scholarly journals Noncoding RNAs in Unexplained Recurrent Spontaneous Abortions and Their Diagnostic Potential

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Ningyi Jia ◽  
Jian Li
Keyword(s):  
Noncoding Rnas ◽  
Circulatory System ◽  
Screening Tests ◽  
Spontaneous Abortions ◽  
Recurrent Spontaneous Abortions ◽  
Disease States ◽  
Current State ◽  
Diagnostic Potential ◽  
Unexplained Recurrent Spontaneous Abortion ◽  
Underlying Mechanisms

Unexplained recurrent spontaneous abortion (URSA) is defined as the loss of two or more consecutive pregnancies before the 20th week of gestation with normal findings on routine screening tests. Our understanding of the cellular and molecular pathogenesis of URSA is still far from complete. Noncoding RNAs (ncRNAs) play a pivotal role in transcription and expression. The functions of ncRNAs may also improve understanding of URSA pathogenesis. Because of their stability in the circulatory system and at the maternal-fetal interface, it may be possible to use ncRNAs as biomarkers for certain disease states. Here, we provide a narrative review of the current state of knowledge about ncRNAs associated with URSA. The possibility of developing a diagnostic tool using ncRNAs is discussed. The underlying mechanisms of how ncRNAs may lead to the onset of URSA are explored in this review.

scholarly journals From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3688
Author(s):  
Jéssica Fernanda Barazetti ◽  
Tayana Shultz Jucoski ◽  
Tamyres Mingorance Carvalho ◽  
Rafaela Nasser Veiga ◽  
Ana Flávia Kohler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Estrogen Receptor Alpha ◽  
Expression Patterns ◽  
Tamoxifen Resistance ◽  
Hormone Receptor Positive ◽  
Current State ◽  
Main Driver ◽  
Underlying Mechanisms ◽  
Multiple Signaling

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality among women. Two thirds of patients are classified as hormone receptor positive, based on expression of estrogen receptor alpha (ERα), the main driver of breast cancer cell proliferation, and/or progesterone receptor, which is regulated by ERα. Despite presenting the best prognosis, these tumors can recur when patients acquire resistance to treatment by aromatase inhibitors or antiestrogen such as tamoxifen (Tam). The mechanisms that are involved in Tam resistance are complex and involve multiple signaling pathways. Recently, roles for microRNAs and lncRNAs in controlling ER expression and/or tamoxifen action have been described, but the underlying mechanisms are still little explored. In this review, we will discuss the current state of knowledge on the roles of microRNAs and lncRNAs in the main mechanisms of tamoxifen resistance in hormone receptor positive breast cancer. In the future, this knowledge can be used to identify patients at a greater risk of relapse due to the expression patterns of ncRNAs that impact response to Tam, in order to guide their treatment more efficiently and possibly to design therapeutic strategies to bypass mechanisms of resistance.

Immunogenetic and serological investigations in nonpregnant and in pregnant women with a history of recurrent spontaneous abortions

1994 ◽  
Vol 27 (2) ◽  
pp. 95-109 ◽  
Author(s):  
Gertrud Mueller-Eckhardt ◽  
Peter Mallmann ◽  
Jürgen Neppert ◽  
Annette Lattermann ◽  
Anette Melk ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortions ◽  
Recurrent Spontaneous Abortions ◽  
History Of

The Current State of Relationship Science: A Cross-Disciplines Review of Key Themes, Theories, Researchers and Journals

2021 ◽  
pp. 026540752110476
Author(s):  
Jennifer A Sharkey ◽  
Jacqueline S Feather ◽  
Sonja Goedeke
Keyword(s):  
Scoping Review ◽  
Scientific Knowledge ◽  
Interdisciplinary Research ◽  
Romantic Relationship ◽  
Descriptive Analysis ◽  
Theory Development ◽  
Current State ◽  
Relationship Processes ◽  
State Of Research ◽  
Underlying Mechanisms

This article provides a circumscribed descriptive analysis of the current state of research worldwide related to adult romantic relationship processes and their underlying mechanisms. A scoping review was used to gather data. This yielded 15,418 eligible articles from 1,687 different academic journals. From these, we outline key themes and theories arising in the last seven decades and note the most prolific journals and authors. The study of relational wellbeing has focused on overt behaviors such as communication and commitment, on underlying attitudes and motives such as empathy and contempt, and on substrates and circumstances such as neurobiological functioning and life stressors. The results reveal the strong interdisciplinary research underpinnings of the field of relationship science and show up key influences over its expansion. Results are intended to give an overview of key peer reviewed research that has contributed to the development of current scientific knowledge and theory development in this field.

Question-and-Answer Forum

CNS Spectrums ◽  
2007 ◽  
Vol 12 (S4) ◽  
pp. 13-13
Keyword(s):  
Functional Disability ◽  
Neuroprotective Effect ◽  
Neurodevelopmental Disorder ◽  
Historical Context ◽  
Brain Diseases ◽  
Delayed Treatment ◽  
Disease States ◽  
At Risk Children ◽  
Underlying Mechanisms ◽  
The Impact

AbstractSchizophrenia is a neurodevelopmental disorder associated with persistent symptomatology, severe functional disability, and residual morbidity characteristic of neurodegenerative brain diseases. The illness begins with genetic susceptibility and generally expresses itself after puberty through subtle changes that begin during the prodromal stage. Symptoms get progressively worse and tend to become more resistant to treatment with each relapse. Evidence for a neuroprotective effect of some forms of early treatment is beginning to emerge. While the underlying mechanisms remain uncertain, atypical antipsychotics may counteract some of the progressive deteriorative effects by enhancing synaptic plasticity and cellular resilience. However, identifying and treating patients in the earliest disease states presents methodological challenges as there is no consensus on the best methods of intervention and differences in at-risk children are not readily detectable or substantial enough to predict which ones will develop schizophrenia.In this expert roundtable supplement, Jeffrey A. Lieberman, MD, reviews the historical context of progressive deterioration in schizophrenia. Next, Diana O. Perkins, MD, MPH, reviews some of the challenges to early identification of illness as well as the impact of early versus delayed treatment. Finally, L. Fredrik Jarskog, MD, focuses on the neurobiology of functional progression in schizophrenia as well as pharmacology and the potential for neuroprotection.

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