scholarly journals Thyrotoxicosis Associated with Ustekinumab Treatment for Psoriasis

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Bayanne Olabi ◽  
Shanti Ayob
Keyword(s):  
Decision Making ◽  
Monoclonal Antibody ◽  
Adverse Effects ◽  
Interleukin 12 ◽  
Long Term Effects ◽  
Thyroid Status ◽  
Large Populations ◽  
Nature Awareness ◽  
Long Term Studies

Biologic treatments have revolutionised the management of psoriasis in recent years; however, data on their safety profile in large populations and long-term effects are being gathered on an ongoing basis. Ustekinumab is a monoclonal antibody that targets interleukin-12/23 used in the treatment of moderate-to-severe psoriasis. Here, we report the case of a 32-year-old Caucasian gentleman who developed thyrotoxicosis following the commencement of ustekinumab treatment. Following control of thyroid status by the Endocrinology team, this recurred after recommencement of ustekinumab on two further occasions over a 5-year period. This is the second known reported association of this nature. Awareness of these possible adverse effects is imperative in managing patients and informing decision-making, and further long-term studies will help elucidate the precise safety profiles of biologic treatments.

scholarly journals How advances in epidemiology are influencing older adult psychiatry

2020 ◽  
Vol 26 (2) ◽  
pp. 104-105
Author(s):  
Natalie Shoham ◽  
Claudia Cooper
Keyword(s):  
Mendelian Randomisation ◽  
Long Term Effects ◽  
Controlled Clinical Trials ◽  
Individual Traits ◽  
Large Populations ◽  
Adult Psychiatry ◽  
Changes In Risk ◽  
Randomised Controlled ◽  
Long Term Studies

SUMMARYShortcomings of randomised controlled clinical trials include their high cost, which often precludes very long-term studies and very large populations, and ethical constraints of randomisation. Observational studies are a valuable alternative and we outline their use in epidemiological research to study very long-term effects of lifestyle and medication on dementia, to explore (using Mendelian randomisation) the association between Alzheimer's dementia and individual traits, and to evaluate population-wide health inequalities and lifespan changes in risk factors for psychiatric illness.

Incest: What do we Really Know about It?

1987 ◽  
Vol 21 (4) ◽  
pp. 430-440 ◽  
Author(s):  
R. Kosky
Keyword(s):  
Adverse Effects ◽  
Sexual Activity ◽  
Sexual Intercourse ◽  
Current Knowledge ◽  
Epidemiological Studies ◽  
Scientific Basis ◽  
Long Term Effects ◽  
Clinical Series ◽  
General Populations

The literature on incest is reviewed. Current knowledge rests on a very insecure scientific basis and has been mainly derived from small, highly selected clinical series. Recently, some important epidemiological studies of general populations have been reported, but the results of prevalence are inconsistent. Overall, however, it appears that incest, when defined in terms of sexual intercourse, occurs in less than 1% of the population, but other forms of intrafamilial sexual activity may affect 10% of females before they are 16 years of age. Some children are more at risk than others. Because information has generally been derived from court or treatment samples, we are unclear about the long-term effects of incest experiences but, overall, the impression is that incest has markedly adverse effects, especially if it is accompanied by violence and threats and is directed, as it usually is, at the young pre-pubescent child.

scholarly journals Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats

2021 ◽  
Vol 22 (16) ◽  
pp. 8899
Author(s):  
Marina Gabaglio ◽  
Erica Zamberletti ◽  
Cristina Manenti ◽  
Daniela Parolaro ◽  
Tiziana Rubino
Keyword(s):  
Adverse Effects ◽  
Chronic Administration ◽  
Female Rats ◽  
Acid Decarboxylase ◽  
Long Term Effects ◽  
Gabaergic Neurotransmission ◽  
Long Term Consequences ◽  
Adolescent Exposure ◽  
Long Term Adverse Effects

Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, delta-9-tetrahydrocannabinol (THC). However, these studies investigated the effects of pure THC, without taking into account other cannabinoids present in the cannabis plant. Interestingly, cannabidiol (CBD) content seems to mitigate some of the side effects of THC, at least in adult animals. Thus, in female rats, we evaluated the long-term consequences of a co-administration of THC and CBD at a 3:1 ratio, chosen based on the analysis of recently confiscated illegal cannabis samples in Europe. CBD content is able to mitigate some of the long-term behavioral alterations induced by adolescent THC exposure as well as long-term changes in CB1 receptor and microglia activation in the prefrontal cortex (PFC). We also investigated, for the first time, possible long-term effects of chronic administration of a THC/CBD combination reminiscent of “light cannabis” (CBD:THC in a 33:1 ratio; total THC 0.3%). Repeated administration of this CBD:THC combination has long-term adverse effects on cognition and leads to anhedonia. Concomitantly, it boosts Glutamic Acid Decarboxylase-67 (GAD67) levels in the PFC, suggesting a possible lasting effect on GABAergic neurotransmission.

