scholarly journals Differences in Brain Metabolic Impairment between Chronic Mild/Moderate TBI Patients with and without Visible Brain Lesions Based on MRI

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Keiichi Ito ◽  
Yoshitaka Asano ◽  
Yuka Ikegame ◽  
Jun Shinoda
Keyword(s):  
Fdg Pet ◽  
Traffic Accidents ◽  
Brain Metabolism ◽  
Statistical Tests ◽  
Brain Lesions ◽  
Cognitive Tests ◽  
Mri Findings ◽  
Moderate Traumatic Brain Injury ◽  
Group A ◽  
Group B

Introduction.Many patients with mild/moderate traumatic brain injury (m/mTBI) in the chronic stage suffer from executive brain function impairment. Analyzing brain metabolism is important for elucidating the pathological mechanisms associated with their symptoms. This study aimed to determine the differences in brain glucose metabolism between m/mTBI patients with and without visible traumatic brain lesions based on MRI.Methods.Ninety patients with chronic m/mTBI due to traffic accidents were enrolled and divided into two groups based on their MRI findings. Group A comprised 50 patients with visible lesions. Group B comprised 40 patients without visible lesions. Patients underwent FDG-PET scans following cognitive tests. FDG-PET images were analyzed using voxel-by-voxel univariate statistical tests.Results.There were no significant differences in the cognitive tests between Group A and Group B. Based on FDG-PET findings, brain metabolism significantly decreased in the orbital gyrus, cingulate gyrus, and medial thalamus but increased in the parietal and occipital convexity in Group A compared with that in the control. Compared with the control, patients in Group B exhibited no significant changes.Conclusions.These results suggest that different pathological mechanisms may underlie cognitive impairment in m/mTBI patients with and without organic brain damage.

scholarly journals PREVALENCE OF HEPATIC STEATOSIS AMONG CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS AND ITS ASSOCIATION WITH NUTRITIONAL STATUS

2019 ◽  
Vol 37 (4) ◽  
pp. 435-441
Author(s):  
Amanda Oliva Gobato ◽  
Ana Carolina Junqueira Vasques ◽  
Antonio Fernando Ribeiro ◽  
Roberto Massao Yamada ◽  
Gabriel Hessel
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Children And Adolescents ◽  
Hepatic Steatosis ◽  
Statistical Tests ◽  
The Body ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B

ABSTRACT Objective: To determine the prevalence of hepatic steatosis (HS) in children and adolescents with cystic fibrosis (CF) and associate it with nutritional status. Methods: Cross-sectional study with children and adolescents with CF diagnosis. Weight and height were used to calculate the body mass index (BMI) and subsequent classification of the nutritional status. The midarm circumference (MAC), triceps skinfold thickness (TSF) and midarm muscle circumference (MAMC) were used to evaluate body composition. Abdominal ultrasonography was performed for diagnosis of HS. The statistical tests used were Student’s t test, Mann-Whitney test and chi-square test with significance level of 5%. Results: 50 patients with CF were evaluated, 18 (36%) were diagnosed with HS (Group A) and 32 (64%) without HS (Group B). The mean age of Group A was 13,2±4,9 years old and Group B 11,7±4,9; for BMI, the value for Group A was 18,0±4,1 and Group B was 15,7±3,8; the TSF of Group A was 8,4±3,5 mm and Group B was 7,0±2,5 mm. For these variables, there was no significant difference between the groups. The mean of MAC and MAMC differed significantly between the groups, being higher in the HS group, with p values of 0,047 and 0,043. Conclusions: The frequency of HS in patients with CF is high and it is not related to malnutrition, according to the parameters of BMI, TSF and MAMC. The values of MAC and MAMC indicated a greater reserve of muscle mass in patients with HS.

Blunt Cardiac Injury: A Single-Center 15-Year Experience

2020 ◽  
Vol 86 (4) ◽  
pp. 354-361
Author(s):  
Jin-Mou Gao ◽  
Hui Li ◽  
Gong-Bin Wei ◽  
Chao-Pu Liu ◽  
Ding-Yuan Du ◽  
...  
Keyword(s):  
Traffic Accidents ◽  
Early Recognition ◽  
Cardiac Injury ◽  
Shock Rate ◽  
Thoracic Injury ◽  
Trauma Patients ◽  
Myocardial Contusion ◽  
Blunt Cardiac Injury ◽  
Group A ◽  
Group B

