Primary Alopecia Neoplastica: A Novel Case Report and Literature Review

2021 ◽  
pp. 1-11
Author(s):  
Kelly E. Flanagan ◽  
Laura J. Burns ◽  
James T. Pathoulas ◽  
Chloe J. Walker ◽  
Isabel Pupo Wiss ◽  
...  
Keyword(s):  
Literature Review ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Cutaneous Metastasis ◽  
Amelanotic Melanoma ◽  
Hair Follicles ◽  
Unique Case ◽  
Desmoplastic Melanoma ◽  
Comprehensive Literature Review ◽  
Scalp Lesion

Alopecia neoplastica (AN) is caused by neoplastic cells damaging hair follicles, resulting in patchy hair loss like cicatricial alopecia and alopecia areata. AN has predominantly described cutaneous metastasis to the scalp from primary visceral malignant tumors. Less frequently, AN results from a primary scalp neoplasm. Compared to “secondary AN,” there is a paucity of literature on “primary AN.” Herein, we present a comprehensive literature review of primary AN and introduce a unique case of amelanotic melanoma causing primary AN. Including our presented case, 11 cases of primary AN have been reported with causative scalp neoplasms including angiosarcoma, hemangioendothelioma, syringomatous carcinoma, ectopic extramammary Paget’s disease, and primary desmoplastic melanoma. 27.3% (3 of 11) of cases were misdiagnosed and treated for a primary alopecia, and 36.4% (4 of 11) of lesions were present for multiple years or an unknown amount of time, likely due to difficulty in recognizing scalp lesion or misdiagnosis. All patients required surgical excision with 36.4% (4 of 11) requiring chemotherapy, radiation, or photodynamic therapy. Two patients with scalp angiosarcoma died from their aggressive disease. Due to the risks of malignant primary AN if allowed to progress, primary AN should be considered in patients presenting with scarring alopecia.

scholarly journals Synovial sarcoma of the hand-wrist: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Serenella Serinelli ◽  
Lorenzo Gitto ◽  
Daniel J. Zaccarini
Keyword(s):  
Literature Review ◽  
Synovial Sarcoma ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Caucasian Woman ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Synovial Sarcomas ◽  
Uncommon Case

Abstract Background Synovial sarcomas are infrequent malignant tumors occurring mostly in adolescents and young adults. The occurrence of synovial sarcoma in the hand-wrist area is rare (4 to 8.5% of all synovial sarcomas in different studies). Case presentation This report documents an uncommon case of synovial sarcoma occurring in the hand-wrist of a 69-year-old Caucasian woman. She was subsequently treated with surgical excision and radiotherapy without recurrence after follow up. Conclusions This paper aims to characterize the demographic, pathologic, and clinical features with a literature review. The present literature review confirms that hand-wrist synovial sarcomas are more frequent among males and subjects 10 to 40 years old. Most cases in this location are usually not larger than 5 cm in size. The five-year survival rate is higher than that reported in a previous review on hand synovial sarcomas, and this suggests an improved survival in recent decades.

scholarly journals Repair of Defect in Thoracic Wall Associated with Neoplasms—Literature Review

2018 ◽  
Vol 10 (4) ◽  
pp. 245
Author(s):  
Josiane Morais Pazzini ◽  
Rafael Ricardo Huppes ◽  
Jorge Luiz Costa Castro ◽  
Pedro Carvalho Cassino ◽  
Stella Habib Moreira ◽  
...  
Keyword(s):  
Literature Review ◽  
Chest Wall ◽  
Adjuvant Treatment ◽  
Respiratory Function ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Thoracic Wall ◽  
Safety Margins ◽  
Materials Used

