Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

2016 ◽  
Vol 42 (3-4) ◽  
pp. 169-185 ◽  
Author(s):  
Iwona Bojar ◽  
Magdalena Stasiak ◽  
Anna Cyniak-Magierska ◽  
Dorota Raczkiewicz ◽  
Andrzej Lewiński
Keyword(s):  
Postmenopausal Women ◽  
Cognitive Functions ◽  
Vital Signs ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Status ◽  
Free Triiodothyronine ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Potential Association ◽  
Total Triiodothyronine

Background: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). Methods: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms. The thyroid hormone tests were assessed by an accredited laboratory. Results and Conclusion: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.

Hyponatraemia due to hypothyroidism: a rare side effect from pomalidomide

2021 ◽  
Vol 14 (3) ◽  
pp. e240168
Author(s):  
Anum Qureshi ◽  
Ji Hyun Rhee
Keyword(s):  
Side Effect ◽  
Thyroid Stimulating Hormone ◽  
Acth Stimulation Test ◽  
Acth Stimulation ◽  
Free Triiodothyronine ◽  
Normal Limits ◽  
Rare Side Effect ◽  
Total Triiodothyronine ◽  
Immunomodulatory Drug ◽  
Antithyroid Peroxidase Antibody

Pomalidomide is an immunomodulatory drug used for relapsed and refractory multiple myeloma (RRMM). Hypothyroidism is an uncommon side effect of pomalidomide. We present a 70-year-old male patient with RRMM on daratumumab, pomalidomide and dexamethasone, who presented with 2 weeks of fatigue. Laboratory values showed sodium of 120 mEq/L, plasma osmolarity of 256 mOsm/kg, urine osmolarity of 648 mOsm/kg and urine sodium of 93 mEq/L. Adrenocorticotropic hormone (ACTH) stimulation test was within normal limits. Thyroid-stimulating hormone (TSH) was 88.6 IU/mL (0.380–4.700 IU/mL), total triiodothyronine (TT3) <21 ng/mL (0.8–2 ng/mL), free thyroxine (fT4) 0.10 ng/dL (0.93–1.70 ng/dL) and free triiodothyronine (fT3) <0.5 pg/mL (2.3–4.2 pg/mL). Antithyroid peroxidase antibody was 726 IU/mL (<9 IU/mL). TSH 1 year ago was 2.88 IU/mL and TT3 was 1.06 ng/mL. He was started on levothyroxine with improvement in his symptoms, sodium level and thyroid functions. The most likely culprit was pomalidomide. Checking thyroid functions before and periodically while on pomalidomide is important in screening for this possible side effect.

scholarly journals Effect of interactions between APOE and ESR1 polymorphisms on cognitive functions in postmenopausal women

2021 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Jarosław Pinkas ◽  
Iwona Bojar ◽  
Mariusz Gujski ◽  
Beata Sarecka-Hujar ◽  
Alfred Owoc ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Cognitive Functions ◽  
Visual Memory ◽  
Vital Signs ◽  
Memory Processing ◽  
Pcr Rflp ◽  
The Central Nervous System ◽  
Polymorphic Variants ◽  
Pvuii Polymorphism ◽  
The Impact

IntroductionDuring menopause the level of estrogens is decreased, which may lead to cognitive impairment or dementia. Some forms of genetic polymorphism were found to be related to cognitive functions, including APOE and ESR1 (PvuII and XbaI) polymorphisms. In the present study we aimed to analyze the impact of interactions between APOE and ESR1 polymorphisms on cognitive functions in the group of postmenopausal women.Material and methodsThe study group consisted of 266 postmenopausal women aged 50–65 years without symptoms of dementia. A computerized battery of the Central Nervous System Vital Signs (CNS VS) test was used to diagnose cognitive functions. APOE and ESR1 polymorphisms were genotyped using multiplex PCR and PCR-RFLP methods, respectively. Statistical analysis was performed using two-way analysis of variance in Statistica software.ResultsThe best memory, visual memory, processing and psychomotor speeds were found in women carrying the C allele of the PvuII polymorphism (TC + CC genotypes) in the presence of the APOE 2/3 genotype, while a lower outcome was noted in women with 3/3, and the lowest if they had the 4 allele. In the case of women with TT genotype of the PvuII polymorphism, cognitive functioning did not decrease in women with the 4 allele. A similar effect on cognitive functions was observed for AG + GG genotypes of the XbaI and APOE polymorphisms. Women who simultaneously carried CC PvuII and GG XbaI genotypes had the lowest cognitive functions.ConclusionsInteractions of polymorphic variants of APOE and ESR1 genes influenced cognitive functions in postmenopausal women.

