Relationship between Serum Uric Acid and Serum Oxidative Stress Markers in the Japanese General Population

Abstract Background Oxidative stress is involved in many diseases including diabetes and cancer. Numbers of studies have suggested its involvement in the pathogenesis of periodontal diseases. The aim of this study was to evaluate the levels of biochemical parameters and oxidative stress markers in plasma of healthy and chronic periodontitis patients. Methods One hundred thirty subjects were divided into two groups; patients (mean age = 42 ± 13.6 y.o) and control (mean age = 44.8 ± 12.6 y.o). Patients and healthy subjects were free from any infection, coronary or heart disease, diabetes or liver failure. Total cholesterol, LDLc, HDLc, Triglycerides (TG), creatinine, uric acid (UA), glucose and urea levels as well as the activities of enzymatic antioxidants such as catalase, glutathione reductase (GR) and total antioxidant capacity (TAOC), were measured in plasma samples using colorimetric assays. Statistical differences between groups were determined by Student’s t-test and p ≤ 0.05 was considered as significant. Results Periodontitis patients exhibited significant decrease in the activities of catalase, TAOC, GR and TG, cholesterol, LDLc, glucose, HDLc, uric acid levels in plasma samples in comparison with healthy subjects. However, no statistically significant differences in the levels of creatinine and urea were observed between the two groups. Conclusion The reduction of plasma antioxidant activities (Catalase, TAOC, GR) may have a role in the pathogenesis of periodontal diseases. Our findings suggest a decrease in the host capacity to control the damage caused by oxidative stress. Therefore, therapeutic strategies, aiming at modulating the oxidative stress could be considered as potential tools for the prevention or treatment of periodontal diseases and their potential systemic effects on the general health.

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Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Platelets ◽

10.3109/09537104.2013.790013 ◽

2013 ◽

Vol 25 (3) ◽

pp. 202-206 ◽

Cited By ~ 8

Author(s):

Masanori Shimodaira ◽

Tomohiro Niwa ◽

Koji Nakajima ◽

Mutsuhiro Kobayashi ◽

Norinao Hanyu ◽

...

Keyword(s):

Gender Differences ◽

Uric Acid ◽

General Population ◽

Serum Uric Acid ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Japanese General Population ◽

The Relationship

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P6232Exploring the bottom of J-shaped curve association between serum uric acid and cardiovascular risks: description using a large Japanese general population

European Heart Journal ◽

10.1093/eurheartj/ehz746.0834 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

S Kawasoe ◽

T Kubozono ◽

S Ojima ◽

H Miyahara ◽

S Maenohara ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Uric Acid ◽

Cardiovascular Risk ◽

General Population ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Body Mass ◽

Cardiovascular Risks ◽

Japanese General Population

Abstract Background The J-shaped association between serum uric acid (SUA) and cardiovascular risks is known. However, the bottom of the J-shaped curve has not been elucidated because of the lack of epidemiological knowledge about hypouricemia. Purpose To explore the SUA levels related to the most preferable cardiovascular risks using data from a Japanese general population. Methods Data from 246,923 individuals (111,117 men and 135,806 women) who underwent routine health checkups between January 2001 and December 2015 were analyzed. The participants were divided into quartiles according to their SUA levels, and patients with hypouricemia (SUA level <2.0 mg/dL) were subdivided into two groups according to their distributions. We compared their characteristics, including their cardiovascular risks. Results The prevalence of hypouricemia was 0.46% overall, 0.21% for men, and 0.66% for women (P<0.001). The subjects with hypouricemia were divided into two groups according to SUA level: a lower hypouricemia group (0.4–1.1 mg/dL, which included a peak at 0.7–0.8 mg/dL) and a higher hypouricemia group (1.4–2.0 mg/dL). The two groups exhibited significanly different characteristics in several variables: body mass index and triglyceride in men, and age, body mass index, triglyceride, low-density lipoprotein cholesterol, and renal function in women. Furthermore, several cardiovascular risk factors showed the most preferable values in subjects with SUA 1.4–2.0 mg/dL (Figure). Conclusions There were two independent distributions in subjects with SUA ≤2.0 mg/dL. The individuals with SUA 1.4–2.0 mg/dL exhibited the most preferable values for several cardiovascular risk factors, suggesting an association with the bottom of the J-shaped curve between SUA and cardiovascular risks.

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SERUM URIC ACID LEVEL AND PREVALENCE OF ATRIAL FIBRILLATION IN 285,882 JAPANESE GENERAL POPULATION

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(15)61514-5 ◽

2015 ◽

Vol 65 (10) ◽

pp. A1514

Author(s):

Shin Kawasoe ◽

Shiro Yoshifuku ◽

Takuro Kubozono ◽

Hironori Miyahara ◽

Naoya Oketani ◽

...

