scholarly journals Depression, Anxiety, and Suicidal Ideation in Patients with Atopic Eczema in a Prospective Study in Leipzig, Germany

2021 ◽  
pp. 1-6
Author(s):  
Paula Kage ◽  
Laura Poblotzki ◽  
Samira Zeynalova ◽  
Julia Zarnowski ◽  
Jan-Christoph Simon ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Atopic Eczema ◽  
Life Quality ◽  
Depression Scale ◽  
Rank Correlation ◽  
Severity Index ◽  
Epidemiologic Studies ◽  
Depression And Anxiety ◽  
Spearman’S Rank Correlation ◽  
A Prospective Study

<b><i>Background:</i></b> Atopic eczema (AE) is known to be associated with depression and anxiety. We aimed at investigating the occurrence of selected psychological comorbidities in patients with AE under treatment in our university dermatological department. <b><i>Methods:</i></b> Monocentric prospective examination of adult AE patients using PO-SCORAD (Patient-Oriented Severity Scoring of AD), EASI (Eczema Area and Severity Index), POEM (Patient-Oriented Eczema Measure), DLQI (Dermatologic Life Quality Index), LSNS-6 (Lubben Social Network Scale 6), CES-D (Center for Epidemiologic Studies Depression Scale), HADS-D and -A (Hospital Anxiety and Depression Scale), and GAD-7 (Generalized Anxiety Disorder Scale-7) was carried out. We looked for correlations between AE severity and psychosocial comorbidities. Data were compared with age- and sex-matched controls from nonatopic subjects. Statistics: Mann-Whitney U test and Spearman’s rank correlation were used. <b><i>Results:</i></b> Eighty-four patients (44 women, median age 35.0 years, range: 19.4–92.8 years) were included. PO-SCORAD was 40.4 [23.4–55.4] (median [interquartile range]), EASI 9.3 [3.4–18.9], POEM 16 [8–24], and DLQI 10 [4–18]. Compared with 161 from the healthy LIFE-Adult cohort controls, our patients with AE had significantly higher scores for HADS, GAD-7, and CES-D (<i>p</i> &#x3c; 0.001, respectively), but there was no increase in the LSNS score (18 vs. 19; <i>p</i> = 0.067). Within the group of AE patients, there was a significant correlation of the subjective skin severity and the depression and anxiety values: POEM significantly correlated with GAD-7, CES-D, and HADS-A and -D (<i>p</i> &#x3c; 0.001). PO-SCORAD significantly correlated with GAD-7 and CES-D (<i>p</i> &#x3c; 0.05). EASI correlated neither with HADS-A or -D nor with CES-D. Patients with suicidal thoughts, plans, or attempts in the last 12 months had significantly more severe AE than those without (POEM 25 [15.3–26] vs. 15 [7–23]; <i>p</i> = 0.013, and PO-SCORAD 51.6 [40.2–63] vs. 20.5 [20.7–52]; <i>p</i> = 0.014). <b><i>Conclusion:</i></b> Patients with AE being currently under treatment in our department had significantly increased scores indicating depression and anxiety. Suicidal tendency was increased in patients with severe AE. <b><i>Key Message:</i></b> AE patients may develop depression, anxiety, and suicidal ideation. Patient-oriented scores may help identifying high-risk patients.

Comprehensive cancer cachexia staging and its impact in the outpatient oncology setting: A phase II study

