scholarly journals Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Pengyu Gao ◽  
Dan Zou ◽  
Ansha Zhao ◽  
Ping Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cell Function ◽  
Survival Rates ◽  
Circulatory System ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Design And Optimization ◽  
Targeting Efficiency ◽  
Blood Circulatory System

Achievement of high targeting efficiency for a drug delivery system remains a challenge of tumor diagnoses and nonsurgery therapies. Although nanoparticle-based drug delivery systems have made great progress in extending circulation time, improving durability, and controlling drug release, the targeting efficiency remains low. And the development is limited to reducing side effects since overall survival rates are mostly unchanged. Therefore, great efforts have been made to explore cell-driven drug delivery systems in the tumor area. Cells, particularly those in the blood circulatory system, meet most of the demands that the nanoparticle-based delivery systems do not. These cells possess extended circulation times and innate chemomigration ability and can activate an immune response that exerts therapeutic effects. However, new challenges have emerged, such as payloads, cell function change, cargo leakage, and in situ release. Generally, employing cells from the blood circulatory system as cargo carriers has achieved great benefits and paved the way for tumor diagnosis and therapy. This review specifically covers (a) the properties of red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, and mesenchymal stem cells; (b) the loading strategies to balance cargo amounts and cell function balance; (c) the cascade strategies to improve cell-driven targeting delivery efficiency; and (d) the features and applications of cell membranes, artificial cells, and extracellular vesicles in cancer treatment.

scholarly journals Insights into Multifunctional Nanoparticle-Based Drug Delivery Systems for Glioblastoma Treatment

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2262
Author(s):  
Mohd Khan ◽  
Subuhi Sherwani ◽  
Saif Khan ◽  
Sultan Alouffi ◽  
Mohammad Alam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Survival Rates ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Membrane Receptors ◽  
Therapeutic Effects ◽  
Microvascular Proliferation

Glioblastoma (GB) is an aggressive cancer with high microvascular proliferation, resulting in accelerated invasion and diffused infiltration into the surrounding brain tissues with very low survival rates. Treatment options are often multimodal, such as surgical resection with concurrent radiotherapy and chemotherapy. The development of resistance of tumor cells to radiation in the areas of hypoxia decreases the efficiency of such treatments. Additionally, the difficulty of ensuring drugs effectively cross the natural blood–brain barrier (BBB) substantially reduces treatment efficiency. These conditions concomitantly limit the efficacy of standard chemotherapeutic agents available for GB. Indeed, there is an urgent need of a multifunctional drug vehicle system that has potential to transport anticancer drugs efficiently to the target and can successfully cross the BBB. In this review, we summarize some nanoparticle (NP)-based therapeutics attached to GB cells with antigens and membrane receptors for site-directed drug targeting. Such multicore drug delivery systems are potentially biodegradable, site-directed, nontoxic to normal cells and offer long-lasting therapeutic effects against brain cancer. These models could have better therapeutic potential for GB as well as efficient drug delivery reaching the tumor milieu. The goal of this article is to provide key considerations and a better understanding of the development of nanotherapeutics with good targetability and better tolerability in the fight against GB.

Circulatory Cells as Tumortropic Carrier for Targetability Improvement

2020 ◽  
Vol 17 ◽  
Author(s):  
Dan Zou ◽  
Yajun Weng ◽  
Ping Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Function ◽  
Incubation Temperature ◽  
Survival Rates ◽  
Controlled Drug Release ◽  
Membrane Receptors ◽  
Circulation Time ◽  
Targeting Efficiency

Background: How to achieve high targeting efficiency for drug delivery system is still one of the most important issues that tumor diagnosis and non-surgical therapies faced. Although nanoparticle-based drug delivery system made an amount of progress in extending circulation time, improving targetability, controlled drug release etc., yet the targeting efficiency remained low, and the development was limited to reduce side effects with overall survival rates unchanged or improved a little. Objective: This paper aims to review current researches on the cell-driven drug delivery systems, and discuss the potential obstacles and directions for cell-based cancer therapies and diagnosis. Methods: More than one hundred references were collected, and this paper focused on red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, mesenchymal stem cells, cell membrane, artificial cells and extracellular vesicles, then summarized 1) the utilizable properties, 2) balancing cargo-loading amounts and cell function, 3) cascade strategies for targetability improvement. Main findings: circulatory cells and their derivatives were featured by good biocompatibility, long circulation time in blood, unique chemo-migration and penetration ability. On the base of backpack and encapsulation approach, cargo loading amounts and cell function could be balanced through regulating membrane receptors, particle material/size/shape/structure and incubation temperature, etc. The cell-driven drug delivery system met most of the demands that nanoparticle-based delivery system failed to for effective tumortropic delivery. Conclusion: Despite of new challenges, cell-driven drug delivery system generally brought great benefits to and shed a light on for cancer therapy and diagnosis.

Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

2021 ◽  
Vol 61 ◽  
pp. 102241
Author(s):  
Kantaporn Kheawfu ◽  
Surachai Pikulkaew ◽  
Thomas Rades ◽  
Anette Müllertz ◽  
Louise von Gersdorff Jørgensen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Clove Oil ◽  
Design And Optimization

Recent Strategic Developments in the Use of Superdisintegrants for Drug Delivery

2020 ◽  
Vol 26 (6) ◽  
pp. 701-709
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Drug Bioavailability ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Innovative Materials

Improving drug bioavailability in the pharmaceutical field is a challenge that has attracted substantial interest worldwide. The controlled release of a drug can be achieved with a variety of strategies and novel materials in the field. In addition to the vast development of innovative materials for improving therapeutic effects and reducing side effects, the exploration of remarkable existing materials could encourage the discovery of diverse approaches for adapted drug delivery systems. Recently, superdisintegrants have been proposed for drug delivery systems as alternative approaches to maximize the efficiency of therapy. Although superdisintegrants are well known and used in solid dosage forms, studies on strategies for the development of drug delivery systems using superdisintegrants are lacking. Therefore, this study reviews the use of superdisintegrants in controlled drug release dosage formulations. This overview of superdisintegrants covers developed strategies, types (including synthetic and natural materials), dosage forms and techniques and will help to improve drug delivery systems.

Delivery Systems for RNA Interference Therapy: Current Technologies and Limitations

2020 ◽  
Vol 20 (5) ◽  
pp. 356-372
Author(s):  
Yi Wang
Keyword(s):  
Drug Delivery ◽  
Rna Interference ◽  
Drug Delivery Systems ◽  
Viral Vectors ◽  
Therapeutic Potential ◽  
Circulatory System ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Innovative Drug ◽  
Target Disease

In recent years, RNA interference technology has been extensively studied for its therapeutic potential against a wide variety of diseases. It aims to silence the expression of undesired genes associated with the target disease by the administration of RNA interference agents. However, these agents (nucleic acids) are unstable in the circulatory system and lack target specificity. Drug delivery systems are, therefore, crucial for the successful practice of the technique. A wide array of delivery systems has been developed to conquer these challenges, such as viral vectors, inorganic drug carriers, polymeric carriers and lipid-based carriers, with, however, significant limitations. In addition to the existing technologies, novel, innovative drug delivery systems, such as the configurable xenobot, are emerging at a rapid pace and have the potential to take the realm of biomedicine to the next level. This review summarizes technical difficulties in the development of drug delivery systems and current technologies developed for delivering RNAi agents with a discussion on their limitations.

scholarly journals Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

2012 ◽  
Vol 431 (1-2) ◽  
pp. 161-175 ◽  
Author(s):  
Ana Maria Sierra Villar ◽  
Beatriz Clares Naveros ◽  
Ana Cristina Calpena Campmany ◽  
Monserrat Aróztegui Trenchs ◽  
Coloma Barbé Rocabert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Design And Optimization ◽  
Enhanced Dissolution

Environment-sensitive hydrogels as potential drug delivery systems for the treatment of periodontitis

2020 ◽  
Vol 10 (7) ◽  
pp. 975-985
Author(s):  
Jie Huang ◽  
Zirun Wang ◽  
Sigdel Krishna ◽  
Qin Hu ◽  
Ming Xuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Alveolar Bone ◽  
Delivery Systems ◽  
Periodontal Pocket ◽  
Therapeutic Effects ◽  
Pathogenic Microorganisms ◽  
Medical Problems ◽  
Treatment Frequency ◽  
Periodontal Tissues

Periodontitis is an inflammatory disease caused by pathogenic microorganisms colonized in periodontal pocket. The disease leading to the destruction of periodontal tissues including gums, periodontal ligaments, dental cementum and alveolar bone has been regarded as a latent risk factor of other medical problems. The therapeutic effects of periodontitis are unsatisfactory currently, though a great many strategies have been used to enhance the results of its treatments. Recently, environment-sensitive hydrogels have been proposed to be drug delivery systems for this disease, which possesses environment-response, less system side effects as well as reduced treatment frequency. In this mini-review, we present the changes of periodontitis micro-environment, and then introduce various environment-sensitive hydrogels as drug delivery systems in the treatment of periodontitis. Finally, the limitations and aspects to improve of this vehicle applied to the treatment of periodontitis are discussed. We hope this review will provide better understanding of the hydrogel applications in periodontitis therapy.

scholarly journals Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 975
Author(s):  
Shahrukh Zaman Akash ◽  
Farjana Yesmin Lucky ◽  
Murad Hossain ◽  
Asim Kumar Bepari ◽  
G. M. Sayedur Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Burst Release ◽  
Therapeutic Effects ◽  
Microbial Infection ◽  
Temperature Responsive ◽  
On Demand

The development of externally controlled drug delivery systems that can rapidly trigger drug release is widely expected to change the landscape of future drug carriers. In this study, a drug delivery system was developed for on-demand therapeutic effects. The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater. The application of mild temperature (45 °C) to the drug-loaded paraffin film allowed a rapid stimulus response within a short time (5 min). This system exploits regular drug release and the rapid generation of mild heat to trigger a burst release of 80% within 6 h of any locally administered drug. The in vitro drug release studies and in vivo therapeutic activity were observed for local anesthesia and wound healing using a neomycin-loaded film. The studies demonstrated on-demand drug release with minimized inflammation and microbial infection. This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.

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