A CROSS SECTIONAL STUDY OF LIPID PROFILE IN NON-DIABETICS WITH STROKE IN URBAN CHITRADURGA

Background. The amount of evidence regarding the relation between serum lipids, lipoproteins and cerebrovascular accident is not adequate. The atherogenecity of diabetics and non-diabetics are different. Therefore, non-diabetic patients were included in the study. Objective. To study lipid abnormalities in non-diabetic stroke patients in our setup. Methods. The study was carried out at the Department of General Medicine, BMCH, Chitradurga, during the period from June 2020 to December 2020. The lipid profile and the fasting blood sugar rates of 50 stroke patients without diabetes were studied. Their serum samples were assessed for fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) by using standard biochemical methods. Results. The age distribution of the subjects was from 19 to 72 years with a mean age of patients 54.8±15.75 years. Among patients 31 (62%) were males and 19 (38%) were females. Among the study subjects 58% were hypertensive, 76% were smokers, 32% were alcoholics and 34% had family history of cerebrovascular accident. Among ischemic stroke group, the most common deranged value in the ischemic group was decreased HDL deranged in 54.1% of patients; the second most common deranged value – increased VLDL deranged in 40.5%. Among the hemorrhagic group the most common deranged value was also decreased HDL, which was deranged in 46.1% of patients and the second most common deranged value – increased total cholesterol, which was deranged in 53.8% patients. Conclusion. Lipid profile should be considered while predicting the risk of stroke.

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A case control study: to evaluate the lipid profile in ischemic and hemorrhagic stroke

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20211039 ◽

2021 ◽

Vol 7 (4) ◽

pp. 235

Author(s):

Chandan Sharma ◽

Ashima Badyal

Keyword(s):

Ischemic Stroke ◽

Lipid Profile ◽

Total Cholesterol ◽

Serum Lipid ◽

Hemorrhagic Stroke ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Serum Lipid Profile ◽

Stroke Patients ◽

Mean Values

Background: Stroke, be it ischemia or hemorrhage, is the most common clinical manifestation of cerebrovascular disease of which more than 99% are due to arterial involvement and less than 1% due to venous involvement. The aim of the present study was to assess the lipid profile of patients with ischemic and hemorrhagic stroke and to compare it with control group.Methods: This study was conducted in the Department of Medicine in collaboration with Department of Biochemistry between February 2018 to August 2018 on 50 patients of infarct and 50 patients of hemorrhagic stroke admitted in GMC Jammu and 50 healthy controls. Serum was analyzed for estimation of serum lipid profile including total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), by using fully automatic analyzer. Results: More than 54% of patients and controls belonged aged more than 60 years, with a total of 81 males and 69 females. Mean values of total cholesterol (233.53±27.09 mg) and LDL (165.89±30.54 mg) showed up higher in hemorrhagic stroke patients however higher mean values of triglycerides (177.80±40.44 mg) showed up in ischemic stroke patients. Serum cholesterol was abnormal among 50% ischemic and 54% hemorrhagic patients. A significant association is found between raised cholesterol, LDL, abnormal HDL and ischemic stroke.Conclusions: A significant rise in total cholesterol level was found in case of both the groups, therefore high risk patients with stroke should be regularly screened for serum lipid profile.

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Relationship of Glycated Haemoglobin with Lipid Profile among Patients with Type 2 Diabetes Mellitus

BIRDEM Medical Journal ◽

10.3329/birdem.v7i1.31271 ◽

2017 ◽

Vol 7 (1) ◽

pp. 43-47 ◽

Cited By ~ 1

Author(s):

Tasrina Shamnaz Samdani ◽

Palash Mitra ◽

Muhammad Abdur Rahim

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

Lipid Profile ◽

Significant Positive Correlation ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Diabetic Patients ◽

