Analyzing Gastric Lavage of Gastric Cancer Patients: A Prospective Observational Study on Cytopathology and Determination of Intragastric CEA, CA 19.9, CA 72.4, and CA 50

2016 ◽  
Vol 60 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Edoardo Virgilio ◽  
Enrico Giarnieri ◽  
Monica Montagnini ◽  
Rosaria D''Urso ◽  
Antonella Proietti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Gastric Lavage ◽  
Control Group ◽  
Roc Curve Analysis ◽  
Cutoff Value ◽  
Ca 19.9 ◽  
Ca 50 ◽  
Gastric Cancer Patients

Objectives: To investigate gastric lavage (GL) cytopathology and immunometric analysis as novel clinicopathologic and prognostic parameters for gastric cancer (GC). Study Design: In 38 patients with gastric adenocarcinoma, we performed a cytopathologic analysis and an immunometric assay of GL using four tumor markers (CEA, CA 19.9, CA 72.4, and CA 50). The intragastric tumor marker levels were compared with a control group consisting of 41 non-GC patients to determine a statistically significant cutoff value. Results: GL cytopathology demonstrated the presence of cancer cells in 13 (34.2%) of the 38 GC patients: such a finding correlated to the parameters pT and pN with a statistically significant validity (p < 0.0267 and p < 0.0306, respectively). Measurement of intragastric CA 19.9 and CA 50 attained a statistically significant cutoff value (p < 0.002 and p < 0.0096, respectively), which was invalidated by the low sensitivity of the ROC curve analysis. Conclusions: In contrast to determination of its tumor markers, GL cytopathology correlated well with pT and pN staging parameters. Should this and other features be corroborated by future studies, the GL cytology test could be routinely used to detect aggressive types of GC even at early stages and result in important progress in the knowledge, staging, prediction, as well as management and follow-up of this inauspicious type of cancer.

scholarly journals Association of Multiple Tumor Markers With Gastric Cancer Patients

2021 ◽  
Author(s):  
Xiaoyang Li ◽  
Sifeng Li ◽  
Zhenqi Zhang ◽  
Dandan Huang
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Detection Sensitivity ◽  
Control Group ◽  
Multiple Tumor ◽  
Group 3 ◽  
Gastric Cancer Patients ◽  
And Control ◽  
Combined Detection ◽  
Positive Population

Abstract Background: To explore the correlation between multiple tumor markers and gastric cancer.Methods: We selected 268 newly-treated patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chip, and then the results were statistically analyzed by SPSS.Results: (1)We concluded that gastric cancer was significantly related to gender, age, AFP, CEA, CA125, CA199, and CA242 (P＜0.001). After CA199 and CA242 were stratified by gender, the OR of the male was 30.400 and 31.242 respectively, while the OR of the female was 3.424. After CA125 was stratified by age, among patients with gastric cancer over 54 years old, The risk of occurrence in the CA125-positive population was 16.673 times that in CA125-negative patient; and among patients less than or equal to 54 years old, CA125-positive was not a risk factor for gastric cancer(P=0.082); (2)AFP, CEA, CA125, CA199, CA242 in M1 stage were statistically significant compared with M0 stage and control group (P<0.001), but AFP (P=0.045) and CA125 (P=0.752) were not statistically significant compared with M0 stage and control group; (3)The combined detection sensitivity of multiple tumor markers were 41.79%.Conclusions: Our research shows that gastric cancer is associated with age, gender, and the positive of AFP, CEA, CA125, CA199, and CA242. The positive of AFP and CA125 is related to the distant metastasis of gastric cancer; The combined detection of multiple tumor markers can be used for initial screening of gastric cancer to a certain extent.

scholarly journals Association of Multiple Tumor Markers with gastric cancer patients

2021 ◽  
Author(s):  
Xiaoyang Li ◽  
Sifeng Li ◽  
Zhenqi Zhang ◽  
Dandan Huang
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Detection Sensitivity ◽  
Control Group ◽  
Multiple Tumor ◽  
Group 3 ◽  
Gastric Cancer Patients ◽  
And Control ◽  
Combined Detection ◽  
Positive Population

