scholarly journals Value of Magnifying Chromoendoscopy and Magnifying Optical Enhancement Technology in Classifying Colorectal Polyps: A Prospective Controlled Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Ying-Hao Song ◽  
Ruo-Xin Xu ◽  
Yong Zhang ◽  
Meng-Xuan Xing ◽  
Li-Dong Xu ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Diagnostic Value ◽  
Colorectal Polyps ◽  
Controlled Study ◽  
Predictive Values ◽  
Enhancement Technology ◽  
Polyp Type ◽  
Magnifying Chromoendoscopy ◽  
Virtual Chromoendoscopy ◽  
Sensitivity Specificity

Background and Aims. Magnifying chromoendoscopy (ME-CE) through the observation of pit patterns is a productive way to distinguish between neoplastic and nonneoplastic polyps. Magnifying optical enhancement technology (ME-OE) is an emerging virtual chromoendoscopy imaging technology and appeared to be a promising approach. However, this information is currently not available. This study is aimed at comparing the differential diagnostic value of ME-CE and OE for neoplastic and nonneoplastic polyps. Patients and Methods. Consecutive patients undergoing colonoscopy were randomized (1 : 1) into examination by ME-OE or ME-CE. Histopathological findings were utilized as the reference standard. Accuracy, sensitivity, specificity, and positive and negative predictive values of two endoscopy methods were compared using ME-OE (were classified according to the JNET classification) and ME-CE (were classified according to the Kudo pit pattern classification), respectively, and the time to predict the histological polyp type was compared. And the agreements between the pathological and clinical diagnosis by ME-OE or ME-CE were analyzed. Results. A total of 365 polyps were found in the 220 patients included (ME-OE: 185; ME-CE: 180.202 had nonneoplastic polyps, 163 had neoplastic polyps). The diagnostic accuracy of ME-OE was higher than that of ME-CE (93% vs. 92%, p > 0.05 ). The average diagnosis time was lower in ME-OE than ME-CE ( 83 ± 26.4   s vs. 194 ± 17.7   s , p < 0.001 ). The agreements between the pathological and clinical diagnosis were at least substantial in both groups. Conclusion. ME-OE was superlative to ME-CE in predicting the histology of polyps. OE devoted classification would possibly similarly enhance the endoscopist performance. The trial is registered with ChiCT2000032075.

Clinical Diagnostic Value of Two-Dimensional and Four-Dimensional Echocardiography in Fetal Cardiac Tumor

2021 ◽  
Vol 7 (5) ◽  
pp. 1271-1278
Author(s):  
Jing Wang ◽  
Yu Zhang ◽  
Yushi Zhang ◽  
Lin Zhang* ◽  
Xiaojie Pan ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Cardiac Tumor ◽  
Diagnostic Value ◽  
Ultrasonic Diagnosis ◽  
Pathological Examination ◽  
Two Dimensional ◽  
Clinical Diagnostic ◽  
Dimensional Echocardiography ◽  
Sensitivity Specificity ◽  
Two Dimensional Echocardiography

This paper aims to investigate the clinical diagnostic value of two-dimensional and four-dimensional echocardiography in fetal cardiac tumor. Material and Methods: A total of 24 pregnant women whose fetus had suspected cardiac tumor in The No.4 Hospital 1946 Jinan Shandong from February 2011 to April 2018 were selected as objects of study, including 18 cases whose fetus was pathologically diagnosed with fetal cardiac tumor (+) and 6 cases whose fetus was diagnosed with fetal cardiac tumor (−). Results:These patients were retrospectively analyzed. The tumor site, size, activity and fetal edema predicted using two-dimensional and four-dimensional ultrasound images were compared with pathological examination results, and the diagnostic value of the two kinds of echocardiography in fetal cardiac tumor was analyzed. The echocardiographic results revealed that there were no statistically significant differences in the four-dimensional ultrasonic diagnosis and two-dimensional ultrasonic diagnosis results compared with pathological diagnosis results (p>0.05). In terms of the diagnostic value, the sensitivity, specificity and diagnostic accordance rate in the clinical diagnosis of fetal cardiac tumor were 66.67%, 50.00% and 62.5%, respectively, in two-dimensional echocardiography, and 94.44%, 83.33% and 91.67%, respectively, in four-dimensional echocardiography. Conclusions: Echocardiography can determine the activity, shape, site, size, etc., of primary cardiac tumor. Two-dimensional and four-dimensional ultrasonic diagnosis can be used to observe the fetal cardiac tumor, thus making an early diagnosis. The sensitivity, specificity and diagnostic accordance rate of four-dimensional echocardiography in the clinical diagnosis of fetal cardiac tumor are significantly higher than those of two-dimensional echocardiography, so four-dimensional echocardiography has higher diagnostic value in fetal cardiac tumor.