Positive Correlation

Background: Glycated hemoglobin (HbA1c) is widely used as an index of mean glycaemia, a measure of risk for the development of diabetic complications and a measure of the quality of diabetes care. Patients with type 2 diabetes have an increased prevalence of dyslipidemia. Treatment of dyslipidaemia improves cardiovascular outcomes. The aim of this study was to determine the impact of glycemic control on lipid profile.Methods: This cross-sectional study was conducted among 300 type 2 diabetic patients admitted in BIRDEM General Hospital from November 2013 to April 2015. Fasting blood samples were collected and different lipid fractions along with fasting blood glucose and HbA1c were estimated. Pearsons correlation test was applied to evaluate the correlation between HbA1c and components of lipid profile.Results: The mean value of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDLC), fasting blood glucose (FBG) and HbA1c were higher and high density lipoprotein-cholesterol (HDL-C) was lower in females when compared with these values for males. HbA1c had significant positive correlation with LDL-C (p=0.045) and negative correlation with HDL-C (p=0.024). Serum lipid profile and glycaemic controls were significantly (p=0.000) better in older age group (age ? 50 years).Conclusions: Significant positive correlation of HbA1c with lipid profiles specially LDL-C suggested that HbA1c can also be used as predictor of dyslipidemia in addition to glycemic control.Birdem Med J 2017; 7(1): 43-47

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ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-5-29-33 ◽

2013 ◽

Vol 12 (5) ◽

pp. 29-33

Author(s):

S. A. Matveeva

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipoprotein Cholesterol ◽

Blood Lipid Profile ◽

Glucose Levels ◽

Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.

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“STUDY OF TOTAL CHOLESTEROL (TC), TRIACYLGLYCEROLS (TG), HIGH DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C) IN TYPE II DIABETES MELLITUS.”

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i2.14535 ◽

2017 ◽

Vol 10 (2) ◽

pp. 116 ◽

Cited By ~ 2

Author(s):

Smita V Patil ◽

Anita P Mandare ◽

Gaikwad B Pandurang

Keyword(s):

Diabetes Mellitus ◽

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Diabetic Patients ◽

Type 2 Dm

Objective: There are probably 100 million people in the world with diabetes mellitus (DM), and incidences of diabetes are on the rise. Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardiovascular disorders. The aim of this study is to investigate the total cholesterol (TC), triacylglycerols (TGs), high-density lipoprotein cholesterol (HDL-C) in Type 2 DM, and healthy controls.Methods: The study was conducted on 50 controls and 50 Type 2 diabetic subjects between age group of 30 and 60 years. Serum TC was determined by an enzymatic (cholesterol oxidase/phenol-aminophenazone [PAP]) colorimetric method and TGs were determined by an enzymatic (glycerol phosphate oxidase-PAP) method, and HDL-C was estimated by a precipitant method. Statistical analysis was done using unpaired t-test.Results: The mean value of TC, TGs, and HDL-C in normal subjects is 165.5±24.24, 118.7±41.58, 28.38±7.85 mg/dl, respectively, and the value of TC, TGs, and HDL-C in diabetic patients is 179±31.69, 164.35±27.93, 25.4±6.86 mg/dl, respectively. The observed difference in the means of TC, TGs, and HDL-C in normal and diabetic are statistically significant (p<0.05).Conclusion: From the present study, it is concluded that TC, TGs, and HDL-C levels for all persons with Type 2 DM should be done as a routine test. Furthermore, early diagnosis and treatment of dyslipidemia can be used as a preventive measure for the development of cardiovascular disease in Type 2 diabetes.Keywords: Diabetes mellitus, Dyslipidemia, Lipid profile, Total cholesterol, Triglycerides, High-density lipoprotein cholesterol.

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Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals

International Journal of Endocrinology ◽

10.1155/2010/945053 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Prakash Chandra ◽

Sukhdeep S. Basra ◽

Tai C. Chen ◽

Vin Tangpricha

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Statistical Significance ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Testosterone Therapy ◽

Serum Leptin ◽

Atherogenic Lipid Profile

Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50–125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52±11to40±7 mg/dL)(P<.001). The mean LDL(P=.316), triglyceride(P=.910), and total cholesterol(P=.769)levels remained unchanged. In a subset of subjects, we measured serum leptin levels which were reduced by 25% but did not reach statistical significance(P=.181)while resistin levels remained unchanged. We conclude that testosterone therapy in FTM transsexuals can promote an increased atherogenic lipid profile by lowering HDL and possibly reduce serum leptin levels. However, long-term studies are needed to determine whether decreases in HDL result in adverse cardiovascular outcomes.

