Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings

Aims:Oxidative stress is increased during the acute phases of bipolar disorder (BD). Our aim here was to analyze oxidative stress biomarkers in patients with BD during euthymia and their siblings.Method:A cross-sectional study was performed in euthymic patients with BD-I (n=48), unaffected siblings (n=23) and genetically unrelated healthy controls (n=21). Protein carbonyl content (PCC), total antioxidant capacity (TRAP), lipid peroxidation (TBARS) and uric acid were measured as biomarkers of oxidative stress in blood.Results:The antioxidant capacity (TRAP) was lower (p<0.001) in patients with BD compared to their siblings and controls, whereas no differences were observed in PCC, TBARS or uric acid. In patients, the concentrations of TRAP and TBARS were positively associated with the dose of valproic acid (p<0.05 and p<0.001, respectively). The concentrations of these biomarkers were not significantly associated with any of socio-demographic and clinical variables.Conclusion:A selective reduction in antioxidant capacity is present in BD during euthymia state, whereas other markers of oxidative stress are unaltered during euthymia. Siblings did not show any alterations in oxidative stress biomarkers. Oxidative stress might represent a state-dependent marker in BD. The association between treatment with valproic acid and oxidative stress markers in euthymia deserves further studies.

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PSXV-30 Late-Breaking: Oxidative stress biomarkers in blood plasma and pre-rigor tissues of beef cattle induced by hydrogen peroxide

Journal of Animal Science ◽

10.1093/jas/skab235.695 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 379-380

Author(s):

Chelsie B Dahlgren ◽

Dishnu Sajeev ◽

Thu Dinh ◽

Daniel Rivera ◽

Hunter Goodson

Keyword(s):

Oxidative Stress ◽

Hydrogen Peroxide ◽

Blood Plasma ◽

Fixed Effects ◽

Oxidative Stress Markers ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Stress Markers ◽

Muscle Tissues ◽

In Blood Plasma

Abstract This study examined the oxidative stress biomarkers in blood plasma and pre-rigor tissues of beef heifers induced by hydrogen peroxide. Cattle (365 ± 38 kg; n = 18) were supplemented with ground corn and soybean hulls while grazing cool and warm-season pastures, then shipped and finished at a commercial feedlot in Iowa. Animals were blocked into three groups based on initial clusters of oxidative stress markers. Two treatments of either 20 mg hydrogen peroxide/kg BW (OX, n = 9) or 10 mL of saline (CON, n = 9) were equally and randomly assigned to animals within each group. On the day before slaughter, the OX and CON treatments were administered intravenously through the jugular vein. Blood samples were collected immediately before (T0) and 90 min after (T90) treatment and centrifuged into plasma and pre-rigor muscles were collected at the neck (splenius) during slaughter; both were frozen in liquid nitrogen and stored at -80ºC. Blood plasma and muscle tissues were analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), and glutathione peroxidase activity (GPx). Muscle tissues were also analyzed for glutathione (GSH). The data were analyzed as a randomized complete block design with repeated measures with treatment, time, and their interaction as fixed effects. Oxidative stress treatment did not affect TAC and TBARS values (P ≥ 0.137). However, T0 plasma had 0.47 mM less (P = 0.009) and 5.84 μM more (P < 0.001) of TAC and TBARS, respectively, than T90 plasma. Although CON had 27.73 nmol/min/mL more GPx at T0 (P = 0.039), such activity did not differ in both groups at T90 (P = 0.542). Treatment did not affect oxidative stress markers in pre-rigor tissues (P ≥ 0.184). Inducing oxidative stress by hydrogen peroxide had minimal effects on biomarkers in blood and muscle tissues.

