Inflammation and Not Cardiovascular Risk Factors Is Associated With Short Leukocyte Telomere Length in 13- to 16-Year-Old Adolescents

This study assessed whether telomere length is related to chronic conditions, cardiovascular risk factors, and inflammation in women aged 65 to 74 from Northeast Brazil. Participants were selected from two sources, a representative sample of the International Mobility in Aging Study (n = 57) and a convenience sample (n = 49) recruited at senior centers. Leukocyte telomere length was measured by quantitative polymerase chain reaction from blood samples in 83 women. Natural log-transformed telomere/single copy gene ratio was used as the dependent variable in the analysis. Blood analyses included inflammatory markers (high-sensitivity C-reactive protein and interleukin-6), total, low-density lipoprotein and high-density lipoprotein cholesterol, triglycerides, glucose and glycosylated hemoglobin. Self-rated health, chronic conditions, cardiovascular risk factors and inflammatory markers were not associated with telomere length. No significant independent association was found between telomere length and anthropometric measures or blood markers, even after adjusting for age, education and adverse childhood events among these older women in Northeast Brazil. Our results did not confirm the hypothesis that chronic conditions, cardiovascular risk factors or inflammation are associated with shorter telomere length in these women who have exceptional survival relative to the life expectancy of their birth cohort.

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RELATION OF CARDIOVASCULAR RISK FACTORS AND LEUKOCYTE TELOMERE LENGTH

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2016-3-52-57 ◽

2016 ◽

Vol 15 (3) ◽

pp. 52-57 ◽

Cited By ~ 1

Author(s):

I. D. Strajesko ◽

I. N. Tkacheva ◽

D. U. Akasheva ◽

E. V. Dudinskaya ◽

M. V. Agaltsov ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Telomere Length ◽

Leukocyte Telomere Length

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Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease

Aging Cell ◽

10.1111/j.1474-9726.2007.00321.x ◽

2007 ◽

Vol 6 (5) ◽

pp. 639-647 ◽

Cited By ~ 216

Author(s):

Sofie Bekaert ◽

Tim De Meyer ◽

Ernst R. Rietzschel ◽

Marc L. De Buyzere ◽

Dirk De Bacquer ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Telomere Length ◽

Middle Aged ◽

Aged Population

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INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2014-3-11-17 ◽

2014 ◽

Vol 13 (3) ◽

pp. 11-17 ◽

Cited By ~ 3

Author(s):

A. S. Kruglikova ◽

I. D. Strajesko ◽

O. N. Tkacheva ◽

D. U. Akasheva ◽

E. V. Plokhova ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Cardiovascular Risk ◽

Cardiovascular Diseases ◽

Arterial Hypertension ◽

Cardiovascular Risk Factors ◽

Telomere Length ◽

Body Mass ◽

Vascular Aging ◽

Wall Stiffness

Aim.To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors for cardiovascular diseases (smoking, arterial hypertension, obesity, dyslipidemia, fasting hyperglycemia). The telomere length and telomerase activity was measured by polymerase chain reaction. The thickness of intima-media complex (TIMC) and presence of atherosclerotic plaques (ASP) were measured by duplex scanning of right and left carotid arteries. Pulse wave velocity (PWV) was measured by applanation tonometry. Biochemical tests done by standard.Results.PWV significantly correlated with age, body mass index, glycosilated hemoglobin level, fasting glycemia and telomere length. Presence of ASP and increased TIMC significantly correlated with age, body mass index, arterial hypertension, dyslipidemia.Conclusion.Increase of arterial wall stiffness and subclinical atherosclerotic disease have different causes. The level of PWV more linked with carbohydrate metabolism disorder, and TIMC and ASP are linked with lipid disorders.

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Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients

BMC Geriatrics ◽

10.1186/s12877-019-1383-9 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Are A. Kalstad ◽

Sjur Tveit ◽

Peder L. Myhre ◽

Kristian Laake ◽

Trine B. Opstad ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Fatty Acids ◽

Cardiovascular Risk ◽

Linoleic Acid ◽

Elderly Patients ◽

Polyunsaturated Fatty Acids ◽

Telomere Length ◽

Leukocyte Telomere Length ◽

Omega 3

Abstract Background Telomeres are non-coding sequences at the end of eukaryote chromosomes, which in complex with associated proteins serve to protect subtelomeric DNA. Telomeres shorten with each cell division, are regarded as a biomarker for aging and have also been suggested to play a role in atherosclerosis and cardiovascular disease (CVD). The aim of the present study was to explore the associations between leukocyte telomere length and serum polyunsaturated fatty acids, diet, cardiovascular risk factors and features of myocardial infarction (MI) in elderly patients. Methods The material is based upon the first 299 included patients in the OMEMI trial, where patients aged 70–82 years of age are randomized to receive omega-3 supplements or corn oil (placebo) after MI. Patients were included 2–8 weeks after the index MI. DNA was extracted from whole blood, and leukocyte telomere length (LTL) was analyzed by qPCR and reported as a number relative to a reference gene. Serum long chain polyunsaturated fatty acid (LCPUFA) content was analyzed by gas chromatography. Diet was evaluated with the validated SmartDiet food frequency questionnaire. Medical records, patient interviews and clinical examination provided previous medical history and anthropometric data. Non-parametric statistical tests were used. Results Median (25, 75 percentile) LTL was 0.55 (0.42, 0.72). Patients had a median age of 75 years, 70.2% were male and 45.2% used omega-3 supplements. There was a weak, but significant correlation between LTL and linoleic acid (r = 0.139, p = 0.017), but not with other LCPUFAs. There was a trend towards longer telomeres with a healthier diet, but this did not reach statistical significance (p = 0.073). No associations were found between LTL and CVD risk factors or features of MI. Conclusions In our population of elderly with a recent myocardial infarction LTL was associated with linoleic acid concentrations, but not with other LCPUFAs. Patients with a healthy diet tended to have longer telomeres. The limited associations may be due to age and the narrow age-span in our population. Further studies, designed to detect longitudinal changes should be performed to explore the role of telomeres in cardiovascular aging. Trial registration Clinical trials no. NCT01841944, registration date April 29, 2013.