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Prevalence of Elevated Non-HDL Cholesterol among Patients with Diabetes in An Iranian Population

International Journal of Medical Laboratory ◽

10.18502/ijml.v7i2.2909 ◽

2020 ◽

Author(s):

Asma Kheirollahi ◽

Azam Karkhaneh

Keyword(s):

High Density Lipoprotein ◽

Lipid Profile ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lipoprotein Cholesterol ◽

Diabetic Patients ◽

Data Set ◽

Patients With Diabetes ◽

Routine Assessment

Background and Aims: Non-high density lipoprotein cholesterol (non- HDL-C), which reflects all cholesterol present in potentially atherogenic lipoprotein particles, might be a useful marker of atherosclerosis in diabetic subjects. In the present study, we evaluated the prevalence of high non-HDL-C in patients with dyslipidemia in diabetic and non-diabetic subjects following LDL-C assessment as the first goal of therapy. Materials and Methods: A data set of 2142 individuals was included in the study. All values of lipid profile were compared between non-diabetic and diabetic groups and the prevalence of dyslipidemia was evaluated in two groups. Results and Conclusions: According to the results, 48% of patients with diabetes achieved combined LDL-C ≤2.5 mmol/L and non-HDL ≤3.3 mmol/L targets, and 58.2% of diabetic patients achieved LDL-C goal while only 50.2% attained non-HDL-C goal. Also, the results indicated that non-HDL-C significantly heightened in patients with diabetes. Therefore, non-HDL-C needs to be calculated as a routine assessment in patients with diabetes.

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Cholesterol-Lowering Effect of Concentrated Pomegranate Juice Consumption in Type II Diabetic Patients with Hyperlipidemia

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.76.3.147 ◽

2006 ◽

Vol 76 (3) ◽

pp. 147-151 ◽

Cited By ~ 67

Author(s):

Ahmad Esmaillzadeh ◽

Farideh Tahbaz ◽

Iraj Gaieni ◽

Hamid Alavi-Majd ◽

Leila Azadbakht

Keyword(s):

Total Cholesterol ◽

Disease Risk ◽

Density Lipoprotein ◽

Activity Level ◽

Pomegranate Juice ◽

Lipoprotein Cholesterol ◽

Hypoglycemic Agents ◽

Rank Test ◽

Diabetic Patients ◽

Type Ii

This study was undertaken to assess the effect of concentrated pomegranate juice consumption on lipid profiles of type II diabetic patients with hyperlipidemia (total cholesterol or triglycerides ≥ 200 mg/dL). In this pilot study 22 diabetic patients were recruited from the Iranian Diabetes Society. They were free of any other chronic diseases. The patients were followed for eight weeks to obtain more detailed data about their diet before concentrated pomegranate juice (CPJ) consumption period began. In this pre-study period a 24-hour food recall and a food record (containing flavonoid-rich foodstuffs) were completed every ten days. At the end of the eighth week, anthropometric and biochemical assessments were done. Thereafter the patients consumed 40 g CPJ for eight weeks. During this period, dietary assessment was continued. After completion of the study anthropometric and blood indices were evaluated again. The Wilcoxon signed-rank test was used for statistical analysis. P-value was considered significant at p < 0.05. There were 14 women (63.6%) and 8 men (36.4%) in this survey. Mean (± SD) of age, weight, and duration of diabetes were 52.5 (± 5.2) years, 71.5 (± 10.3) kg, and 7.9 (± 6.6) years, respectively. After consumption of concentrated pomegranate juice significant reductions were seen in total cholesterol (p < 0.006), low-density lipoprotein-cholesterol (LDL-c) (p < 0.006), LDL-c/high-density lipoprotein-cholesterol (HDL-c) (p < 0.001), and total cholesterol/HDL-c (p < 0.001). However there were no significant changes in serum triacylglycerol and HDL-c concentrations. Anthropometric indices, physical activity level, types and doses of oral hypoglycemic agents, and the intake of nutrients and flavonoid-rich foodstuffs did not change during the CPJ consumption period. It is concluded that CPJ consumption could modify heart disease risk factors in these hyperlipidemic patients. Therefore, its inclusion in their diets may be beneficial.

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Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Journal of Evidence-Based Complementary & Alternative Medicine ◽

10.1177/2156587217737683 ◽

2017 ◽

Vol 22 (4) ◽

pp. 798-804 ◽

Cited By ~ 7

Author(s):

Reyhaneh Shokoohi ◽

Saeed Kianbakht ◽

Mohammad Faramarzi ◽

Masoud Rahmanian ◽

Farzaneh Nabati ◽

...