The major malignant tumors found on the chest wall are sarcomas, including osteosarcomas, chondrosarcomas, fibrosarcomas, and hemangiosarcomas. Treatment of cancer, as well as chronic chest wall conditions, require radical surgical excision of the involved tissues. In addition to surgery, chemotherapy plays a role as adjuvant treatment in tumors affecting the chest wall, reducing chances of metastasis and prolonging the disease. The restoration of the chest wall has the main objective to restore the respiratory function, for this, a procedure is necessary that keeps the chest closed and stable. There are many materials used for chest repair, such as autogenous, synthetic, homologous and heterologous tissues. The main objective of this literature review is to address the main malignancies that affect the chest wall, as well as the resources most used to repair the damage caused by aggressive surgery in an attempt to promote greater safety margins.

scholarly journals Pyogenic granuloma under nail: A rare localization

2021 ◽  
Vol 12 (e) ◽  
pp. e61-e61
Author(s):  
Aida Oulehri ◽  
Zakia Douhi ◽  
Kaoutar Acheboune ◽  
Hanane Baybay
Keyword(s):  
Negative Impact ◽  
Malignant Tumors ◽  
Correct Diagnosis ◽  
Surgical Excision ◽  
Pyogenic Granuloma ◽  
Capillary Hemangioma ◽  
Amelanotic Melanoma ◽  
Primary Role ◽  
X Rays ◽  
Vascular Structures

Pyogenic granuloma (PG) – also known as lobular capillary hemangioma – is a benign vascular tumour that occurs on the skin and mucous membranes, it’s can arise spontaneously, in sites of injury, or within capillary malformations [1]. Because malignant tumors, such as amelanotic melanoma, can be misdiagnosed as PG, histopathology is mandatory for the correct diagnosis, even though dermoscopy can play a primary role in the prompt recognition of PG, showing highly repetitive patterns that can support the diagnosis [2]. In particular, the presence of reddish homogeneous area, white rail lines are strongly suggestive of PG; even more so when associated together. On the other hand, with dermoscopy, it is not uncommon to detect ulceration and vascular structures that do not rule out malignancies [3]. Vascular structures are observed in 45% of cases, they can be linear-irregular or polymorphic and atypical [2]. Despite its benign nature, GP can have a significant negative impact on patients’ quality of life, and therefore appropriate therapy is needed. This is a 35-year-old patient with a history of trauma to his left hand dating back 3 months before his admission. He presents with a nodule under his left thumb, which has been evolving for 2 months, fixed in depth and sometimes-bleeding (Fig. 1). The nodule was slightly painful. X-rays of the thumb were normal. On dermoscopy (Fig. 2), we noted the presence of vascular lagoons with fibrous septal and linear vessels. We suspected a botryomyoma or achromic melanoma. Surgical excision was performed (Fig. 3) with an anatomopathological study in favour of a pyogenic granuloma.

Pediatric spinal clear cell meningioma

2009 ◽  
Vol 3 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Chaim B. Colen ◽  
Mahmoud Rayes ◽  
Jamal McClendon ◽  
Raja Rabah ◽  
Steven D. Ham
Keyword(s):  
Literature Review ◽  
Mr Imaging ◽  
Spinal Canal ◽  
Clear Cell ◽  
Pediatric Population ◽  
Unique Case ◽  
Clear Cell Meningioma ◽  
Comprehensive Literature Review ◽  
Intradural Extramedullary

In this report the authors describe a unique case of spinal clear cell meningioma in a 13-year-old girl. Clear cell meningiomas (CCMs) are not uncommon. To the authors' knowledge, 14 cases of pediatric CCM occurring in the spinal canal have been reported. Factors lending resistance to meningioma initiation and invasion are analyzed. This 13-year-old girl presented with pain radiating down her left leg. Admission MR imaging showed an inhomogeneous enhancing intradural-extramedullary mass at the L4–5 level. Resection revealed a CCM, and radiotherapy was subsequently administered. Postoperatively there has been no recurrence in > 2 years. In this paper the authors report a case of CCM and provide a comprehensive literature review on this disease. Current recommendations for its management are still debatable, especially in the pediatric population, and the authors propose an algorithm for its treatment and surveillance.

Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

2020 ◽  
Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona
Keyword(s):  
Literature Review ◽  
Retrospective Review ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Spontaneous Pneumomediastinum ◽  
Nonaccidental Trauma ◽  
Comprehensive Literature Review ◽  
Healthy Infants ◽  
History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

Modern aspects of tactics in the genital herpes viral infection (literature review)

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 67-73
Author(s):  
T Yu Pestrikova ◽  
E A Yurasova ◽  
I V Yurasov ◽  
A V Kotelnikova
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Genital Herpes ◽  
Fetal Death ◽  
Malignant Tumors ◽  
Adult Population ◽  
Viral Disease ◽  
Intrauterine Fetal Death ◽  
Complicated Course ◽  
Simplex Virus

Genital herpes affects all population groups. 98% of the adult population worldwide have antibodies to the herpes simplex virus (HSV-1 or 2). This viral infection is a significant medical and social problem. HSV can lead to a complicated course of pregnancy, causing miscarriages, premature birth, intrauterine fetal death, systemic viral disease in newborns. There is evidence that HSV has a connection with malignant tumors of the prostate and cervix, contributing to their development. This literature review contains modern aspects of epidemiology, etiology, pathogenesis, clinic, diagnosis, treatment of genital herpes, including its recurring forms with valacyclovir (Valvir). Indications for hospitalization of patients with genital herpes were noted and the prognosis of this pathology was determined. The tactics of managing pregnant women with this pathology is presented.

Conceptualización del desempeño exportador: análisis de los avances en la literatura de los negocios internacionales

Oikos ◽  
2016 ◽  
Vol 19 (40) ◽  
pp. 137
Author(s):  
Roberto Horta
Keyword(s):  
Performance Analysis ◽  
Literature Review ◽  
International Business ◽  
Export Performance ◽  
Comprehensive Literature Review

RESUMENEl objetivo de este artículo es el de analizar el concepto “desempeño exportador”, concepto muy usado en la literatura relacionada con los negocios internacionales, a los efectos de aportar a su conceptualización y medición. Para ello, se efectúa una amplia revisión de la literatura y se analizan los avances realizados por los investigadores a los efectos de aportar a las dimensiones y formas de medir este concepto. Se concluye que se trata de un concepto en el cual siguen existiendo diversos enfoques, aunque existen avances importantes en la forma de operacionalizar el desempeño exportador.Palabras clave: conceptualización, desempeño exportador, negocios internacionales.Conceptualization of export performance: analysis of developments in the literature of international business ABSTRACTThe aim of this paper is to analyze the concept of "export performance" concept very use in the literature of international business, in order to contribute to its conceptualization and measurement. For this, a comprehensive literature review is performed and the progress made by researchers to contribute to the dimensions and ways of measuring this concept is discussed. Concluded that it is a concept which still exist several approaches, although there are significant advances in how to operationalize export performance.Keywords: conceptualization, export performance, international business.Conceptualização do desempenho exportador: a análise dos avanços na literatura dos negócios internacionais RESUMO O objetivo deste artigo é analisar o conceito de "desempenho exportador", conceito utilizado amplamente na literatura sobre negócios internacionais, aos efeitos de contribuir para a conceituação e medição. Para fazer isso, se faz uma extensa revisão da literatura e analisam-se os avanços realizados pelos pesquisadores aos efeitos de contribuir nas dimensões e formas de medir este conceito. Conclui-se que se trata de um conceito no qual continuam existindo diversas abordagens, apesar dos avanços significativos na forma de operacionalizar o desempenho exportador.Palavras-chave: conceituação, desempenho exportador, negócios internacionais.

Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani
Keyword(s):  
Oxidative Stress ◽  
Drug Discovery ◽  
Literature Review ◽  
Structural Modification ◽  
Therapeutic Potential ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Triazole Derivatives ◽  
Comprehensive Literature Review ◽  
The Common

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.

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