scholarly journals The Clinical Relevance of Serum NDKA, NMDA, PARK7, and UFDP Levels with Phlegm-Heat Syndrome and Treatment Efficacy Evaluation of Traditional Chinese Medicine in Acute Ischemic Stroke

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xiuxiu Han ◽  
Yonghong Gao ◽  
Bin Ma ◽  
Ying Gao ◽  
Yikun Sun ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Evaluation System ◽  
Blood Stasis ◽  
Development Program ◽  
Deficiency Syndrome ◽  
Blood Stasis Syndrome ◽  
Efficacy Evaluation ◽  
Patient Reported ◽  
Tcm Syndrome ◽  
Heat Syndrome

According to the methods of Patient-Reported Outcome (PRO) based on the patient reports internationally and referring to U.S. Food and Drug Administration (FDA) guide, some scholars developed this PRO of stroke which is consistent with China’s national conditions, and using it the feel of stroke patients was introduced into the clinical efficacy evaluation system of stoke. “Ischemic Stroke TCM Syndrome Factor Diagnostic Scale (ISTSFDS)” and “Ischemic Stroke TCM Syndrome Factor Evaluation Scale (ISTSFES)” were by “Major State Basic Research Development Program of China (973 Program) (number 2003CB517102).” ISTSFDS can help to classify and diagnose the CM syndrome reasonably and objectively with application of syndrome factors. Six syndrome factors, internal-wind syndrome, internal-fire syndrome, phlegm-dampness syndrome, blood-stasis syndrome, qi-deficiency syndrome, and yin-deficiency syndrome, were included in ISTSFDS and ISTSFES. TCM syndrome factor was considered to be present if the score was greater than or equal to 10 according to ISTSFDS. In our study, patients with phlegm-heat syndrome were recruited, who met the diagnosis of both “phlegm-dampness” and “internal-fire” according to ISTSFDS. ISTSFES was used to assess the syndrome severity; in our study it was used to assess the severity of phlegm-heat syndrome (phlegm-heat syndrome scores = phlegm-dampness syndrome scores + internal-fire syndrome scores).

scholarly journals Clinical and Epidemiological Investigation of TCM Syndromes of Patients with Coronary Heart Disease in China

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yi Ren ◽  
Minzhou Zhang ◽  
Keji Chen ◽  
Shijie You ◽  
Jianjun Li ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
South China ◽  
Blood Stasis ◽  
Deficiency Syndrome ◽  
Blood Stasis Syndrome ◽  
The South ◽  
The North ◽  
Tcm Syndrome ◽  
North And South

To compare the regional differences in TCM syndromes of patients with coronary heart disease (CHD) between North and South China. A total of 624 patients with a diagnosis of CHD, confirmed by coronary angiography, were included in the comparative analysis to determine the occurrence pattern, characteristics of TCM syndrome distribution, and differences in syndrome combinations and major syndrome types (deficiency or excess) between North and South China. The incidence of CHD tended to be higher in North China (54.6%) compared with that in South China (45.4%). The proportions of patients with a qi-deficiency syndrome (83.7%), turbid phlegm syndrome (68.9%), or blood stasis syndrome (91.5%) were generally higher in the South group, while the proportion of patients with a cold congelation syndrome (7.9%) was identified to be obviously higher in the North group (P<0.01). Moreover, compared with that in the South group, the overall frequency of syndrome combinations tended to be lower in the North group (P<0.01); and the most common types of TCM syndrome were excess syndrome (193, 56.6%) and primary deficiency and secondary excess syndrome (244, 86.2%) in the North and South groups, respectively (P<0.01). A regional difference does exist in the TCM syndromes of patients with CHD between North and South China, indicating that the prevention and treatment of CHD in South China should not only focus on promoting blood circulation and removing blood stasis, but also include supplementing qi and eliminating phlegm

scholarly journals Study on the TCM Syndromes Evolution and Chinese Herbal Characteristics of Type 2 Diabetes Patients with Different Courses of Disease in TCM “Heat Stage”: A Real-World Study

