scholarly journals Analysis of the Mechanism and Safety of Bisphosphonates in Patients with Lung Cancer and Bone Metastases

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Gao Zhang ◽  
Hu Gong ◽  
Hanqiao Xu
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Bone Metastases ◽  
Immune Function ◽  
Serum Calcium ◽  
Research Group ◽  
Good Effect ◽  
Control Group ◽  
Inflammatory Factor

Objective. To explore the mechanism and safety of bisphosphonates in patients with lung cancer and bone metastases. Method. A total of 104 patients with lung cancer and bone metastases in our hospital were selected and randomly divided into two groups: control group ( n = 54 ) and research group ( n = 50 ). Chemotherapy was given to the control group, and the research group was treated with bisphosphonate drugs. The quality of life, HAMA, HAMD score, VAS score, treatment effect, serum calcium and KPS score, inflammatory factor levels, and immune function were compared between the two groups. Result. The quality of life in both groups was significantly increased ( P < 0.05 ). The HAMA and HAMD scores of the research group decreased significantly than those of the control group after treatment ( P < 0.05 ). The VAS scores of the two groups were significantly reduced ( P < 0.05 ). The effective rates of treatment in the control group and the research group were 81.5% and 96.0%, respectively. Serum calcium was significantly decreased, and KPS score was significantly increased at weeks 1 and 6 after treatment, and the change was more obvious in the research group ( P < 0.05 ). The levels of inflammatory factors in the two groups were significantly reduced, and the immune indicators were significantly increased. Conclusion. Bisphosphonates have good effect on patients with lung cancer and bone metastases, which can improve anxiety and depression, reduce pain score, improve serum calcium level and immune function, and reduce inflammatory response. Therefore, bisphosphonate drug therapy is worth widely used.

scholarly journals Efficacy and safety of electro-acupuncture (EA) on insomnia in patients with lung cancer: study protocol of a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hongyu Yue ◽  
Shuang Zhou ◽  
Huangan Wu ◽  
Xuan Yin ◽  
Shanshan Li ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Survivors ◽  
Controlled Trial ◽  
Control Group ◽  
Life Questionnaire ◽  
Efficacy And Safety ◽  
Symptom Scale ◽  
Significance Level

Abstract Background Cancer-related insomnia (CRI) is one of the most prevalent complaints among cancer survivors and severely impairs patients’ quality of life. As a popular non-pharmacological alternative treatment, acupuncture provides a good clinical curative effect on insomnia. The aim of this trial is to evaluate efficacy and safety of electro-acupuncture on insomnia in patients with lung cancer. Method This is a protocol for a multicenter randomized single-blinded sham-controlled trial. We will randomly assign 252 eligible patients with lung cancer-related insomnia into two groups at a ratio of 1:1, the treatment group (EA) and the control group (sham EA). All treatment will be given 3 times per week for 8 weeks, and a 12-week follow-up will be conducted. The primary outcome will be measured by the Pittsburgh Sleep Quality Index (PSQI). The secondary outcomes will include sleep parameters recorded from the actigraphy, scores from Quality of Life Questionnaire Core-30 (QLQ-C30), and Patient Health Questionnaire-9 (PHQ-9). All adverse effects during the trial will be assessed by the Treatment Emergent Symptom Scale (TESS). All analyses will be based on ITT principle and performed with the statistical software SPSS (version 24.0) by t test, rank-sum test, chi-square, and so on. A two-sided significance level will be set at 5%. Discussion This large-sample trial protocol will evaluate the efficacy of electro-acupuncture on insomnia in patients with lung cancer. This protocol, if proven to be effective, will contribute to filling the gap in treatment options in the CRI field and provide a promising intervention for insomnia in lung cancer survivors. Trial registration ChiCTR ChiCTR1900026395. Registered on 8 October 2019, http://www.chictr.org.cn/showproj.aspx?proj=44068

scholarly journals Effect of Root Canal Therapy Combined with Full Crown Restoration on the Level of Inflammatory Factors and Chewing Function in Patients with Cracked Teeth and Chronic Pulpitis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Ying Lu ◽  
Ning Wu ◽  
Bin Ma ◽  
Feng Qin
Keyword(s):  
Quality Of Life ◽  
Research Group ◽  
Root Canal ◽  
Serum Levels ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Root Canal Therapy ◽  
Total Incidence

