Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

SummaryIncreased serum levels of endogenous as well as exogenous estrogen are regarded to be responsible for acquired activated protein C (APC) resistance. It was the objective of this study to evaluate whether the physiological increase in serum estradiol concentration during the normal menstrual cycle affects the individual’s sensitivity to APC. Seventy-two women with normal menstrual cycles were included in the study. Blood samples for analysis of estradiol (E2), progesterone (P4) and APC resistance were drawn at two time points of the menstrual cycle (day 3–5 and day 22–25). Two methods of measuring APC resistance were used: the activated partial thromboplastin time (aPTT)-based assay and the endogenous thrombin potential (ETP)-based APC resistance test. Independent of the method used, no changes in APC resistance were found, even though the E2 concentration increased significantly between the two menstrual phases. No correlations between E2 levels and APC resistance, P4 levels and APC resistance or changes in E2 concentrations and changes in APC resistance were detected. Ten women were carriers of the factor VLeiden mutation. Their baseline APC resistance was increased, but their response to elevated E2 during the menstrual cycle did not differ from that of non-carriers. In conclusion, our observations suggest that physiological differences in serum levels of estradiol and progesterone between the early follicular and the luteal phase in a normal menstrual cycle do not have any significant impact on the individual’s sensitivity to APC.

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Serum estradiol concentration, estradiol-toprogesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients

European Annals of Allergy and Clinical Immunology ◽

10.23822/eurannaci.1764-1489.09 ◽

2017 ◽

Vol 49 (04) ◽

pp. 161

Author(s):

A. Semik-Orzech ◽

S. Skoczyński ◽

W. Pierzchała

Keyword(s):

Menstrual Cycle ◽

Luteal Phase ◽

Serum Estradiol ◽

Asthma Patients ◽

Estradiol Concentration

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Effect of spraying of fine water particles on facial skin moisture and viscoelasticity in adult women

Skin Research and Technology ◽

10.1111/srt.12648 ◽

2018 ◽

Vol 25 (3) ◽

pp. 294-298 ◽

Cited By ~ 1

Author(s):

Naoki Nishimura ◽

Shinsuke Inoue ◽

Keiko Yokoyama ◽

Satoshi Iwase

Keyword(s):

Adult Women ◽

Facial Skin ◽

Skin Moisture

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Effects of menstrual cycle and menopause on internal carotid artery shear-mediated dilation in women

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00810.2020 ◽

2020 ◽

Author(s):

Erika Iwamoto ◽

Rintaro Sakamoto ◽

Wakako Tsuchida ◽

Kotomi Yamazaki ◽

Tatsuki Kamoda ◽

...

Keyword(s):

Menstrual Cycle ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Endothelial Function ◽

Internal Carotid ◽

Premenopausal Women ◽

Cycle Phase ◽

Serum Estradiol ◽

Cross Sectional ◽

Potential Index

This study aimed to elucidate the effects of change in estrogen during the menstrual cycle and menopause on shear-mediated dilation of the internal carotid artery (ICA), a potential index of cerebrovascular endothelial function. Shear-mediated dilation of the ICA and serum estradiol were measured in 11 premenopausal (Pre-M, 21±1yrs), 13 perimenopausal (Peri-M, 49±2yrs), and 10 postmenopausal (Post-M, 65±7yrs) women. Measurements were made twice within the Pre-M group at their early follicular (EF, lower estradiol) and late follicular (LF, higher estradiol) phases. Shear-mediated dilation was induced by 3min of hypercapnia (target PETCO2 +10mmHg from individual baseline) and was calculated as the percent rise in peak diameter relative to baseline diameter. ICA diameter and blood velocity were simultaneously measured by Doppler ultrasound. In Pre-M, shear-mediated dilation was higher during the LF phase than during the EF phase (P<0.01). Comparing all groups, shear-mediated dilation was reduced across the menopausal transition (P<0.01), and Pre-M during the LF phase showed the highest value (8.9±1.4%) compared with other groups (Pre-M in EF, 6.4±1.1%; Peri-M, 5.5±1.3%; Post-M, 5.2±1.9%, P<0.05 for all). Shear-mediated dilation was positively correlated with serum estradiol even after adjustment of age (P<0.01, r=0.55, age-adjusted; P=0.02, r=0.35). Collectively, these data indicate that controlling the menstrual cycle phase is necessary for the cross-sectional assessments of shear-mediated dilation of the ICA in premenopausal women. Moreover, current findings suggest that a decline in cerebrovascular endothelial function may be partly related to the reduced circulating estrogen levels in peri- and postmenopausal women.

