scholarly journals Clinical Presentation and Microarray Analysis of Peruvian Children with Atypical Development and/or Aberrant Behavior

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Merlin G. Butler ◽  
Kelly Usrey ◽  
Jennifer L. Roberts ◽  
Stephen R. Schroeder ◽  
Ann M. Manzardo
Keyword(s):  
High Resolution ◽  
Young Children ◽  
Microarray Analysis ◽  
Low Income ◽  
Clinical Presentation ◽  
Recessive Gene ◽  
Aberrant Behavior ◽  
Buccal Cells ◽  
Isolation And Identification ◽  
Infants And Young Children

We report our experience with high resolution microarray analysis in infants and young children with developmental disability and/or aberrant behavior enrolled at the Centro Ann Sullivan del Peru in Lima, Peru, a low income country. Buccal cells were collected with cotton swabs from 233 participants for later DNA isolation and identification of copy number variation (deletions/duplications) and regions of homozygosity (ROH) for estimating consanguinity status in 15 infants and young children (12 males, 3 females; mean age ± SD = 28.1 m ±   7.9 m; age range 14 m–41 m) randomly selected for microarray analysis. An adequate DNA yield was found in about one-half of the enrolled participants. Ten participants showed deletions or duplications containing candidate genes reported to impact behavior or cognitive development. Five children had ROHs which could have harbored recessive gene alleles contributing to their clinical presentation. The coefficient of inbreeding was calculated and three participants showed first-second cousin relationships, indicating consanguinity. Our preliminary study showed that DNA isolated from buccal cells using cotton swabs was suboptimal, but yet in a subset of participants the yield was adequate for high resolution microarray analysis and several genes were found that impact development and behavior and ROHs identified to determine consanguinity status.

scholarly journals Dynamic Oral Texture Properties of Selected Indigenous Complementary Porridges Used in African Communities

Foods ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 221 ◽  
Author(s):  
James Makame ◽  
Tanita Cronje ◽  
Naushad M. Emmambux ◽  
Henriette De Kock
Keyword(s):  
Young Children ◽  
Low Income ◽  
Nutrient Intake ◽  
Control Method ◽  
Protein Energy Malnutrition ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Texture Properties ◽  
Protein Energy ◽  
Infants And Young Children

Child malnutrition remains a major public health problem in low-income African communities, caused by factors including the low nutritional value of indigenous/local complementary porridges (CP) fed to infants and young children. Most African children subsist on locally available starchy foods, whose oral texture is not well-characterized in relation to their sensorimotor readiness. The sensory quality of CP affects oral processing (OP) abilities in infants and young children. Unsuitable oral texture limits nutrient intake, leading to protein-energy malnutrition. The perception of the oral texture of selected African CPs (n = 13, Maize, Sorghum, Cassava, Orange-fleshed sweet potato (OFSP), Cowpea, and Bambara) was investigated by a trained temporal-check-all-that-apply (TCATA) panel (n = 10), alongside selected commercial porridges (n = 19). A simulated OP method (Up-Down mouth movements- munching) and a control method (lateral mouth movements- normal adult-like chewing) were used. TCATA results showed that Maize, Cassava, and Sorghum porridges were initially too thick, sticky, slimy, and pasty, and also at the end not easy to swallow even at low solids content—especially by the Up-Down method. These attributes make CPs difficult to ingest for infants given their limited OP abilities, thus, leading to limited nutrient intake, and this can contribute to malnutrition. Methods to improve the texture properties of indigenous CPs are needed to optimize infant nutrient intake.

scholarly journals Case Report: Prolapsed Ureterocele—A Differential Diagnosis of Urethral Cists

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Francisco Renan Doth Sales ◽  
Georgia Alexsandra Colantonio Dourado ◽  
Ana Carolina Montes Ribeiro ◽  
Humberto de Holanda Madeira Barros ◽  
David Sucupira Cristino ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Urinary Tract ◽  
Young Children ◽  
Clinical Presentation ◽  
Cystic Dilatation ◽  
Distal Ureter ◽  
Urethral Prolapse ◽  
Infants And Young Children ◽  
Vulvar Mass

