scholarly journals FibroAtlas: A Database for the Exploration of Fibrotic Diseases and Their Genes

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Jinying Liu ◽  
Dezhi Sun ◽  
Jiale Liu ◽  
Hao Xu ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Environmental Factors ◽  
Clinical Manifestations ◽  
Extensive Literature ◽  
Supporting Evidence ◽  
Ecm Proteins ◽  
Complex Process ◽  
Fibrotic Diseases ◽  
Shed Light

Background. Fibrosis is a highly dynamic process caused by prolonged injury, deregulation of the normal processes of wound healing, and extensive deposition of extracellular matrix (ECM) proteins. During fibrosis process, multiple genes interact with environmental factors. Over recent decades, tons of fibrosis-related genes have been identified to shed light on the particular clinical manifestations of this complex process. However, the genetics information about fibrosis is dispersed in lots of extensive literature. Methods. We extracted data from literature abstracts in PubMed by text mining, and manually curated the literature and identified the evidence sentences. Results. We presented FibroAtlas, which included 1,439 well-annotated fibrosis-associated genes. FibroAtlas 1.0 is the first attempt to build a nonredundant and comprehensive catalog of fibrosis-related genes with supporting evidence derived from curated published literature and allows us to have an overview of human fibrosis-related genes.

scholarly journals Ignoring matrix boundaries when the LKB1 master kinase is gone

2014 ◽  
Vol 207 (2) ◽  
pp. 167-169 ◽  
Author(s):  
Erik H.J. Danen
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Tumor Suppressor ◽  
Embryonic Development ◽  
Immune Responses ◽  
Cell Movement ◽  
Metastatic Spread ◽  
Ecm Proteins ◽  
The Many ◽  
Migration Of Cells

Gradients of soluble attractants as well as extracellular matrix (ECM) proteins serve as cues for directional cell movement. Such “chemotaxis” and “haptotaxis” steers migration of cells during embryonic development, wound healing, and immune responses. In this issue, Chan et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201404067) show that the tumor suppressor LKB1 controls haptotaxis through the microtubule affinity-regulating kinase (MARK) family, one of the many substrates of the LKB1 master kinase. In the absence of this pathway, melanoma cells migrate irrespective of ECM gradients, which may explain the increased metastatic spread observed in LKB1-deficient tumors.

The Skin and the Physiology of Normal Wound Healing

2020 ◽  
Author(s):  
Timothy W. King ◽  
Sahil K. Kapur
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factors ◽  
Wound Care ◽  
Normal Wound Healing ◽  
Inflammatory Phase ◽  
Complex Process

This review presents normal wound healing as a complex process that is generally carried out in three overlapping stages: an inflammatory phase, a proliferative phrase (made up of fibroplasia, contraction, neovascularization, and granulation), and a remodeling phase. In addition, wound healing occurs under the influence of multiple cytokines, growth factors, and extracellular matrix signals. Figures show the layers of the skin and the cycles of wound healing.  This review contains 6 highly rendered figures, 8 tables, and 47 references Keywords: wound, wound care, healing, epithelialization, migration, granulation

The Skin and the Physiology of Normal Wound Healing

2020 ◽  
Author(s):  
Timothy W. King ◽  
Sahil K. Kapur
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factors ◽  
Wound Care ◽  
Normal Wound Healing ◽  
Inflammatory Phase ◽  
Complex Process

This review presents normal wound healing as a complex process that is generally carried out in three overlapping stages: an inflammatory phase, a proliferative phrase (made up of fibroplasia, contraction, neovascularization, and granulation), and a remodeling phase. In addition, wound healing occurs under the influence of multiple cytokines, growth factors, and extracellular matrix signals. Figures show the layers of the skin and the cycles of wound healing.  This review contains 6 highly rendered figures, 8 tables, and 47 references Keywords: wound, wound care, healing, epithelialization, migration, granulation

Coaxial Nanofibrous Scaffolds Mimicking the Extracellular Matrix Transition in Wound Healing Process Promote Skin Regeneration through enhancing Immunomodulation

2021 ◽  
Author(s):  
Luyao Sun ◽  
Jing Li ◽  
Wendong Gao ◽  
Miao Shi ◽  
Fengling Tang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Healing Process ◽  
Skin Regeneration ◽  
Wound Healing Process ◽  
Dynamic Features ◽  
Cell Behaviors ◽  
Ecm Proteins ◽  
Nanofibrous Scaffolds ◽  
Improve Wound Healing

Numerous studies have shown scaffolds incorporated with ECM proteins could regulate cell behaviors and improve wound healing. However, most ECM-containing scaffolds fail to capture the dynamic features of native ECM....

