scholarly journals Polyphenols as Key Players for the Antileukaemic Effects of Propolis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Murtala B. Abubakar ◽  
Wan Zaidah Abdullah ◽  
Siti Amrah Sulaiman ◽  
Boon Suen Ang
Keyword(s):  
Cell Lines ◽  
Biological Activities ◽  
Epidemiological Studies ◽  
Leukaemia Cell ◽  
Phenolic Contents ◽  
Treatment And Prevention ◽  
History Of ◽  
Cell Growth And Proliferation

Propolis (a bee product) which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenolic contents have both been reported to exhibit antileukaemic effects in various leukaemia cell lines. The ability of the polyphenols found in propolis to arrest cell cycle and induce apoptosis and differentiation in addition to inhibition of cell growth and proliferation makes them promising antileukaemic agents, and hence, they are believed to be a key to the antileukaemic effects of propolis in different types of leukaemia. This paper reviews the molecular bases of antileukaemic activity of both crude propolis and individual polyphenols on various leukaemia cell lines, and it indicates that propolis has the potential to be used in both treatment and prevention of leukaemia. This however needs further evaluation byin vitro,in vivo, and epidemiological studies as well as clinical trials.

Phytoestrogens after breast cancer.

2001 ◽  
pp. 129-134 ◽  
Author(s):  
P This ◽  
A De La Rochefordi√®re ◽  
K Clough ◽  
A Fourquet ◽  
H Magdelenat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Media Coverage ◽  
Breast Cancer Survivors ◽  
Hormone Replacement ◽  
Epidemiological Studies ◽  
In Vivo Studies ◽  
History Of ◽  
The Media

The current extension of the indications for adjuvant chemotherapy, which predisposes to early menopause, and the media coverage of the benefits of hormone replacement therapy (HRT) have led patients with a history of breast cancer to seek treatments for estrogen deprivation. In breast cancer survivors, most physicians avoid HRT because of concern regarding the potential promotion of growth of occult malignant cells by estrogens, due to the estrogen dependence of breast cancer. Soy phytoestrogens are being promoted as the 'natural alternative' to HRT and have been available without restrictions for several years as nutritional supplements. In this paper, data on the complex mammary effects of phytoestrogens in epidemiological studies, in in vitro studies, as well as in in vivo studies on animal carcinogenesis are reviewed. The potential benefits and risks of phytoestrogens are analyzed, and the prescription of phytoestrogens to postmenopausal women after breast cancer and the coprescription with the anti-estrogen tamoxifen are discussed. The absence of controlled trials and technical checking of extraction and titration in these preparations on 'free sale' raise a new problem in terms of public health and justify close reasoning and a cautious attitude of physicians, as well as straight information given to women, especially after breast cancer.

scholarly journals Chalcone Derivatives: Role in Anticancer Therapy

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 894
Author(s):  
Yang Ouyang ◽  
Juanjuan Li ◽  
Xinyue Chen ◽  
Xiaoyu Fu ◽  
Si Sun ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Full Description ◽  
Chalcone Derivatives ◽  
Treatment And Prevention ◽  
Convenient Synthesis ◽  
Prevention Of Cancer ◽  
Cell Cycle Disruption

Chalcones (1,3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids, which are common simple chemical scaffolds found in many naturally occurring compounds. Many chalcone derivatives were also prepared due to their convenient synthesis. Chalcones as weandhetic analogues have attracted much interest due to their broad biological activities with clinical potentials against various diseases, particularly for antitumor activity. The chalcone family has demonstrated potential in vitro and in vivo activity against cancers via multiple mechanisms, including cell cycle disruption, autophagy regulation, apoptosis induction, and immunomodulatory and inflammatory mediators. It represents a promising strategy to develop chalcones as novel anticancer agents. In addition, the combination of chalcones and other therapies is expected to be an effective way to improve anticancer therapeutic efficacy. However, despite the encouraging results for their response to cancers observed in clinical studies, a full description of toxicity is required for their clinical use as safe drugs for the treatment of cancer. In this review, we will summarize the recent advances of the chalcone family as potential anticancer agents and the mechanisms of action. Besides, future applications and scope of the chalcone family toward the treatment and prevention of cancer are brought out.