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20530-e20530
Author(s):  
D. Blum ◽  
J. Hess ◽  
A. Omlin ◽  
G. Jurt ◽  
F. Strasser ABHPM
Keyword(s):  
Cancer Care ◽  
Factor Model ◽  
Descriptive Analysis ◽  
Depression Scale ◽  
Rank Correlation ◽  
Care Physician ◽  
Spearman’S Rank Correlation ◽  
Hospital Anxiety Depression Scale ◽  
Loss Of Appetite ◽  
Anxiety Depression

e20530 Background: Symptom management in advanced cancer is based on appropriate and feasible syndrome staging. To test whether 1. various factors predict involuntary weight loss [WL], 2. patients [pts] attending a cachexia clinic [CC] improve nutritional intake [NI], and 3. eating-related distress [ERD] is a consequence of cachexia or psychological issues. Methods: The multidisciplinary CC (nurse, nutritionist, psycho-oncologist, palliative cancer care physician) applies standardized assessments (Symptom Visual Analogue Scales [VAS, 0=none, 10=severe], 2-day NI diary [% of calculated needs: calories, protein], secondary causes for impaired NI, weight history (2 months WL), Body Mass Index [BMI], C-reactive Protein [mg/dl, normal 8), ERD-VAS, Hospital Anxiety Depression Scale, spirituality [FICA]). Interventions include nutritional counseling, palliative cancer care and psychosocial supportive measures. Descriptive analysis, Spearman‘s Rank correlation and Factor analysis (Eigenvalue >1) were performed. Results: 58 pts (age 65 years [mean; range: 38, 85]; 28F/30M; cancer types: 24 GI, 13 GU, 12 lung/ENT, 9 other; survival 151 days [7, 776]) had 6.9% WL (-6, 22; 21%<2%), 21 kg/m2 BMI (15, 26), 52 CRP (1, 272; 32% normal), 5.6 anorexia, 1.6 anxiety, 6 HADS-A, 1.3 depression, 9 HADS-D, 68% of NI needs (1466kcal [400, 2700], 47g protein [15, 108]). WL correlated with NI kcal (r=-.29, p=.038) and protein (-.3,.035), not anorexia (.16), BMI (.032) or CRP (-.08); a 2 factor model (NI/anorexia/WL [.83/.79/.70], CRP/BMI [.86/.75] explains 67% variability. At second visit (21 days; 13, 64) 15/19 pts increased kcal (400kcal) and 15/16 protein (32g) NI, 6/17 weight. ERD correlated with anorexia (r=.56, p=.001) and depression (.48,.002), not anxiety (.23), WL (.038) or survival (-.15). A 3 factor model (ERD/anxiety/depression [.71/.85/.92], anorexia/survival [.82/.65], WL [.84]) explains 75% variability. Conclusions: A combination of clinical variables seems needed to characterize patients with involuntary WL. Most patients attending 2 consecutive cachexia clinic visits respond to multidimensional interventions. ERD seems to be associated both with loss of appetite and depression, not by WL or survival. Further testing of this intervention seems justified. [Table: see text]

scholarly journals Anxiety and depression among adolescent students at higher secondary school

BIBECHANA ◽  
2016 ◽  
Vol 14 ◽  
pp. 103-109 ◽  
Author(s):  
M Bhandari
Keyword(s):  
Academic Performance ◽  
Secondary School ◽  
Correlation Coefficient ◽  
Mental Health Problems ◽  
Rank Correlation ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Adolescent Students ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient

This study was conducted to assess the association of depression and anxiety with selected variables; low academic performance and poor parent adolescent relationship among the adolescent students at Arniko Higher Secondary school at Biratnagar. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) tools were used for data collection. Spearman’s Rank Correlation Coefficient and Chi Square test were applied to assess the significant variables. The findings of the study revealed that there was significant correlation between total depression and total anxiety score i.e. Spearman’s rank correlation coefficient value was 0.554 (p = 0.000). The study also found that the depression and anxiety were significantly associated with type of family (p =0.005 & p = 0.015).  The depression was significantly associated with academic performance of adolescent students (p = 0.030) and major accident in the family (p =0.009). Similarly, the anxiety was significantly associated with parental fight (p = 0.007), conflict with father (p = 0.019), and death of family member (p = 0.016). It can be concluded that adolescent anxiety and depression are significant mental health problems so further studies are needed to validate the findings. BIBECHANA 14 (2014) 103-109

scholarly journals Metastatic breast cancer patient perception of somatic tumor genomic testing