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Ying Xing ◽  
Min Pi ◽  
Runshun Zhang ◽  
Tiancai Wen
Keyword(s):  
Chinese Herb ◽  
Blood Stasis ◽  
Deficiency Syndrome ◽  
Blood Stasis Syndrome ◽  
Node Degree ◽  
Edge Weight ◽  
Course Of Disease ◽  
Yin Deficiency ◽  
Group 3 ◽  
Heat Syndrome

Objective. The purpose of this study is to analyze and summarize the syndrome distribution, syndrome evolution, and Chinese herb medicine characteristics of T2D in heat stage. Method. In this study, 228 heat-stage T2D patients were divided into three groups based on the course of disease. Group 1 (the course of disease ≤5 years) included 118 patients. Group 2 (5< the course of disease ≤10 years) had 73 patients. Group 3 (the course of disease >10 years) consisted of 37 patients. The main methods used in our study were complex network community partitioning algorithms and Sankey diagram visualization, based on the clinical electronic medical record data we collected. Result. In the three groups, the nodes with the highest node degree are all “heat syndrome.” Edge weight between “heat” and “dampness,” “qi stagnation,” “phlegm,” “liver,” and “stomach” is the largest. During the whole course of treatment, 60.17%, 63.01%, and 62.16% of the patients’ syndromes in groups 1, 2, and 3, respectively, were ascribed to the heat stage all the time. The patients’ syndromes in groups 1 and 2 easily transformed to the syndrome of deficiency of both qi and yin of the spleen and stomach. In group 3, 27% of the patients’ syndromes were easily transformed into kidney yin deficiency and qi deficiency and blood stasis syndrome. The largest Chinese herb communities of the patients whose syndromes did not change after treatment in the three groups were all heat-clearing drugs. The proportion of blood-activating drugs in patients with syndrome changes increased significantly after treatment. Conclusion. (1) The basic syndrome of T2D patients in the heat stage is liver-stomach heat syndrome. (2) T2D patients in the heat stage tend to deteriorate towards the direction of qi and yin deficiency syndrome. However, the longer the course of the disease is, the more likely it is to deteriorate to the direction of kidney yin deficiency syndrome and blood stasis syndrome. (3) Drugs that can help T2D patients in the heat stage to maintain their condition stably are heat-clearing drugs represented by Coptis chinensis, which usually need to be combined with warming interior drugs such as Zingiberis Rhizoma and Pinelliae Rhizoma.

The therapeutic effect and mechanism of Qishen Yiqi dripping pills on cardiovascular and cerebrovascular diseases and diabetic complications

2021 ◽  
Vol 14 ◽  
Author(s):  
Chunlai Zhao ◽  
Wenjia Wang ◽  
Kaijing Yan ◽  
He Sun ◽  
Jihong Han ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Diabetic Nephropathy ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Diabetic Complications ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Syndrome Differentiation ◽  
Therapeutic Effects ◽  
The Common

: The alterations in vascular homeostasis is deeply involved in the development of numerous diseases, such as coronary heart disease, stroke, and diabetic complications. Changes in blood flow and endothelial permeability caused by vascular dysfunction are the common mechanisms for these three types of diseases. The disorders of glucose and lipid metabolism can result in changes of the energy production patterns in endothelium and surrounding cells which may consequently cause local energy metabolic disorders, oxidative stress and inflammatory responses. Traditional Chinese medicine (TCM) follows the principle of the “treatment by the syndrome differentiation”. TCM considers of that coronary heart disease, stroke and diabetes complications all as the type of “Qi deficiency and Blood stasis” syndrome, which mainly happens to the vascular system. Therefore, the common pathogenesis of these three types of diseases suggests the treatment strategy by TCM should be in a close manner and named as “treating different diseases by the same treatment”. Qishen Yiqi dripping pills is a modern Chinese herbal medicine which has been widely used for treatment of patients with coronary heart disease characterized as “Qi deficiency and blood stasis” in China. Recently, many clinical reports have demonstrated the potent therapeutic effects of Qishen Yiqi dripping pills on ischemic stroke and diabetic nephropathy. Based on these reports, we will summarize the clinical applications of Qishen Yiqi dripping pills on coronary heart disease, ischemic stroke and diabetic nephropathy, including the involved mechanisms with basic researches.