scholarly journals Algae as potential repository of anti cancerous natural compounds

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Ankita Mridha ◽  
Santanu Paul
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Leukemia Cell ◽  
Relevant Information ◽  
Cancer Cell Growth ◽  
History Of ◽  
History Of Use ◽  
Promising Source

<p>Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action <em>in vitro</em> as well as <em>in vivo</em> condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.</p>

scholarly journals Holoptelea integrifolia(Roxb.) Planch: A Review of Its Ethnobotany, Pharmacology, and Phytochemistry

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Showkat Ahmad Ganie ◽  
Surender Singh Yadav
Keyword(s):  
Chronic Wounds ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Phytochemical Analysis ◽  
Treatment And Prevention ◽  
Cns Depressant ◽  
Crude Extracts ◽  
Prevention And Treatment

Holoptelea integrifolia(Ulmaceae) is a versatile medicinal plant used in various indigenous systems of medicine for curing routine healthcare maladies. It is traditionally used in the treatment and prevention of several ailments like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, ringworm, eczema, malaria, intestinal cancer, and chronic wounds.In vitroandin vivopharmacological investigations on crude extracts and isolated compounds showed antibacterial, antifungal, analgesic, antioxidant, anti-inflammatory, anthelmintic, antidiabetic, antidiarrhoeal, adaptogenic, anticancer, wound healing, hepatoprotective, larvicidal, antiemetic, CNS depressant, and hypolipidemic activities. Phytochemical analysis showed the presence of terpenoids, sterols, saponins, tannins, proteins, carbohydrates, alkaloids, phenols, flavonoids, glycosides, and quinines. Numerous compounds including Holoptelin-A, Holoptelin-B, friedlin, epifriedlin,β-amyrin, stigmasterol,β-sitosterol, 1, 4-napthalenedione, betulin, betulinic acid, hexacosanol, and octacosanol have been identified and isolated from the plant species. The results of several studies indicated thatH. integrifoliamay be used as an effective therapeutic remedy in the prevention and treatment of various ailments. However, further studies on chemical constituents and their mechanisms in exhibiting certain biological activities are needed. In addition, study on the toxicity of the crude extracts and the compounds isolated from this plant should be assessed to ensure their eligibility to be used as source of modern medicines.

Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications

2019 ◽  
Vol 25 (39) ◽  
pp. 5347-5371 ◽  
Author(s):  
Swathi Putta ◽  
Nagendra Sastry Yarla ◽  
Eswar Kumar K. ◽  
Dhananjaya Bhadrapura Lakkappa ◽  
Mohammad A. Kamal ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Diabetes Management ◽  
Biological Activities ◽  
Vascular Diseases ◽  
Epidemiological Studies ◽  
Glucose Absorption ◽  
Human Consumption ◽  
Gene Expressions

Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases is to be considered. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries. A large number of bioactive anthocyanins, such as cyanidin, malvidin, delphinidin, pelargonidin, peonidin, petunidin and their metabolites have shown multiple biological activities with apparent effects on glucose absorption, glucose uptake, insulin secretion and sensitivity, on the enzymes involved in glucose metabolism, gene expressions, inflammatory mediators, glucose transporters in progression of diabetes and associated complications, such as diabetic retinopathy, nephropathy, neuropathy and diabetic vascular diseases. The versatility of the anthocyanins provides a promising approach for diabetes management than synthetic drugs. Here we summarize the effect of several anthocyanins on many in vitro, in vivo and clinical studies and also reveal the mechanisms which could prevent or reverse the underlying mechanisms of diabetic pathologies including promotion of antioxidant, antihyperlipidemic, anti-inflammatory and anti-apoptotic activities.

scholarly journals Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review

2021 ◽  
Vol 2021 ◽  
pp. 1-23
Author(s):  
D. T. Abeysinghe ◽  
D. D. D. H. Alwis ◽  
K. A. H. Kumara ◽  
U. G. Chandrika
Keyword(s):  
Current Knowledge ◽  
Biological Activities ◽  
Biological Effects ◽  
Herbal Remedies ◽  
Murraya Koenigii ◽  
In Vivo Models ◽  
Treatment And Prevention ◽  
Curry Leaves