Objective. To explore the clinical effect of root canal therapy combined with full crown restoration in patients with cracked teeth and chronic pulpitis. Methods. From May 2018 to June 2020, 87 patients with cracked teeth and chronic pulpitis in our hospital were selected; the patients were randomly divided into the control group and the research group by random number method. The control group only used root canal therapy; the research group used root canal therapy combined with full crown restoration. The therapeutic effect, levels of inflammatory factors, chewing function, periodontal index, complications, and quality of life were compared between the two groups. Results. The total effective rate of the research group (97.78%) was better than the total effective rate of the control group (85.71%) ( P < 0.05 ). Compared with before treatment, the serum levels of interleukin-1β (IL-1β), IL-6, and C-reactive protein (CRP) of the two groups of patients decreased after treatment. After treatment, compared with the control group, the serum levels of IL-1β, IL-6, and CRP in the research group decreased ( P < 0.05 ). Compared with before treatment, the bite force of teeth and chewing efficiency of the two groups of patients increased after treatment. After treatment, compared with the control group, the bite force of teeth and chewing efficiency of the research group increased ( P < 0.05 ). Compared with before treatment, the plaque index (PLI), probing depth (PD), gingival sulcus bleeding index (BI), and gingival index (GI) of the two groups of patients decreased after treatment. After treatment, compared with the control group, the PLI, PD, BI, and GI of the research group decreased ( P < 0.05 ). The total incidence of complications in the research group was (11.11%), and the total incidence of complications in the control group was (16.67%); there was no significant difference between the two groups ( P > 0.05 ). After treatment, compared with the control group, the quality of life scores of the patients in the research group were reduced ( P < 0.05 ). Conclusion. Root canal therapy and full crown restoration have a definite curative effect in patients with cracked teeth and chronic pulpitis, which can improve the inflammatory response, restore chewing function, maintain periodontal health, improve the quality of life, and do not increase the incidence of complications, so it has good application value.

scholarly journals Impact of Educational Self-Efficacy Enhancement Program on Quality of Life, Pain Management, Self-Efficiency Behaviors and Its Impact of Satisfaction among Adults Diabetic Patients with Peripheral Neuropathy Pain: A Randomized Control Trial

2021 ◽  
Author(s):  
Jawad AHMAD Abu-Shennar ◽  
Nurhan Bayraktar
Keyword(s):  
Quality Of Life ◽  
Peripheral Neuropathy ◽  
Pain Management ◽  
Research Group ◽  
Self Efficacy ◽  
Controlled Study ◽  
Control Group ◽  
Diabetic Patients ◽  
Life Questionnaire

