scholarly journals A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Koustov Adhikary ◽  
Moloy Banerjee
Keyword(s):  
Magnetic Field ◽  
Temperature Field ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Magnetic Fluid ◽  
Strong Influence ◽  
Proper Selection ◽  
Magnetic Fluid Hyperthermia ◽  
Linear Pattern ◽  
Selection Of

The thermal effect developed due to the heating of magnetic nanoparticles (MNPs) in presence of external magnetic field can be precisely controlled by the proper selection of magnetic absorption properties of the MNPs. The present paper deals with the numerical simulation of temperature field developed within or outside the tumor, in the presence of an external alternating magnetic field, using a thermofluidic model developed using ANSYS FLUENT®. A three-layer nonuniform tissue structure with one or two blood vessels surrounding the tumor is considered for the present simulation. The results obtained clearly suggest that the volumetric distribution pattern of MNPs within the tumor has a strong influence on the temperature field developed. The linear pattern of volumetric distribution has a strong effect over the two other types of distribution considered herein. Various other important factors like external magnetic field intensity, frequency, vascular congestion, types of MNP material, and so forth are considered to find the influence on the temperature within the tumor. Results show that proper selection of these parameters has a strong influence on the desired therapeutic temperature range and thus it is of utmost importance from the efficacy point of view of magnetic fluid hyperthermia (MFH).

scholarly journals Magnetoviscosity of a Magnetic Fluid Based on Barium Hexaferrite Nanoplates

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1870
Author(s):  
Dmitry Borin ◽  
Robert Müller ◽  
Stefan Odenbach
Keyword(s):  
Magnetic Field ◽  
Experimental Study ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Shear Flow ◽  
Magnetic Fluid ◽  
Barium Hexaferrite ◽  
Dipole Interaction ◽  
Field Dependent ◽  
Fluid Behaviour

This paper presents the results of an experimental study of the influence of an external magnetic field on the shear flow behaviour of a magnetic fluid based on barium hexaferrite nanoplates. With the use of rheometry, the magnetoviscosity and field-dependent yield-stress in the fluid are evaluated. The observed fluid behaviour is compared to that of ferrofluids with magnetic nanoparticles having high dipole interaction. The results obtained supplement the so-far poorly studied topic of the influence of magnetic nanoparticles’ shape on magnetoviscous effects. It is concluded that the parameter determining the observed magnetoviscous effects in the fluid under study is the ratio V2/l3, where V is the volume of the nanoparticle and l is the size of the nanoparticle in the direction corresponding to its orientation in the externally applied magnetic field.

scholarly journals Extracellular and intracellular intermittent magnetic-fluid hyperthermia treatment of SK-Hep1 hepatocellular carcinoma cells based on magnetic nanoparticles coated with polystyrene sulfonic acid

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245286
Author(s):  
Bo-Wei Chen ◽  
Guo-Wei Chiu ◽  
Yun-Chi He ◽  
Chih-Yu Huang ◽  
Hao-Ting Huang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Hepatocellular Carcinoma ◽  
Magnetic Nanoparticles ◽  
Magnetic Fluid ◽  
Sulfonic Acid ◽  
Culture Medium ◽  
Hyperthermia Treatment ◽  
Magnetic Fluid Hyperthermia ◽  
Polystyrene Sulfonic Acid ◽  
Heat Spreading

The use of magnetic nanoparticles (MNPs) magnetized on applying an alternating magnetic field (AMF) to stimulate the thermal characteristics and to induce tumor apoptosis is a currently active area of research in cancer treatment. In previous work, we developed biocompatible and superparamagnetic polystyrene-sulfonic-acid-coated magnetic nanoparticles (PSS-MNPs) as applications for magnetically labeled cell trapping, but without assessment of treatment effects on tumor diseases. In the present work, we examined PSS-MNP-induced magnetic fluid hyperthermia (MFH) on SK-Hep1 hepatocellular carcinoma (HCC) cells for lethal thermal effects with a self-made AMF system; an adjustable AMF frequency generated a variable intensity of magnetic field and induced MNP relaxation. The extracellular and intracellular MFH treatments on a SK-Hep1 cell line were implemented in vitro; the result indicates that the lethal effects were efficient and caused a significantly decreased cell viability of SK-Hep1 cells. As the PSS-MNP concentration decreased, especially in intracellular MFH treatments, the MFH effects on cells, however, largely decreased through heat spreading to the culture medium. On controlling and decreasing the volume of culture medium, the problem of heat spreading was solved. It can be consequently expected that PSS-MNPs would be a prospective agent for intracellular cancer magnetotherapy.

