scholarly journals Application of Nanomaterial in Hydrogels Related to Wound Healing

2022 ◽  
Vol 2022 ◽  
pp. 1-11
Author(s):  
Yangyang Liu ◽  
Shurui Song ◽  
Shuangyong Liu ◽  
Xiaoyan Zhu ◽  
Peige Wang
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Repair ◽  
Antibacterial Properties ◽  
Sustained Drug Release ◽  
Broad Application ◽  
Wound Recovery ◽  
Swelling Rate ◽  
Good Biocompatibility ◽  
Application Prospects

Traditional dressings used for wound repair, such as gauze, have shortcomings; for example, they cannot provide a suitable microenvironment for wound recovery. Therefore, it is necessary to find a better dressing to overcome shortcomings. Hydrogel provides a suitable wet environment, has good biocompatibility, and has a strong swelling rate to absorb exudate. Nanomaterial in hydrogels has been used to improve their performance and overcome the shortcomings of current hydrogel dressings. Hydrogel dressing can also be loaded with nanodrug particles to exert a better therapeutic effect than conventional drugs and to make the dressing more practical. This article reviews the application of nanotechnology in hydrogels related to wound healing and discusses the application prospects of nanohydrogels. After searching for hydrogel articles related to wound healing, we found that nanomaterial can not only enhance the mechanical strength, antibacterial properties, and adhesion of hydrogels but also achieve sustained drug release. From the perspective of clinical application, these characteristics are significant for wound healing. The combination of nanomaterial and hydrogel is an ideal dressing with broad application prospects for wound healing in the future.

scholarly journals Triggering Drug Release and Thermal-Disrupting Interface Induced Mitigation of Composite Photothermal Hydrogel Treating Infectious Wounds

2021 ◽  
Vol 9 ◽  
Author(s):  
Long Hua ◽  
Hu Qian ◽  
Ting Lei ◽  
Wenbin Liu ◽  
Xi He ◽  
...  
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Antibacterial Properties ◽  
Skin Defect ◽  
Antibacterial Ability ◽  
Skin Defects ◽  
Swelling Rate ◽  
Defect Repair ◽  
Good Biocompatibility

Introduction: With the development of photothermal technology, the appearance of composite photothermal hydrogels has increased the selectivity of treating infectious skin defects. However, how to design composite photothermal hydrogel with better antibacterial performance, reduce the resistance rate of bacteria, and the damage rate of normal tissue still needs further study.Methods: The Prussian blue and tannic acid were loaded on polyacrylamide hydrogels. Characterization of DLS, Zeta potential, UV absorption spectrum, hydrogel swelling rate, scanning electronic microscopic, drug release profile, photothermal properties, in vitro cytocompatibility, and antibacterial properties. Experiments were measured by skin defect repair, antibacterial detection, and histological staining experiments.Results: The polyacrylamide hydrogel with photothermal effect and controllable release of tannic acid was successfully prepared. The hydrogel has strong light transmittance and adhesion, and the swelling rate can reach 600%, which improves the self-cleaning ability. SEM results showed the porous structure of hydrogels, promoting cell growth. Through photothermal switches, the composite hydrogel represented adjustable and controllable drug release ability. Combined with the synergistic antibacterial effect of tannic acid, this further enhanced the antibacterial ability and reduced the probability of antibiotic resistance. The in vitro and in vivo experiments showed the hydrogel had good biocompatibility and excellent antibacterial properties, which could promote the repair of infectious skin defects in SD rats.Conclusion: We fabricated a hydrogel with a triggering drug release rate, alleviating heat damage, transparent morphology, mechanical stability, strong adhesion, good biocompatibility, and synergistic antibacterial ability, which presents new treatment options for infectious skin defect repair.

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

2021 ◽  
Vol 36 (5) ◽  
pp. 431-443
Author(s):  
Swetha Andra ◽  
Satheesh kumar Balu ◽  
Rajalakshmi Ramamoorthy ◽  
Murugesan Muthalagu ◽  
Devisri Sampath ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Dressing ◽  
High Surface ◽  
High Surface Area ◽  
Antimicrobial Properties ◽  
Sustained Drug Release ◽  
Gram Positive Bacteria ◽  
Antimicrobial Efficiency ◽  
Cissus Quadrangularis

Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.

scholarly journals Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Woan Sean Tan ◽  
Palanisamy Arulselvan ◽  
Shiow-Fern Ng ◽  
Che Norma Mat Taib ◽  
Murni Nazira Sarian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Wound Dressing ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Dermal Fibroblast ◽  
Wound Dressings ◽  
Dependent Manner ◽  
Synthetic Compound ◽  
Study Results

Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

scholarly journals Tough and tissue-adhesive polyacrylamide/collagen hydrogel with dopamine-grafted oxidized sodium alginate as crosslinker for cutaneous wound healing