Murraya koenigii (M. koenigii), Micromelum minutum (M. minutum), and Clausena indica (C. indica) are three varieties of curry leaves in the family Rutaceae. They have been widely used in Ayurvedic medicine worldwide in the treatment and prevention of various diseases. Earlier findings provide strong evidence to support the three curry leaf species’ potent pharmaceutical and biological effects, including antioxidant, antidiabetic, anti-inflammatory, and antitumor activities. Various parts of these plants, such as leaves, seeds, flowers, and fruit, contain constituents responsible for the modulation of numerous biological processes. Leading constituents of curry leaves play a crucial role in diabetic and anticancer management by regulating various molecular pathways, including Bcl-2, Bax, NF-κB, and TNFα, according to in vitro and in vivo models established. Therefore, this review summarizes the current knowledge on research achievements made in terms of phytoconstituents, their structures, biological activities, and pharmacological actions with clinical studies of curry leaves up to date. The review also emphasizes the necessity for comprehensive research studies on the pharmacological actions and the mechanisms of selected phytochemicals of M. koenigii, M. minutum, and C. indica to validate their efficacy as potent herbal remedies for many ailments.

scholarly journals ERK knockdown suppress cell biological activities via regulation CD59 in breast cancer

2021 ◽  
Author(s):  
Fei Qu ◽  
Yanru Cui ◽  
Shixin Yang ◽  
Zhihua Li ◽  
Jingxian Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Biological Activities ◽  
Cell Number ◽  
Tunel Assay ◽  
Cancer Development ◽  
Breast Cancer Cell Lines ◽  
Breast Cancer Development

IntroductionIt has been unclear that ERK play the effects and relative mechanism in breast cancer development. The purpose of this work was to discuss the ERK play the effect in breast cancer and relative mechanisms.Material and methodsEvaluating ERK and CD59 proteins expression in difference tissue from patients by IHC assay. Using MCF-7 and MDA-MB-231 cell lines which were breast cancer cell lines as target cell lines in our study. In vitro study, evaluating cell biological activities including proliferation, apoptosis, cell cycle, invasion, adherent and migration by MTT, clone test, TUNEL assay, flow cytometry and wound healing. And measuring relative proteins expressions by WB assay. In vivo study, measuring tumor weight and volume, the apoptosis cell number were evaluated by TUNEL assay and relative proteins expressions by IHC assay.ResultsCompared with adjacent normal tissue, the ERK and CD59 proteins expression were significantly increased in breast cancer tissues (P＜0.001, respectively).In vitro and vivo studies, with ERK knockdown, the cell biological activities were significantly depressed with CD59 suppressing (P＜0.001, respectively). And the relative proteins including CD59, PKD, P53, E-cadherin and Vimentin were significantly differences (P＜0.001, respectively).ConclusionsERK play an oncology gene in breast cancer development, ERK inhibitor had effects to suppress breast cancer biological via regulation CD59 in vitro and vivo study.

Evaluation of the In Vivo Acute Toxicity and In Vitro Hemolytic and Immunomodulatory Activities of the Moringa oleifera Flower Trypsin Inhibitor (MoFTI)

2020 ◽  
Vol 27 ◽  
Author(s):  
Leydianne Leite de Siqueira Patriota ◽  
Dayane Kelly Dias do Nascimento Santos ◽  
Bárbara Rafaela da Silva Barros ◽  
Lethícia Maria de Souza Aguiar ◽  
Yasmym Araújo Silva ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Trypsin Inhibitor ◽  
Hemolytic Activity ◽  
Moringa Oleifera ◽  
Biological Activities ◽  
Hematological Parameters ◽  
Behavioral Alterations ◽  
Female Mice