Abstract Background: Peripheral neuropathy pain is common among adult diabetic patients worldwide. Lifestyle behavior modification such as proper diet and exercise, quitting smoking, weight control and regular follow up, as well as enhancement of self-efficacy among adult diabetic patients can be helpful in managing peripheral neuropathy pain and, therefore, improving their quality of life and satisfaction.Aims: This study aims to investigate educational self-efficacy enhancement program's impact on pain management, self-efficiency behaviors, quality of life and satisfaction among adult diabetic patients with peripheral neuropathy pain.Materials and Methods: This randomized controlled study was conducted between October and March 2020 at the Jordanian Ministry of Health settings, where 72 adult diabetic patients with peripheral neuropathy pain were randomly assigned into research group (n = 36) or control group (n = 36), after obtaining ethical approval and informed consents. An educational self-efficacy enhancement program was implemented in the research group only. The instrument used for data collection consisted of Demographic Data Form, Diabetes Pain Intensity Scale, Self-Efficacy Scale, Quality of Life Questionnaire (EQ-5D) and Patient Satisfaction Questionnaire.Results: Statistically significant improvements in pain levels (p = 0.020), self-efficacy score (p = 0.000), quality of life scores (p = 0.000) and best imagined health status (p = 0 .000) were found among research group participants. Furthermore, multiple-linear regression models showed that the implementation of educational self-efficacy enhancement program significantly increased the explained variance of self-efficacy scores (R2 = 0.746, p = 0.000) and quality of life scores (R2 = 0.746, p = 0.000). At the end of implementation, research group participants showed a high overall satisfaction levels (4.33 out of 5). Conclusion: The findings suggest that an educational self-efficacy enhancement program is effective in modifying adult diabetic patients’ lifestyle, enhancing self-efficacy behaviors, managing peripheral neuropathy pain, improving quality of life and satisfaction among adult diabetic patients. It is, therefore, recommended to expand the implementation of this program among adult diabetic patients with peripheral neuropathy pain.

scholarly journals Bone Metastases in Lung Cancer

2021 ◽  
Author(s):  
Ana C. Belzarena
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Current Treatment ◽  
Common Symptom ◽  
Lung Cancer Patients ◽  
Skeletal Related Events ◽  
And Function

Lung cancer patients frequently present with to bone metastases. Such lesions are responsible for increased morbidity, low quality of life, and increased costs to patients and the health care system. Pain is the most common symptom; however, these lesions also present as skeletal related events (SRE) which include pathological fractures, hypercalcemia, spinal cord and nerve compressions and cause the need for surgery and/or radiotherapy. Even though bone metastases are associated with poor prognosis, current treatment multimodalities continue to improve survival. Awareness and effective treatment of these lesions is paramount to maintain a good quality of life and function in lung cancer patients.

scholarly journals Effects of Behavioral Activation on the Quality of Life and Emotional State of Lung Cancer and Breast Cancer Patients During Chemotherapy Treatment

2017 ◽  
Vol 43 (2) ◽  
pp. 151-180 ◽  
Author(s):  
Concepción Fernández-Rodríguez ◽  
Erica Villoria-Fernández ◽  
Paula Fernández-García ◽  
Sonia González-Fernández ◽  
Marino Pérez-Álvarez
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Behavioral Activation ◽  
Emotional State ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment

Research suggests that the progressive abandonment of activities in cancer patients are related to depression and worse quality of life. Behavioral activation (BA) encourages subjects to activate their sources of reinforcement and modify the avoidance responses. This study assesses the effectiveness of BA in improving quality of life and preventing emotional disorders during chemotherapy treatment. One sample of lung cancer patients and another of breast cancer patients were randomized into a BA experimental group (E.G.lung/4sess. n = 50; E.G.breast/6sess. n = 33) and a control group (C.G.lung/4sess. n = 40; C.G.breast/6sess. n = 35), respectively. In each session and in follow-ups (3/6/9 months), all participants completed different assessment scales. The results converge to show the effectiveness of BA, encouraging cancer patients to maintain rewarding activities which can activate their sources of day-to-day reinforcement and modify their experience avoidance patterns. BA appears to be a practical intervention which may improve social and role functioning and the emotional state of cancer patients during chemotherapy treatment.

