the partial effect of independent variables on the dependent variable used the t test. The F test is used to test the effect of the independent variables on the dependent variable together. The results of processing data show there is an influence of product quality on customer satisfaction. Consumer trust affects consumer satisfaction and brand image does not affect consumer satisfaction. Taken together there is the effect of independent variables on the dependent variable. Consumer trust has the most dominant influence on customer satisfaction on line products in Palembang.


2021 ◽  
Vol 5 (2) ◽  
pp. 79-86
Author(s):  
Trisna Sary Lewaru

ABSTRACT This study aims to analyze the factors that influence entrepreneurial intentions among college student. The five independent variables was used include need for achievement, locus of control, self-efficacy, instrumental readiness, entrepreneurship experience. Sample in this research is students on Pattimura University totaling 160 people. Multiple linear regression analysis was used to measure this study. The results of this study indicate that need for achievement, locus of control, entrepreneurship experience have no effect on the intentions of entrepreneurial among students. Whereas instrumental readiness and self-efficacy variable has positive and significant effect on entrepreneurial intention between students of Pattimura University. Keywords : Entrepreneurship, Intentions


2020 ◽  
Author(s):  
Lola Satri ◽  
Alfian

This research has a purpose to know whether relationship marketing and service quality have positive influence to loyalty of customer of saving sikoci at Bank of Nagari branch of Simpang Empat either partially or simultaneously and know which variable is more dominant. The data collection techniques used in this study is a questionnaire. The sample used is 100 customer, with sampling technique using accidental sampling technique. Data analysis technique in this research use multiple linear regression analysis. The results obtained in this study are as follows: (1) Trust has positive effect (944) <(1,984) and not significant (0,348)> (0,05) to loyalty. (2)) Commitment has positive (8,218)> (1,984) and significant (0,000) <(0,05) effect on loyalty. (3) Tangibles has negative (-2,430)> (1,984) and significant (0,017) <(0,05) effect on loyalty. (4) Reliability negatively (-1.570) <(1,984) and insignificant 0, 120> 0.05 to loyalty. (5) Responsiveness has positive effect (5,922)> t table (1,984) and significant (0,000) <(0,05) to loyalty. (6) Warranty has positive effect (1,199) <(1,984) and insignificant 0, 234> 0,05 to loyalty. (7) Empathy has positive effect (186) <(1,984) and insignificant 0, 853> 0,05 to loyalty. From the value of Adjusted R Squere simultaneously produced 566. It means that 56.6% of loyalty variables are influenced by independent variables and the remaining 43.4% is influenced by othervariables.


2018 ◽  
Vol 2 (2) ◽  
pp. 307-316
Author(s):  
Rahayu Saputri ◽  
Nur Rahmah Andayani

  Abstrak   Penelitian pengaruh kepemimpinan dan motivasi kerja bertujuan untuk  untuk menguji pengaruh kepemimpinan dan motivasi kerja terhadap kinerja pegawai baik secara parsial maupun simultan pada PT Cladtek Bi-Metal Manufacturing Batam. Data penelitian dikumpulkan dengan menggunakan metode kuesioner dan analisis data yang digunakan adalah analisis regresi linier berganda menggunakan uji F dan uji T. Pengambilan data dengan menggunakan sensus, sehingga data diambil dari seluruh populasi. Variabel independen terdiri dari kepemimpinan dan motivasi kerja, dan variabel dependennya adalah kinerja pegawai. Penelitian ini dilakukan dengan menguji validitas dan reliabilitas instrument, selanjutnya data dianalisis dan diuji menggunakan Uji F dan Uji t. Hasil penelitian menunjukkan bahwa secara parsial variabel kepemimpinan berpengaruh negatif dan tidak signifikan terhadap kinerja karyawan, dan variabel motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan.  Sedangkan secara simultan variabel kepemimpinan dan variabel motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan. Kata kunci : Kepemimpinan, Motivasi Kerja, Kinerja Pegawai   Abstract   Research influence of leadership and work motivation aims to to test the influence of leadership and work motivation on employee performance either partially or simultaneously at PT Cladtek Bi-Metal Manufacturing Batam. Research data collected by using questionnaire method and data analysis used is multiple linear regression analysis using F test and T test. Intake of data by using census, so that data is taken from entire population. Independent variables consist of leadership and work motivation, and the dependent variable is employee performance. This study was conducted by testing the validity and reliability of the instrument, then the data were analyzed and tested using F Test and T Test. The results showed that the leadership of the influential variables are partially negative and insignificant against the performance of employees, and work motivation variables positive and significant effect on performance of employees.  While simultaneously variable leadership and motivational variables work a positive and significant effect on performance of employees. Keywords: Leadership, Work Motivation, Employee Performance  