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

Uterine Wound Healing: A Complex Process Mediated by Proteins and Peptides

2016 ◽  
Vol 18 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Dario Lofrumento ◽  
Maria Nardo ◽  
Marianna Falco ◽  
Andrea Lieto
Keyword(s):  
Wound Healing ◽  
Complex Process ◽  
Proteins And Peptides

scholarly journals A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae

2021 ◽  
Vol 22 (3) ◽  
pp. 1411
Author(s):  
Caterina Fede ◽  
Carmelo Pirri ◽  
Chenglei Fan ◽  
Lucia Petrelli ◽  
Diego Guidolin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Treatment Strategies ◽  
Clear Understanding ◽  
Pathological Characteristics ◽  
Appropriate Treatment ◽  
Different Types ◽  
Molecular Components ◽  
Entire Network ◽  
Shed Light

The fascia can be defined as a dynamic highly complex connective tissue network composed of different types of cells embedded in the extracellular matrix and nervous fibers: each component plays a specific role in the fascial system changing and responding to stimuli in different ways. This review intends to discuss the various components of the fascia and their specific roles; this will be carried out in the effort to shed light on the mechanisms by which they affect the entire network and all body systems. A clear understanding of fascial anatomy from a microscopic viewpoint can further elucidate its physiological and pathological characteristics and facilitate the identification of appropriate treatment strategies.

scholarly journals Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

Membranes ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Tamara S. Tverdokhlebova ◽  
Ludmila S. Antipina ◽  
Valeriya L. Kudryavtseva ◽  
Ksenia S. Stankevich ◽  
Ilya M. Kolesnik ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vinylidene Fluoride ◽  
Ferroelectric Properties ◽  
Composite Membranes ◽  
Modern Medicine ◽  
In Vivo Studies ◽  
Cytotoxic Effects ◽  
Complex Process ◽  
Purulent Wounds

Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds.

scholarly journals Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications

2021 ◽  
pp. 102500
Author(s):  
Sumama Nuthana Kalva ◽  
Robin Augustine ◽  
Abdulla Al Mamun ◽  
Yogesh Bharat Dalvi ◽  
Namitha Vijay ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Electrospun Membranes

scholarly journals Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression

2020 ◽  
pp. 1-10
Author(s):  
Ahmadshah Farhat ◽  
Gordon A. Ferns ◽  
Korosh Ashrafi ◽  
Mohammad-Hassan Arjmand
Keyword(s):  
Cancer Progression ◽  
Extracellular Enzymes ◽  
Lysyl Oxidase ◽  
Ecm Remodeling ◽  
Complex Process ◽  
High Prevalence ◽  
Different Types ◽  
Fibrotic Diseases ◽  
Gi Cancers ◽  
Improvement In Survival

<b><i>Background:</i></b> Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the association between Lox activity and the progression of GI cancers. Lox proteins are a group of extracellular enzymes that catalyzed the cross-linking of collagen and elastin, so they have important roles in the control of structure and homeostasis of ECM. Abnormal activation and expression of the Lox family of proteins lead to changes in the ECM toward increased rigidity and fibrosis. Stiffness of ECM can contribute to the pathogenesis of cancers. <b><i>Summary:</i></b> Dysregulation of Lox expression is a factor in both fibrotic diseases and cancer. ECM stiffness by Lox overactivity creates a physical barrier against intratumoral concentration of chemotherapeutic drugs and facilitates cancer inflammation, angiogenesis, and metastasis. <b><i>Key Message:</i></b> Because of the roles of Lox in GI cancers, development targeting Lox protein isotypes may be an appropriate strategy for treatment of GI cancers and improvement in survival of patients.

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