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Both Inhibin A and B Respond to Exogenous Follicle-Stimulating Hormone in the Follicular Phase of the Human Menstrual Cycle1

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.83.11.5282 ◽

1998 ◽

Vol 83 (11) ◽

pp. 4167-4169

Author(s):

Henry G. Burger ◽

Nigel P. Groome ◽

David M. Robertson

Keyword(s):

Menstrual Cycle ◽

Follicle Stimulating Hormone ◽

Follicular Phase ◽

Serum Estradiol ◽

Serum Samples ◽

Control Value ◽

Highly Correlated ◽

Human Menstrual Cycle ◽

Dose Dependent Increase ◽

Dose Dependent

To ascertain whether changes in the concentrations of the dimeric inhibins A and/or B (INH-A and INH-B) contributed to the previously described dose-dependent increase in immunoreactive inhibin (INH) in response to FSH during the follicular phase of the human menstrual cycle, both dimers were measured by specific two-site assays in stored serum samples from regularly cycling normal volunteers who had received saline as a control (n = 5) or FSH [100 IU (n = 6) or 200 IU (n = 5)] between days 3–5 of the menstrual cycle. Both INH-A and INH-B showed a dose-dependent increase in response to administered FSH; INH-A rose from 13.5 to 35.9 ng/L (P < 0.01), and INH-B rose from 77.8 to 205 ng/L (P < 0.05) at 36 h after 200 IU FSH. Highly significant correlations were observed between INH and each of the specific inhibin dimers (A: r= 0.79, P < 0.001; B: r = 0.76, P < 0.001), and the responses of the two dimers were also highly correlated (r = 0.59, P < 0.001). The response of each inhibin was also highly correlated with the response of serum estradiol (A: r = 0.45, P < 0.001; B: r = 0.40, P< 0.001). When analyzed by ANOVA, the INH response of INH-B was significantly above the control value at 36 h after treatment with both 100 and 200 IU FSH, whereas the response of INH-A was significant only at 200 IU. It is concluded that the concentrations of both dimeric INH-A and INH-B are stimulated by increases in FSH within the physiological range in the follicular phase of the human menstrual cycle and that both contribute to the previously observed rise in INH.

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Serum Estradiol Concentration as Measured by HPLC-RIA and Bone Mineral Density in Postmenopausal Women during Hormone Replacement Therapy

Hormone Research in Paediatrics ◽

10.1159/000075523 ◽

2004 ◽

Vol 61 (3) ◽

pp. 117-125 ◽

Cited By ~ 5

Author(s):

Toshiyuki Yasui ◽

Hirokazu Uemura ◽

Yuka Umino ◽

Masaya Takikawa ◽

Akira Kuwahara ◽

...

Keyword(s):

Bone Mineral Density ◽

Hormone Replacement Therapy ◽

Replacement Therapy ◽

Postmenopausal Women ◽

Bone Mineral ◽

Hormone Replacement ◽

Serum Estradiol ◽

Mineral Density ◽

Estradiol Concentration

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Estradiol and progesterone levels in the endometrium and the reproductive tract luminal washing during the pre-implantation stages of gestation in the rhesus monkey

Acta Endocrinologica ◽

10.1530/acta.0.1200649 ◽

1989 ◽

Vol 120 (5) ◽

pp. 649-654 ◽

Cited By ~ 4

Author(s):

D. Ghosh ◽

Jayasree Sengupta

Keyword(s):

Menstrual Cycle ◽

Rhesus Monkey ◽

Reproductive Tract ◽

Sex Steroid ◽

Menstrual Cycles ◽

Normal Menstrual Cycle ◽

Ovulatory Period ◽

Hormonal Milieu ◽

Estradiol 17Β ◽

Estradiol Concentration

Abstract. To obtain an understanding of the sex steroid hormonal milieu during early gestation, the concentrations of estradiol-17β and progesterone were measured in endometria and reproductive tract luminal fluids collected during the post-ovulatory period (days 2 to 6) of conception, and of non-mated menstrual cycles of the rhesus monkey (Macaca mulatta). Estradiol content was found to be higher (P< 0.05) in endometria obtained from conception cycles; day-wise analysis revealed higher (P< 0.05) level of tissue estradiol concentration on day 6 of post-ovulation as compared with the normal menstrual cycle. Endometrial progesterone content remained, however, unaltered in both groups of monkeys and thus relatively lower (P< 0.05) endometrial progesterone to estradiol ratios were seen on days 4, 5 and 6 of gestation compared with normal menstrual cycle. There were no significant changes in the profiles and concentrations of estradiol and progesterone in luminal washings. The typical sex steroid hormonal milieu observed in the endometrium during the peri-implantation stage of gestation in conception cycle may be related to the endometrial differentiation towards implantation in the rhesus monkey.

