Abstract P101: Hypertension in Pregnancy and Risk of Hypertension in Later Life: The Bogalusa Heart Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Shengxu Li ◽  
Xu Xiong ◽  
Camilo Fernandez ◽  
Wei Chen ◽  
Sathanur R Srinivasan ◽  
...  

Background: Few studies have examined whether hypertension in pregnancy imposes long-term cardiovascular risk compared to a normal pregnancy. The objective of this study was to examine if previous history of hypertension in pregnancy is a risk for hypertension after pregnancy. Methods: A case-control analysis was performed using the Bogalusa Heart Study database. Cases were defined as women whose systolic blood pressure ≥140 mmHg or diastolic ≥ 90 mmHg, or having hypertension treatment. Controls were defined as women with normal blood pressure. After exclusions, 604 women (67% white and 33% black, aged 32-44 years) were included for analysis. Univariable and multivariable logistic regression were used to estimate the odds ratio (OR) and 95% confidence interval (CI). Results: The prevalence of hypertension in women was 12.1% (73/604). Hypertensive women had higher proportion of previous history of hypertension in pregnancy (25/73, 34%) than normotensive controls (83/531, 13.7%), with an OR of 2.81 (95% CI: 1.64-4.81). After adjustment for age, race, body mass index and smoking, adjusted OR (aOR) of having previous history of hypertension in pregnancy for developing hypertension later was 1.36 (1.00-3.75). In addition, age, black ethnicity and body mass index were associated with hypertension, with aORs of 1.16 (1.09-1.25), 3.73 (2.13-6.52), and 1.09 (1.05-1.13), respectively. Conclusions: Hypertension in pregnancy may be associated with an increased risk of hypertension in later life. Further studies are needed to separate the effect of pregnancy-induced hypertension and pre-exiting chronic hypertension on the subsequent risk of hypertension later in life.

2021 ◽  
Vol 23 (Supplement_B) ◽  
pp. B114-B116
Author(s):  
Kolawole W Wahab ◽  
Philip M Kolo ◽  
Augustine Odili ◽  
Emmanuel Iwuozo ◽  
Ngozi Ifebunandu ◽  
...  

Abstract The aim of this study is to estimate the frequency of undetected hypertension across the six geopolitical zones of Nigeria. We conducted an opportunistic screening of adults aged at least 18 years in the month of May 2019. Participants were recruited by trained volunteers using the May Measurement Month protocol. Blood pressure (BP) was measured using validated digital and mercury sphygmomanometers. We defined hypertension as BP ≥140/90 mmHg or the use of BP-lowering medication. A total of 3646 participants (52.8% females) with a mean age of 44.5 ± 15.7 years were screened. Hypertension was present in 39.2% of the participants but only 55. 4% of these were on antihypertensive medications. Only 46.8% hypertensives who were on medications had their BP controlled (<140/90 mmHg). Previous history of hypertension in pregnancy, alcohol intake and smoking were associated with increased mean systolic and diastolic BPs. The frequency of Nigerians with hypertension is high while only about half of those on antihypertensive medications are controlled. A multi-pronged approach to reduce the burden of hypertension is needed.


2020 ◽  
Author(s):  
◽  
Derek Matsiko Muhoozi

Background: This study aimed at establishing the prevalence and factors associated with hyperglycemia in pregnancy among women attending treatment at antenatal care at the Directorate of obstetrics and gynaecology at Kawempe under the following objectives; to determine the prevalence of hyperglycemia in pregnancy, to establish the factors associated with hyperglycemia in pregnancy.  Methods: The study was cross-sectional and experimental in design that recruited 333 participants from age 18 years and above. The consented participants filled a questionnaire that was taking history and demographics. A blood sample was taken for blood glucose testing and a urine sample was also collected. Data was entered in Epidata 3.1 and exported to SPSS 17.0 for analysis. Descriptive statistics and multivariate analysis was used to determine prevalence and factors associated with hyperglycemia in pregnancy Results:   Laboratory tests revealed that the prevalence of hyperglycemia was 25.3% (84). The following factors were significantly associated with hyperglycemia in pregnancy; age37 years and above (p-value 0.013* OR 2.34), and high Body Mass Index (BMI) (p-value 0.002* OR 3.744). Gravidity of 3-4 times (p-value 0.003*OR3.782), >=5 times (p-value <0.001*and OR3.099), parity of >=5 children (p-value 0.003*OR 3.642), first degree hyperglycaemia (P-value <0.031*OR 5.152), high blood pressure during this pregnancy (0.012*OR 3.622) and high blood pressure while not pregnant (p-value 0.012*OR 1.274).  Conclusion and recommendations: Gestational hyperglycemia is common among women attending care at the directorate of Obstetrics and Gynecology at Kawempe. the commonest factors associated with hyperglycemia in pregnancy are high Body mass index, history of hypertension, history of hyperglycemia, high parity high gravidity, there is no relationship between hyperglycemia and sexually transmitted diseases like HIV, and syphilis.