scholarly journals Marked Biological Variance in Endocrine and Biochemical Markers in Childhood: Establishment of Pediatric Reference Intervals Using Healthy Community Children from the CALIPER Cohort

2013 ◽  
Vol 59 (9) ◽  
pp. 1393-1405 ◽  
Author(s):  
Dana Bailey ◽  
David Colantonio ◽  
Lianna Kyriakopoulou ◽  
Ashley H Cohen ◽  
Man Khun Chan ◽  
...  
Keyword(s):  
Reference Values ◽  
Biochemical Markers ◽  
Troponin I ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Healthy Children ◽  
Free Triiodothyronine ◽  
Laboratory Test Results ◽  
Total Triiodothyronine ◽  
Total Thyroxine

BACKGROUND Reference intervals are indispensable in evaluating laboratory test results; however, appropriately partitioned pediatric reference values are not readily available. The Canadian Laboratory Initiative for Pediatric Reference Intervals (CALIPER) program is aimed at establishing the influence of age, sex, ethnicity, and body mass index on biochemical markers and developing a comprehensive database of pediatric reference intervals using an a posteriori approach. METHODS A total of 1482 samples were collected from ethnically diverse healthy children ages 2 days to 18 years and analyzed on the Abbott ARCHITECT i2000. Following the CLSI C28-A3 guidelines, age- and sex-specific partitioning was determined for each analyte. Nonparametric and robust methods were used to establish the 2.5th and 97.5th percentiles for the reference intervals as well as the 90% CIs. RESULTS New pediatric reference intervals were generated for 14 biomarkers, including α-fetoprotein, cobalamin (vitamin B12), folate, homocysteine, ferritin, cortisol, troponin I, 25(OH)-vitamin D [25(OH)D], intact parathyroid hormone (iPTH), thyroid-stimulating hormone, total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), and free triiodothyronine. The influence of ethnicity on reference values was also examined, and statistically significant differences were found between ethnic groups for FT4, TT3, TT4, cobalamin, ferritin, iPTH, and 25(OH)D. CONCLUSIONS This study establishes comprehensive pediatric reference intervals for several common endocrine and immunochemical biomarkers obtained in a large cohort of healthy children. The new database will be of global benefit, ensuring appropriate interpretation of pediatric disease biomarkers, but will need further validation for specific immunoassay platforms and in local populations as recommended by the CLSI.

scholarly journals THYROID STATUS OF ATHLETES IN VARIOUS DISCIPLINES

2020 ◽  
Vol 20 (S1) ◽  
pp. 5-12
Author(s):  
R Radzhabkadiev ◽  
K Vybornaya ◽  
C Lavrinenko ◽  
A Vasilev
Keyword(s):  
Female Athletes ◽  
Elite Athletes ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
High Serum ◽  
Thyroid Peroxidase ◽  
Thyroid Status ◽  
Free Triiodothyronine ◽  
Male Athletes ◽  
Normal Limits