scholarly journals The Discriminative Efficacy of Retinal Characteristics on Two Traditional Chinese Syndromes in Association with Ischemic Stroke

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Y. Y. Zhuo ◽  
J. M. Wu ◽  
L. Kuang ◽  
Y. M. Qu ◽  
B. Zee ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Characteristics ◽  
Characteristic Curve ◽  
Blood Stasis ◽  
Retinal Vessel ◽  
Added Value ◽  
Blood Stasis Syndrome ◽  
Syndrome Differentiation ◽  
Image Analysis System ◽  
Characteristic Analysis

We aimed to investigate the efficacy of an objective method using AI-based retinal characteristic analysis to automatically differentiate between two traditional Chinese syndromes that are associated with ischemic stroke. Inpatient clinical and retinal data were retrospectively retrieved from the archive of our hospital. Patients diagnosed with cerebral infarction in the department of acupuncture and moxibustion between 2014 and 2018 were examined. Of these, the patients with Qi deficiency blood stasis syndrome (QDBS) and phlegm stasis in channels (PSIC) syndrome were selected. Those without retinal photos were excluded. To measure and analyze the patients’ retinal vessel characteristics, we applied a patented AI-assisted automated retinal image analysis system developed by the Chinese University of Hong Kong. The demographic, clinical, and retinal information was compared between the QDBS and PSIC patients. The t-test and chi-squared test were used to analyze continuous data and categorical data, respectively. All the selected clinical information and retinal vessel measures were used to develop different discriminative models for QDBS and PSIC using logistic regression. Discriminative efficacy and model performances were evaluated by plotting a receiver operating characteristic curve. As compared to QDBS, the PSIC patients had a lower incidence of insomnia problems (46% versus 29% respectively, p=0.023) and a higher tortuosity index (0.45 ± 0.07 versus 0.47 ± 0.07, p=0.027). Moreover, the area under the curve of the logistic model showed that its discriminative efficacy based on both retinal and clinical characteristics was 86.7%, which was better than the model that employed retinal or clinical characteristics individually. Thus, the discriminative model using AI-assisted retinal characteristic analysis showed statistically significantly better performance in QDBS and PSIC syndrome differentiation among stroke patients. Therefore, we concluded that retinal characteristics added value to the clinical differentiation between QDBS and PSIC.

Experimental Study on the Relationship between Tongue Temperature and the Lingual Circulatory System

2013 ◽  
Vol 321-324 ◽  
pp. 708-711
Author(s):  
Hai Wei Xie ◽  
Yan Zhang
Keyword(s):  
Experimental Study ◽  
Animal Model ◽  
Blood Flow ◽  
Blood Stasis ◽  
Circulatory System ◽  
Blood Flow Rate ◽  
Deficiency Syndrome ◽  
Blood Stasis Syndrome ◽  
Vascular Cast ◽  
The Relationship

To study the relationship between tongue temperature and the lingual circulatory system, the blood stasis and blood deficiency syndrome of traditional Chinese medicine (TCM) syndromes were researched by making animal model and vascular cast experiment. The influence of blood stasis and blood deficiency syndrome on tongue temperature and the lingual circulatory system were studied and analyzed. The experimental results indicated that the lingual circulatory system of blood stasis syndrome and that of blood deficiency syndrome were distinctly different in blood flow rate, vascular diameters and the density of small vessel. These differences in circulatory system could induce a change on lingual temperature. This result proves that the tongue temperature has relations with the change of lingual circulatory system.

