scholarly journals Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Aazadehsadat Hashemi Doulabi ◽  
Hamid Mirzadeh ◽  
Nasrin Samadi ◽  
Shadab Bagheri-Khoulenjani ◽  
Mohammad Atai ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Potential Application ◽  
Wound Dressing ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Vinyl Pyrrolidone ◽  
Cross Linking ◽  
Hydrogel Film ◽  
Swelling Degree ◽  
Hydrogel Films

The objective of this work was to prepare hydrogel films, as semi-interpenetrating polymer networks (semi-IPN), based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch) blends. Hydrogel films were prepared by free radical cross-linking of PEGF, an unsaturated aliphatic polyester, in the presence of N-vinyl pyrrolidone (NVP), camphorquinone (CQ), and N,N-dimethyl-p-toluidine (DMPT) as a cross-linking, photoinitiating, and accelerating agent, respectively. The effect of NVP concentration on physicochemical and biological properties of semi-IPN film properties was evaluated. The sol fraction, water vapor transmission rate, and swelling degree of the hydrogel films were also investigated. Antibacterial activity against S. aureus was observed for the photocured blend hydrogels of Ch/PEGF with no toxicity to L929 cells according to the cell viability assays. Blend hydrogel films showing 600 ± 88% of equilibrium swelling degree in water and the lowest sol fraction (3.14 ± 1.22%) were obtained at 20 wt% of NVP content whilst preserving their own cytocompatibility and antibacterial activity. Therefore, this formulation was considered as an optimal semi-IPN blend hydrogel film composition with potential application for wound dressing.

scholarly journals Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 479
Author(s):  
Jingjing Zhang ◽  
Wenqiang Tan ◽  
Qing Li ◽  
Xiaorui Liu ◽  
Zhanyong Guo
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Wound Dressing ◽  
Cross Linking ◽  
And Staphylococcus Aureus ◽  
Hydrogel Films

Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

Emissive Semi-Interpenetrating Polymer Networks for Ink-Jet Printed Multilayer OLEDs

2021 ◽  
Author(s):  
Susanna V. Kunz ◽  
Cameron M. Cole ◽  
Thomas Baumann ◽  
Prashant Murlidhar Sonar ◽  
Soniya Yambem ◽  
...  
Keyword(s):  
Light Emitting Diodes ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Organic Light Emitting Diodes ◽  
Cross Linking ◽  
Solution Processing ◽  
Light Emitting ◽  
Polymer Precursors ◽  
Organic Light ◽  
Ink Jet

Solution-processing of multilayered Organic Light Emitting Diodes (OLEDs) remains a challenge that is often addressed by cross-linking polymer precursors into insoluble networks. Herein, we blend an emissive polymer carrying a...

Graphene oxide and sulfonated polyanion co-doped hydrogel films for dual-layered membranes with superior hemocompatibility and antibacterial activity

2016 ◽  
Vol 4 (10) ◽  
pp. 1431-1440 ◽  
Author(s):  
Chao He ◽  
Zhen-Qiang Shi ◽  
Chong Cheng ◽  
Hua-Qing Lu ◽  
Mi Zhou ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Graphene Oxide ◽  
Potential Application ◽  
Co Doped ◽  
Hydrogel Films

GO based dual-layered membranes with superior hemocompatibility and antibacterial activity have potential application for clinical hemodialysis and many other biomedical therapies.

Thermosensitive Transparent Semi-Interpenetrating Polymer Networks for Wound Dressing and Cell Adhesion Control

2008 ◽  
Vol 9 (4) ◽  
pp. 1313-1321 ◽  
Author(s):  
T. Thimma Reddy ◽  
Arihiro Kano ◽  
Atsushi Maruyama ◽  
Michiko Hadano ◽  
Atsushi Takahara
Keyword(s):  
Cell Adhesion ◽  
Wound Dressing ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Adhesion Control

Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing

2008 ◽  
Vol 3 (3) ◽  
pp. 034115 ◽  
Author(s):  
HaeYong Kweon ◽  
Joo-hong Yeo ◽  
Kwang-gill Lee ◽  
Hyun Chul Lee ◽  
Hee Sam Na ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Silk Fibroin ◽  
Wound Dressing ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals E-Beam Cross-Linking of Complex Hydrogels Formulation: The Influence of Poly(Ethylene Oxide) Concentration on the Hydrogel Properties

Gels ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 27
Author(s):  
Maria Demeter ◽  
Ion Călina ◽  
Anca Scărișoreanu ◽  
Marin Micutz
Keyword(s):  
Ethylene Oxide ◽  
Average Molecular Weight ◽  
Absorbed Dose ◽  
Vinyl Pyrrolidone ◽  
Elastic Behavior ◽  
Cross Linking ◽  
Rheological Analysis ◽  
Swelling Degree ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

In the present study, we report on the complex hydrogels formulations based on collagen-poly(vinyl pyrrolidone) (PVP)-poly(ethylene oxide) (PEO) cross-linked by e-beam irradiation in an aqueous polymeric solution, aiming to investigate the influence of different PEO concentrations on the hydrogel properties. The hydrogel networks’ structure and their composition were investigated using equilibrium swelling degree, complex rheological analysis, and FT-IR spectroscopy. Rheological analysis was performed to determine the elastic (G′) and viscous (G″) moduli, the average molecular weight between cross-linking points (Mc), cross-link density (Ve), and the mesh size (ξ). The effect of the PEO concentration on the properties of the hydrogel was investigated as well. Depending on the PEO concentration added in their composition, the hydrogels swelling degree depends on the absorbed dose, being lower at low PEO concentrations. All hydrogel formulations showed higher G′ values (9.8 kPa) compared to G″ values (0.2 kPa), which shows that the hydrogels have a predominantly elastic behavior. They presented stability greater than 72 h in physiological pH buffers and reached equilibrium after 25 h. The Mc parameter is strongly dependent on the PEO concentration and the absorbed dose for all hydrogel compositions. The cross-linking density increased with the absorbed dose.

scholarly journals Semi-interpenetrating polymer networks based on polyacrylamide and poly[itaconic acid]

2003 ◽  
Vol 57 (11) ◽  
pp. 543-546 ◽  
Author(s):  
Melina Kalagasidis-Krusic ◽  
Biljana Nikolic ◽  
Jovanka Filipovic
Keyword(s):  
Itaconic Acid ◽  
Polymer Network ◽  
Polymer Networks ◽  
Low Ph ◽  
Interpenetrating Polymer Networks ◽  
Polyacrylamide Gel ◽  
Swelling Properties ◽  
Swelling Degree ◽  
Equilibrium Swelling ◽  
Carboxylic Groups

The effect of pH and temperature on the equilibrium swelling properties of PIA/PAAm semi-IPNs were investigated.Semi-IPNs based on polyacrylamide (PAAm) and poly(itaconic acid) (PIA) were prepared by two different techniques, by polymerizing itaconic acid in the presence of polyacrylamide gel (Semi-IPNs-l) and by making the polyacrylamide gel in the presence of previously synthesized poly(itaconic acid) (Semi-IPNs-ll), with different PIA/PAAm mass ratios. The equilibrium swelling degree of an ionic network depends very much on the concentration of ionisable groups. The addition of a small amount of itaconic acid dramatically changes the swelling behavior of PAAm. Increase of the ionic monomer (IA) produces swelling degrees that increase to a high extent when the pH of the buffer solution is higher than the nominal pKa values of the acid groups. Gels with higher IA content swell less than PAAm gels in low pH buffers. At low pH, when complexation due to hydrogen bonding occurs between the carboxylic groups and amide groups of acrylamide, the polymer network collapses and the swelling ratio is low. The presence of hydrogen bonds in the complexes causes additional constraints in the network, acting as a physical crosslinking and makes the network less hydrophilic, because the carboxylic groups on the PIA are occupied in the complexes. As opposed to this, the equilibrium swelling degrees change very little with pH of the solution in nonionic PAAm gel.Hydrogels exhibit continuous changes in water content as a function of temperature. The swelling degree increases with increasing temperature due to gel expansion upon warming.

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