In recent years, the incidence of blunt cardiac injury (BCI) has increased rapidly and is an important cause of death in trauma patients. This study aimed to explore early diagnosis and therapy to increase survival. All patients with BCI during the past 15 years were analyzed retrospectively regarding the mechanism of injury, diagnostic and therapeutic methods, and outcome. The patients were divided into two groups according to the needs of their condition—nonoperative (Group A) and operative (Group B). Comparisons of the groups were performed. A total of 348 patients with BCI accounted for 18.3 per cent of 1903 patients with blunt thoracic injury. The main cause of injury was traffic accidents, with an incidence of 48.3 per cent. In Group A (n = 305), most patients sustained myocardial contusion, and the mortality was 6.9 per cent. In Group B (n = 43), including those with cardiac rupture and pericardial hernia, the mortality was 32.6 per cent. Comparisons of the groups regarding the shock rate and mortality were significant ( P < 0.01). Deaths directly resulting from BCI in Group B were greater than those in Group A ( P < 0.05). In all 348 patients, the mortality rate was 10.1 per cent. When facing a patient with blunt thoracic injury, a high index of suspicion for BCI must be maintained. To manage myocardial contusion, it is necessary to protect the heart, alleviate edema of the myocardium, and control arrhythmia with drugs. To deal with those requiring operation, early recognition and expeditious thoracotomy are essential.

scholarly journals Comparison of the effect of Chamomile and Mefenamic Acid on primary dysmenorrhea, associated symptoms and menstrual bleeding – A randomized clinical trial study

2020 ◽  
Author(s):  
Fatemeh Shabani ◽  
Katayon Vakilian ◽  
Fereshteh Narenji ◽  
Mahbubeh Bozorgi ◽  
Soodabeh Bioos ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Mefenamic Acid ◽  
Statistical Tests ◽  
Primary Dysmenorrhea ◽  
Verbal Scale ◽  
Associated Symptoms ◽  
Ethics Code ◽  
Group A ◽  
Group B

Abstract Background Dysmenorrhea is one of the most common pelvic pains in women, impairing their quality of life.This study investigated the effects of chamomile sachet and mefenamic acid on primary dysmenorrhea, associated symptoms and bleeding. Methods In this randomized clinical trial, 200 female students with primary dysmenorrhea from Arak universities were randomly assigned to two groups. The group (A) received mefenamic acid (250 mg) and group (B) received chamomile (5000 mg) plus one teaspoonful of honey )as a flavoring( for two days before up to the first three days of menstruation, three times a day in two consecutive cycles. Pain severity, associated symptoms and bleeding were assessed using visual analog scale, Andersch-Milsom Verbal Scale and Higham chart, respectively. Data were analyzed by descriptive and inferential statistical tests by SPSS 21. Results Severe pain during two months after intervention was in 6 (6.3%) of group (B) and 6 (6.3%) in group (A) (p = 0.351, p = 0.332). Mean severity of associated symptoms two months after the treatment was( 4.93 ± 3.54) in group (B) and (5.62 ± 3.54 ) in group (A), indicating further reduction in group (B) but not significant (p = 0.278). Mean of bleeding was (88.71 ± 66.4 vs. 70.54 ± 53. 34) in group (B) and (A) respectively, in two months later. therefore decrease in the two groups but was not significant between groups(p = 0.567). Conclusions It seems chamomile sachet can reduce the severity of pain and bleeding similar to mefenamic acid and even further mitigate the symptoms associated with dysmenorrhea. Trial registration: This study was performed with the proposal approval code of 2611, ethics code of (ARAKMU.REC.1395.164) at Arak University of medical sciences and code of IRCT 2016100825031N5 on 2016.11.08.

scholarly journals Study of clinical outcome of patients undergoing intestinal anastomoses with single layer extramucosal technique and double layer anastomoses

2021 ◽  
Author(s):  
Arvind Rai ◽  
Sukantth R. J.
Keyword(s):  
Anastomotic Leak ◽  
Double Layer ◽  
Statistical Tests ◽  
Intestinal Anastomosis ◽  
Single Layer ◽  
Layer Versus ◽  
Intestinal Anastomoses ◽  
Significant Difference ◽  
Group A ◽  
Group B