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Redox Homeostasis and Metabolic Profile in Young Female Basketball Players during In-Season Training

Healthcare ◽

10.3390/healthcare9040368 ◽

2021 ◽

Vol 9 (4) ◽

pp. 368

Author(s):

Rosamaria Militello ◽

Simone Luti ◽

Matteo Parri ◽

Riccardo Marzocchini ◽

Riccardo Soldaini ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Capacity ◽

Training Session ◽

Reactive Oxygen ◽

Enzyme Linked Immunosorbent Assay ◽

Reactive Oxygen Metabolites ◽

Oxidative Stress Markers ◽

Basketball Players ◽

Reactive Oxygen Metabolite ◽

Stress Markers

Background: Most studies on oxidative stress markers and antioxidant levels have been conducted in male athletes, although female participation in sport has increased rapidly in the past few decades. In particular, it could be important to assess oxidative stress markers in relation to the training load because the anaerobic path becomes predominant in high-intensity actions. Methods: Ten female professional basketball players, performing five 2 h-lasting training sessions per week, and 10 sedentary control women were investigated. Capillary blood and saliva samples were collected in the morning before the training session. The antioxidant capacity and the levels of reactive oxygen metabolites on plasma were determined measuring Reactive Oxygen Metabolite and Biological Antioxidant Potential (d-ROMs and the BAP Test). Salivary cortisol was detected by using commercial enzyme-linked immunosorbent assay kit. Results: The antioxidant capacity (BAP value) was significantly higher in elite basketball players (21.2%; p < 0.05). Conversely, cortisol (51%; p < 0.009) and the levels of oxidative species (d-ROM, 21.9%; p < 0.05) showed a significant decrease in elite athletes.

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Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/5763256 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Helenita Antonia de Oliveira ◽

Ednei Luiz Antonio ◽

Gisela Arsa ◽

Eduardo Tadeu Santana ◽

Flávio André Silva ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Capacity ◽

High Intensity ◽

Maximum Load ◽

Exercise Session ◽

Time Interval ◽

Oxidative Stress Markers ◽

Resistive Exercise ◽

Stress Markers ◽

Low Intensity Laser Therapy

The aim of this study was to determine whether oxidative stress markers are influenced by low-intensity laser therapy (LLLT) in rats subjected to a high-intensity resistive exercise session (RE). Female Wistar rats divided into three experimental groups (Ctr: control, 4J: LLLT, and RE) and subdivided based on the sampling times (instantly or 24 h postexercise) underwent irradiation with LLLT using three-point transcutaneous method on the hind legs, which was applied to the gastrocnemius muscle at the distal, medial, and proximal points. Laser (4J) or placebo (device off) were carried out 60 sec prior to RE that consisted of four climbs bearing the maximum load with a 2 min time interval between each climb. Lipoperoxidation levels and antioxidant capacity were obtained in muscle. Lipoperoxidation levels were increased (4-HNE and CL markers) instantly post-RE. LLLT prior to RE avoided the increase of the lipid peroxidation levels. Similar results were also notified for oxidation protein assays. The GPx and FRAP activities did not reduce instantly or 24 h after RE. SOD increased 24 h after RE, while CAT activity did not change with RE or LLLT. In conclusion, LLLT prior to RE reduced the oxidative stress markers, as well as, avoided reduction, and still increased the antioxidant capacity.

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Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2013.06.018 ◽

2013 ◽

Vol 47 (10) ◽

pp. 1396-1402 ◽

Cited By ~ 65

Author(s):

Carolina Gubert ◽

Laura Stertz ◽

Bianca Pfaffenseller ◽

Bruna Schilling Panizzutti ◽

Gislaine Tezza Rezin ◽

...

Keyword(s):

Oxidative Stress ◽

Bipolar Disorder ◽

Healthy Subjects ◽

Mononuclear Cells ◽

Mitochondrial Activity ◽

Oxidative Stress Markers ◽

Peripheral Blood Mononuclear ◽

Stress Markers ◽

Blood Mononuclear Cells ◽

And Oxidative Stress

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Biochemical parameters and oxidative stress markers in Tunisian patients with periodontal disease

BMC Oral Health ◽

10.1186/s12903-019-0912-4 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Ahmed Gharbi ◽

Ali Hamila ◽

Adel Bouguezzi ◽

Azza Dandana ◽

Salima Ferchichi ◽

...

