No added value of the methionine loading test in assessment for venous thrombosis and cardiovascular disease risk

2006 ◽  
Vol 95 (02) ◽  
pp. 380-385 ◽  
Author(s):  
Miranda Keijzer ◽  
Petra Verhoef ◽  
George Borm ◽  
Henk Blom ◽  
Martin den Heijer
Keyword(s):  
Cardiovascular Disease ◽  
At Risk ◽  
Venous Thrombosis ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Added Value ◽  
Loading Test ◽  
Recurrent Venous Thrombosis ◽  
Risk For Thrombosis ◽  
Methionine Loading Test

SummaryHomocysteine isa risk factor for cardiovascular disease and venous thrombosis. Clinical guidelines differ in their recommendation whether or not to measure homocysteine after methionine loading. In this study, we investigated the added value of the methionine loading test next to fasting homocysteine levels for identifying subjects at risk for venous thrombosis or cardiovascular disease, using Receiver Operating Characteristic (ROC) curves.The analysis was performed in 185 patients with recurrent venous thrombosis, 130 patients with cardiovascular disease and 601 controls.The discriminatory power of the fasting homocysteine measurement alone for identifying subjects at risk of venous thrombosis expressed as the area under the ROC curve (AUC) was 0.61 (95%CI 0.56-0.66). Using both a fasting homocysteine measurement and a methionine loading test together yielded a similar AUC of 0.65 (95%CI 0.60-0.69), indicating no added value of methionine loading next to fasting homocysteine measurement in identifying subjects at risk for thrombosis. Similar results where found for cardiovascular disease, with anAUC of 0.62 (95%CI 0.57-0.67) for the fasting homocysteine measurement alone and an AUC of 0.62 (95%CI 0.57-0.67) for the combination of both the fasting and the postload homocysteine measurement. The methionine loading test has no added value next to measuring fasting homocysteine levels for identifying subjects at risk for venous thrombosis or cardiovascular disease and for that reason should not be used in clinical practice.

A Registry to Evaluate Cardiovascular Disease Risk Factors in At-risk Youth

2018 ◽  
Vol 32 ◽  
pp. 43
Author(s):  
Luke Hamilton ◽  
Alejandro de la Torre ◽  
Lisa Guerra ◽  
Amelia Vinson ◽  
Lauren Williams ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
At Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
At Risk Youth

Self-compassion and responses to health information in middle-aged and older women: An observational cohort study

2020 ◽  
pp. 135910532090986
Author(s):  
Brittany N Semenchuk ◽  
Kevin F Boreskie ◽  
Jacqueline L Hay ◽  
Cindy Miller ◽  
Todd A Duhamel ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
At Risk ◽  
Health Behaviors ◽  
Older Women ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Emotional Reactions ◽  
Lifestyle Behaviors ◽  
Self Compassion ◽  
Observational Cohort

The aim of this study was to determine whether self-compassion—orientation to care for oneself during challenges—helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This observational study recruited women ( N = 102) who attended three research visits over 3 weeks to gather information on emotions, intentions, and engagement in health behaviors after women received news they were at risk of cardiovascular disease. Self-compassion negatively associated with emotional responses and associated with intentions and engagement in health behaviors after receiving news of their cardiovascular disease risk. Self-compassion was associated with adaptive lifestyle behaviors.

Social media for health promotion: What messages are women receiving about cardiovascular disease risk by the Canadian Heart and Stroke Foundation?

2017 ◽  
Vol 25 (8) ◽  
pp. 1017-1029 ◽  
Author(s):  
Christine A Gonsalves ◽  
Kerry R McGannon ◽  
Robert J Schinke
Keyword(s):  
Cardiovascular Disease ◽  
At Risk ◽  
Social Media ◽  
Health Promotion ◽  
Content Analysis ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
User Comments ◽  
Behaviour Changes ◽  
Healthy Behaviour

The aim of this study was to explore the meanings of women’s cardiovascular disease constructed within the Canadian Heart and Stroke Foundation Facebook page. Posts from Heart and Stroke Foundation and public user comments surrounding the launch of the Heart and Stroke Foundation re-branding were of interest. Ethnographic content analysis was employed to analyse text ( n = 40), images ( n = 32), videos ( n = 6), user comments and replies ( n = 42) from November 2016 to March 2017. Constructions (re)presented on Facebook of ‘typical’ women at risk and risk reduction were problematic as women most at risk were excluded through the use of consumerist, medicalized identities which also excluded promotion of healthy behaviour changes.