On the in Vitro Hyperthermia of Magnetic Fluid in AC Magnetic Field

2009 ◽  
Author(s):  
Junfeng Jiang ◽  
Ruoyu Hong ◽  
Xiaohui Zhang ◽  
Hongzhong Li
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Volume Fraction ◽  
Maximum Temperature ◽  
Magnetic Fluid Hyperthermia ◽  
Ac Magnetic Field ◽  
Hyperthermia Therapy ◽  
Good Biocompatibility ◽  
High Chemical Stability

Hyperthermia therapy for cancer has attracted much attention nowadays. The study on the heat transfer in the magnetic fluid and the tumor is crucial for the successful application of magnetic fluid hyperthermia (MFH). Water-based Fe3O4 magnetic fluid is expected to be a most appropriate candidate for MFH due to the good biocompatibility, high saturation magnetization, super-paramagnetization and high chemical stability. In this paper, we explore the heat generation and transfer in magnetic fluid which is placed under an AC magnetic field. It is found that the amplitude and the frequency of alternating magnetic field, particle size and volume fraction have a pronounce influence on maximum temperature of hyperthermia.

Mittag–Leffler Function as an Approximant to the Concentrated Ferrofluid’s Magnetization Curve

2021 ◽  
Vol 5 (4) ◽  
pp. 147
Author(s):  
Petr A. Ryapolov ◽  
Eugene B. Postnikov
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Magnetization Curve ◽  
Force Fields ◽  
Physical Characteristics ◽  
Concentrated Solutions ◽  
Static Magnetization ◽  
Simple Tool ◽  
Technical Systems

In this work, we show that the static magnetization curve of high-concentrated ferrofluids can be accurately approximated by the Mittag–Leffler function of the inverse external magnetic field. The dependence of the Mittag–Leffler function’s fractional index on physical characteristics of samples is analysed and its growth with the growing degree of system’s dilution is revealed. These results provide a certain background for revealing mechanisms of hindered fluctuations in concentrated solutions of strongly interacting of the magnetic nanoparticles as well as a simple tool for an explicit specification of macroscopic force fields in ferrofluid-based technical systems.

scholarly journals STABILITY OF A VISCOUS INCOMPRESSIBLE CONDUCTING LIQUID LAYER OF A CYLINDRICAL SHAPE IN AN INHOMOGENEOUS TEMPERATURE FIELD AND A MAGNETIC FIELD OF A VACUUM ARC CURRENT THROUGH IT

2021 ◽  
pp. 91-97
Author(s):  
O.L. Andrieieva ◽  
B.V. Borts ◽  
А.F. Vanzha ◽  
I.М. Korotkova ◽  
V.I. Tkachenko
Keyword(s):  
Magnetic Field ◽  
Temperature Field ◽  
External Magnetic Field ◽  
Fluid Layer ◽  
Vacuum Arc ◽  
Cylindrical Shape ◽  
Conducting Liquid ◽  
Inhomogeneous Temperature ◽  
Inhomogeneous Temperature Field ◽  
Arc Current

Convective mass transfer in a cylindrical viscous incompressible conductive fluid layer in an inhomogeneous temperature field and in the external magnetic field of the vacuum arc current through it is theoretically investigated in this work. For a horizontal layer of a viscous, incompressible, conducting liquid of a cylindrical shape, located in a temperature field inhomogeneous in height and in an external magnetic field of a vacuum arc current flowing through it, the original equations are written. These equations consist of linearized equations for small velocity perturbations, small deviations from the equilibrium values of temperature, pressure, and magnetic field strength. The considered boundary value problem is solved for the case of free boundaries. Comparison of the experimental data with theoretical calculations made it possible to determine the rotation velocity of the steel melt during vacuum arc melting.