 Background: Intestinal anastomosis is one of the common surgeries for cases like bowel obstruction, incarcerated hernias, benign and malignant tumours of small and large bowel. The ideal intestinal anastomosis does not leak and allow normal function of the gastrointestinal tract. This study compared single layer versus double layer  intestinal anastomosis in terms of duration, postoperative complications like anastomotic leak.Methods: A total of 100 patients admitted in Hamidia hospital, based on history and clinical examinations and radiological examinations, placed in two groups, group A (single layer anastomosis) and group B (double layer anastomosis) and were operated by a qualified surgical specialist. Data analysis of anastomotic time, anastomotic leak was done and statistical tests of significance were applied. A p value less than 0.05 is considered as significant.Results: In group A (single layer) the time required to perform in 30 (60%) patients is between 16-20 minutes. In double layer, maximum were done in between 26 to 30 minutes, 32 (64%). In our study of 100 patients, there were 6 anastomotic leaks, of which four of them were in group A (single layer) and 2 of them in group B (double layer).Conclusions: In our study, the duration required to perform a single layer intestinal anastomosis is significantly lesser when compared to double layer. There is no significant difference in anastomotic leak between two groups. Less time with no difference in complications, a move towards single layer anastomosis should be preferred.

scholarly journals A CRITICAL EVALUATION OF KADALI KANDA (Musa paradisiaca Linn.Rhizome) CHURNA AND KWATHA IN AMLAPITTA

2021 ◽  
Vol 9 (2) ◽  
pp. 367-373
Author(s):  
Veeresh S. M ◽  
Mohan Kumari K. M
Keyword(s):  
Clinical Features ◽  
Functional Dyspepsia ◽  
Statistical Tests ◽  
Critical Evaluation ◽  
Gastrointestinal System ◽  
Musa Paradisiaca ◽  
Clinical Observations ◽  
Group A ◽  
Group B

Amlapitta is one of the Annavahasroto vikara (gastrointestinal system) described in many classical Ayur-vedic texts. Modern luxurious lifestyle and sendentary habits of people have been inviting so many diseas-es like Prameha (Diabetis), Amavata (Arthritis), Amlapitta (Gastritis) etc. The cardinal features of Amlapit-ta includes utklesha (nausea), hritdaha (heartburn), kantadaha (throat burn), amlodgara (sour and bitter belching), chardi (vomiting), kukshidaha (abdominal burn) etc. The present study was taken up to evaluate efficacy of Kadali kanda churna and Kadali kanda kwatha in Urdwaga Amlapitta (Functional dyspepsia). A total of 20 patients having clinical features of Urdwaga Amlapitta were selected and randomly divided into 2 groups with 10 patients each. Group A was treated with Kadali kanda churna and Group B was treated with Kadali kanda kwatha. Subjective parameters were suitably graded to assess the results based on the clinical observations. Statistical tests were applied to analyze the results. In the present study it was observed that the percentage of success of Group A was 93.75% and that of Group B was 65%. Group A showed better results when compared to Group B.

scholarly journals 40 days and 40 nights: Clinical characteristics of major trauma and orthopaedic injury comparing the incubation and lockdown phases of COVID-19 infection

2020 ◽  
Vol 1 (7) ◽  
pp. 330-338 ◽  
Author(s):  
Bisola Ajayi ◽  
Alex Trompeter ◽  
Magnus Arnander ◽  
Philip Sedgwick ◽  
Darren F. Lui
Keyword(s):  
Clinical Characteristics ◽  
Traffic Accidents ◽  
Major Trauma ◽  
Road Traffic ◽  
Trauma Centre ◽  
Orthopaedic Patients ◽  
Major Trauma Centre ◽  
Group A ◽  
Group B ◽  
The Uk

Aims The first death in the UK caused by COVID-19 occurred on 5 March 2020. We aim to describe the clinical characteristics and outcomes of major trauma and orthopaedic patients admitted in the early COVID-19 era. Methods A prospective trauma registry was reviewed at a Level 1 Major Trauma Centre. We divided patients into Group A, 40 days prior to 5 March 2020, and into Group B, 40 days after. Results A total of 657 consecutive trauma and orthopaedic patients were identified with a mean age of 55 years (8 to 98; standard deviation (SD) 22.52) and 393 (59.8%) were males. In all, 344 (approximately 50%) of admissions were major trauma. Group A had 421 patients, decreasing to 236 patients in Group B (36%). Mechanism of injury (MOI) was commonly a fall in 351 (52.4%) patients, but road traffic accidents (RTAs) increased from 56 (13.3%) in group A to 51 (21.6%) in group B (p = 0.030). ICU admissions decreased from 26 (6.2%) in group A to 5 (2.1%) in group B. Overall, 39 patients tested positive for COVID-19 with mean age of 73 years (28 to 98; SD 17.99) and 22 (56.4%) males. Common symptoms were dyspnoea, dry cough, and pyrexia. Of these patients, 27 (69.2%) were nosocomial infections and two (5.1%) of these patients required intensive care unit (ICU) admission with 8/39 mortality (20.5%). Of the patients who died, 50% were older and had underlying comorbidities (hypertension and cardiovascular disease, dementia, arthritis). Conclusion Trauma admissions decreased in the lockdown phase with an increased incidence of RTAs. Nosocomial infection was common in 27 (69.2%) of those with COVID-19. Symptoms and comorbidities were consistent with previous reports with noted inclusion of dementia and arthritis. The mortality rate of trauma and COVID-19 was 20.5%, mainly in octogenarians, and COVID-19 surgical mortality was 15.4%. Cite this article: Bone Joint Open 2020;1-7:330–338.