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PREMATURE AGING INDICES IN PATIENTS WITH MODERATE CARDIOVASCULAR RISK

International Medical Journal ◽

10.37436/2308-5274-2021-1-1 ◽

2021 ◽

pp. 5-9

Author(s):

A. O. Radchenko ◽

T. M. Bondar ◽

A. V. Potapenko

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Telomere Length ◽

Age Groups ◽

The Body ◽

Premature Aging ◽

Biological Age ◽

Associated Diseases ◽

Age Related

Aging is characterized with a gradual aggravation of organ function throughout life and can occur both physiologically and prematurely. With premature aging there is an early decrease in the adaptive mechanisms of all physiological systems of the body, there is a significant reduction in physical and mental activities, that contributes to the early development of age−related pathology. Genetic and epigenetic factors, as well as environmental ones can be the causes of different rates of aging. It is not possible to accurately determine the onset of old age by biological characteristics, because people with the same calendar age are not always the same as for biological one. To establish the association of age−related disease factors with the markers of premature aging and biological age in the patients of various age groups, a study was performed in the patients aged 25−44 and 45−59 years with moderate cardiovascular risk in accordance with the SCORE scale. The primary task for predicting and preventing the age−associated diseases is to identify genetic, molecular and cellular factors that determine the rate of aging and increase the risk of age−associated diseases. The role of cardiovascular risk factors in premature aging has been determined. It is established that the most important factors that lead to an increase in biological age and formation of age−associated diseases are the disorders of lipid and carbohydrate metabolism and level of oxidative stress, importance of which progresses with age. The relationship between cardiovascular risk factors and biological age, estimated with different methods, their influence on telomere length, that allows the designing of an algorithm to determine the markers of premature aging in different age groups for early and effective prevention of metabolic−associated diseases, has been established. Key words: biological age, cardiovascular risk, premature aging, telomere length.

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Relative Telomere Length and Cardiovascular Risk Factors

Biomolecules ◽

10.3390/biom9050192 ◽

2019 ◽

Vol 9 (5) ◽

pp. 192 ◽

Cited By ~ 5

Author(s):

Moritz Koriath ◽

Christian Müller ◽

Norbert Pfeiffer ◽

Stefan Nickels ◽

Manfred Beutel ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Telomere Length ◽

Ldl Cholesterol ◽

Smoking Status ◽

Hdl Cholesterol ◽

Population Based ◽

Relative Telomere Length

(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere biology is relevant to several human disorders and diseases, specifically cardiovascular disease. To better understand the link between cardiovascular disease and telomere length, we studied the effect of relative telomere length (RTL) on cardiovascular risk factors in a large population-based sample. (2) Methods: RTL was measured by a real-time quantitative polymerase chain reaction in subjects of the population-based Gutenberg Health Study (n = 4944). We then performed an association study of RTL with known cardiovascular risk factors of smoking status as well as systolic and diastolic blood pressure, body mass index (BMI), LDL cholesterol, HDL cholesterol, and triglycerides. (3) Results: A significant correlation was shown for RTL, with age as a quality control in our study (effect = −0.004, p = 3.2 × 10−47). Analysis of the relation between RTL and cardiovascular risk factors showed a significant association of RTL in patients who were current smokers (effect = −0.016, p = 0.048). No significant associations with RTL were seen for cardiovascular risk factors of LDL cholesterol (p = 0.127), HDL cholesterol (p = 0.713), triglycerides (p = 0.359), smoking (p = 0.328), diastolic blood pressure (p = 0.615), systolic blood pressure (p = 0.949), or BMI (p = 0.903). In a subsequent analysis, we calculated the tertiles of RTL. No significant difference across RTL tertiles was detectable for BMI, blood pressure, lipid levels, or smoking status. Finally, we studied the association of RTL and cardiovascular risk factors stratified by tertiles of age. We found a significant association of RTL and LDL cholesterol in the oldest tertile of age (effect = 0.0004, p = 0.006). (4) Conclusions: We determined the association of relative telomere length and cardiovascular risk factors in a population setting. An association of telomere length with age, current smoking status, as well as with LDL cholesterol in the oldest tertile of age was found, whereas no associations were observed between telomere length and triglycerides, HDL cholesterol, blood pressure, or BMI.

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