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FORMULASI SEDIAAN MASKER WAJAH MENGGUNAKAN EKSTRAK ETANOL BUNGA KECOMBRANG (ETLINGERA ELATIOR) TERHADAP KELEMBABAN KULIT WAJAH

JURNAL FARMASIMED (JFM) ◽

10.35451/jfm.v2i2.364 ◽

2020 ◽

Vol 2 (2) ◽

pp. 63-68

Author(s):

Chandra Pranata ◽

Novidawati Boru Situmorang ◽

Romauli Anna Teresia Marbun

Keyword(s):

Natural Antioxidants ◽

Facial Skin ◽

Ginger Extract ◽

Face Surface ◽

Facial Mask ◽

Flower Extract ◽

Extract Concentration ◽

The Face ◽

Skin Moisture ◽

Etlingera Elatior

ABSTRACT Skin is an essential and vital organ and a reflection of health. Natural antioxidants such as flavonoids, polyphenols and Sapponin are believed to increase moisture on the skin. This ability is the main reason for using Torch Ginger flower extract which is formulated into a form of facial mask in the form of clay facial mask. Objective: To formulate facial moisturizing mask preparations using the extract of Torch Ginger(Etlingera elatior). This study used the Torch Ginger Flower extract facial moisturizing mask formulation method with a concentration of 0 (Blank), 5% and 10%. Evaluation of mask preparations included homogeneity, stability of dosage at temperatures of 80C and 250C, Organoleptic test and pH of preparations. Measurements of skin moisture activity were measured using alar Skin Analyzer which was tested on the face surface 3cm wide. The results showed that the preparation was stable in terms of odor, color and was at a pH of 4.2-6.3 using observations of litmus discoloration. Effectiveness of facial skin moisture with 10% Torch Ginger extract concentration is more effective to produce results at a concentration of 5% and blank. Conclusion: Torch Ginger flower extract can be formulated into preparations of face masks with various concentrations and has the effect of moisturizing the skin and brightening the complexion. Keywords: Torch Ginger Flower Extract, Facial Mask, Clay Facial Mask, Facial Skin Moisture

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Influence of Ischemia-reperfusion Injury on Endothelial Function in Men and Women with Similar Serum Estradiol Concentrations

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00147.2021 ◽

2021 ◽

Author(s):

Sophie Lalande ◽

Holden W. Hemingway ◽

Caitlin P. Jarrard ◽

Amy M. Moore ◽

Albert H. Olivencia-Yurvati ◽

...

Keyword(s):

Menstrual Cycle ◽

Endothelial Function ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Circulatory Arrest ◽

Duplex Ultrasound ◽

Follicular Phase ◽

Serum Estradiol ◽

Early Follicular Phase ◽

Artery Flow

Prior data suggest that relative to the early follicular phase, women in the late follicular phase are protected against endothelial ischemia-reperfusion (I/R) injury when estradiol concentrations are highest. In addition, endothelial I/R injury is consistently observed in men with naturally low endogenous estradiol concentrations that are similar to women in the early follicular phase. Therefore, the purpose of this study was to determine if the vasodeleterious effect of I/R injury differs between women in the early follicular phase of the menstrual cycle and age-matched men. We tested the hypothesis that I/R injury would attenuate endothelium-dependent vasodilation to the same extent in women and age-matched men with similar circulating estradiol concentrations. Endothelium-dependent vasodilation was assessed via brachial artery flow-mediated dilation (duplex ultrasound) in young healthy men (N = 22) and women (N = 12) before (pre-I/R) and immediately after I/R injury (post-I/R), which was induced via 20 min of arm circulatory arrest followed by 20 min reperfusion. Serum estradiol concentrations did not differ between sexes (men, 115.0 ± 33.9 pg ml-1 vs. women, 90.5 ± 40.8 pg ml-1; P = 0.2). The magnitude by which I/R injury attenuated endothelium-dependent vasodilation did not differ between men (pre-I/R, 5.4 ± 2.4 % vs. post-I/R 3.0 ± 2.7 %;) and women (pre-I/R, 6.1 ± 2.8 % vs. post-I/R 3.7 ± 2.7 %; P = 0.9). Our data demonstrate that I/R injury similarly reduces endothelial function in women in the early follicular phase of the menstrual cycle and age-matched men with similar estradiol concentrations.

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