Ureterocele is a cystic dilatation of submucosal distal ureter. It presents a higher incidence in infants and young children but is rare in adults. The urethral prolapse of ureterocele is extremely rare, and its clinical presentation includes vulvar mass, hematuria, and urinary tract dysfunction. We present a case of ureterocele prolapse in a 45-year-old woman who has a 3-day-evolution vulvar mass and intense urethral bleeding. The patient underwent armed cystoscopy and ureteroscopy, ureterocele resection, and biopsy. She evolved with good postoperative condition and was then discharged.

scholarly journals Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Pertussis Epidemic

2021 ◽  
Vol 9 ◽  
Author(s):  
Sainan Chen ◽  
Yuqing Wang ◽  
Anrong Li ◽  
Wujun Jiang ◽  
Qiuyan Xu ◽  
...  
Keyword(s):  
Young Children ◽  
Medical Records ◽  
Clinical Presentation ◽  
Leukocyte Count ◽  
Clinical Manifestations ◽  
Human Bocavirus ◽  
Acute Bronchiolitis ◽  
Laboratory Examination ◽  
A Prospective Study ◽  
Infants And Young Children

Objective: In recent years, the incidence of Bordetella pertussis infection in infants and young children has been increasing. Multiple studies have suggested that B. pertussis may be one of the pathogens of bronchiolitis in infants and young children. However, the prevalence and clinic characteristic of B. pertussis in bronchiolitis is controversial. This prospective descriptive study evaluated the prevalence and clinical manifestations of infants and young children hospitalized for bronchiolitis with B. pertussis.Methods: Children hospitalized with bronchiolitis were eligible for a prospective study for 36 months from January 1, 2017, to December 31, 2019. Besides B. pertussis, 10 common respiratory viruses and Mycoplasma pneumoniae (MP) were confirmed by laboratory tests. Medical records of patients were reviewed for demographic, clinical characteristics, and laboratory examination.Results: A total of 1,092 patients with bronchiolitis were admitted. B. pertussis was detected in 78/1,092 (7.1%) patients. Of the 78 patients with B. pertussis bronchiolitis, coinfections occurred in 45 (57.7%) patients, most frequently with human rhinovirus (28/78, 35.9%), followed by MP (9/78, 11.4%), and human bocavirus (6/78, 7.7%). The peak incidence of B. pertussis infection was in May. A high leukocyte count could help distinguish B. pertussis–associated acute bronchiolitis from other acute bronchiolitis etiologies. After excluding coinfections, children with B. pertussis–only bronchiolitis exhibited a milder clinical presentation than those with RSV-only infection; also, children with MP-only and other pathogen infections revealed similar severity. The morbidity of B. pertussis was common (31/78, 39.7%) in infants with bronchiolitis under 3 months.Conclusion: In summary, B. pertussis is one of the pathogens in children with bronchiolitis, and coinfection of B. pertussis with other viruses is common in bronchiolitis. B. pertussis should be considered when patients hospitalized with bronchiolitis present a longer course and have an elevated leukocyte count. Patients with B. pertussis–associated bronchiolitis present a milder clinical presentation.

scholarly journals Dietary Diversity Practice and Associated Factors Among Infants and Young Children in Haramaya Town, Ethiopia

2017 ◽  
Vol 6 (3) ◽  
pp. 243 ◽  
Author(s):  
Berhe Gebremichael ◽  
Gudina Egata ◽  
Nega Assefa
Keyword(s):  
Young Children ◽  
Low Income ◽  
Associated Factors ◽  
Dietary Diversity ◽  
Statistical Significance ◽  
P Value ◽  
Healthy Children ◽  
Eastern Ethiopia ◽  
Study Participants ◽  
Infants And Young Children

Optimum child feeding is crucial for growth, development, and better health in later life. Dietary diversity is a critical part of the feeding practices. However, there is limited evidence on dietary diversity practice in low-income countries, like Ethiopia. This study assessed dietary diversity practice and associated factors among mothers of infants and young children aged 6-23 months in Haramaya Town, Eastern Ethiopia<strong>. </strong>Community based cross-sectional study design was used and study participants were selected by simple random sampling. Data were collected using a pre-tested questionnaire by face-to-face interview. The collected data were entered to EpiData version 3.1 and exported to SPSS version 22.0 for analysis. Characteristics of the study participants were described by using frequencies, percentages, summary measures, and tables. Bi-variable and multi-variable analyses were used to identify the associated factors. Statistical significance was declared at p-value &lt; 0.05. The study included 635 participants yielding to a response rate of 98.1%. The prevalence of dietary diversity practice was 25.2%. Mothers learned up to secondary level or above [(AOR=2.97, 95% CI: (1.26, 6.99)], mothers who had job [(AOR=3.21, 95% CI: (1.41, 7.29)], older children [(AOR=2.51, 95% CI: (1.45, 4.34)], male children [(AOR= 2.08, 95% CI: (1.29, 3.33)], healthy children [(AOR=2.65, 95% CI: 1.36, 5.16)] and richest households [(AOR=4.45, 95% CI: 1.94, 10.22)] were associated with dietary diversity practice. Generally, the dietary diversity practice was low. Therefore, attention should be given to mothers with no formal education and efforts should be done to improve the socioeconomic status of the households.

