The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

Gastric cancer is the fifth most common malignancy all over the world, and the factors that can affect progress and prognosis of the gastric cancer patients are various, such as TNM stages, invasive depth, and lymph node metastasis ratio. T cell immunity is important component of human immunity system and immunity responding to tumor and dysfunction or imbalance of T cell immunity will lead to serious outcomes for body. T cell immunity includes many different types of cells, CD4+ T cell, CD8+ T cell, memory cell, and so on, and each of them has special function on antitumor response or tumor immune escape which is revealed in lung cancer, colorectal cancer, breast cancer, ovarian cancer, and so on. But its correlation with gastric cancer is not clear. Our review was preformed to explore the relationship between the progress and prognosis of gastric cancer (GC) and T cell immunity. According to recent researches, T cell immunity may have an important role in the progress and prognosis of GCs, but its function is affected by location, category, related molecule, and interaction between the cells, and some effects still are controversial. More researches are needed to clarify this correlation.

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Neutrophils diminish T-cell immunity to foster gastric cancer progression: the role of GM-CSF/PD-L1/PD-1 signalling pathway

Gut ◽

10.1136/gutjnl-2017-313923 ◽

2017 ◽

Vol 66 (11) ◽

pp. 1878-1880 ◽

Cited By ~ 13

Author(s):

Xu Zhang ◽

Wenrong Xu

Keyword(s):

Gastric Cancer ◽

T Cell ◽

Cancer Progression ◽

Signalling Pathway ◽

T Cell Immunity ◽

Gm Csf ◽

Cell Immunity ◽

Gastric Cancer Progression

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Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

Frontiers in Oncology ◽

10.3389/fonc.2020.00629 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Yinghong Shi ◽

Jiahui Zhang ◽

Zheying Mao ◽

Han Jiang ◽

Wei Liu ◽

...

Keyword(s):

Gastric Cancer ◽

T Cell ◽

Cancer Cells ◽

Extracellular Vesicles ◽

T Cell Immunity ◽

Gastric Cancer Cells ◽

Cell Immunity

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Prognostic and Predictive Value of Cadherin 11 for Patients with Gastric Cancer and Its Correlation with Tumor Microenvironment: Results from Microarray Analysis

BioMed Research International ◽

10.1155/2020/8107478 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16

Author(s):

Zhijun Feng ◽

Xue Li ◽

Zhijian Ren ◽

Jie Feng ◽

Xiaodong He ◽

...

Keyword(s):

Gastric Cancer ◽

Tumor Microenvironment ◽

Epithelial To Mesenchymal Transition ◽

Immune Escape ◽

Vital Role ◽

Potential Therapeutic Target ◽

Tumor Immune Escape ◽

Mesenchymal Transition ◽

Gastric Cancer Patients ◽

Cancer Tissues

Gastric cancer is a disease characterized by inflammation, and epithelial-to-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) both play a vital role in epithelial-driven malignancy. In the present study, we performed an integrated bioinformatics analysis of transcriptome data from multiple databases of gastric cancer patients and worked on a biomarker for evaluating tumor prognosis. We found that cadherin 11 (CDH11) is highly expressed not only in gastric cancer tissues but also in EMT molecular subtypes and metastatic patients. Also, we obtained evidence that CDH11 has a significant correlation with infiltrating immune cells in the tumor microenvironment (TME). Our findings reflected that CDH11 likely plays an important role in tumor immune escape and could provide a prognostic biomarker and potential therapeutic target for patients with gastric cancer.

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Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting

Blood ◽

10.1182/blood-2008-03-148007 ◽

2009 ◽

Vol 113 (21) ◽

pp. 5167-5175 ◽

Cited By ~ 43

Author(s):

Anna M. Keller ◽

Yanling Xiao ◽

Victor Peperzak ◽

Shalin H. Naik ◽

Jannie Borst

Keyword(s):

Dendritic Cells ◽

T Cell ◽

Cd8 T Cell ◽

T Cell Response ◽

T Cell Immunity ◽

Cell Immunity ◽

Immature Dendritic Cells ◽

Anticancer Vaccines ◽

Cd8 T Cell Memory ◽

T Cell Help

Abstract The use of dendritic cells (DCs) as anticancer vaccines holds promise for therapy but requires optimization. We have explored the potential of costimulatory ligand CD70 to boost the capacity of DCs to evoke effective CD8+ T-cell immunity. We show that immature conventional DCs, when endowed with CD70 expression by transgenesis, are converted from a tolerogenic state into an immunogenic state. Adoptively transferred CD70-expressing immature DCs could prime CD8+ T cells, by CD27, to become tumor-eradicating cytolytic effectors and memory cells with a capacity for robust secondary expansion. The CD8+ T-cell response, including memory programming, was independent of CD4+ T-cell help, because the transferred immature DCs were loaded with major histocompatibility complex class I–restricted peptide only. Without CD70 expression, the DCs generated abortive clonal expansion, dysfunctional antitumor responses, and no CD8+ T-cell memory. CD70-expressing CD8+ DCs were the primary subset responsible for CD8+ T-cell priming and performed comparably to fully matured DCs. These data highlight the importance of CD27/CD70 interactions at the T-cell/DC interface and indicate that CD70 should be considered in the design of DC vaccination strategies.

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