Influence of different training methods on cardiovascular disease risk markers after cessation of anabolic steroids abuse in bodybuilders at risk

2021 ◽  
pp. 1-12
Author(s):  
S.M.S. Hashemi ◽  
H. Arazi
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
At Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Training Methods ◽  
Risk Markers ◽  
Cvd Risk ◽  
Training Groups ◽  
Significant Difference

Evidence suggests that anabolic-androgenic steroid (AAS) abuse induces adverse effects on cardiovascular disease (CVD). However, it is unclear whether different training methods are effective in reducing these consequences. This study aims to compare the effects of aerobic training (AT), resistance training (RT), and combined training (CT) on CVD risk markers in professional bodybuilders at risk after cessation of AAS abuse. Forty bodybuilders were randomly assigned to one of four groups: control (n=10), AT (n=10), RT (RT, n=10), and CT (n=10) groups. Before and after eight weeks of training, the high sensitivity C-reactive protein (hs-CRP), haematocrit (HCT), homocysteine (HCY), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and blood pressure (BP) were measured. Significant decreases within groups in HCY and CRP were observed (P<0.05). However, decreases were greater in training groups, and there was a significant difference between control and training groups (P<0.05). Increase in NT-proBNP, and decreases in systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels were significant only in training groups (P<0.005). The increase of NT-proBNP was significant in the CT when compared to the RT (P<0.05). The present study found that discontinuing AAS consumption can improve some CVD risk markers in professional bodybuilders, but this effect could be improved if various modalities of training were performed. Accompanying AT with RT was also discovered to have a greater impact on some markers (including NT-proBNP).

Methionine-Loading and Random Homocysteine Tests Have No Added Value in Risk Assessment for Venous and Arterial Thrombosis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1486-1486
Author(s):  
Willem M. Lijfering ◽  
Nic J.G.M. Veeger ◽  
Jan-Leendert P. Brouwer ◽  
Marlene H.W. van de Poel ◽  
Jan van der Meer
Keyword(s):  
At Risk ◽  
Relative Risk ◽  
Venous Thrombosis ◽  
Arterial Thrombosis ◽  
Loading Test ◽  
Relative Risks ◽  
Increased Risk ◽  
Loading Tests ◽  
Not At Risk ◽  
Methionine Loading Test