Keyword(s):

Oxidative Stress ◽

Uric Acid ◽

Healthy Subjects ◽

Biochemical Parameters ◽

Periodontal Diseases ◽

Enzymatic Antioxidants ◽

Plasma Samples ◽

Oxidative Stress Markers ◽

Stress Markers ◽

And Oxidative Stress

Abstract Background Oxidative stress is involved in many diseases including diabetes and cancer. Numbers of studies have suggested its involvement in the pathogenesis of periodontal diseases. The aim of this study was to evaluate the levels of biochemical parameters and oxidative stress markers in plasma of healthy and chronic periodontitis patients. Methods One hundred thirty subjects were divided into two groups; patients (mean age = 42 ± 13.6 y.o) and control (mean age = 44.8 ± 12.6 y.o). Patients and healthy subjects were free from any infection, coronary or heart disease, diabetes or liver failure. Total cholesterol, LDLc, HDLc, Triglycerides (TG), creatinine, uric acid (UA), glucose and urea levels as well as the activities of enzymatic antioxidants such as catalase, glutathione reductase (GR) and total antioxidant capacity (TAOC), were measured in plasma samples using colorimetric assays. Statistical differences between groups were determined by Student’s t-test and p ≤ 0.05 was considered as significant. Results Periodontitis patients exhibited significant decrease in the activities of catalase, TAOC, GR and TG, cholesterol, LDLc, glucose, HDLc, uric acid levels in plasma samples in comparison with healthy subjects. However, no statistically significant differences in the levels of creatinine and urea were observed between the two groups. Conclusion The reduction of plasma antioxidant activities (Catalase, TAOC, GR) may have a role in the pathogenesis of periodontal diseases. Our findings suggest a decrease in the host capacity to control the damage caused by oxidative stress. Therefore, therapeutic strategies, aiming at modulating the oxidative stress could be considered as potential tools for the prevention or treatment of periodontal diseases and their potential systemic effects on the general health.

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Protective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study

BioMed Research International ◽

10.1155/2020/5487659 ◽

2020 ◽

Vol 2020 ◽

pp. 1-15 ◽

Cited By ~ 1

Author(s):

Aein Azarang ◽

Omid Farshad ◽

Mohammad Mehdi Ommati ◽

Akram Jamshidzadeh ◽

Reza Heidari ◽

...

Keyword(s):

Oxidative Stress ◽

Hepatic Steatosis ◽

Bacillus Coagulans ◽

Male Rats ◽

Health Priorities ◽

Oxidative Stress Markers ◽

Oxidative Stress Biomarkers ◽

Nonalcoholic Fatty Liver ◽

Stress Markers ◽

And Oxidative Stress

Background. Treating nonalcoholic fatty liver disease (NAFLD) is considered one of the public health priorities in the past decade. So far, probiotics have represented promising results in controlling the signs and symptoms of NAFLD. However, attempts to find the ideal probiotic strain are still ongoing. The present study is designed to find the best strain amongst suitable probiotic strains according to their ability to ameliorate histopathological and oxidative stress biomarkers in hepatic steatosis-induced rats. Methods. Initially, four probiotics species, including Lactobacillus (L.) acidophilus, L. casei, L. reuteri, and Bacillus coagulans, were cultured and prepared as a lyophilized powder for animals. The experiment lasted for fifty days. Initially, hepatic steatosis was induced by excessive ingestion of D-fructose in rats for eight weeks, followed by eight weeks of administering probiotics and D-fructose concurrently. Forty-two six-week-old male rats were alienated to different groups and were supplemented with different probiotics ( 1 ∗ 10 9 CFU in 500 mL drinking water). After eight weeks, blood and liver samples were taken for further evaluation, and plasma and oxidative stress markers corresponding to liver injuries were examined. Results. Administration of probiotics over eight weeks reversed hepatic and blood triglyceride concentration and blood glucose levels. Also, probiotics significantly suppressed markers of oxidative stress in the liver tissue. Conclusions. Although some of the single probiotic formulations were able to mitigate oxidative stress markers, mixtures of probiotics significantly ameliorated more symptoms in the NAFLD animals. This enhanced effect might be due to probiotics’ cumulative potential to maintain oxidative stress and deliver improved lipid profiles, liver function markers, and inflammatory markers.

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