Aim. The article deals with the assessment of the thyroid status of athletes engaged in physical activity of varying intensity. Materials ant methods. 146 elite athletes involved in bobsleigh, biathlon, shooting and snowboarding participated in the study. We determined the serum concentration of thyroid stimulating hormone (TSH), free triiodothyronine (f.T3), free thyroxin (f.T4) and thyroid peroxidase antibodies (TPO-ab) with the COBAS e411 immunochemistry analyzer (Roche, Germany). The integral thyroid index ((f.T3 + f.T4)/TSH) was used for the assessment of the level of function of the thyroid proper. The conversion index of thyroxin to triiodothyronine (f.T4/ f.T3) was also studied. Results. 40 % of the bobsleigh athletes examined and 29 % of the snowboarders had high serum f.T3. The concentration of f.T4 in all examined athletes both male and female was within normal limits. Approximately 25 % of the male athletes examined had low II values. Among female athletes, 25 % of shooters and 33 % of bobsleigh athletes had low II values. In male biathletes and bobsleigh athletes, TPO-ab was 56 % higher than in shooters and snowboarders. In 43 % of bobsleigh athletes, 19 % of shooters, 10 % of biathletes and snowboarders, the content of TSH in males exceeded the reference intervals. Among females, TSH was high in 25 % of shooters and bobsleigh athletes. Conclusion. There were no statistically significant differences in the content of thyroid hormones in the compared sports groups, which can probably be explained by the activity of deiodinases at the local, intracellular level. At the same time, in a large number of respondents surveyed, the indicators of II and TPO-ab were outside the physiological norm.

scholarly journals Subacute Thyroiditis Presenting as Idiopathic Intracranial Hypertension

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Kanyanatt Boonyatarp ◽  
Kanoksri Samintharapanya ◽  
Thanawat Vongchaiudomchoke ◽  
Nuttaya Wachiraphansakul
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Case Reports ◽  
Vital Signs ◽  
Thyroid Stimulating Hormone ◽  
Subacute Thyroiditis ◽  
Free Triiodothyronine ◽  
Case Presentation ◽  
First Case ◽  
The Brain

Background. Several case reports have illustrated a rare neurological manifestation, idiopathic intracranial hypertension (IIH), in patients with thyrotoxicosis. However, none were diagnosed with thyroiditis. We report the case of a patient with subacute thyroiditis who presented with severe intractable headache due to IIH. Case Presentation. A 36-year-old woman visited Lampang Hospital in February 2021 complaining of neck pain and progressive severe intractable headache. Her vital signs and neurological examination were normal. Thyroid examination revealed a single 1 cm right thyroid nodule. A computed tomography (CT) scan of her brain illustrated diffuse brain edema. However, CT angiography and venography of the brain did not show abnormalities. The opening pressure of the cerebrospinal fluid was elevated (27 cmH2O). The free triiodothyronine level was 6.19 pg/mL, free thyroxine was 2.32 ng/dL, and thyroid-stimulating hormone was 0.0083 μIU/mL. Anti-Tg was positive at a low titer, but anti-TPO was negative. TRAb was also negative. Methimazole and acetazolamide were prescribed and monitored. The symptoms resolved completely within 2 weeks of onset. Thyroid hormones had returned to normal by 8 weeks. Conclusion. This is the first case report of subacute thyroiditis presenting with IIH.

Diagnosis and investigation in endocrine disorders

2018 ◽  
Author(s):  
John Newell-Price ◽  
Alia Munir ◽  
Miguel Debono
Keyword(s):  
Adrenal Glands ◽  
Clinical Problem ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Endocrine Disorders ◽  
Dynamic Tests ◽  
Thyroid Status ◽  
Gadolinium Enhancement ◽  
Free Triiodothyronine ◽  
The Common

This chapter introduces the reader to some of the common investigations used in the diagnosis of endocrine disorders. Tests used to diagnose disorders of the thyroid, pituitary, and adrenal glands are discussed. Measurement of plasma levels of thyroid-stimulating hormone, free thyroxine, and free triiodothyronine define the thyroid status. Imaging of the thyroid is usually done in the first instance by ultrasonography. The investigation of pituitary disorders involves measurement of the levels of the multiple pituitary hormones, with basal and dynamic tests as appropriate to the clinical problem. Imaging of the pituitary is typically done using magnetic resonance with gadolinium enhancement. Adrenal disorders (which include hyperaldosteronism, Cushing’s syndrome, and adrenal insufficiency) can be investigated with a range of basal and dynamic tests.