scholarly journals Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI

2020 ◽  
Vol 08 (03) ◽  
pp. E360-E367
Author(s):  
Shinichi Kataoka ◽  
Shin-ei Kudo ◽  
Masashi Misawa ◽  
Hiroki Nakamura ◽  
Kenichi Takeda ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Blood Vessel ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Colorectal Polyps ◽  
Hyperplastic Polyps ◽  
Predictive Values ◽  
Neoplastic Lesions ◽  
Sensitivity Specificity ◽  
Time Diagnosis

Abstract Background and study aims Real-time diagnosis of colorectal polyps is needed to prevent unnecessary resection of benign polyps. The vessels in hyperplastic polyps sometimes mimic the characteristic meshed capillary network of neoplastic lesions on non-magnified narrow-band imaging (NBI). Endocytoscopy in conjunction with NBI (EC-NBI) enables more detailed vessel observation. The current study evaluated whether EC-NBI can accurately diagnose small colorectal lesions with visible vessels on non-magnified NBI. Patients and methods This retrospective study was conducted from January to December 2016. During colonoscopy, lesion images were obtained using NBI and EC-NBI. On EC-NBI, lesions were classified as having “clear,” “unclear,” or “invisible” blood vessel margins. All specimens were resected and pathologically examined, and the association between vessel margin findings and pathological diagnosis was assessed. The lesion surface to vessel depth was measured in clear, unclear, and invisible lesions. Results Among 114 adenomas, 108 were clear, while six were unclear. Among 36 hyperplastic polyps, eight were clear, while 28 were unclear. A micro-network (MN) pattern was seen in 106 of 114 adenomas, and four of 36 hyperplastic polyps. The sensitivity, specificity, correct diagnostic rate, and positive and negative predictive values of clear blood vessel margins or a MN pattern as an adenoma index were 98.2 %, 69.4 %, 91.3 %, 91.1 %, and 92.6 %, respectively. EC-NBI correctly diagnosed 69.4 % (25/36) of hyperplastic polyps. The lesion surface–blood vessel distance was greater in unclear versus clear lesions (P < 0.001), and invisible versus unclear lesions (P < 0.001). Conclusions EC-NBI may effectively differentiate hyperplastic polyps with visible vessels from adenomas. Blood vessel depth affects visibility.

scholarly journals Diagnostic accuracy of MRA and MRI for the bursal-sided partial-thickness rotator cuff tears: a meta-analysis

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Tao Huang ◽  
Jian Liu ◽  
Yupeng Ma ◽  
Dongsheng Zhou ◽  
Liang Chen ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Mr Arthrography ◽  
Diagnostic Value ◽  
Rotator Cuff Tears ◽  
Cochrane Library ◽  
Predictive Values ◽  
Partial Thickness ◽  
Sensitivity Specificity

Abstract Background Numerous quantitatively studies have focused on the diagnosis of bursal-sided partial-thickness rotator cuff tears (RCTs); however, the accuracy of magnetic resonance imaging (MRI) and MR arthrography (MRA) remains inconclusive. This study was performed systematically to compare the diagnostic value of MRA and MRI for the bursal-sided partial-thickness RCTs. Methods Three electronic databases, PubMed, Embase, and Cochrane Library, were utilized to retrieve articles comparing the diagnostic value of MRA and MRI for detecting bursal-sided partial-thickness RCTs. After screening and diluting out the articles that met the inclusion criteria to be used for statistical analysis, the pooled evaluation indexes include sensitivity, specificity, positive and negative predictive values, diagnostic odds ratio (DOR), and the area under the receiver operating characteristic curve (AUC). Results Twelve studies involving 1740 patients and 1741 shoulders were identified. The pooled sensitivity, specificity, DOR, and AUC of MRA to diagnose bursal-sided partial-thickness RCTs were 0.77 (95% CI, 0.67–0.85), 0.98 (95% CI, 0.95–0.99), 73.01 (95% CI, 35.01–152.26), and 0.88 (95% CI, 0.85–0.91), respectively. The pooled sensitivity, specificity, DOR, and AUC of MRI were 0.77 (95% CI, 0.66–0.86) and 0.96 (95% CI, 0.81–0.99), and 37.12 (95% CI, 8.08–170.64) and 0.82 (95% CI, 0.78–0.85), respectively. Conclusions This meta-analysis reveals that MRA and MRI have similar diagnostic value for the diagnosis of bursal-sided partial-thickness rotator cuff tears.