Ifosfamide, Carboplatin, and Etoposide With Midcycle Vincristine Versus Standard Chemotherapy in Patients With Small-Cell Lung Cancer and Good Performance Status: Clinical and Quality-of-Life Results of the British Medical Research Council Multicenter Randomized LU21 Trial

2005 ◽  
Vol 23 (33) ◽  
pp. 8371-8379 ◽  
Author(s):  
Nicholas Thatcher ◽  
Wendi Qian ◽  
Peter I. Clark ◽  
Penelope Hopwood ◽  
Robert J. Sambrook ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Performance Status ◽  
Small Cell ◽  
Control Group ◽  
Small Cell Lung ◽  
Standard Chemotherapy

Purpose Ifosfamide, carboplatin, etoposide, and vincristine, alone and in combination, are highly active against small-cell lung cancer (SCLC). This trial was designed to investigate whether survival could be improved by a regimen of all four drugs (ICE-V) compared with standard chemotherapy in patients with SCLC and good performance status, and to assess the patients’ quality of life (QL). Patients and Methods Patients were randomly assigned to receive six cycles of either ICE-V at 4-week intervals without dose reduction or standard chemotherapy administered according to local practice. The recommended standard control regimens were cyclophosphamide, doxorubicin, and etoposide; and cisplatin and etoposide. Results A total of 402 patients were randomly assigned, and 350 (87%) patients have died. Overall survival was longer in the ICE-V group (hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P = .0049), median survival was 15.6 months in the ICE-V group and 11.6 months in the control group, and 2-year survival rates were 20% and 11%, respectively. There was no evidence that the relative survival benefit for ICE-V was less in extensive-stage than in limited-stage patients. An increased rate of septicemia was reported in the ICE-V group (15% v 7% in the control group), but this did not result in an increase in reported treatment-related deaths (four patients [2%] in both groups). The findings on QL were broadly similar in both groups, with some benefit in favor of ICE-V. Conclusion Compared with standard chemotherapy, the ICE-V regimen improves overall survival without QL penalties, despite an increased but manageable level of toxicity.

scholarly journals Effects of Post-Surgical Parenteral Nutrition on Patients with Gastric Cancer

2018 ◽  
Vol 49 (4) ◽  
pp. 1320-1328 ◽  
Author(s):  
Yanchun Jin ◽  
Chunming Yong ◽  
Keyu Ren ◽  
Dan Li ◽  
Hao Yuan
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Parenteral Nutrition ◽  
Immune Function ◽  
Psychological Status ◽  
Control Group ◽  
Study Group ◽  
Cd8 Cells ◽  
Group 1

Background/Aims: In this study, we investigated the effect of post-surgical parenteral nutrition on patients with gastric cancer (GC) and its possible mechanism. Methods: A total of 108 patients were invited to assess for eligibility and 28 patients were excluded. The eighty patients were randomized to either a study group (1 L peripheral intravenous nutrition, 700 kcal) or a control group (1 L isotonic electrolyte solution). Parenteral nutrition was started on day 1 post-surgery and maintained for 4-8 days. Levels of albumin (ALB), prealbumin (PAB), hemoglobin (Hb) were measured before and after treatment. Self-rating Scale of Life Quality (SSLQ) and Quality of life (QoL) was assessed to analyze the patients’ quality of life. Psychological status was evaluated using both the Hospital Anxiety and Depression Scale (HADS-A/D) and the Patient Health Questionnaire-9 (PHQ-9). Immune function was evaluated by flow cytometric analysis of the levels of CD3+, CD4+, and CD8+ cells. Results: Following post-surgical parenteral nutrition, the levels of ALB, PAB and Hb were significantly higher in the study group than those in the control group. QoL and SSLQ scores were also significantly increased, while HAD-A/D and PHQ-9 scores were significantly reduced. Furthermore, the percentages of CD3+ and CD4+ cells, but not CD8+ cells, as well as the CD4+/CD8+ ratio were significantly increased in the study group. There were no significant differences in these parameters between the control and study group prior to surgery. Conclusion: The results suggest that post-surgical parenteral nutrition can significantly improve the nutritional and psychological status, QoL, and immune function of patients treated surgically for GC.

scholarly journals Effect of Bisphosphonates, Denosumab, and Radioisotopes on Bone Pain and Quality of Life in Patients with Non–Small Cell Lung Cancer and Bone Metastases: A Systematic Review

