scholarly journals Study on Main Drugs and Drug Combinations of Patient-Controlled Analgesia Based on Text Mining

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xing Jin ◽  
Ying Wu
Keyword(s):  
Cluster Analysis ◽  
Text Mining ◽  
Association Analysis ◽  
Relevant Literature ◽  
Reference Value ◽  
Patient Controlled Analgesia ◽  
Combination Rules ◽  
Pubmed Database ◽  
Pain Knowledge

In recent years, with the continuous understanding of pain knowledge and the continuous improvement of quality of life requirements, patient-controlled analgesia (PCA) has been widely used in a variety of pain patients. In this study, text mining technology was used to analyze relevant literature, try to find out the main drugs of PCA, classify the drugs, and dig out the important drug combination rules. PCA studies were retrieved from PubMed database in recent 10 years, and the bibliographic information of the literatures was taken as mining sample. First, the names of the drugs in the sample were identified by MetaMap package; then, Bicomb software was used to extract high-frequency drugs for the word frequency analysis and to construct a drug-sentence matrix. Finally, “hclust” package and “arules” package of R were used for the cluster analysis and association analysis of drugs. 39 main PCA drugs were screened out. Morphine, dexmedetomidine, and fentanyl were the top three drugs. Through cluster analysis, these drugs were divided into two clusters, one containing 26 common drugs and the other containing 13 core drugs. The association analysis of these drugs was carried out, and 22 frequent itemsets and 6 association rules were obtained. The maximum frequent 1-itemset was {Morphine} and the maximum frequent 2-itemset was {Morphine, Ropivacaine}. The research results have certain guidance and reference value for clinicians and researchers. In addition, it provides a way to study the relationship between drugs from the perspective of text mining.

scholarly journals Study on the main drugs and drug combinations of patient-controlled analgesia based on text mining

2019 ◽  
Author(s):  
Xing Jin ◽  
Ying Wu ◽  
Lei Hou
Keyword(s):  
Cluster Analysis ◽  
Text Mining ◽  
Association Analysis ◽  
Reference Value ◽  
Multimodal Analgesia ◽  
Patient Controlled Analgesia ◽  
Combination Rules ◽  
Pubmed Database ◽  
Pain Knowledge

Abstract Background In recent years, with the continuous understanding of pain knowledge and the continuous improvement of quality of life requirements, patient-controlled analgesia (PCA) has been widely used in a variety of pain patients. In the treatment of PCA, more and more patients use multimodal analgesia (MMA). In this study, text mining technology was used to analyze relevant literatures, try to find out the main drugs of PCA, classify the drugs, and dig out the important drug combination rules. Methods PCA literatures were retrieved from Pubmed database in recent 10 years, and the bibliographic information of the literatures was taken as mining samples. First, the names of the drugs in the sample is identified by MetaMap package, then Bicomb software was used to extract high-frequency drugs for word frequency analysis and to construct a drug-phrase matrix. Finally, ‘hclust’ package and ‘arules’ package of R were used for cluster analysis and association analysis of drugs. Results 39 main PCA drugs were screened out, Morphine, Dexmedetomidine and Fentanyl were the top three drugs. Through cluster analysis, these drugs are divided into two clusters, one containing 26 common drugs and the other containing 13 core drugs. The association analysis of these drugs was carried out and 22 frequent itemsets and 6 association rules were obtained. The maximum frequent 1-itemsets were {Morphine} and the maximum frequent 2-itemsets were {Morphine, Ropivacaine}. Conclusions The research results have certain guidance and reference value for clinicians and researchers. In addition, it provides a way to study the relationship between drugs from the perspective of text mining.

Azithromycin-induced Aphthous Stomatitis: A Case Series

2019 ◽  
Vol 14 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Ehsan T. Moghadam ◽  
Ali Tafazoli
Keyword(s):  
Adverse Effect ◽  
Medical Literature ◽  
Relevant Literature ◽  
Case Series ◽  
Database Search ◽  
Aphthous Stomatitis ◽  
Search Process ◽  
Pubmed Database ◽  
One Year

Background: Azithromycin is one of the most popular antibiotics in current clinical practice. This medication generally considered to be safe and well-tolerated in different demographic populations. Like any other drug, azithromycin use is not without risk and adverse effects. In recent years, cardiovascular accidents have been announced as its major and most important side effect. But azithromycin use can be accompanied with less recognized complications which are significantly discomforting. In this article, we presented a neglected adverse effect of azithromycin in medical literature which is aphthous stomatitis. Methods: We detected three cases with this complication in our center during a one-year period. All the accessible clinical data were recorded and PubMed database was explored to assess the relevant literature. Results: The patients had aphthous stomatitis within 24 hours of the first dose which was healed in about 2 to 3 weeks. Naranjo scoring system showed a probable stage for this adverse drug reaction. There was no such a report in our database search process. Conclusion:: It could be stated that aphthous stomatitis is an important adverse effect of azithromycin that can affect the patient’s quality of life during therapy and in the majority of cases, it can be neglected by healthcare practitioners.