scholarly journals Recent advances in understanding and treating vasculitis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1436 ◽  
Author(s):  
Matthew J. Koster ◽  
Kenneth J. Warrington
Keyword(s):  
Monoclonal Antibody ◽  
Clinical Trials ◽  
Long Term Effects ◽  
Dose Frequency ◽  
Treatment Regimens ◽  
Recent Advances ◽  
Short And Long Term ◽  
Anti Cd20 ◽  
Long Term Adverse Effects

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dose, frequency, duration, and long-term effects of treatment. The aim of this article is to provide an overview of the current information, recent advances, ongoing clinical trials, and future treatment possibilities in AAV.

A troubled View of Current Trends in Forensic Psychiatry

1974 ◽  
Vol 2 (2) ◽  
pp. 135-157 ◽  
Author(s):  
Seymour L. Halleck
Keyword(s):  
Decision Making ◽  
Forensic Psychiatry ◽  
Good Reason ◽  
Legal Issues ◽  
Social Conditions ◽  
Decision Making Process ◽  
Long Term Effects ◽  
Social Purpose ◽  
Current Trends

Increasing involvement of psychiatrists in legal issues seems inevitable. As the courts are being asked to resolve more and more social conflicts they have understandably sought the assistance of specialists who allegedly bring expertise and prestige to the decision-making process. While psychiatrists can sometimes help the courts make more informed decisions, there is good reason to question whether much of current psychiatric involvement in legal issues serves a useful social purpose. Psychiatrists are also spending more time in the courtroom defending certain treatments of patients that had never before been questioned. The validity of attacks on certain psychiatric practices and the potential long-term effects on the treatment of patients must be reappraised in terms of current social conditions.

scholarly journals A Cohort Study on Long-Term Adverse Effects of Parental Drinking: Background and Study Design

2015 ◽  
Vol 9s2 ◽  
pp. SART.S23329 ◽  
Author(s):  
Ingunn Olea Lund ◽  
Anne Bukten ◽  
Elisabet E. Storvoll ◽  
Inger Synnøve Moan ◽  
Svetlana Skurtveit ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Adverse Outcomes ◽  
Registry Data ◽  
Long Term Effects ◽  
Risk Levels ◽  
General Population Cohort ◽  
Parental Drinking ◽  
The Rich ◽  
Long Term Adverse Effects

Although many studies have addressed adverse outcomes in children of parents with alcohol abuse/dependence, less is known about the possible long-term effects of more normative patterns of parental alcohol consumption, including drinking at lower risk levels and heavy episodic or binge drinking. The extent of harm from parental drinking may therefore be underestimated. With this research proposal, we describe a project that aims to assess possible long-term adverse effects of parental drinking by combining survey and nationwide registry data. Advantages of a longitudinal general population cohort design include that it allows for detailed information on parental drinking through survey data and identification of possible negative long-term health and social outcomes from exposure to parental drinking 1–19 years after exposure through continuously updated nationwide registers. The rich information available from combining survey and registry data allows us to take into account important confounders, mediators, and moderators.

scholarly journals A Qualitative Study to Identify Perceptual Barriers to Antiretroviral Therapy (ART) Uptake and Adherence in HIV Positive People from UK Black African and Caribbean Communities

2019 ◽  
Vol 23 (9) ◽  
pp. 2514-2521
Author(s):  
Elizabeth Glendinning ◽  
◽  
Johanna Spiers ◽  
Jonathan A. Smith ◽  
Jane Anderson ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Adverse Effects ◽  
Hiv Positive ◽  
Long Term Effects ◽  
Structured Interviews ◽  
Framework Analysis ◽  
Black African ◽  
Black Caribbean ◽  
Feeling Overwhelmed

Abstract To inform the development of interventions to increase uptake and adherence to antiretroviral therapy (ART), we explored perceptions of ART in semi-structured interviews with 52 men and women from UK black African and black Caribbean communities. Verbatim transcripts were analyzed using framework analysis. Perceptions of ART could be grouped into two categories: doubts about the personal necessity for ART and concerns about potential adverse effects. Doubts about necessity stemmed from feeling well, doubts about the efficacy of ART, religious beliefs and the belief that treatment was futile because it could not cure HIV. Concerns about adverse effects included the fear that attending HIV services and taking treatment would lead to disclosure of HIV, feeling overwhelmed at the prospect of starting treatment soon after diagnosis, fears about side effects and potential long-term effects, and physical repulsion. The findings will facilitate the development of interventions to increase uptake and adherence to ART.

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