scholarly journals Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia

2019 ◽  
Vol 36 (1) ◽  
pp. 686-700 ◽  
Author(s):  
Olivia L. Lanier ◽  
Olena I. Korotych ◽  
Adam G. Monsalve ◽  
Dayita Wable ◽  
Shehaab Savliwala ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Fluid ◽  
Magnetic Fluid Hyperthermia

Hot-Film Measurement of Natural Convection in Liquid Gallium With and Without Magnetic Fields

Volume 1 ◽  
2004 ◽  
Author(s):  
B. Xu ◽  
B. Q. Li ◽  
D. E. Stock
Keyword(s):  
Magnetic Field ◽  
Temperature Field ◽  
Natural Convection ◽  
External Magnetic Field ◽  
Narrow Range ◽  
Temperature Fields ◽  
Liquid Gallium ◽  
Numerical Predictions ◽  
Velocity And Temperature Fields ◽  
Hot Film

The velocity and temperature fields induced by natural convection in liquid gallium were measured. Measurements were taken with and without an external magnetic field applied to the liquid gallium. The velocity field was measured with a hot-film anemometer and the temperature field with a thermocouple. The hot film was calibrated over a narrow range of temperatures in a rotating turntable filled with liquid gallium. The external magnetic field damped both the velocity and temperature fields compared to similar conditions when no external magnetic field was present. The experimental results compared reasonably well with previous numerical predictions.

scholarly journals Synthesis of Poly-Sodium-Acrylate (PSA)-Coated Magnetic Nanoparticles for Use in Forward Osmosis Draw Solutions

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1238 ◽  
Author(s):  
Irena Ban ◽  
Sabina Markuš ◽  
Sašo Gyergyek ◽  
Miha Drofenik ◽  
Jasmina Korenak ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Osmotic Pressure ◽  
Forward Osmosis ◽  
Superparamagnetic Nanoparticles ◽  
Molar Ratio ◽  
Sodium Acrylate ◽  
Molar Ratios ◽  
Magnetite Phase

The synthesis of magnetic nanoparticles (MNPs) coated with hydrophilic poly-sodium-acrylate (PSA) ligands was studied to assess PSA-MNP complexes as draw solution (DS) solutes in forward osmosis (FO). For MNP-based DS, the surface modification and the size of the MNPs are two crucial factors to achieve a high osmolality. Superparamagnetic nanoparticles (NP) with functional groups attached may represent the ideal DS where chemical modifications of the NPs can be used in optimizing the DS osmolality and the magnetic properties allows for efficient recovery (DS re-concentration) using an external magnetic field. In this study MNPs with diameters of 4 nm have been prepared by controlled chemical co-precipitation of magnetite phase from aqueous solutions containing suitable salts of Fe2+ and Fe3+ under inert atmosphere and a pure magnetite phase could be verified by X-ray diffraction. Magnetic colloid suspensions containing PSA-coated MNPs with three different molar ratios of PSA:MNP = 1:1, 1:2 and 1:3 were prepared and assessed in terms of osmotic pressure, aggregation propensity and magnetization. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the presence of PSA on coated MNPs and pristine PSA-MNPs with a molar ratio PSA:MNP = 1:1 exhibited an osmotic pressure of 30 bar. Molar ratios of PSA:MNP = 1:2 and 1:3 lead to the formation of less stabile magnetic colloid solutions, which led to the formation of aggregates with larger average hydrodynamic sizes and modest osmotic pressures (5.5 bar and 0.2 bar, respectively). After purification with ultrafiltration, the 1:1 nanoparticles exhibited an osmotic pressure of 9 bar with no aggregation and a sufficient magnetization of 25 emu/g to allow for DS regeneration using an external magnetic field. However, it was observed that the amount of PSA molecules attached to the MNPs decreased during DS recycling steps, leaving only strong chelate-bonded core-shell PSA as coating on the MNPs. This demonstrates the crucial role of MNP coating robustness in designing an efficient MNP-based DS for FO.

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