2016 ◽  
Vol 11 (2) ◽  
pp. 155-173 ◽  
Author(s):  
Lizza E.L. Hendriks ◽  
Bregtje C.M. Hermans ◽  
Marieke H.J. van den Beuken—van Everdingen ◽  
Monique M.H. Hochstenbag ◽  
Anne-Marie C. Dingemans
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Systematic Review ◽  
Small Cell Lung Cancer ◽  
Bone Metastases ◽  
Cell Lung Cancer ◽  
Bone Pain ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study

2018 ◽  
Vol 129 (1) ◽  
pp. 71-83 ◽  
Author(s):  
Sidsel Bragstad ◽  
Marianne Flatebø ◽  
Gerd Karin Natvig ◽  
Geir Egil Eide ◽  
Geir Olve Skeie ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Brain Metastases ◽  
Bone Metastases ◽  
Gamma Knife ◽  
Gamma Knife Surgery ◽  
Female Sex ◽  
Patient Reported

OBJECTIVELung cancer (LC) patients who develop brain metastases (BMs) have a poor prognosis. Estimations of survival and risk of treatment-related deterioration in quality of life (QOL) are important when deciding on treatment. Although we know of several prognostic factors for LC patients with BMs, the role of QOL has not been established. Authors of this study set out to evaluate changes in QOL following Gamma Knife surgery (GKS) for BMs in LC patients and QOL as a prognostic factor for survival.METHODSForty-four of 48 consecutive LC patients with BMs underwent GKS in the period from May 2010 to September 2011, and their QOL was prospectively assessed before and 1, 3, 6, 9, and 12 months after GKS by using the Functional Assessment of Cancer Therapy–Brain (FACT-BR) questionnaire. A mixed linear regression model was used to identify potential predictive factors for QOL and to assess the effect of GKS and the disease course on QOL at follow-up.RESULTSMean QOL as measured by the brain cancer subscale (BRCS) of the FACT-BR remained stable from baseline (score 53.0) up to 12 months post-GKS (57.1; p = 0.624). The BRCS score improved for 32 patients (72.3%) with a total BM volume ≤ 5 cm3. Mean improvement in these patients was 0.45 points each month of follow-up, compared to a decline of 0.50 points each month despite GKS treatment in patients with BM volumes > 5 cm3 (p = 0.04). Asymptomatic BMs (p = 0.01), a lower recursive partitioning analysis (RPA) classification (p = 0.04), and a higher Karnofsky Performance Scale (KPS) score (p < 0.01) at baseline were predictors for a high, stable QOL after GKS. After multivariate analysis, a high KPS score (p < 0.01) remained the only positive predictor of a high, stable QOL post-GKS.Median survival post-GKS was 5.6 months (95% CI 1.0–10.3). A higher BRCS score (p = 0.01), higher KPS score (p = 0.01), female sex (p = 0.01), and the absence of liver (p = 0.02), adrenal (p = 0.02), and bone metastases (p = 0.03) predicted longer survival in unadjusted models. However, in multivariate analyses, a higher BRCS score (p < 0.01), female sex (p = 0.01), and the absence of bone metastases (p = 0.02) at GKS remained significant predictors. Finally, the BRCS score’s predictive value for survival was compared with the values for the variables behind well-known prognostic indices: age, KPS score, extracranial disease status, and number and volume of BMs. Both BRCS score (p = 0.01) and BM volume (p = 0.05) remained significant predictors for survival in the final model.CONCLUSIONSPatient-reported QOL according to the BRCS is a predictor of survival in patients with BMs and may be helpful in deciding on the optimal treatment. Gamma Knife surgery is a safe and effective therapeutic modality that improves QOL for LC patients with a BM volume ≤ 5 cm3 at treatment. Careful follow-up and salvage therapy on demand seem to prevent worsening of QOL due to relapse of BMs.

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