Determination of Traces Heavy Metals from Solid Residues Formed by Combustion of Lignite in Relation to Degree of Accessibility in Soil and Plants

2017 ◽  
Vol 68 (10) ◽  
pp. 2363-2366
Author(s):  
Delia Nica Badea
Keyword(s):  
Heavy Metals ◽  
Power Plant ◽  
Thermal Power ◽  
Reference Value ◽  
Combustion Products ◽  
Toxic Heavy Metals ◽  
Area Of Influence ◽  
Risk Potential

The paper evaluates the presence and content of traces of heavy metals Hg, Pb, Ni, Cd (total forms) from coal and solid combustion products, the degree of transfer and accessibility in the area of influence of a lignite power plant. The content of toxic heavy metals in residues are characterized by RE Meiji [ 1 (Pb and Hg) and REMeij �1 (Ni and Cd) for the filter ash. Pb and Ni content in the soil exceeds normal values, and Pb exceeds and alert value for sensitive soils around the residue deposit (70.20 mg.Kg-1). The degree of accessibility of the metals in plants (TF), reported at the Khan reference value (0.5), indicates a significant bioaccumulation level for the metals: Cd (1.9) and Hg (0.6) inside the deposit; Cd (0.39) at the base of the deposit, Hg (0.8) in the area of the thermal power plant. The trace levels of heavy metals analyzed by GFAAS and CVAAS (Hg), indicates a moderate risk potential for food safety and quality of life in the studied area.

Methods for the Determination of the Purity of Exosomes

2020 ◽  
Vol 25 (42) ◽  
pp. 4464-4485 ◽  
Author(s):  
Katarzyna Kluszczyńska ◽  
Liliana Czernek ◽  
Wojciech Cypryk ◽  
Łukasz Pęczek ◽  
Markus Düchler
Keyword(s):  
Drug Transport ◽  
Biological Fluids ◽  
Drug Carriers ◽  
Biological Functions ◽  
Isolation And Purification ◽  
Pubmed Database ◽  
High Concentrations ◽  
Targeted Release

Background: Exosomes open exciting new opportunities for advanced drug transport and targeted release. Furthermore, exosomes may be used for vaccination, immunosuppression or wound healing. To fully utilize their potential as drug carriers or immune-modulatory agents, the optimal purity of exosome preparations is of crucial importance. Methods: Articles describing the isolation and purification of exosomes were retrieved from the PubMed database. Results: Exosomes are often separated from biological fluids containing high concentrations of proteins, lipids and other molecules that keep vesicle purification challenging. A great number of purification protocols have been published, however, their outcome is difficult to compare because the assessment of purity has not been standardized. In this review, we first give an overview of the generation and composition of exosomes, as well as their multifaceted biological functions that stimulated various medical applications. Finally, we describe various methods that have been used to purify small vesicles and to assess the purity of exosome preparations and critically compare the quality of these evaluation protocols. Conclusion: Combinations of various techniques have to be applied to reach the required purity and quality control of exosome preparations.

Yoga and Wellness—Key Insights from the Study on General Yoga Programme

2021 ◽  
Vol 14 (1) ◽  
pp. 51-63
Author(s):  
Rabindra Acharya ◽  
Gopal P. Mahapatra ◽  
Kadamibini Acharya
Keyword(s):  
Relevant Literature ◽  
Health And Wellness ◽  
Human Beings ◽  
Recent Past ◽  
Facilitative Role ◽  
Quality Of Living ◽  
The Impact ◽  
Simplified Form

Human beings have always strived towards excellence and progress since time immemorial. Industrialisation, automation and technological disruptions have led to increased comfort and quality of living of human beings and enhanced output, productivity and efficiency. Consequently, of late, health and wellness are receiving increased attention globally. Stress and stress-related diseases and workplace-related ailments have significantly increased over the last few decades and gained attention from society and industrial organisations. In the recent past, in the coronavirus pandemic context, wellness has been focused upon in many countries, communities and organisations worldwide. Yoga has been part of the Indian ethos for centuries. In this article, the authors discuss the General Yoga Programme (GYP), its broad coverage, and the impact it has had on the participants in terms of their wellness. With the help of a survey of the participants and linking it to relevant literature and research in the field, the authors highlight how GYP is a useful tool for enhancing various wellness dimensions. They recommend that GYP in its simplified form can be extended to the workplace; and also, HR professionals can play a facilitative role in the process.

scholarly journals Identification of Research Trends in Aging in Place Using Text Mining Analysis