2019 ◽  
Author(s):  
Elizabeth J. Adams ◽  
Sarah Asad ◽  
Raquel E. Reinbolt ◽  
Katharine A. Collier ◽  
Mahmoud Abdel-Rasoul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Self Efficacy ◽  
Depression Scale ◽  
Metastatic Breast ◽  
Epidemiologic Studies ◽  
Genomic Testing ◽  
Depression And Anxiety ◽  
Demographic Groups ◽  
Wide Range

Abstract Purpose: To assess metastatic breast cancer (MBC) patient perceptions and comprehension of tumor genomic testing and to evaluate associations with psychological wellbeing. Methods: In a prospective, single institution, single-arm trial, patients with MBC underwent next-generation sequencing at study entry, with sequencing results released at progression. Patients who completed surveys before undergoing sequencing were included in the study (n=58). We administered four validated psychosocial measures: Center for Epidemiologic Studies Depression Scale, Beck Anxiety Inventory, Trust in Physician Scale, and Communication and Attitudinal Self-Efficacy scale for Cancer. Genetic comprehension was assessed using 7-question objective and 6-question subjective measures. Longitudinal data were assessed using paired Wilcoxon signed rank and McNemar’s test of agreement. Results: There were no significant differences between the beginning and end of study in depression, anxiety, physician trust, or self-efficacy (median time on study: 7.6 months). Depression and anxiety were positively associated with each other and both negatively associated with self-efficacy. Self-efficacy decreased from pre- to post-genomic testing (p=0.05). There was a wide range of objective genetics comprehension and comprehension was significantly lower in non-white patients (p=0.02) and patients with lower income (p=0.04). Patients expressed increased confidence in their ability to teach others about genetics at end of study. Conclusions: This is the only study, to our knowledge, to longitudinally evaluate multiple psychological metrics in MBC as patients undergo tumor genomic testing. Among patients with MBC, depression and anxiety metrics were negatively correlated with patient self-efficacy. Patients undergoing somatic genomic testing had limited genomic knowledge, which varied by demographic groups.

scholarly journals Psychological characteristics and associations between kidney transplant recipients and biologically related or unrelated living donors: a retrospective observational study

2020 ◽  
Author(s):  
Hyewon Park ◽  
Yujin Lee ◽  
Hee-Jung Jee ◽  
Heon-Jeong Lee ◽  
Jun Gyo Gwon ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Minnesota Multiphasic Personality Inventory ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Psychological Characteristics ◽  
Depression And Anxiety ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Positive Correlation ◽  
Personality Patterns

Abstract Background : Although recipients and donors in living kidney transplantation are exposed to psychological distress, including depression and anxiety during the pre-operative period, only a few studies have evaluated their psychological relationship. This study aimed at determining the psychological characteristics and correlation between transplant recipients and donors as well as at investigating it in relation to biologically related and unrelated donors. Methods : This retrospective study on living kidney transplantation at the Korea University Anam Hospital was conducted from April 2008 to June 2019. While participants’ personality patterns were assessed using the Minnesota Multiphasic Personality Inventory-2(MMPI-2), their mood states before transplantation were evaluated via both the State-Trait Anxiety Inventory (STAI) and The Center for Epidemiologic Studies Depression Scale (CES-D). Statistical analysis was performed using a paired t-test and Spearman’s correlation analyses. Results : The recipient group showed a significantly higher sub-score in hypochondriasis (t =-4.49, P=.0001), depression (t =-3.36, P=.0015), hysteria (t =-3.30, P=.0018), STAI-T (t =-2.14, P=0.0372), and CES-D (t =-3.93, P=.0003) than donor group. A comparison of the psychological association between the recipient and donor groups revealed a significant positive correlation in the STAI-S (r=.357, P=.009) and CES-D (r=.362, P=.008). When assessing the difference in correlation based on the biological relationship between the recipients and donors, there is a positive correlation in CES-D (r=.415, P=.0202) in biologically related donors and recipients. In biologically unrelated but emotionally related group, recipients’ STAI-S score and donors’ STAI-S (r=0.413, P=.163), STAI-T (r=.559, P=009) score is positively correlated, and recipients’ STAI-T score and donors’ STAI-S (r=.466, P=.033), STAI-T (r=.520, P=.016) score is also positively correlated. Besides, recipients’ CES-D and donors’ STAI-S (r=.529, P=.014) and STAI-T (r=.560, P=.008) score show a positive correlation. Conclusions : The study indicated that transplantation recipients suffered from a higher level of depression and anxiety compared to the donors before transplantation. The findings suggest that recipients are more depressive and anxious than donors, and psychological problems like depression and anxiety can be shared in living kidney transplantation donors and recipients, especially in biologically unrelated but emotionally related groups.