Abstract BackgroundTo explore the correlation between multiple tumor markers and gastric cancer. MethodsWe selected 268 newly-treated patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chip, and then the results were statistically analyzed by SPSS. Results(1)We concluded that gastric cancer was significantly related to gender, age, AFP, CEA, CA125, CA199, and CA242 (P＜0.001). After CA199 and CA242 were stratified by gender, the OR of the male was 30.400 and 31.242 respectively, while the OR of the female was 3.424. After CA125 was stratified by age, among patients with gastric cancer over 54 years old, The risk of occurrence in the CA125-positive population was 16.673 times that in CA125-negative patient; and among patients less than or equal to 54 years old, CA125-positive was not a risk factor for gastric cancer(P=0.082); (2)AFP, CEA, CA125, CA199, CA242 in M1 stage were statistically significant compared with M0 stage and control group (P<0.001), but AFP (P=0.045) and CA125 (P=0.752) were not statistically significant compared with M0 stage and control group; (3)The combined detection sensitivity of multiple tumor markers were 41.79%.ConclusionsOur research shows that gastric cancer is associated with age, gender, and the positive of AFP, CEA, CA125, CA199, and CA242. The positive of AFP and CA125 is related to the distant metastasis of gastric cancer; The combined detection of multiple tumor markers can be used for initial screening of gastric cancer to a certain extent.

CLINICAL SIGNIFICANCE OF SERUM CAVEOLIN-1 LEVELS IN GASTRIC CANCER PATIENTS

2018 ◽  
Vol 40 (4) ◽  
pp. 323-327 ◽  
Author(s):  
F Tas ◽  
S Karabulut ◽  
K Erturk ◽  
D Duranyildiz
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Histological Grade ◽  
Clinical Importance ◽  
Disease Stage ◽  
Control Group ◽  
Tissue Samples ◽  
Caveolin 1 ◽  
Study Results ◽  
Gastric Cancer Patients

Aim: Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. Key

DETERMINATION OF P53 GENE CODON 72 POLYMORPHISMS IN PATIENTS WITH GASTRIC CANCER

2013 ◽  
pp. 11-17
Author(s):  
Thi Tuy Ha Nguyen ◽  
Thi Minh Thi Ha
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
P53 Gene ◽  
Diffuse Gastric Cancer ◽  
Codon 72 ◽  
Cancer Group ◽  
Pcr Rflp ◽  
Gastric Cancer Patients ◽  
The Relationship

Background: The role of p53 gene in the gastric cancer is still controversial. This study is aimed at determining the rate of the p53 gene codon 72 polymorphisms in gastric cancer patients and evaluating the relationship between these polymorphisms and endoscopic and histopathological features of gastric cancer. Patients and methods: Sixty eight patients with gastric cancer (cases) and one hundred and thirty six patients without gastric cancer (controls) were enrolled. p53 gene codon 72 polymorphisms were determined by PCR-RFLP technique with DNA extracted from samples of gastric tissue. Results: In the group of gastric cancer, Arginine/Argnine, Arginine/Proline and Proline/Proline genotypes were found in 29.4%, 42.7% and 27.9%, respectively. The differences of rates were not statistically significant between cases and controls (p > 0,05). In males, the Proline/Proline genotype was found in 38.1% in patients with gastric cancer and more frequent in patients without gastric cancer (15.7%, p = 0,01). An analysis of ROC curve showed that the cut-off was the age of 52 in the Proline/Proline genotype, but it was 65 years old in the Arginine/Proline genotype. The Proline/Proline genotype was found in 41.9% in Borrmann III/IV gastric cancer, this rate was higher than Borrmann I/II gastric cancer (16.2%, p = 0.037) and also higher than controls (18.4%, p = 0,01). The rate of Proline/Proline genotype was 41.7% in the diffuse gastric cancer, it was higher than in controls (p = 0,023). Conclusion: No significative difference of rate was found in genotypes between gastric cancer group and controls. However, there was the relationship between Proline/Proline genotype and gastric cancer in males, Borrmann types of gastric cancer, the diffuse gastric cancer. Key words: polymorphism, codon 72, p53 gene, PCR - RFLP, gastric cancer.

scholarly journals Tag-72, CA 19.9 and CEA as Tumor Markers in Gastric Cancer

1994 ◽  
Vol 33 (7) ◽  
pp. 747-751 ◽  
Author(s):  
Xavier Filella ◽  
Jose Fuster ◽  
Rafael Molina ◽  
Juan Jose Grau ◽  
Luis Grande ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Ca 19.9

Preoperative Tumor Markers Independently Predict Survival in Stage III Gastric Cancer Patients: Should We Include Tumor Markers in AJCC Staging?