Background: Protease inhibitors have been isolated from plants and present several biological activities, including immunomod-ulatory action. Objective: This work aimed to evaluate a Moringa oleifera flower trypsin inhibitor (MoFTI) for acute toxicity in mice, hemolytic activity on mice erythrocytes and immunomodulatory effects on mice splenocytes. Methods: The acute toxicity was evaluated using Swiss female mice that received a single dose of the vehicle control or MoFTI (300 mg/kg, i.p.). Behavioral alterations were observed 15–240 min after administration, and survival, weight gain, and water and food consumption were analyzed daily. Organ weights and hematological parameters were analyzed after 14 days. Hemolytic activity of MoFTI was tested using Swiss female mice erythrocytes. Splenocytes obtained from BALB/c mice were cultured in the absence or presence of MoFTI for the evaluation of cell viability and proliferation. Mitochondrial membrane potential (ΔΨm) and reactive oxygen species (ROS) levels were also determined. Furthermore, the culture supernatants were analyzed for the presence of cytokines and nitric oxide (NO). Results: MoFTI did not cause death or any adverse effects on the mice except for abdominal contortions at 15–30 min after administration. MoFTI did not exhibit a significant hemolytic effect. In addition, MoFTI did not induce apoptosis or necrosis in splenocytes and had no effect on cell proliferation. Increases in cytosolic and mitochondrial ROS release, as well as ΔΨm reduction, were observed in MoFTI-treated cells. MoFTI was observed to induce TNF-α, IFN-γ, IL-6, IL-10, and NO release. Conclusion: These results contribute to the ongoing evaluation of the antitumor potential of MoFTI and its effects on other immunological targets.

Metabolomics of Healthy Berry Fruits

2019 ◽  
Vol 25 (37) ◽  
pp. 4888-4902 ◽  
Author(s):  
Gilda D'Urso ◽  
Sonia Piacente ◽  
Cosimo Pizza ◽  
Paola Montoro
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
In Vivo Studies ◽  
Bioactive Metabolites ◽  
Active Metabolites ◽  
Positive Effects ◽  
Cell Functions ◽  
Berry Fruits

The consumption of berry-type fruits has become very popular in recent years because of their positive effects on human health. Berries are in fact widely known for their health-promoting benefits, including prevention of chronic disease, cardiovascular disease and cancer. Berries are a rich source of bioactive metabolites, such as vitamins, minerals, and phenolic compounds, mainly anthocyanins. Numerous in vitro and in vivo studies recognized the health effects of berries and their function as bioactive modulators of various cell functions associated with oxidative stress. Plants have one of the largest metabolome databases, with over 1200 papers on plant metabolomics published only in the last decade. Mass spectrometry (MS) and NMR (Nuclear Magnetic Resonance) are the most important analytical technologies on which the emerging ''omics'' approaches are based. They may provide detection and quantization of thousands of biologically active metabolites from a tissue, working in a ''global'' or ''targeted'' manner, down to ultra-trace levels. In the present review, we highlighted the use of MS and NMR-based strategies and Multivariate Data Analysis for the valorization of berries known for their biological activities, important as food and often used in the preparation of nutraceutical formulations.

Tamarix articulata (T. articulata) - An Important Halophytic Medicinal Plant with Potential Pharmacological Properties

2019 ◽  
Vol 20 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Abdullah M. Alnuqaydan ◽  
Bilal Rah
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
In Vivo Model ◽  
Drug Candidate ◽  
Phytochemical Analysis ◽  
Pharmacological Properties

Background:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in combination with other plant extracts against different ailments since ancient times.Methods:Electronic database survey via Pubmed, Google Scholar, Researchgate, Scopus and Science Direct were used to review the scientific inputs until October 2018, by searching appropriate keywords. Literature related to pharmacological activities of T. articulata, Tamarix species, phytochemical analysis of T. articulata, biological activities of T. articulata extracts. All of these terms were used to search the scientific literature associated with T. articulata; the dosage of extract, route of administration, extract type, and in-vitro and in-vivo model.Results:Numerous reports revealed that T. articulata contains a wide spectrum of phytochemical(s), which enables it to have a wide window of biological properties. Owing to the presence of high content of phytochemical compounds like polyphenolics and flavonoids, T. articulata is a potential source of antioxidant, anti-inflammatory and antiproliferative properties. In view of these pharmacological properties, T. articulata could be a potential drug candidate to treat various clinical conditions including cancer in the near future.Conclusion:In this review, the spectrum of phytochemical(s) has been summarized for their pharmacological properties and the mechanisms of action, and the possible potential therapeutic applications of this plant against various diseases discussed.

Sign in / Sign up

Export Citation Format

Share Document