scholarly journals Aerobic Training Associated with Arginine Supplementation Reduces Collagen-Induced Platelet Hyperaggregability in Rats under High Risk to Develop Metabolic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Nadia A. V. Motta ◽  
Milla M. Fumian ◽  
Renata F. Medeiros ◽  
Gabriel F. Lima ◽  
Christianne B. V. Scaramello ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Serum Levels ◽  
Aerobic Exercise Training ◽  
Platelet Response ◽  
Inflammatory Biomarker ◽  
Platelet Hyperaggregability ◽  
Arginine Supplementation

Background. Increased platelet response is seen in individuals with metabolic syndrome. Previous reports have shown that arginine supplementation and aerobic exercise training enhance vascular nitric oxide (NO) activity and inhibit platelet hyperaggregability; however, the effects of their association remain unknown.Aim. To investigate whether arginine supplementation and aerobic exercise association may exert beneficial effects, reducing platelet hyperaggregability in rats under high risk to develop metabolic syndrome.Methods. Wistar rats were divided into two groups: control (C) and fructose (F – water with 10% of fructose). After two weeks, the F group was subdivided into four groups: F, the same as before; fructose + arginine (FA – 880 mg/kg/day of L-arginine by gavage); fructose + training (FT); and fructose + arginine + training (FTA). Treatment lasted for eight weeks.Results. The fructose administration was able to increase the collagen-induced platelet aggregation (27.4 ± 2.7%) when compared to the C group (8.0 ± 3.4%). Although the arginine supplementation (32.2 ± 6.3%) or aerobic training (23.8 ± 6.5%) did not promote any change in platelet collagen-induced hyperaggregability, the association of arginine supplementation and aerobic exercise promoted an inhibition of the platelet hyperaggregability induced by fructose administration (13.9 ± 4.4%) (P<0.05). These effects were not observed when ADP was employed as an agonist. In addition, arginine supplementation associated with aerobic exercise promoted a decrease in interleukin-6 (IL-6) and interleukin-8 (IL-8) serum levels when compared to the fructose group, demonstrating an anti-inflammatory effect.Conclusions. Our data indicate an important role of arginine supplementation associated with aerobic exercise, reducing platelet hyperaggregability and inflammatory biomarker levels in rats under high risk to develop metabolic syndrome.

scholarly journals Effect of 12 Months of Exercise with Stachys Lavandulifolia Consumption on anxiety, Metabolic Syndrome Profiles and Antioxidant Defense and Lipid Peroxidation in Women with Syndrome Metabolic

2020 ◽  
Author(s):  
Ali osali ◽  
Alireza Rostami
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Peroxidation ◽  
Aerobic Exercise ◽  
Antioxidant Defense ◽  
Training Group ◽  
Serum Levels ◽  
Control Group ◽  
Negative Effects ◽  
Beneficial Effects ◽  
Before And After

Abstract BackgroundThe purpose of this study was to investigate the effect of 12 months of aerobic exercise combining stachys lavandulifolia (S. lavandulifolia) consumption on anxiety, Metabolic Syndrome profiles and antioxidant defense (Glutathione) and lipid peroxidation (Malondialdehyde) in 50-65 years old women with syndrome metabolic.Methods48 women with syndrome Metabolic were randomly divided into four groups: exercise (n=12), exercise+S. lavandulifolia (n=12), S. lavandulifolia (n=12) and control group (n=12). S. lavandulifolia groups consumed 3 g aerial parts of S. lavandulifolia daily. Training groups performed an exercise protocol of aerobic exercise for 12 months (three sessions per week). Blood samples were obtained before and after training period for antioxidant indicators and lipid degradation measurement. Also, Beck anxiety questionnaire used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.ResultsA significant increase was observed in serum levels of Malondialdehyde (P =0.004), Catalase indexes (Pvalue= 0.01), and Glutathione (P=0.001) in the training group and S. lavandulifolia groups after 12 months. Body weight, BMI, and SBP and Anexiety was decreased significantly greater in exercise +S. lavandulifolia group compared to control, exercise and S. lavandulifolia groups (P=0.001)ConclusionAnxiolytic effect and Anti-Oxidative Stress Activity was seen, so taking S. lavandulifolia along with exercises may have beneficial effects on reinforcement the antioxidant system and prevention of anxiety and The negative effects of indicators related to cardiovascular disease in women with metabolic syndrome.