2018 ◽  
Vol 25 (9) ◽  
pp. 2703-2712 ◽  
Author(s):  
Jian-Xian Lin ◽  
Wei Wang ◽  
Jun-Peng Lin ◽  
Jian-Wei Xie ◽  
Jia-bin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Stage Iii ◽  
Ajcc Staging ◽  
Gastric Cancer Patients

Study of Fe3O4-PPy Core-Shell Nanocomposite in the Diagnosis of Tumor Markers in the Tissues of Early Gastric Cancer Patients

2021 ◽  
Vol 21 (2) ◽  
pp. 935-942
Author(s):  
Jiang Wu ◽  
Tao Wu ◽  
Peng Chen ◽  
Lan Pang ◽  
A Bu Du Re He Man-A Li Mu Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Carbohydrate Antigen ◽  
Detection Sensitivity ◽  
Control Group ◽  
Core Shell ◽  
Observation Group ◽  
Gastric Tissue

In order to study Fe3O4-Polypyrrole (Fe3O4-PPy) core-shell nanocomposite in the diagnosis of tumor markers in the diseased gastric tissues of early cancer patients, a total of 160 cases of patients, who were confirmed as early gastric cancer by gastroscopy or postoperative pathology at a designated hospital of the study from December 2014 to December 2018, were selected as research objects and were divided into two groups of observation and control group with 80 cases in each group. For each patient in the two groups, two pieces of diseased gastric tissue were firstly taken through gastroscopy; then the observation group applied Fe3O4-PPy with the particle diameter of 150-350 nm as carrier to detect the contents of carbohydrate antigen 19-9 (CA19-9), alpha-fetoprotein (AFP), carbohydrate antigen 242 (CA242), carcinoembryonic antigen (CEA) and carbohydrate antigen 72-4 (CA72-4) in the diseased gastric tissue, while the control group directly detected the contents of corresponding tumor markers; after the detections, the sensitivity, specificity and diagnostic efficiency of each marker in the two groups of patients were calculated, and receiver operating characteristics (ROC) curves with the areas under the curves (AUC) were drawn to analyze the correlation between the level of Fe3O4-PPy and the detection efficiency of gastric cancer markers. The results show that the detection sensitivity (82.17%, 80.32%, 79.48%, 84.63%, and 85.66%) and specificity (76.75%, 79.66%, 81.07%, 83.47%, and 85.24%) of CA19-9, AFP, CA242, CEA, and CA72-4 in the tumor tissue of patients in observation group for the diagnosis of early gastric cancer are higherthan the sensitivity (78.66%, 79.25%, 76.18%, 82.11%, and 83.45%) and specificity (74.37%, 76.94%, 77.24%, 81.22%, and 81.59%) of that in control group with statistically significant differences (P < 0.05). Therefore, it is believed that the Fe3O4-PPy is of great significance for the detection of early gastric tumor markers in the tissues of patients with early gastric cancer, and has certain value for the auxiliary diagnosis of early gastric cancer and the observation of therapeutic effects. This study results provide a reference for the further researches of Fe3O4-PPy in the diagnosis of tumor markers in patients with early gastric cancer.

Clinical significance of serum tumor marker for advanced gastric cancer with palliative chemotherapy: A retrospective study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15524-e15524
Author(s):  
Yahui Zhu ◽  
Baorui Liu ◽  
Jia Wei ◽  
Juan Du ◽  
Ju Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Retrospective Study ◽  
Advanced Gastric Cancer ◽  
Tumor Markers ◽  
Statistical Significance ◽  
Survival Rates ◽  
Hepatic Metastases ◽  
Predictive Biomarkers ◽  
Clinical Value ◽  
Gastric Cancer Patients

e15524 Background:The predictive value of tumor markers has been previously reported a lot. However, the studies focused on advanced gastric cancer are few. In this study, we tried to investigate the relationship between the tumor markers of advanced gastric cancer and clinical characteristics, therapeutic effect of chemotherapy, and prognosis. Methods:A retrospective study including 146 advanced gastric cancer who had not received any previous anticancer therapy was performed. Blood samples for CEA, AFP, CA125, CA72-4, CA242 and CA19-9 were taken from patients before chemotherapy and monthly during their treatments. Statistical analysis was performed to predict the clinical value of these tumor markers. Results:CEA yielded an ROC value of 0.621 in predicting lymph node metastasis in gastric cancer, which was significantly higher than any of other markers. CA125 had the highest sensitivity, specificity and accuracy in gastric cancer patients with peritoneal metastasis. AFP and CEA were more frequently positive in patients with hepatic metastases. The response rate of Decreasing group, Stable group and Increasing group based on CA19-9, CEA, CA72-4, CA125 and CA242 levels achieved statistical significance. Positive cases of CA125, CA242, CA19-9 and CA72-4 showed poor prognosis, and significant differences in 3 year-survival rates were observed for CA125 and CA242. Conclusions:We found that different tumor markers in gastric cancer indicated different metastasis sits. CEA, CA242, CA19-9, CA125 and CA72-4 are predictive biomarkers in evaluating the effectiveness of chemotherapy. The elevated CA125, CA242, CA19-9 and CA72-4 levels at diagnosed had association with shorter overall survivals, especially CA125 and CA242.

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