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 50-50
Author(s):  
Ha Neul Kim ◽  
Seok In Nam
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Text Mining ◽  
Independent Living ◽  
Daily Life ◽  
Aging In Place ◽  
Research Trends ◽  
Life Activity ◽  
Daily Life Activity

Abstract Since 1980s professionals and social service providers have focused on aging at the place where people lived. This is the initial concept of the Aging in Place (AIP). Over 40 years, the topics have developed and extended to other disciplines welcoming different perspectives in the study of AIP. Therefore, this study aims to understand the overall research trends in Aging in Place (AIP) studies using text mining analysis to track the evolvement of AIP subtopics not only in Gerontology but also in various fields. To identify the topic trends, we collected the titles, abstracts, and keywords from 1,372 international articles that were published from 1981 to 2019. Then, keywords were extracted and cleaned based on precedent literature and discussions. We analyzed the keywords based on the degree of centrality and visualized the keyword-networks using VOSviewer and Pajek. Top-most popular keywords are “independent living”, “housing”, “older adults”, “home care”, “daily life activity” and “quality of life.” The change in topic trends shows that in the 1980s to early-2000s, research focused on organization and management level of intervention, home(housing) for the older adults, long term care. In the mid-2010s, health-related topics such as daily life activity, health service, health care delivery and quality of life have emerged. Recently, the topics have extended further to technology, caregiver, well-being, and environment design, environmental planning that support independent living of oneself. The research result shows that the interdisciplinary approach regarding AIP is not only inevitable but also encouraged for an in-depth discussion of the field.

scholarly journals Evaluation of Environmental Information Disclosure of Listed Companies in China’s Heavy Pollution Industries: A Text Mining-Based Methodology

2021 ◽  
Vol 13 (10) ◽  
pp. 5415
Author(s):  
Rongjiang Cai ◽  
Tao Lv ◽  
Xu Deng
Keyword(s):  
Text Mining ◽  
Information Disclosure ◽  
Listed Companies ◽  
Environmental Information ◽  
Evaluation Framework ◽  
Scoring Method ◽  
Study Results ◽  
Environmental Information Disclosure ◽  
Heavy Pollution

Environmental information disclosure (EID) of listed companies is a significant and essential reference for assessing their environmental protection commitment. However, the content and form of EID are complex, and previous assessment studies involved manual scoring mainly by the experts in this field. It is subjective and has low timeliness. Therefore, this paper proposes an automatic evaluation framework of EID quality based on text mining (TM), including the EID index system’s construction, automatic scoring of environmental information disclosure quality, and EID index calculation. Furthermore, based on the EID of 801 listed companies in China’s heavy pollution industry from 2013 to 2017, case studies are conducted. The case study results show that the overall quality of the EID of listed companies in China’s heavily polluting industries is low, and there is a gap differentiation between the 16 industries. Compared with the subjective manual scoring method, TM evaluation can evaluate the quality of EID more effectively and accurately. It has great potential and can become an essential tool for the sustainable development of society and listed companies.

scholarly journals Whole Body Vibration Exercises and the Improvement of the Flexibility in Patient with Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Danúbia da Cunha Sá-Caputo ◽  
Pedro Ronikeili-Costa ◽  
Rafaelle Pacheco Carvalho-Lima ◽  
Luciana Camargo Bernardo ◽  
Milena Oliveira Bravo-Monteiro ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Muscle Power ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Mineral Density ◽  
Level Of Evidence ◽  
Body Vibration ◽  
Pubmed Database ◽  
Number Of Publications

Vibrations produced in oscillating/vibratory platform generate whole body vibration (WBV) exercises, which are important in sports, as well as in treating diseases, promoting rehabilitation, and improving the quality of life. WBV exercises relevantly increase the muscle strength, muscle power, and the bone mineral density, as well as improving the postural control, the balance, and the gait. An important number of publications are found in the PubMed database with the keyword “flexibility” and eight of the analyzed papers involving WBV and flexibility reached a level of evidence II. The biggest distance between the third finger of the hand to the floor (DBTFF) of a patient with metabolic syndrome (MS) was found before the first session and was considered to be 100%. The percentages to the other measurements in the different sessions were determined to be related to the 100%. It is possible to see an immediate improvement after each session with a decrease of the %DBTFF. As the presence of MS is associated with poorer physical performance, a simple and safe protocol using WBV exercises promoted an improvement of the flexibility in a patient with MS.

scholarly journals Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Sanober Nusrat ◽  
Elsie Gulick ◽  
David Levinthal ◽  
Klaus Bielefeldt
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Fecal Incontinence ◽  
English Language ◽  
Controlled Trial ◽  
Neuromuscular Diseases ◽  
Anorectal Dysfunction ◽  
Pubmed Database ◽  
Marginal Improvement

Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions.

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