Keyword(s):

Type 2 Diabetes ◽

Glycemic Control ◽

Lipid Profile ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Controlled Clinical Trial ◽

Cholesterol Levels

The present study was conducted to explore the efficacy and safety of a herbal combination in the treatment of women with hyperlipidemic type 2 diabetes. The herbal combination capsule (600 mg) contained Terminalia chebula fruit extract (200 mg), Commiphora mukul (200 mg), and Commiphora myrrha oleo-gum-resin (200 mg), and the placebo capsule contained 600 mg toast powder. The patients in one group took the herbal combination and those in the other group took placebo capsules 3 times a day for 3 months. In the herbal combination–treated patients, the fasting blood glucose, total cholesterol, and low-density lipoprotein cholesterol levels were decreased and hidh-density lipoprotein cholesterol levels was increased significantly at the endpoint compared with the placebo and baseline. Other blood parameters such as glycosylated hemoglobin, triglyceride, blood urea nitrogen, creatinine, SGOT, and SGPT levels were not significantly changed after 3 months in both groups. In conclusion, the herbal combination improves glycemic control and lipid profile in women with hyperlipidemic type 2 diabetes without any adverse events.

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Assessment of Plasma Lipid Profile among Sudanese Menopausal Women in Khartoum state-Sudan

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1836 ◽

2019 ◽

Vol 12 (04) ◽

pp. 2037-2041

Author(s):

Alneil Hamza ◽

Moadah Abbas ◽

Elyasa Elfaki ◽

Mariam Ibrahim ◽

Ezeldine K Abdalhabib ◽

...

Keyword(s):

Cardiovascular Disease ◽

Lipid Profile ◽

Total Cholesterol ◽

Postmenopausal Women ◽

Plasma Lipid ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

P Value ◽

Time Duration ◽

Study Results

Postmenopausal women tend to have significant changes in lipid profile when compared with premenopausal women. Incidence of cardiovascular disease after menopause believed to occur due to changes in the plasma lipid levels. This study was conducted to estimate and compare serum levels of total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) among Sudanese pre and postmenopausal women. 94 participant women were enrolled in this cross-sectional study. 47 post-menopause women age 48 - 70 years and 47 pre-menopause women age 25-47 years. Estimation of serum lipid profile was carried out using Biosystems colorimetric methods and results statistics were computed by using SPSS. A significant increase in total cholesterol(TC), triglyceride, and LDL-c with a significant decrease in (HDL-c) level among postmenopausal women where found, when compared with pre-menopause women (P-value= <0.05). Total cholesterol and LDL-C level were observed significantly increased according to three interval time duration of menopausal onset (p=0.009 and p=0.034). A positive correlation was observed between the age of and total cholesterol levels in postmenopausal women (R=0.463, P-value =0.001). Study results revealed that postmenopausal status was associated with substantial changes in lipid profile that considered risk factors for cardiovascular disease in Sudanese women.

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Effect of Palm Oil, Palm Olein, Palm Kernel Oil and Their Blends on the Lipid Profile of Albino Rats

Journal of Applied Sciences and Environmental Management ◽

10.4314/jasem.v25i8.21 ◽

2021 ◽

Vol 25 (8) ◽

pp. 1421-1425

Author(s):

O.B. Imoisi ◽

V.O. Ezoguan ◽

M.I. Imafidon

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Palm Oil ◽

Palm Olein ◽

Palm Kernel ◽

Density Lipoprotein ◽

The Body ◽

Lipoprotein Cholesterol ◽

Palm Kernel Oil ◽

Kernel Oil

Edible oils play an important role in the body as carriers of essential fatty acids, this essential fatty acids are not produced in the body but gotten from diet we consume. This study examined the effect of palm oil, palm olein, palm kernel oil and their blends (PKO: POL and POL: PKO) on the lipid profile of Albino rats. The aim was to investigate the nutritional and health effects of these oils. Serum was used in the biochemical analysis of lipid profile using Randox Laboratories (England) kit. High density lipoprotein cholesterol in rats fed diets containing unheated and unblended PKO was lower than the recommended range and palm olein and their blends were all higher than the recommended range of 40-59mg/dL. Palm kernel oil fortified diet significantly increased triglyceride levels while; total cholesterol levels were considered to be acceptable except for palm kernel oil and its blends. Palm kernel oil and higher blend of palm kernel oil increased significantly very low density lipoprotein cholesterol above the recommended limit of 2-30mg/dl. Low density lipoprotein cholesterol values in this study were far below the recommended limit for PKO and higher blends of PKO. In conclusion palm oil helps to lower total cholesterol concentration by stimulating the synthesis of protective HDL-C. Palm kernel oil increases total triglyceride and total cholesterol levels.

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