Radiographically negative stress-related bone injury

1998 ◽  
Vol 39 (4) ◽  
pp. 416-420 ◽  
Author(s):  
J. Hodler ◽  
H. Steinert ◽  
M. Zanetti ◽  
U. Frölicher ◽  
J. Rogala ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Bone Scintigraphy ◽  
Imaging Modality ◽  
Diagnostic Value ◽  
Bone Diseases ◽  
Two Phase ◽  
Predictive Values ◽  
Bone Injury ◽  
Initial Imaging ◽  
Sensitivity Specificity

Purpose: To assess the diagnostic value of MR imaging relative to two-phase bone scintigraphy in radiographically negative stress-related injuries. Material and Methods: Sixteen consecutive patients presenting with stressrelated bone injuries and normal standard radiographs were examined with two-phase bone scans and MR imaging. MR imaging protocols varied according to the region to be examined. The MR and scintigraphic images were evaluated blindly and separately by respectively two radiologists and two nuclear medicine physicians. The standard of reference was represented by a combination of clinical and scintigraphic findings as well as clinical follow-up. Results: For MR imaging, sensitivity, specificity, and positive and negative predictive values for the presence of stress-related injuries for the two readers were 69/63%, 100/80%, 100/91%, and 50/40%, respectively. Interobserver agreement was good (kappa=0.62). For scintigraphy, all abnormal and normal findings were correctly identified. Conclusion: For patients with clinically suspected stress-related injuries and a low probability of other active bone diseases (such as infection or neoplasm), bone scintigraphy should be the initial imaging modality.

scholarly journals TP8.1.12 Diagnostic Utility of MRI in the Evaluation of Potential Malignancy in Patients Presented with Nipple Discharge

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Nixon Phua Cher Yang ◽  
Muhammad Adeel Javed Butt ◽  
Parmvir Singh Nijjar ◽  
Saung Phyu ◽  
Musa Barkeji
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
Ductal Carcinoma ◽  
Nipple Discharge ◽  
Diagnostic Value ◽  
Predictive Values ◽  
Imaging Tool ◽  
Additional Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Sensitivity Specificity

Abstract Aims Nipple discharge is a presentation commonly seen at breast clinics. It is conventionally evaluated with physical examination and sonography( or mammography). The aim of this study is to investigate the diagnostic value of magnetic resonance imaging (MRI) as an additional imaging tool in the evaluation of potential malignancy in patients presented with nipple discharge. Methods A retrospective evaluation of 85 patients with nipple discharge who underwent breast ultrasound (USS) and MRI between 04/06/2008 and 25/10/2019 was conducted. Clinical notes, radiographic reports and biopsy results were reviewed. Sensitivity, specificity, positive predictive value and negative predictive value of USS and MRI were calculated. Results Out of the 85 patients (all female; mean age 45.33 +/- 12.93 years old) with nipple discharge, 11 were found to have biopsy-proven malignancy (invasive ductal carcinoma/ ductal carcinoma in situ; 12.94% risk). USS failed to identify seven malignancies (27.27% sensitivity) while MRI missed three malignancies (72.72% sensitivity). USS falsely identified four malignancies from 74 patients with no malignancy (94.59% specificity) while MRI only falsely identified one case (98.65% specificity). For patients with negative USS results (U1/U2/U3) or negative MRI results (BI-RADS category 1,2 or 3), the negative predictive values of USS is 89.74% while that of MRI is 96.05%. The positive predictive values of USS and MRI are 42.86% and 88.88% respectively. Conclusion Compared to USS, MRI has a higher sensitivity, specificity, positive predictive value and predictive value. It will be a valuable addition to the standard nipple discharge evaluation workup to help rule out malignancy.

scholarly journals Diagnostic Value of Rapid Biophysical Profile in Comparison to Biophysical Profile in Pregnant Women with Insulin-dependent Diabetes

2020 ◽  
Author(s):  
Nasrin Soufizadeh ◽  
Fariba Farhadifar ◽  
Saghar Tamri ◽  
Sara Behafarid ◽  
Karim Sharifi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Roc Curve ◽  
Diagnostic Value ◽  
Insulin Dependent Diabetes ◽  
Care Process ◽  
Predictive Values ◽  
Biophysical Profile ◽  
Insulin Dependent ◽  
Sensitivity Specificity