COMPARATIVE FREQUENCY OF DETECTION OF ENTEROPATHOGENIC E. COLI, SALMONELLA AND SHIGELLA IN RECTAL SWAB CULTURES FROM INFANTS AND YOUNG CHILDREN

PEDIATRICS ◽  
1957 ◽  
Vol 19 (3) ◽  
pp. 411-423
Author(s):  
Merlin L. Cooper ◽  
Helen M. Keller ◽  
Edward W. Walters
Keyword(s):  
Young Children ◽  
Rectal Swab ◽  
Multiple Infections ◽  
First Year ◽  
Isolation And Identification ◽  
E Coli ◽  
Salmonella Infections ◽  
Number Of Patients ◽  
First Year Of Life ◽  
Infants And Young Children

The present report supplies the details and results of a study of 2,865 patients during a period of 2 years, March 1, 1954, to March 1, 1956. The purpose of the study was to determine the comparative frequency of isolation of Salmonella, Shigella and nine serotypes of enteropathogenic E. coli from rectal swab cultures obtained from infants and young children admitted to the Children's Hospital. The technic for the isolation and identification of enteropathogenic E. coli is described. A diagnostic polyvalent E. coli antiserum prepared in our laboratory was very helpful in the preliminary detection of nine serotypes of enteropathogenic E. coli. Salmonellae were isolated from 85 patients, Shigellae from 88 and one of the nine serotypes of enteropathogenic E. coli from each of 188 patients. Seventeen serotypes of Salmonella were isolated from 85 patients. Salmonella sp. (Type oranienburg) and Sal. typhimurium were isolated most frequently. Shigellae were isolated from a total of 88 patients; Sh. sonnei from 53 and five serotypes of Sh. flexneri from 35 patients. One of the nine serotypes of enteropathogenic E. coli was isolated from each of 188 patients. E. coli 055:B5 was detected in cultures from 63 patients and was detected most frequently. E. coli 0111:B4, 0126:B16 and 026:B6 were found next most frequently. Of the 361 patients from whom Salmonella, Shigella or enteropathogenic E. coli were isolated, rectal swab cultures were obtained at the time of admission from 317. Of these, 287 (91%) were positive. The incidence of diarrhea in the three groups was comparable: 95% of the patients from whom Salmonellae were isolated, 98% of patients from whom Shigellae were isolated and 92% of patients harboring enteropathogenic E. coli. Infections due to Salmonella or enteropathogenic E. coli were more frequent in the first year of life and infections due to Shigella occurred more frequently in the second year of life. The majority of patients with diarrhea and with rectal swab cultures negative for Salmonella, Shigella and enteropathogenic E. coli were in the first year of life. The incidence of Salmonella infections did not show any seasonal predominance; the Shigella infections were most frequent in September and October and the enteropathogenic E. coli infections in November and October. The highest incidence of diarrheal infections among patients whose rectal swab cultures were negative for these three groups of bacteria occurred in December and January of each of the 2 years of this study. The incidence of enteropathogenic E. coli infections exceeded those due to Shigella or Salmonella during 15 of the 24 months of this study. Sporadic infections due to these three groups of bacteria occurred throughout the 2-year period. Successive and/or multiple infections with Salmonella, Shigella or enteropathogenic E. coli occurred in 15 paients. Infection with one serotype of enteropathogenic E. coli did not protect seven patients from subsequent infection with another serotype. The convalescent carrier rate was 36.6% for the patients with Salmonella infections, 2.6% for those with Shigella infections and 8.3% for those from whom enteropathogenic E. coli had been isolated. The mortality rate was 1.2% among patients with Salmonella infections and 1.6% among the patients from whom enteropathogenic E. coli had been isolated. None of the patients with Shigella infections died. The large number of patients, 889, with diarrhea and with rectal swab cultures negative for Salmonella, Shigella and enteropathogenic E. coli indicates a need for continued investigation into the etiology of diarrhea in infants and young children.