scholarly journals BuqiTongluo Granule for Ischemic Stroke, Stable Angina Pectoris, Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis Syndrome: Rationale and Novel Basket Design

2021 ◽  
Vol 12 ◽  
Author(s):  
Weidi Liu ◽  
Li Zhou ◽  
Luda Feng ◽  
Dandan Zhang ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Peripheral Neuropathy ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Diabetic Peripheral Neuropathy ◽  
Blood Stasis ◽  
Empirical Support ◽  
Blood Stasis Syndrome ◽  
Stable Angina Pectoris ◽  
Basket Trial

Background: BuqiTongluo (BQTL) granules are herbal phenotypic drugs for Qi deficiency and blood stasis (QDBS) syndrome. Its discovery relied primarily on knowledge of observable phenotypic changes associated with diseases. Although BQTL granules have been widely advocated by Chinese Medicine (CM) practitioners, its use lacks empirical support.Aim of the study: In this basket trial, the efficacy of BQTL granules in multiple diseases that have the QDBS syndrome in common will be compared with placebo.Materials and Methods: The BuqiTongluo granule for Qi deficiency and blood stasis syndrome (BOSS) study is a basket herbal trial (ClinicalTrials.gov, NCT04408261). It will be a double-blinded, randomized, placebo-controlled, parallel, multicenter, clinical trial. In total, 432 patients (1:1:1 ischemic stroke, stable angina pectoris, and diabetic peripheral neuropathy), who meet the operationalized diagnostic criteria for QDBS syndrome, have been recruited and randomized in a ratio of 1:1 to receive 6 weeks’ treatment with BQTL granules or placebo. The primary outcome is the change in the QDBS syndrome score at week 6 from baseline. Secondary outcomes include objective outcome measures for the three diseases and adverse events. Omics will help to understand these responses by molecular events.Conclusion: QDBS syndrome is a common phenotypic marker that was hypothesized to predict whether patients with multiple diseases would respond to this targeted therapy. No previous basket trial has assessed the potential efficacy of an herbal intervention for multiple diseases. The unique promise of the trial is its ability to exploit a disease phenotype to discover novel treatments for three diseases for which the root cause is unknown, complex, or multifactorial, and for which scientific understanding is insufficient to provide valid molecular targets.

scholarly journals Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Qiao-Hong Liu ◽  
Bin-Bin Zhang ◽  
Lin Xu ◽  
Xiao-Ping Shen ◽  
Ya-Mei Hai ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Deficiency Syndrome ◽  
Individual Level ◽  
Spleen Deficiency ◽  
Medication Information ◽  
Level Data ◽  
Tcm Syndrome ◽  
Heat Syndrome

Traditional Chinese medicine (TCM) has a long history in the treatment of chronic hepatitis B (CHB) based on the syndrome identification. Previous studies reported CHB patients with damp-heat (DH) syndrome accompanied with a severe liver function damage, but lacked the medication analysis. In this study, we analyzed 999 CHB patients with unidentified individual-level data from database to explore clinical features of two common syndromes of CHB patients based on the real world. Compared with the spleen deficiency (SD) syndrome, the CHB patients with DH syndrome had a significantly higher level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ( P < 0.05 ) but took more immunomodulators and hepatoprotective drugs ( P < 0.1 ). Similarly, in the follow-up of 207 patients after 3 months, the improvement trend of ALT and AST of patients with sustained SD syndrome was significantly better than those whose TCM syndrome changed from SD to DH ( P < 0.05 ). The logistic model indicated DH syndrome was a significant negative factor for reducing ALT level in CHB patients (OR = 4.854, P = 0.032 ). This study suggests that CHB patients with DH syndrome have potentially more serious and sustained liver damage than the SD syndrome, which provides a reference for the personalized management of CHB patients from the perspective of TCM syndromes.

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