2019 ◽  
Vol 3 (2) ◽  
pp. 224
Author(s):  
IRNI SEPTIANI ◽  
INSIATININGSIH INSIATININGSIH

The growth of Modern Stores in Indonesia is very rapid, experiencing growth from year to year, this condition is offset by demand from large communities and increasingly enjoys the convenience and comfort of shopping in modern stores. However, Sleman Regency D.I. Yogyakarta provides a number of rules as outlined in Regional Regulation No. 18 of 2012 concerning Licensing of Shopping Centers and Modern Stores, which it is hoped that this regulation will have a significant impact on equitable distribution between modern shops and traditional markets in Sleman Regency, YogyakartaReferring to the Regional Regulation, this research was carried out to see the impact of the application of the Modern Shop business permit to the existence of traditional markets in Sleman Regency D.I. Yogyakarta. In this study 200 samples were taken by distributing 250 questionnaires with a distribution of 125 questionnaires to managers and modern shop owners and 125 questionnaires to traditional shop owners in the traditional market of Sleman Regency D.I. Yogyakarta, which finally received 200 questionnaires. The method used for sampling is a non probability sampling method that is sampling by specifying specific criteria on respondents. Data collection techniques using questionnaires that have been tested for validity and reliability. Data analysis techniques using multiple linear regression analysis and data processed with SPSS software. The variables used in this study are 4 independent variables namely Business Location Aspects, Social Aspects, Partnership Aspects with MSMEs and Use of Local Workers Aspects, and 1 dependent variable namely the Existence of Traditional Markets. From the results of the research analysis it was concluded that the business location aspect variable (X1) had no impact on the existence of traditional markets with negative B1 (- 0.799) and t count was smaller than t table, Variable Social Aspects (X2) had no impact on the existence of Traditional Markets with B2 negative (-1,334) and t count smaller than t table, Variable Aspects of Partnership with MSME (X3) have an impact on the existence of Traditional Markets with positive B3 (9,153) and t count is greater than t table, Variable Aspects of Use of Power Local Work (X4) has an impact on the existence of Traditional Markets with positive B4 (1,646) and t count is greater than t table, and the four Independent Variables together have an impact on the dependent variable The existence of Traditional Market Sleman DIY Regency is allegedly also influenced by variables other variables not examined in this study.Keywords : modern shop, traditional market, Sleman Regency D.I. Yogyakarta, Existence of Traditional Markets


PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243589
Author(s):  
Hiroshi Akima ◽  
Akito Yoshiko ◽  
Régis Radaelli ◽  
Madoka Ogawa ◽  
Kaori Shimizu ◽  
...  

Muscle quality is well-known to decrease with aging and is a risk factor for metabolic abnormalities. However, there is a lack of information on race-associated differences in muscle quality and other neuromuscular features related to functional performance. This study aimed to compare muscle quality, function, and morphological characteristics in Japanese and Brazilian older individuals. Eighty-four participants aged 65–87 years were enrolled in the study (42 Japanese: 23 men, 19 women, mean age 70.4 years; 42 Brazilians: 23 men, 19 women, mean age 70.8 years). Echo intensity (EI) and muscle thickness (MT) of the quadriceps femoris were measured using B-mode ultrasonography. A stepwise multiple linear regression analysis with EI as a dependent variable revealed that MT was a significant variable for Japanese participants (R2 = 0.424, P = 0.001), while MT and subcutaneous adipose tissue (SCAT) thickness were significant variables for Brazilian participants (R2 = 0.490, P = 0.001). A second stepwise multiple linear regression analysis was performed after excluding MT and SCAT thickness from the independent variables. Sex and age for Japanese participants (R2 = 0.381, P = 0.001) and lean body mass and body mass index for Brazilian participants (R2 = 0.385, P = 0.001) were identified as significant independent variables. The present results suggest that MT is closely correlated with muscle quality in Japanese and Brazilian older individuals. Increases in muscle size may induce decreases in intramuscular adipose tissue and/or connective tissues, which are beneficial for reducing the risks of metabolic impairments in Japanese and Brazilian older individuals.


2019 ◽  
Vol 1 (1) ◽  
pp. 9-16
Author(s):  
Akbarrudin Karisma Putra

This study aims to determine how much influence both partially and simultaneously leadership, motivation and work discipline that occur in CV Kiong Ho Surabaya. This research is included in quantitative research, namely the data used in this study in the form of numbers. The sample from this study was CV Kiong Ho Surabaya employees which numbered 35 respondents. Using the disproportionate stratified random sampling model and the collected data were analyzed using multiple linear regression analysis. The independent variables used in this study are leadership, work motivation, work discipline. While the performance of CV Kiong Ho Surabaya employees is the dependent variable. This study uses primary data, namely data collection by distributing questionnaires. The results showed that the results of the F test showed that employee performance was influenced jointly by leadership, work motivation, work discipline. And the results of partial tests, independent variables consisting of leadership, work motivation, work discipline.


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