Clinical Presentation of Diarrhea in Iranian Infants and Young Children during One Year

2006 ◽  
Vol 101 ◽  
pp. S542-S543
Author(s):  
Naghmeh Jafarinia ◽  
Sven Lofdahl ◽  
Cheif Microbio ◽  
Babak Noorinayer ◽  
Nahid Arjmand ◽  
...  
Keyword(s):  
Young Children ◽  
Clinical Presentation ◽  
One Year ◽  
Infants And Young Children

scholarly journals Complementary Feeding Practices and Associated Factors Among Infants and Young Children 6–23 Months in Fort Portal Kabarole District Uganda (P11-049-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sharon Bagaaya ◽  
Henry Wamani ◽  
Richard Kajura
Keyword(s):  
Young Children ◽  
Low Income ◽  
Associated Factors ◽  
Complementary Feeding ◽  
Dietary Diversity ◽  
Feeding Practices ◽  
Cross Sectional Study ◽  
Child Feeding ◽  
Cross Sectional ◽  
Infants And Young Children

Abstract Objectives To determine the prevalence of appropriate complementary feeding practices and associated factors among infants and young children 6–23 months in Fort Portal municipality Kabarole Uganda Methods A community based cross sectional study was conducted among 206 mothers/caregivers of infants and young children 6–23 months using both quantitative and qualitative methods. Probability proportionate to population size technique was used to select study subjects. A pretested WHO standard questionnaire for measuring infant and young child feeding practices was adopted for assessing complementary feeding practices. Appropriate complementary feeding was defined as attaining both minimum meal frequency and minimum dietary diversity in the last 24 hours. Prevalence ratios and there 95% confidence intervals were generated. Modified poisson regression analysis method was used to generate factors associated with appropriate complementary feeding. Five focus group discussions were conducted to capture participants perceptions on appropriate complementary feeding practices. Results The prevalence of appropriate complementary feeding was 21.4%. Formal employment (PR: 7.05; CI:1.69-29.36), cohabiting (PR: 2.15; CI: 1.10-4.18) and having no child illness (PR: 1.85; CI: 0.88-4.35) were associated with appropriate complementary feeding. Qualitative results showed that inadequate information and low income as major challenges towards appropriate complementary feeding practices. Conclusions Appropriate complementary feeding practices were low. unless interventions such as; health services access and women entrepreneurship are put in place, the inappropriate complementary feeding practices are unlikely to change. Funding Sources Ministry of Health Uganda. Supporting Tables, Images and/or Graphs

scholarly journals Estimated Dietary Intakes of Arachidonic Acid and Docosahexaenoic Acid in Infants and Young Children Living in Developing Countries

2016 ◽  
Vol 69 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Stewart Forsyth ◽  
Sheila Gautier ◽  
Norman Salem Jr.
Keyword(s):  
Developing Countries ◽  
Arachidonic Acid ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Young Children ◽  
Docosahexaenoic Acid ◽  
Acid Composition ◽  
Low Income ◽  
Early Life ◽  
Infants And Young Children

Background/Aims: There are only few data on dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) intake in infants from developing countries, and current global recommendations on intake during early life may not reflect the needs of the world's most vulnerable infants. The aim of the study was to provide estimates of intake of ARA and DHA in infants and young children aged 6-36 months who live in developing countries. Methods: FAO Food Balance Sheets and fatty acid composition data from Australian food composition tables were utilized to generate mean per capita intake estimates for DHA and ARA in developing countries. The median daily intake of DHA and ARA in children age 6-36 months in each country was determined by combining the fatty acid composition of breast milk and complementary foods with the estimated intakes being weighted according to median duration of any breastfeeding. Results: The median daily dietary intake for ARA and DHA across 76 developing countries was 64.0 and 48.9 mg/day, respectively. The lowest complementary food intake of ARA and DHA was present in countries with the lowest gross national income and highest birth rates. Conclusion: Global recommendations on ARA and DHA in early life need to reflect the specific needs of infants and families living in low income countries, and country-specific food policies should address gaps between recommended and achieved intakes.

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