Keyword(s):

Atrial Fibrillation ◽

Uric Acid ◽

General Population ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Japanese General Population

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Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190307165355 ◽

2020 ◽

Vol 20 (1) ◽

pp. 77-86 ◽

Cited By ~ 3

Author(s):

Amparo Tatay-Manteiga ◽

Vicent Balanzá-Martínez ◽

Giovana Bristot ◽

Rafael Tabarés-Seisdedos ◽

Flavio Kapczinski ◽

...

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Valproic Acid ◽

Uric Acid ◽

Antioxidant Capacity ◽

Oxidative Stress Markers ◽

Oxidative Stress Biomarkers ◽

Protein Carbonyl Content ◽

Stress Biomarkers ◽

Stress Markers

Aims:Oxidative stress is increased during the acute phases of bipolar disorder (BD). Our aim here was to analyze oxidative stress biomarkers in patients with BD during euthymia and their siblings.Method:A cross-sectional study was performed in euthymic patients with BD-I (n=48), unaffected siblings (n=23) and genetically unrelated healthy controls (n=21). Protein carbonyl content (PCC), total antioxidant capacity (TRAP), lipid peroxidation (TBARS) and uric acid were measured as biomarkers of oxidative stress in blood.Results:The antioxidant capacity (TRAP) was lower (p<0.001) in patients with BD compared to their siblings and controls, whereas no differences were observed in PCC, TBARS or uric acid. In patients, the concentrations of TRAP and TBARS were positively associated with the dose of valproic acid (p<0.05 and p<0.001, respectively). The concentrations of these biomarkers were not significantly associated with any of socio-demographic and clinical variables.Conclusion:A selective reduction in antioxidant capacity is present in BD during euthymia state, whereas other markers of oxidative stress are unaltered during euthymia. Siblings did not show any alterations in oxidative stress biomarkers. Oxidative stress might represent a state-dependent marker in BD. The association between treatment with valproic acid and oxidative stress markers in euthymia deserves further studies.

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Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study

BMC Nephrology ◽

10.1186/s12882-019-1291-4 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 5

Author(s):

Sachimi Kubo ◽

Yoko Nishida ◽

Yoshimi Kubota ◽

Aya Higashiyama ◽

Daisuke Sugiyama ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Renal Function ◽

Uric Acid ◽

Kidney Disease ◽

General Population ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Japanese General Population

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P0778INVESTIGATION THE EFFECT OF SERUM URIC ACID ON NEW-ONSET AND PROGRESSION OF CHRONIC KIDNEY DISEASE(CKD) IN JAPANESE GENERAL POPULATION : IKI EPIDEMIOLOGICAL STUDY OF ARTHEROSCLEROSIS AND CHRONIC KIDNEY DISEASE(ISSA-CKD) RETROSPECTIVE PHASE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0778 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Kazuhiro Tada ◽

Toshiki Maeda ◽

Koji Takahashi ◽

Kenji Ito ◽

Tetsuhiko Yasuno ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Uric Acid ◽

Kidney Disease ◽

General Population ◽

Confidence Interval ◽

Serum Uric Acid ◽

Health Check ◽

Ckd Progression ◽

Japanese General Population ◽

New Onset

Abstract Background and Aims Chronic kidney disease is one of the most urgent public health issue in Japan as well as other countries. Many risk factors for development and progression of CKD have been recognized, such as hypertension, diabetes, obesity. However, it is still unclear whether increase of serum uric acid has negative impact on kidney function. The aim of this study is to investigate how serum uric acid influences the new-onset and progression of CKD in Japanese general population. Method The Iki epidemiological Study of atherosclerosis And Chronic Kidney Disease (ISSA-CKD) is a population-based retrospective cohort study using annual health check-up data in the Iki Island (Nagasaki Prefecture, Japan), which has approximately 27,000 residents. A total of 7,645 residents underwent annual health check-ups from fiscal year 2008 to 2016. After excluding residents who visited only 1 health check-up and those with missing information of serum creatinine or serum uric acid, a total of 5507 adults were included in the present analysis. The outcome of the present analysis was new-onset of CKD (reduction in estimated glomerular filtration rate [eGFR] less than 60mL/min/1.73m2 or development of proteinuria among participants without CKD at baseline) and CKD progression (worsening of the stages of eGFR or proteinuria according to the KDIGO guideline among participants with CKD at baseline). Results During a mean follow-up of 4.6 years, 757 (16.7%) new-onset CKD and 193 (19.7%) progression of CKD were observed. Serum uric acid had significant relationship with new-onset CKD even after adjustment for sex, age, obese, hypertension, dyslipidemia, and diabetes mellitus: hazard ratio 1.14 per 1 mg/dL increase, 95% confidence interval 1.07-1.21, P<0.001). On the other hand, serum uric acid did not have significant relationship with CKD progression: hazard ratio 1.08 per 1 mg/dL increase, 95% confidence interval 0.96-1.21, P=0.190). Similar results were observed for hyperuricemia defined as serum uric acid level ≥7mg/dl. Conclusion The findings of the present analysis show that serum uric acid was significantly associated with increased risks of new onset of CKD, but was not associated with progression of CKD in Japanese general population.

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