The relationship between fatigue and depression and anxiety symptoms among front-line clinical workers during the COVID-19 pandemic (Preprint)

2020 ◽  
Author(s):  
Xiaofei Li ◽  
Ye Li ◽  
Hong Liang ◽  
Nianshi Wang ◽  
Zhixin Fan ◽  
...  
Keyword(s):  
Online Survey ◽  
Depression Scale ◽  
Educational Background ◽  
Epidemiologic Studies ◽  
Mental Fatigue ◽  
Depression And Anxiety ◽  
Physical Fatigue ◽  
Front Line ◽  
Cross Sectional ◽  
Psychological Pressure

BACKGROUND The initial outbreak of the COVID-19 disease occurred in Wuhan, China around the Spring Festival in 2020. In the face of such a high-intensity catastrophic epidemic response, Chinese doctors and nurses faced huge psychological pressure including fear, anxiety, and depression. OBJECTIVE The purpose of our study is to test the association between front-line clinical workers' fatigue and depression and anxiety during the COVID-19 epidemic. METHODS The current study is a cross-sectional, online survey administered to 275 healthcare professionals in Wuhan from February 22, 2020 to February 29, 2020. All respondents completed a questionnaire via WeChat, which collected demographics and responses on the Self-Rating Anxiety Scale (SAS), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Fatigue Scale-14 (FS-14). RESULTS A total of 275 participants completed the survey, including 46 doctors (16.73%) and 229 nurses (83.27%). Depression was significantly positively associated with physical fatigue (OR 1.61, 95% CI 1.41-1.83), mental fatigue (OR 1.98, 95% CI 1.60-2.45), and the total score (OR 1.56, 95% CI 1.39-1.75) after adjusting for age, occupation, gender, educational background, marital status, having children, years working, job title, and supporting time in Wuhan. Significant positive associations were also observed between the symptoms of anxiety and physical fatigue (OR 1.64, 95% CI 1.44-1.87), mental fatigue (OR 2.11, 95% CI 1.71-2.60), and the total score (OR 1.58, 95% CI 1.42-1.71) in the adjusted model. Similar associations between fatigue, depression, and anxiety were found in the analyses stratified by gender and occupation. CONCLUSIONS The current study demonstrated that, among the front-line clinical workers in Wuhan, fatigue is significantly associated with depression and anxiety and mental fatigue contributes to a greater risk than physical fatigue on the mental health of clinical workers. Males and doctors were found to be more vulnerable to psychological problems such as depression and anxiety under fatigue, suggesting the need for targeted psychological interventions.

scholarly journals A-49 To Nap or Not to Nap? The Influence of Napping on Recovery Outcomes Following Concussion