Abstract 12949: Aerobic Exercise After an ICD: Results of the 6 Month Follow-Up in the Anti-Arrhythmic Effects of Exercise After an ICD Trial

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Cynthia M Dougherty ◽  
Robb Glenny ◽  
Peter Kudenchuk ◽  
Robert Burr
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Cardiopulmonary Exercise Testing ◽  
Aerobic Exercise Training ◽  
Cardiopulmonary Function ◽  
Exercise Maintenance ◽  
Peak Vo2 ◽  
O2 Pulse

Introduction: The Anti-Arrhythmic Effects of Exercise Trial reported that aerobic exercise training for 8 weeks after an implantable cardioverter defibrillator (ICD) significantly improved the primary outcome of cardiopulmonary function without ICD shocks or adverse events. This is a report on the longer term outcomes at 24 weeks of exercise maintenance that was continued after aerobic training. Hypothesis: When 8 weeks of aerobic exercise training is followed by aerobic exercise maintenance (50% reduction in the amount of walking), cardiopulmonary function [peak VO2, EX time, VO2 at AT, O2 pulse, METS, Maximum HR] will be maintained without an increase in ICD shocks or hospitalizations. Methods: 160 subjects (80/group) with a prior ICD implant (40% primary and 60% secondary prevention), mean age 55 +12 years, 78% male, 84% Caucasian, 100% beta-blocked, and mean EF%=40%, entered a RCT comparing aerobic exercise to usual care (UC). At baseline, 8 and 24 weeks, participants completed cardiopulmonary exercise testing using a modified Balke treadmill protocol. Aerobic training= 8 weeks of home walking 1 hour/day on 5 days/week at 60-80% of maximum HR using the Karvonen formula, was followed by aerobic maintenance (EX)= 16 weeks of home walking for 150 min/week. ICD shocks and hospitalizations were verified with medical records. Analysis of variance was used to determine group x time effects on study outcomes. Results: Aerobic maintenance significantly increased peak VO2 ml/kg/min, p<0.000 (EX 26.9+7.7, UC 23.4+6.0), EX minutes, p<0.000 (EX 16:27+ 6:36; UC 13:24+4:33), VO2 at AT ml/kg/min, p=0.001 (EX 23.0+6.8; UC 19.8+5.8), O2 pulse p=0.01 (EX 18.7+5.5; UC 16.8+4.9), and METS, p<0.001 (EX 7.6+2.2; UC 6.7+1.8). Maximum HR was unchanged. The number of ICD shocks related to exercise was =1: 3 in UC and 1 in exercise received an ICD shock or ATP during follow-up. There were 11 hospitalizations in each group, none were related to exercise. Conclusions: Aerobic exercise maintenance for 16 weeks that followed aerobic exercise training for 8 weeks, maintained gains in cardiopulmonary function despite reducing the amount of walking by half (300 min vs. 150 min). Aerobic exercise in patients with an ICD is safe without increasing the number of ICD shocks or hospitalizations.

scholarly journals Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome – CORRIGENDUM

2017 ◽  
Vol 118 (11) ◽  
pp. 998-998
Author(s):  
Renata Medeiros ◽  
Thaiane Gaique ◽  
Thais Bento-Bernardes ◽  
Raquel Kindlovits ◽  
Tamiris Gomes ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Aerobic Training ◽  
Metabolic Alterations ◽  
The Metabolic Syndrome

scholarly journals Effect of 6 Weeks of Aerobic Training with Nanocurcumin Consumption on IL1β, Nitric Oxide, and Depression in Women with Metabolic Syndrome

2021 ◽  
Author(s):  
Ali Osali ◽  
Alireza Rostami
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Inflammatory Diseases ◽  
Training Group ◽  
Moderate Intensity ◽  
Obese People ◽  
Significant Difference ◽  
Before And After

Abstract Backgrounds and ObjectivesThe use of anti-inflammatory supplements is important in improving the executive function of obese people. The aim of this research was to investigate the effect of 6 weeks of aerobic exercise with moderate intensity and consumption of nanocurcumin on IL1β, nitric oxide, and depression in women aged 60-65 with metabolic syndrome. Materials and Methods44 women with metabolic syndrome (MetS) were randomly selected and divided into four groups of 10, including MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS NanoCurcumin (MCU), MetS control (MC Training groups performed an exercise protocol of aerobic exercise for 6 weeks (three sessions per week). Blood samples were obtained before and after the training period for antioxidant indicators and lipid degradation measurement. Also, the Beck anxiety questionnaire was used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.ResultsThere was a significant difference in IL1β, nitric oxide (NO), and depression before and after exercise in all three experimental groups (p≤0.05). Also, the results showed a significant difference in the level of NO and depression in the research groups. The highest decrease in these variables was observed in the aerobic training group and training with nanocurcumin consumption group (p≤0.05).ConclusionThese findings indicated that six-week nanocurcumin supplementation with aerobic training is a suitable method for reducing IL1β and NO and depression, preventing metabolic, cardiovascular, and inflammatory diseases in women with metabolic syndrome.Name of the registry: IR.SEMUMS.REC.1396.107Trial registration number: IRCT2017082335857N1

scholarly journals Assessment of Propolis Supplementation on Serum Concentrations of Liver Enzymes in Endurance Athletes with Four Weeks Aerobic Training