scholarly journals An Open Label, Randomized, Parallel Efficacy, Active Controlled Clinical Study to Compare the Efficacy of Nirgundi Patra and Erandamuladi Niruha Basti in Yoga Basti Pattern in Gridhrasi (Sciatica)

2020 ◽  
Vol 11 (3) ◽  
pp. 540-546
Author(s):  
Vishnu B ◽  
James Chacko ◽  
Mahesh C Kundagol ◽  
Devipriya Soman
Keyword(s):  
Indian Population ◽  
Statistical Tests ◽  
Low Back ◽  
Open Label ◽  
Exclusion Criteria ◽  
Single Drug ◽  
Daunting Task ◽  
Group A ◽  
Group B ◽  
Controlled Clinical Study

It is estimated that Low back pain afflicts nearly two thirds of the Indian population at some point in their life. Erandamuladi Niruha Basti is a widely practiced and proven formulation that is used in Gridhrasi (Sciatica). It contains more than 20 ingredients, which can be a daunting task for an ayurvedic practitioner in a clinic to procure. Hence the literary search was done with a view to find out other effective formulations which were preferably single drug formulations. Nirgundi patra Kashaya was mentioned by acharya Chakrapanidatta in Vatavyadhi Adhikarana of Chakradatta. Nirgundi itself has anti-inflammatory and analgesic properties, so this Kashaya was selected as a Basti to be compared with Erandamuladi Niruha Basti in Yoga Basti pattern. 30 patients were randomized into two groups, Group A and Group B based on a set of inclusion and exclusion criteria. Group A was given Nirgundi Patra Kashaya Niruha and Murchita Tila Taila Anuvasana and Group B patients were given Erandamuladi Niruha and Murchita Tila Taila Anuvasana. Objective and Subjective parameters were evaluated before the start of the treatment and at the end of the treatment. The parameters were evaluated using relevant statistical tests. The result showed that even though all the patients had relief after the treatment, he percentage of relief was more across all parameters in case of Group B. This showed that, Nirgundi patra Kashaya was effective in the treatment of Gridhrasi in Basti formulation, but, Erandamuladi Niruha Basti produced much significant relief.

Evaluation of Resting Tongue Position in Partially Edentulous and Completely Edentulous Patients

2020 ◽  
Vol 3 (1) ◽  
pp. 73-78
Author(s):  
Dinesh Sharma Bhusal ◽  
Bebina Shrestha
Keyword(s):  
Statistical Tests ◽  
Chi Square ◽  
Edentulous Mandible ◽  
Tongue Position ◽  
Chi Square Test ◽  
Group A ◽  
Edentulous Patients ◽  
The Stability ◽  
Group B

Introduction: Resting tongue position is of crucial importance in the stability and retention of complete denture, particularly of the mandible. The retracted position of the tongue has been found to be higher in edentulous subjects when compared to dentate subjects and highest in completely edentulous individuals. Objectives: To evaluate the resting tongue position in completely edentulous as well as partially edentulous patients. Methods: 50 edentulous and 50 partially edentulous (mandible) subjects were taken. The edentulous group was divided into two groups according to the duration of edentulousness. Group A: Recently extracted edentulous subjects (< 1 year), Group B: Long term edentulous subjects (> 1 years). The partially edentulous group was divided into 4 groups according to Kennedy classification. The resting tongue positions of all the individuals were determined. The data was analyzed using SPSS statistical tests like mean, standard deviation, proportion, Chi-square test and Independent T-test. Results: In complete edentulous group, the abnormal upper was the most frequent (38%). In partial edentulous group, the normal lower was the most frequently observed tongue position with 34%. The abnormal tongue position was found in 68% and 40% in completely edentulous and partially edentulous subjects respectively. Conclusion: Retracted resting tongue position is found to be higher in completely edentulous subjects than partially edentulous ones.