2020 ◽  
Vol 35 (5) ◽  
pp. 645-645
Author(s):  
A J Zynda ◽  
K M Petit ◽  
M Anderson ◽  
C P Tomczyk ◽  
T Covassin
Keyword(s):  
College Students ◽  
Symptom Severity ◽  
Recovery Time ◽  
Rank Correlation ◽  
Symptom Scale ◽  
Significant Group ◽  
Spearman’S Rank Correlation ◽  
Time Interaction ◽  
Medical Clearance ◽  
A Prospective Study

Abstract Objective To determine the influence of nap frequency on daily symptom severity and recovery time following concussion in college students. Method A prospective study of college students within 72 hours of a diagnosed concussion was performed. Participants reported nap occurrence (yes/no) and daily concussion symptoms using the Post-Concussion Symptom Scale (PCSS) for six days. Participants were categorized into frequent (&gt;2 naps) and infrequent (&lt;3 naps) nap groups. Recovery time was defined as total days from injury to unrestricted medical clearance. A mixed between-within ANOVA evaluated changes in daily symptom severity between nap groups, while Spearman’s Rank Correlation assessed the relationship between the number of days napping and recovery time. Results Thirty-four participants (23 female, 11 male; age = 19.91 ± 1.38 years) were included, with 22 in the infrequent nap group and 12 in the frequent nap group. Average recovery time for the infrequent nap group was 13.85 days compared to 18.8 days in the frequent nap group. There was no significant group x time interaction for daily symptom severity (Wilks’ λ = 0.85, F(5,24) = 0.85, p = 0.53, η2 = 0.15). There was a significant main effect for time, with daily symptom severity improving following concussion (Wilks’ λ = 0.31, F(5,24) = 10.66, p &lt; 0.001, η2 = 0.69), but there was no significant group effect (F(1,28) = 0.79, p = 0.38, η2 = 0.03). Overall, the more naps taken, the longer the recovery time (Rs = 0.46, p = 0.01). Conclusions Findings from the present study suggest that frequent napping does not affect symptom severity following concussion. Further research is needed to elucidate the association between the number of naps and recovery time.

scholarly journals Depression and Anxiety in Women During Pregnancy in Slovenia / Depresija In Anksioznost Pri Ženskah Med Nosečnostjo V Sloveniji

2015 ◽  
Vol 54 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Nuša Podvornik ◽  
Vislava Globevnik Velikonja ◽  
Peter Praper
Keyword(s):  
Pregnant Women ◽  
Trait Anxiety ◽  
State Anxiety ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Symptoms Of Depression ◽  
Health Complications ◽  
High Trait Anxiety

Abstract Objective. The aim of the study was to evaluate the prevalence of elevated depression and anxiety among pregnant women and to examine its correlation with medical complications and socio-demographic characteristics. Methods. The study is based on a cross-sectional design of a sample of 348 women in three trimesters of pregnancy who received routine obstetrical care at the University Medical Centre Ljubljana, Department of Obstetrics and Gynaecology. The responding women filled out a questionnaire on socio-demographic variables, the Centre for Epidemiologic Studies Depression Scale CES-D and the State Trait Anxiety Inventory STAI. Results. 21.7% of pregnant women were identified as suffering from elevated depression symptomatology, 15.7% reported high state anxiety and 12.5% had high trait anxiety. No significant differences in depression and anxiety across pregnancy trimesters were found. The women who have suffered from health complications during previous pregnancies showed higher state anxiety; those experiencing complications during their current pregnancy reported more intense symptoms of depression and of state and trait anxiety than women free of complications. Less educated, lower income and mothers of many children in the third pregnancy trimester reported more intensive symptoms of depression and trait anxiety. Conclusions. Elevated depression and anxiety are frequent among pregnant women. The results draw attention to the need for early detection and treatment of depression and anxiety during pregnancy

scholarly journals Diagnostics of Fibrosis in Alcoholic Liver Damage

2019 ◽  
Vol 26 (4) ◽  
pp. 76-83
Author(s):  
E. N. Travenko ◽  
V. A. Porodenko
Keyword(s):  
Liver Damage ◽  
Rank Correlation ◽  
Severity Index ◽  
Pathological Process ◽  
Spearman’S Rank Correlation ◽  
Weak Activity ◽  
Histological Activity ◽  
Student’S T ◽  
Histopathological Studies ◽  
Adh Activity