Population-specific reference values for thyroid hormones on the Abbott ARCHITECT i2000 analyzer

2004 ◽  
Vol 42 (5) ◽  
Author(s):  
Manuel González-Sagrado ◽  
Francisco Javier Martín-Gil
Keyword(s):  
Thyroid Hormones ◽  
Reference Values ◽  
Patient Population ◽  
Laboratory Data ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Total Triiodothyronine ◽  
Abbott Architect

AbstractReliable reference ranges are important in the interpretation of laboratory data, and it is incumbent on each laboratory to verify that the ranges they use are appropriate for the patient population they serve. The objective of this study was to determine population-specific reference ranges for thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and total triiodothyronine (TT3) on the Abbott ARCHITECT

NO LONGTERM SEVERE THYROID DYSFUNCTION SEEN IN PATIENTS WITH PREEXISTING REDUCED SERUM TT3 CONCENTRATIONS AFTER A SINGLE LARGE DOSE OF IODINATED CONTRAST

2020 ◽  
Vol 26 (8) ◽  
pp. 840-845
Author(s):  
Si Hai-Long ◽  
Qin Qin ◽  
Liu Yuan-Yuan ◽  
Zhao Bing-Rang
Keyword(s):  
Thyroid Dysfunction ◽  
Coronary Intervention ◽  
Thyroid Stimulating Hormone ◽  
World Health ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
Iodinated Contrast ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Health Organization

Objective: After an intravenous bolus injection of 100 mL of iodinated contrast agent (370 mgI/mL), the amount of iodine atoms entering the blood is tens of thousands of times the daily dose of iodine recommended by the World Health Organization. However, the effect of iodinated contrast in patients with nonthyroidal illness, manifested as reduced serum total triiodothyronine (TT3) concentrations, is unclear. We studied the effect of iodinated contrast on thyroid function and auto-antibodies in patients with reduced TT3 after diagnosis and treatment of coronary heart disease. Methods: This was a prospective cohort study. One hundred and fifty-four stable angina pectoris patients with reduced TT3 and normal thyroid-stimulating hormone (TSH), free thyroxine (FT4), and reverse triiodothyronine (rT3) were enrolled from January, 2017, to June, 2018. All subjects had no history of thyroid dysfunction and had no recent infections, tumors, trauma, or other critical illnesses. Fourty-one patients underwent coronary angiography and 113 patients underwent coronary intervention. Results: There were 6 patients (3.9%) with hypothyroidism and 30 patients (19.5%) developed subclinical hypothyroidism (SCHypo) on the first day after surgery. There were 6 patients (3.9%) with hypothyroidism, 6 patients (3.9%) with SCHypo, and 18 patients (11.7%) with subclinical hyperthyroidism (SCHyper) at the first month postsurgery. There were 23 patients (14.9%) with SCHyper and 6 patients (3.9%) with SCHypo at the sixth month after surgery. No patient with longterm severe thyroid dysfunction occurred during follow-up. The levels of free triiodothyronine, FT4, TT3, total thyroxine, and TSH showed statistically significant changes at 1 day, and 1, 3, and 6 months postoperative ( P<.005). The level of rT3 showed no statistically significant change at 1, 3, and 6 months postoperative ( P>.05). The levels of thyroglobulin antibody and thyroid peroxidase antibody decreased at 6 months postoperative ( P<.001). Conclusion: The risk of subclinical thyroid dysfunction and transient hypothyroidism occurred with a single large dose of iodinated contrast in the diagnosis and treatment of coronary heart disease, but no longterm severe thyroid dysfunction occurred. Patients with preoperative thyroid antibody elevation were more likely to have subclinical thyroid dysfunction after surgery. Abbreviations: FT3 = free triiodothyronine; FT4 = free thyroxine; PCI = percutaneous coronary intervention; rT3 = reverse triiodothyronine; SCHyper = subclinical hyperthyroidism; SCHypo = subclinical hypothyroidism; TGAB = thyroglobulin antibody; TPOAB = thyroid peroxidase antibody; TT3 = total triiodothyronine; TT4 = total thyroxine; TSH = thyroid-stimulating hormone; WHO = World Health Organization

scholarly journals Subclinical hypothyroidism is associated with migraine: A case-control study

Cephalalgia ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Elisa Rubino ◽  
Innocenzo Rainero ◽  
Francesca Garino ◽  
Costanza Vicentini ◽  
Flora Govone ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Biochemical Parameters ◽  
Clinical Characteristics ◽  
Case Control Study ◽  
Case Control ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Antibodies ◽  
Free Triiodothyronine ◽  
Potential Association ◽  
Control Study