Objective: Having a rapid and low cost diagnostic approach in assessment of fetal wellbeing is an important goal for prenatal care process. The aim of this study was to determine the diagnostic value of rapid biophysical profile (rBPP) in comparison to biophysical profile (BPP). Materials and methods: In this study 142 pregnant women with insulin-dependent diabetes referred to Besat Hospital (Sanandaj, Iran) were evaluated in terms of fetal health. Age, gestational age and non-stress test (NST) data of patients were collected. The fetuses were evaluated using the standard BPP and selected rBPP methods. Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were calculated. The receiver operating characteristic (ROC) curve was plotted. The data were analyzed in Stata 14 software, using appropriate statistical analyses. Results: The mean ± standard deviation (SD) of maternal age and gestational age of the studied subjects were 30.6 ± 6.3 and 35.6 ± 1.5 weeks, respectively. The frequency of normal cases were 126 (88.7%) in the BPP method and 121 (85.2%) in the rBPP method. The results showed that sensitivity, specificity, PPV and NPV of rBPP in this study were 56.2%, 90.5%, 42.8% and 94.2%, respectively. The area under the ROC curve was 73.3%. Pearson Test showed a significant correlation between scores obtained through BPP and rBPP methods (p < 0.001). Conclusion: Considering the high profile of the sensitivity and PPV of the RBPP method compared to BPP, rBPP method has a better capacity to discriminate non-distressed fetuses from distress-exposed fetuses. It can also be used as a quick and easy method in crowded centers with limited evaluation tests, where not much skill is needed.

scholarly journals Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms

Digestion ◽  
2020 ◽  
pp. 1-13
Author(s):  
Masaya Esaki ◽  
Takeshi Yamamura ◽  
Masanao Nakamura ◽  
Keiko Maeda ◽  
Tsunaki Sawada ◽  
...  
Keyword(s):  
Colorectal Neoplasms ◽  
Endoscopic Ultrasound ◽  
Interobserver Agreement ◽  
Diagnostic Yield ◽  
Ultrasound Elastography ◽  
Depth Of Invasion ◽  
Clinical Issue ◽  
Predictive Values ◽  
Magnifying Chromoendoscopy ◽  
Sensitivity Specificity

<b><i>Introduction:</i></b> We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated with the risk of metastasis. <b><i>Methods:</i></b> Consecutive patients with suspected superficial colorectal neoplasms, evaluated by MCE, EUS, and EUS-EG, for whom endoscopic submucosal dissection was considered, were enrolled in 2018 (derivation study) and in 2019–2020 (validation study). The primary clinical endpoint was the diagnostic yield differentiating intramucosal and shallow submucosal neoplasms from deep submucosal (dSM) and advanced colorectal cancers. In addition, inter- and intra-observer agreements of the elastic score of colorectal neoplasm (ES-CRN) were evaluated by 2 expert and 2 non-expert endoscopists. <b><i>Results:</i></b> Thirty-one (33 lesions) and 50 (55 lesions) patients were enrolled in the derivation and validation studies, respectively. Sensitivity, specificity, positive, and negative predictive values, and accuracy of assessment of the depth of submucosal or deeper invasion in the derivation and validation groups were as follows: EUS-EG, 100/88.2/86.7/100/93.3% and 77.8/86.1/73.7/88.6/83.3%; MCE, 66.7/94.4/90.9/77.3/81.8% and 84.2/91.4/84.2/91.4/88.9%; and EUS, 93.3/77.8/77.8/93.3/84.8% and 89.5/65.7/58.6/92.0/74.1%, respectively. For the 2 expert endoscopists, interobserver agreement for the ES-CRN (first and second assessments) in the derivation group was 0.84 and 0.78, respectively; these values were 0.73 and 0.49, respectively, for the 2 non-expert endoscopists. <b><i>Discussion/Conclusion:</i></b> All 3 modalities presented similar diagnostic yield. Inter- and intra-observer agreements of the ES-CRN were substantial, even for non-expert endoscopists. Therefore, EUS-EG may be a useful modality in determining the depth of invasion in colorectal neoplasms.