Abstract Hyperhomocysteinemia is a risk factor for venous and arterial thrombosis. Different diagnostic strategies are used to identify subjects at risk of thrombosis, related to hyperhomocysteinemia. Measurements of fasting and methionine-loading levels are usually recommended. Alternatively, random homocysteine measurements may simplify the procedure. Random levels < 10 and > 20 μmol/l are considered to indicate normohomocysteinemia and hyperhomocysteinemia, respectively, while consecutive fasting and methionine-loading tests are required at levels 10–20 μmol/l. We performed a study to assess the most suitable strategy in a large cohort of families with hereditary (index) deficiencies of protein S, protein C or antithrombin. Random, fasting and methionine-loading homocysteine samples were measured in 713 relatives. According to predefined cut-off levels hyperhomocysteinemic and normohomocysteinemic relatives were identified and their absolute risks of thrombosis were compared. Relatives with random homocysteine levels > 20 μmol/l were not at risk of venous or arterial thrombosis compared to relatives with levels < 10 μmol/l (relative risks 0.9 [95% CI, 0.4–2.3] and 1.7 [0.5–5.7], respectively). Fasting hyperhomocysteinemia (homocysteine levels > 18.5 μmol/l) was associated with an increased risk of venous and arterial thrombosis (relative risks 2.6 [1.3–4.8] and 3.7 [1.5–8.4)], respectively) (Table). Relatives with normal fasting homocysteine levels, but methionine-loading hyperhomocysteinemia (homocysteine levels > 58.8 μmol/l) were not at risk; relative risk 0.8 (0.2–1.9) for venous thrombosis and 1.1 (0.2–3.9) for arterial thrombosis. Exclusion of relatives with an index deficiency did not alter the risk estimates, while annual incidences of normohomocysteinemic relatives decreased to 0.19% per year (0.12–0.29), which is comparable with the annual incidence in the normal population. As only fasting homocysteine identified subjects at risk of thrombosis, random homocysteine and methionine-loading tests can be omitted in clinical practice. Venous Thrombosis Observation Relatives Incidence/year (%) Relative Risk years with event (95% CI) (95% CI) * Methionine-loading performed in relatives with no fasting hyperhomocysteinemia Fasting Homocysteine No hyperhomocysteinemia 10408 55 0.53 (0.40–0.69) Reference Hyperhomocysteinemia 804 11 1.37 (0.68–2.45) 2.6(1.3–4.8) Methionine-loading test* No hyperhomocysteinemia 9341 50 0.54 (0.40–0.71) Reference Hyperhomocysteinemia 986 4 0.41 (0.11–1.04) 0.8(0.2–1.9) Arterial Thrombosis Fasting Homocysteine No hyperhomocysteinemia 11096 21 0.19 (0.12–0.29) Reference Hyperhomocysteinemia 1004 7 0.70 (0.28–1.44) 3.7(1.5–8.4) Methionine-loading test* No hyperhomocysteinemia10008 10008 19 0.19 (0.11–0.30) Reference Hyperhomocysteinemia 1000 2 0.20 (0.02–0.72) 1.1(0.2–3.9)

scholarly journals The Role of Atherosclerotic Cardiovascular Risk Enhancers in the Prediction of Cardiovascular Events: Tehran Lipid and Glucose Study

2020 ◽  
Author(s):  
Farzad Hadaegh ◽  
Samaneh Asgari ◽  
Fatemeh Moosaie ◽  
Meysam Orangi ◽  
Farzaneh Sarvghadi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Predictive Power ◽  
Cox Regression ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Added Value ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cox Regression Analysis

Abstract Background: To assess the effect of the atherosclerotic cardiovascular disease risk enhancing factors (ASCVD-REFs) on incident cardiovascular disease (CVD) events among non-diabetic individuals with borderline and intermediate ACC/AHA score during 10 and 15-year follow-up. Moreover, the added value of these ASCVD-REFs on the predictive power of the pooled cohort equations (PCE) was examined. Methods: A total of 1204 adults aged 40-75 years, free from CVD at baseline with low-density lipoprotein cholesterol (LDL-C) between 70-189 mg/dl, were included. Unadjusted Cox regression analysis was used. The predictive ability of each significant ASCVD-REFs was estimated using the cut-point-free integrated discrimination improvement (IDI).Results: During 10-year follow up, 181 CVD events (including 73 hard CVD) occurred. For hard CVD events, the high blood pressure (BP) component (i.e. ≥130/85 mmHg) of metabolic syndrome (Mets) (Hazard ratio: HR (95% CI; 1.67(1.03-2.70)) and positive history of preeclampsia (5.06(1.17-22.0)) were significant ASCVD-REFs. During the longer follow-up, Mets and its components of high waist circumference (WC) and high BP significantly increased the risk. As for CVD events, the Mets and its high BP and high WC components significantly increased the risk. However, in the ACC/AHA adjusted score, these covariates did not significantly improve the predictive power of the CVD or hard CVD. Conclusions: The high BP was the most consistent and independent ASCVD-REFs in the prediction of all CVD and hard CVD, among the population with borderline/intermediate risk. Hence, considering pharmacologic therapies for patients with high BP and high LDL-C might be beneficial for preventive initiatives.

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