Background Recent studies suggested a potential association between both overt and subclinical hypothyroidism and migraine. Aims of this study were to estimate the comorbidity of migraine in patients with subclinical hypothyroidism and to evaluate associated clinical characteristics. Methods Using a case-control strategy, 151 consecutive subclinical hypothyroidism patients (mean age 48.36 ± 15.86 years) and 150 controls (mean age 50.86 ± 9.19 years) were recruited. In all subjects, migraine characteristics were collected through a direct interview. Clinical and biochemical parameters (thyroid-stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid antibodies) were compared between subclinical hypothyroidism patients in comorbidity with migraine and subclinical hypothyroidism patients without migraine. Results The prevalence of lifetime migraine was significantly higher in subclinical hypothyroidism patients in comparison with controls (46% vs. 13%, p < 0.001; OR 5.80; 95% CI = 3.35–10.34). Both migraine without and with aura were significantly higher in subclinical hypothyroidism patients than controls ( p < 0.001 and p = 0.010, respectively). Thyroid hormones and concentrations of antibodies did not differ between subclinical hypothyroidism patients with and without migraine. Interestingly, a comorbidity for autoimmune diseases was observed in subclinical hypothyroidism patients with migraine in respect to those without migraine ( p = 0.005). Conclusions Our data suggest that migraine is more frequent in patients with subclinical hypothyroidism in respect to controls. Further studies are needed in order to confirm this association.

P5513Relation of thyroid hormones level to the extent of myocardial injury in patients with acute coronary syndrome

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Badran ◽  
G Soltan ◽  
A Belal
Keyword(s):  
Acute Coronary Syndrome ◽  
Thyroid Hormones ◽  
Myocardial Injury ◽  
Troponin I ◽  
Thyroid Stimulating Hormone ◽  
Gensini Score ◽  
Thyroid Status ◽  
Free Triiodothyronine ◽  
Coronary Syndrome ◽  
Significant Difference

Abstract Objective Previous studies have identified that abnormal thyroid hormonal status is associated with worse prognosis especially in coronary artery disease (CAD). The present study further explores whether thyroid hormones associated with size of myocardial injury and extent of CAD in patients with acute coronary syndrome (ACS). Methods In this study, we enrolled 120 consecutive patients (52% male, mean age 54.2±6.4 years) who were admitted to ICU with ACS and having coronary angiography. All patients underwent testing for thyroid function status [thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4)], cardiac troponin I (cTnI), cardiac enzymes, C-reactive protein (CRP). Risk profile, clinical characteristics and angiographic results (Gensini score) were also analyzed. Results 43.3% of patients presented with STEMI, 33.3% with NSTEMI and 23.3% unstable angina. CK-MB, troponin and CRP were significantly higher in STEMI compared with NSTEMI group (P<0.0001). Abnormal thyroid status was prevalent in 13.4% of total population; Low FT3 syndrome in 6.7%, subclinical hypothyroidism in 5% and clinical hypothyroidism in 1.7%. Lower thyroid hormone levels showed significantly lower HDL (P<0.02), higher triglyceride level& CRP and cTnI (P<0.007), higher rate of in hospital complications including recurrent angina, CHF and cardiogenic shock (P<0.001) and more severe CAD using Gensini score (P<0.0001). However, there was no significant difference in abnormal thyroid status between STEMI and NSTEMI. After adjusting for conventional risk factors, FT3 showed direct correlation to LV EF% (r=0.62, P<0.000) and inverse correlation to LV internal dimension (r=−0.57, P<0.0001), troponin (r=−0.27, P<0.03), CRP (r=−0.39, P<0.003), Gensini score (r=−0.48, P<0.0001) and number of in hospital complications (r=−0.62, P<0.0001). From a linear stepwise regression analysis low EF% (β: 0.032, 95% CI: 0.009–0.055, P<0.007) and presence of complications (β: 0.625, 95% CI: 1.194–0.056, P<0.03) are independent predictors of low FT3. Conclusions In ACS, the lower thyroid hormones levels are associated with larger myocardial injury, more severe CAD and higher rate of complications especially during their hospital course.

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