2021 ◽  
Vol 25 (1) ◽  
pp. 25-30
Author(s):  
Mojtaba Mahdavi Asiabar ◽  
◽  
Mokhtar Nasiri Farsani ◽  
Nematollah Gheibi ◽  
◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Aerobic Training ◽  
Liver Enzymes ◽  
Cell Function ◽  
Serum Levels ◽  
Exercise Group ◽  
Cellular Level ◽  
Endurance Athletes ◽  
Serum Concentrations ◽  
Significant Difference

Background: Aerobic and intense exercises with an increase in free radicals cause damages at the cellular level, heart disease, cancer, and the development of aging processes, which one of its symptoms is increased serum concentrations of liver enzymes. Objective: The purpose of this study was to investigate the concurrent effect of four weeks of aerobic training and propolis supplementation on the activity of liver enzymes, including ALT, AST, and SOD in endurance athletes. Methods: Thirty-two male athletes (age: 21±1.4 years) in track and field were randomly divided into three groups: exercise group, exercise with placebo group, and exercise with supplement group. Propolis supplementation was taken as two tablets (500 mg) twice a day and aerobic exercise was performed for 4 weeks and in 24 sessions with an intensity of 60 to 65% of heart rate. The statistical method was done using one-way ANOVA and Tukey post hoc test by SPSS v. 18 software. Findings: The results showed that there was a statistically significant difference between groups in serum levels of SOD, AST, and ALT (P<0.05). There was not a statistically significant difference between the exercise group and placebo+exercise group in serum levels of SOD, AST, and ALT (P>0.05). Conclusion: The results showed that aerobic exercise alone can increase SOD levels and propolis supplementation with aerobic exercise can reduce AST and ALT serum levels and lead to improved liver cell function.

scholarly journals Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice

2020 ◽  
Vol 21 (20) ◽  
pp. 7582
Author(s):  
Jonatan Dassonvalle ◽  
Francisco Díaz-Castro ◽  
Camila Donoso-Barraza ◽  
Carlos Sepúlveda ◽  
Francisco Pino-de la Fuente ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Energy Balance ◽  
Aerobic Exercise ◽  
High Fat Diet ◽  
Aerobic Exercise Training ◽  
Metabolic Effects ◽  
Obese Mice ◽  
High Fat ◽  
Epididymal Fat ◽  
Glucocorticoid Response

Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid receptor (GR) response, and moreover whether a moderate aerobic exercise prevents the alteration in GR response induced by obesity. Methods: To evaluate the GR response in obese mice, we fed C57BL6J mice with a high-fat diet (HFD) for 12 weeks. Before mice were sacrificed, we injected them with dexamethasone. To assess the exercise role in GR response, we fed mice an HFD and subjected them to moderate aerobic exercise three times a week. Results: We found that mice fed a high-fat diet for 12 weeks developed hepatic GC hypersensitivity without changes in the gastrocnemius or epididymal fat GR response. Therefore, moderate aerobic exercise improved glucose tolerance, increased the corticosterone plasma levels, and prevented hepatic GR hypersensitivity with an increase in epididymal fat GR response. Conclusion: Collectively, our results suggest that mice with HFD-induced obesity develop hepatic GR sensitivity, which could enhance the metabolic effects of HFD in the liver. Moreover, exercise was found to be a feasible non-pharmacological strategy to prevent the deregulation of GR response in obesity.

Determining the effect size of aerobic exercise training on the standard lipid profile in sedentary adults with three or more metabolic syndrome factors: a systematic review and meta-analysis of randomised controlled trials

2021 ◽  
pp. bjsports-2021-103999
Author(s):  
Gina Wood ◽  
Emily Taylor ◽  
Vanessa Ng ◽  
Anna Murrell ◽  
Aditya Patil ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Lipid Profile ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Aerobic Exercise Training ◽  
Meta Regression ◽  
Randomised Controlled

ObjectivesTo estimate the change in the standard lipid profile (SLP) of adults diagnosed with ≥3 metabolic syndrome (MetS) factors following aerobic exercise training (AET); and to investigate whether study/intervention covariates are associated with this change.DesignSystematic review with univariate meta-analysis and meta-regression.Data sourcesEnglish language searches of online databases from inception until July 2020.Eligibility criteria(1) Published randomised controlled human trials with study population ≥10 per group; (2) sedentary adults with ≥3 MetS factors but otherwise free of chronic disease, not pregnant/lactating; (3) AET-only intervention with duration ≥12 weeks; and (4) reporting pre–post intervention SLP outcomes.ResultsVarious univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly (P<.001) improved all lipids (mmol/L mean difference ranges, 95% CIs): total cholesterol, –0.19 (–0.26 to –0.12) to –0.29 (−0.36 to –0.21); triglycerides, −0.17 (–0.19 to –0.14) to –0.18 (−0.24 to –0.13); high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15); and low-density lipoprotein-cholesterol (LDL-C), –0.12 (–0.16 to –0.9) to –0.20 (−0.25 to –0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C.ConclusionAerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with ≥3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C.PROSPERO registration numberCRD42020151925.

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