scholarly journals 40 days and 40 nights: Clinical characteristics of major trauma and orthopaedic injury comparing the incubation and lockdown phases of COVID-19 infection

2020 ◽  
Vol 1 (7) ◽  
pp. 330-338 ◽  
Author(s):  
Bisola Ajayi ◽  
Alex Trompeter ◽  
Magnus Arnander ◽  
Philip Sedgwick ◽  
Darren F. Lui
Keyword(s):  
Clinical Characteristics ◽  
Traffic Accidents ◽  
Major Trauma ◽  
Road Traffic ◽  
Trauma Centre ◽  
Orthopaedic Patients ◽  
Major Trauma Centre ◽  
Group A ◽  
Group B ◽  
The Uk

Aims The first death in the UK caused by COVID-19 occurred on 5 March 2020. We aim to describe the clinical characteristics and outcomes of major trauma and orthopaedic patients admitted in the early COVID-19 era. Methods A prospective trauma registry was reviewed at a Level 1 Major Trauma Centre. We divided patients into Group A, 40 days prior to 5 March 2020, and into Group B, 40 days after. Results A total of 657 consecutive trauma and orthopaedic patients were identified with a mean age of 55 years (8 to 98; standard deviation (SD) 22.52) and 393 (59.8%) were males. In all, 344 (approximately 50%) of admissions were major trauma. Group A had 421 patients, decreasing to 236 patients in Group B (36%). Mechanism of injury (MOI) was commonly a fall in 351 (52.4%) patients, but road traffic accidents (RTAs) increased from 56 (13.3%) in group A to 51 (21.6%) in group B (p = 0.030). ICU admissions decreased from 26 (6.2%) in group A to 5 (2.1%) in group B. Overall, 39 patients tested positive for COVID-19 with mean age of 73 years (28 to 98; SD 17.99) and 22 (56.4%) males. Common symptoms were dyspnoea, dry cough, and pyrexia. Of these patients, 27 (69.2%) were nosocomial infections and two (5.1%) of these patients required intensive care unit (ICU) admission with 8/39 mortality (20.5%). Of the patients who died, 50% were older and had underlying comorbidities (hypertension and cardiovascular disease, dementia, arthritis). Conclusion Trauma admissions decreased in the lockdown phase with an increased incidence of RTAs. Nosocomial infection was common in 27 (69.2%) of those with COVID-19. Symptoms and comorbidities were consistent with previous reports with noted inclusion of dementia and arthritis. The mortality rate of trauma and COVID-19 was 20.5%, mainly in octogenarians, and COVID-19 surgical mortality was 15.4%. Cite this article: Bone Joint Open 2020;1-7:330–338.

Impact of FDG-PET to detect recurrence of head and neck squamous cell carcinoma

2007 ◽  
Vol 137 (4) ◽  
pp. 647-653 ◽  
Author(s):  
Sophie P$eAri$eA ◽  
Alexis Hugentobler ◽  
Bertrand Susini ◽  
Sona Balogova ◽  
Dany Grahek ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Fdg Pet ◽  
First Year ◽  
Therapeutic Impact ◽  
Curative Therapy ◽  
Positron Emission ◽  
Group A ◽  
Group B ◽  
The Impact

Objective Prospectively evaluate the impact of fluorodeoxy-glucose-fluorine-18 positron emission tomography (FDG-PET) in the management of recurrence of advanced head and neck squa-mous cell carcinoma during the first year after treatment. Study Design Seventy patients were followed-up every 6 to 8 weeks during the first year after initial combined curative therapy. FDG-PET, together with conventional imaging and en-doscopy were performed systematically at 1 year (group A) or prompted earlier in case of clinically suspicious recurrence (group B). The referring physician evaluated the impact of FDG-PET on the patient's management. Another clinician checked the pertinence of decisions. Results FDG-PET had a therapeutic impact in 8 of 43 group A patients and in 16 of 27 group B patients; the overall rate was 34%. This change was pertinent in 5 of 8 and 14 of 16 cases, respectively. Overall pertinence rate of decisions was 90% versus 70% without FDG-PET. Conclusions FDG-PET had a significant overall therapeutic impact; the induced decisions were either pertinent or just led to “futile” noninvasive examinations. Systematic FDG-PET had a significantly lesser impact in comparison with FDG-PET motivated by clinical suspicion.

Sign in / Sign up

Export Citation Format

Share Document