Feasibility of Thyroid Imaging Reporting and Data System Classification in Predicting Thyroid Malignancy

2019 ◽  
Vol 85 (12) ◽  
pp. 1345-1349
Author(s):  
Ahmet Cem Dural ◽  
Nuri Alper Sahbaz ◽  
Cevher Akarsu ◽  
Sezer Akbulut ◽  
Rustu Turkay ◽  
...  
Keyword(s):  
Predictive Value ◽  
Daily Practice ◽  
Diagnostic Value ◽  
Data System ◽  
Thyroid Malignancy ◽  
Predictive Values ◽  
Thyroid Imaging ◽  
Ultrasound Findings ◽  
Risk Of Malignancy ◽  
Sensitivity Specificity

In this study, we aimed to evaluate the diagnostic value of thyroid imaging reporting and data system (TIRADS) in the estimation of malignancy and assess the concordance between TIRADS and the histopathology results of the postoperative specimens. Consecutive ultrasound imaging records of patients with multinodular goiter from January 2010 to December 2017 who underwent surgery were retrospectively reviewed. The risk of malignancy of each TIRADS category was determined, and correlation with pathology was assessed. The patients with malignant cytology findings (Bethesda 6) who were categorized TIRADS 6 were excluded from the study. The positive and negative predictive values, sensitivity, specificity, and accuracy of the TIRADS classification were calculated on a 2 x 2 table with their own formulas. A total of 1457 patients were evaluated, and 1122 of these were included in the study. The risk of malignancy for nodules evaluated as TIRADS 2 was 0.6 per cent, TIRADS 3 was 13.1 per cent, TIRADS 4a was 20 per cent, TIRADS 4b was 61.1 per cent, TIRADS 4c was 85.7 per cent, and TIRADS 5 was 93.3 per cent. The positive predictive value of TIRADS classification was found to be 43.4 per cent, negative predictive value was found to be 90.7 per cent, sensitivity was found to be 78 per cent, specificity was found to be 68.4 per cent, and accuracy was found to be 70.7 per cent for our institution. The TIRADS classification based on suspicious ultrasound findings is reliable in predicting thyroid malignancy and can be routinely used in daily practice.

Assessment of the diagnostic value of microsatellite instability in the urine of bladder cancer patients.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 384-384
Author(s):  
Hussein Mustafa Khaled ◽  
Abdel-Rahman Zekri ◽  
Mai B Mohamed ◽  
Fatma M Diab ◽  
Mona Abdellateif ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Microsatellite Instability ◽  
Tumor Tissue ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Urine Samples ◽  
Tissue Samples ◽  
Predictive Values ◽  
Promising Tool ◽  
Sensitivity Specificity

384 Background: Microsatellite alterations in urine sediments have proved to be a promising tool for detection of bladder cancer (BC) due to its high sensitivity and specificity. Methods: We assessed the possible prognostic and predictive values of microsatellite alterations in tissue samples and urine sediments obtained from Egyptian patients with BC, and their utility as diagnostic, prognostic and predictive value. Microsatellite instability (MSI) and loss of heterozygosity (LOH) were assessed using 13 microsatellite markers in tumor tissue and urine sediments of 30 patients with BC. The concordance between MSI in tissue and urine samples was determined. Results: We found that MSI was more frequent than LOH (100% and 46.7%; respectively). D16S310, MBP and IFN-α showed the highest MSI frequency in urine samples (70%, 70% and 66.67%; respectively), while MBP, ACTBP2 and D9S171 (66.67%, 63.33%, and 60%; respectively) were the most frequently detected in tumor tissue. All markers correlated significantly with the pathological subtypes (more frequent in TCC) and hematuria. The concordance between tissue and urine was statistically significant for , D9S171, D16S476, FGA and ACTBP2 (P = 0.04, 0.015, 0.02 and 0.007; respectively). When we combined D16S476 and D9S171, the sensitivity, specificity, PPV and NPV reached (80.0%, 75.0%, 82.8% and 71.4%; respectively) for diagnosis of BC . Conclusions: Thus MSI in urine sediments could be a sensitive and reliable method for diagnosis of BC.

scholarly journals PP13 and PAPP-A in the First and Second Trimesters: Predictive Factors for Preeclampsia?

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Narges Moslemi Zadeh ◽  
Farshad Naghshvar ◽  
Sepideh Peyvandi ◽  
Parand Gheshlaghi ◽  
Sara Ehetshami
Keyword(s):  
Early Diagnosis ◽  
Predictive Factors ◽  
Statistical Tests ◽  
Protein A ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Control Group ◽  
Case Group ◽  
Predictive Values ◽  
Sensitivity Specificity

Background. Preeclampsia affects 5-6% of all pregnancies. Predictive factors of preeclampsia can be helpful in early diagnosis of this disease. In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia. Methods. This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011. Blood samples were drawn in weeks 11–13 and 24–28 of pregnancy. Of them who developed preeclampsia were considered as case group. A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age. PAPP-A and PP13 serum levels were measured. Data were analyzed using proper statistical tests. Results. PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia (P<0.001). The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia. Conclusion. It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.

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