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 42123-42132 ◽  
Author(s):  
Zhongxiang Bai ◽  
Weihua Dan ◽  
Guofei Yu ◽  
Yanjun Wang ◽  
Yining Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Tissue Regeneration ◽  
Wound Repair ◽  
Tissue Adhesive ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Collagen Hydrogel ◽  
Good Biocompatibility ◽  
Oxidized Sodium Alginate

Natural collagen has good biocompatibility and ability to promote tissue regeneration; however, its low flexibility and easy degradation hinder its applications in wound repair.

scholarly journals 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1584 ◽  
Author(s):  
Si ◽  
Xing ◽  
Ding ◽  
Zhang ◽  
Yin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Wound Dressing ◽  
Wound Repair ◽  
Click Reaction ◽  
Antibacterial Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Rheological Test

：Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility. HA can be Ultraviolet (UV)-crosslinked by modification with methacrylic anhydride (HA-MA) and crosslinked by modification with 3,3'-dithiobis(propionylhydrazide) (DTP) (HA-SH) via click reaction. In the study presented in this paper, a 3D-bioprinted, double-crosslinked, hyaluronic-acid-based hydrogel for wound dressing was proposed. The hydrogel was produced by mixing HA-MA and HA-SH at different weight ratios. The rheological test showed that the storage modulus (G') of the HA-SH/HA-MA hydrogel increased with the increase in the HA-MA content. The hydrogel had a high swelling ratio and a high controlled degradation rate. The in vitro degradation test showed that the hydrogel at the HA-SH/HA-MA ratio of 9:1 (S9M1) degraded by 89.91% ± 2.26% at 11 days. The rheological performance, drug release profile and the cytocompatibility of HA-SH/HA-MA hydrogels with loaded Nafcillin, which is an antibacterial drug, were evaluated. The wound dressing function of this hydrogel was evaluated by Live/Dead staining and CCK-8 assays. The foregoing results imply that the proposed HA-SH/HA-MA hydrogel has promise in wound repair applications.

scholarly journals Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Kai Wang ◽  
Su Pan ◽  
Zhiping Qi ◽  
Peng Xia ◽  
Haotian Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Mechanical Strength ◽  
Metallic Nanoparticles ◽  
Wound Repair ◽  
Antibacterial Properties ◽  
Collagen Deposition ◽  
Natural Polymer ◽  
Biological Affinity ◽  
Metal Nanocomposites

Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and moderate antibacterial properties are the drawbacks restricting its further clinical application. Many researchers have adopted the use of nanotechnology, in particular metallic nanoparticles (MNPs), in order to improve the mechanical strength and specific antibacterial properties of chitosan composites, with promising results. Furthermore, chitosan naturally functions as a reducing agent for MNPs, which can also reduce cytotoxicity. Thus, CS, in combination with MNPs, exhibits antibacterial activity, excellent mechanical strength, and anti-inflammatory properties, and it has great potential to accelerate the process of wound healing. This review discusses the current use of CS and MNPs in wound healing and emphasises the synergy and the advantages for various applications in wound healing.

Preparation of Chitosan-Based Fiber Reticulated Medical Dressing and Its Application in Wound Care

2020 ◽  
Vol 12 (6) ◽  
pp. 921-931
Author(s):  
Peiying Han ◽  
Jie Ma ◽  
Min Lin ◽  
Xiaoyan Cai ◽  
Fang Fang
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Wound Area ◽  
Cell Compatibility ◽  
Wound Recovery ◽  
Liquid Absorption ◽  
Healing Of Wounds ◽  
Chitosan Fiber

With the continuous development of medical dressings, patients start to focus on how to take care of wounds caused by different reasons. Therefore, there is a need for medical dressings that can stop the bleeding and promote the healing of wounds with excellent biological properties. This study produced seven different dressing samples by combining chitosan fiber and hydroentanglement technique. The different dressings were characterized and analyzed for biological properties. At the same time, 60 New Zealand rabbits were selected for wound care experiments. Respectively, the wounds were constructed and were treated with sample 1 and sample 3, which were selected as experimental materials from the prepared dressing samples. Besides, the polyacrylate (SAP) and common gauze were taken as the control materials. Then, different dressings were used to cover the wounds of rabbits. Three days later, the dressings were changed every few days to observe the wounds. At the same time, the wound area and wound healing scores of the sample 1 group, sample 3 group, and SAP group were counted at 7 days, 14 days and 21 days after the operations. During the experiment, the chitosan fiber-based fiber web dressing showed excellent hygroscopicity and rigidity. For the comparison of biological properties, different samples all had excellent cell compatibility and antibacterial properties. Meanwhile, the antibacterial properties of sample 1 and sample 3 were all above 90%. For the wound care experiment, the adsorbent rate of sample 1 dressing was the fastest in the first 8 min, reaching 70% of the maximum liquid absorption. For the comparison of the wound recovery area and wound healing scores, compared with SAP and common gauze, the medical dressings based on composite chitosan fiber-hydroentanglement technique had better wound recovery performance. This has proved that the medical dressings proposed in this study have better wound care performances.

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