Aim. In this article, the authors determine the severity (index) of histological activity (HAI) and fi brosis in various forms of alcoholic liver disease drawing on the autopsy material, as well as suggest a marker for detecting fi brosis.Materials and methods. The authors studied 110 autopsies and histopathological studies of people who died from ethanol poisoning in the setting of various forms of alcoholic liver damage (95) and traumatic brain injury – control (15). Alcohol dehydrogenase (ADH) activity was studied through histochemical methods; values were estimated through the quantitative morphometry of the histochemical reaction product using the MORFOLOG program developed at the Department for Forensic Medicine (V.A. Porodenko, 1996). Statistical analysis was performed using the STATISTICA 10 software package and a created Exсel database. In order to determine the signifi cance between two compared values, the Student’s t-test was employed. Correlations were estimated using the Spearman’s rank correlation coeffi cient (r).Results. The study revealed various degrees of histological activity and fi brosis in the setting of alcoholic steatosis, hepatitis and cirrhosis. The initial liver damage is characterised by minimal / weak activity and F0–F2 stage of fi brosis. With the progression of the pathological process in the liver, HAI is estimated as moderate and severe (F2–F4 stage of fi brosis). There is a correlation between the development of perisinusoidal and pericellular fi broses (r = –0.655), septae (r = –0.435), connective tissue in the portal tracts and around a vein (r = –0.517) and the number of medium caliber vessels in the liver, as well as between the portal vein diameter and the development of perisinusoidal and pericellular fi broses (r = 0.377). The authors noted high and moderate positive correlation between the ADH activity in zone 3 of the liver acini and the development of necroses and fi brosis, minor cholestases, expansion of the perisinusoidal spaces. The calculated index of fi brosis and ischemic liver damage correlates with its impaired morphofunctional state.Conclusion. The obtained data indicate that fi brosis develops in the early stages of alcoholic liver damage, whose severity can be assessed using the proposed method for determining the index of fi brosis and ischemic liver damage, given that it refl ects both the structural and functional state of the organ.

scholarly journals Hand Eczema: Quality of Life and Disease Severity in an Outpatient Portuguese Population

2018 ◽  
Vol 76 (2) ◽  
pp. 137-142
Author(s):  
Rui Pedro Santos ◽  
Laura Igreja ◽  
Cristina Resende ◽  
Teresa Pereira ◽  
Celeste Brito
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Life Quality ◽  
Severity Index ◽  
Hand Eczema ◽  
Common Disease ◽  
Female Predominance ◽  
Duration Of Disease ◽  
A Prospective Study

Introduction: Hand eczema is a very common disease with a significant social and occupational impact.Objectives: To characterize a Portuguese outpatient population with hand eczema; to evaluate the impairment of the disease in quality of life (QoL); to relate the disease severity with QoL.Methods: The authors designed a prospective study. Information about atopy, psoriasis, occupational exposure and duration of disease, was recorded. The QoL was assessed by the DLQI questionnaire (Dermatology Life Quality Index) and the severity was assessed using the hand eczema severity index (HECSI). All participants were patch tested.Results: Eighty-five patients were included with a female predominance (78.8%). The median DLQI was 9.0. We found statistically significant differences in the variable HECSI between genders with greater impact in males. A significant positive correlation was found between HECSI and DLQI. DLQI and HECSI were independent of atopy, psoriasis or etiology. Increasing age significantly affects DLQI but not HECSI.Conclusions: Hand eczema has a significant impact in QoL. Although the disease is more prevalent among women it was found to be of greater severity among men. The QoL seems to be influenced by disease severity and increasing age but it was independent of the other studied variables.

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