2020 ◽  
Author(s):  
◽  
Derek Matsiko Muhoozi

Abstract Background: This study aimed at establishing the prevalence and factors associated with hyperglycemia in pregnancy among women attending treatment at antenatal care at the Directorate of obstetrics and gynaecology at Kawempe under the following objectives; to determine the prevalence of hyperglycemia in pregnancy, to establish the factors associated with hyperglycemia in pregnancy. Methods: The study was cross-sectional and experimental in design that recruited 333 participants from age 18 years and above. The consented participants filled a questionnaire that was taking history and demographics. A blood sample was taken for blood glucose testing and a urine sample was also collected. Data was entered in Epidata 3.1 and exported to SPSS 17.0 for analysis. Descriptive statistics and multivariate analysis was used to determine prevalence and factors associated with hyperglycemia in pregnancy Results: Laboratory tests revealed that the prevalence of hyperglycemia was 25.3% (84). The following factors were significantly associated with hyperglycemia in pregnancy; age37 years and above (p-value 0.013* OR 2.34), and high Body Mass Index (BMI) (p-value 0.002* OR 3.744). Gravidity of 3-4 times (p-value 0.003*OR3.782), >=5 times (p-value <0.001*and OR3.099), parity of >=5 children (p-value 0.003*OR 3.642), first degree hyperglycaemia (P-value <0.031*OR 5.152), high blood pressure during this pregnancy (0.012*OR 3.622) and high blood pressure while not pregnant (p-value 0.012*OR 1.274). Conclusion and recommendations: Gestational hyperglycemia is common among women attending care at the directorate of Obstetrics and Gynecology at Kawempe. the commonest factors associated with hyperglycemia in pregnancy are high Body mass index, history of hypertension, history of hyperglycemia, high parity high gravidity, there is no relationship between hyperglycemia and sexually transmitted diseases like HIV, and syphilis.


Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Shengxu Li ◽  
Xu Xiong ◽  
Camilo Fernandez ◽  
Wei Chen ◽  
Sathanur S Srinivasan ◽  
...  

Background: Hypertension in pregnancy is an important cause of both maternal and fetal morbidity and mortality. Whether hypertension in pregnancy has its risk factor(s) in childhood is not known. The objective of this study was to examine the association between childhood risk factors and hypertension in pregnancy later in life. Methods: A nested case-control analysis was performed based on the longitudinal Bogalusa Heart Study cohort (67% white and 33% black), with an average follow-up period of 26.2 years. Cases were defined as women who had hypertension during pregnancy and had normal blood pressure measurements after the pregnancy (n=82). Controls were defined as women with normal blood pressure without hypertension in pregnancy (n=454). Childhood risk factors included body mass index (BMI), systolic and diastolic blood pressure, high- and low-density lipoprotein cholesterols, and triglycerides. Univariable and multivariable logistic regression were used to estimate the odds ratio (OR) and 95% confidence interval (CI), with childhood risk factors standardized to age- and race-specific z-scores based on the total population of 5419 female subjects. Results: Cases and controls had comparable age in childhood (10.1 vs 9.8 years, P=0.53). Cases vs controls had higher BMI (19.1 vs 17.6 kg/m2, P<0.001) and systolic blood pressure (101.8 vs 99.2 mm Hg, P=0.002) in childhood. In univariable analysis, significant childhood predictors for having hypertension in pregnancy included BMI (OR corresponding to 1 age- and race-specific standard deviation change =1.45, 95% CI: 1.15-1.83) and systolic blood pressure (1.48, 1.15-1.89). BMI and systolic blood pressure remained as significant predictors for having hypertension in pregnancy in multiple regression analysis (1.34, 1.03-1.75 and 1.33, 1.01-1.74, respectively). Conclusions: Childhood BMI and systolic blood pressure are significant predictors for having pregnancy-induced hypertension in adulthood, which underscores the importance of childhood risk factors assessment and early intervention.


2014 ◽  
pp. S403-S409 ◽  
Author(s):  
O. AUZKÝ ◽  
R. DEMBOVSKÁ ◽  
J. MRÁZKOVÁ ◽  
Š. NOVÁKOVÁ ◽  
L. PAGÁČOVÁ ◽  
...  

Preclinical atherosclerosis may represent a risk factor for venous thromboembolism (VTE). In longitudinal study we followed longitudinally 96 patients (32 men) with thrombophilias with (n=51) and without (n=45) history of VTE. In both groups we studied the changes of preclinical atherosclerosis at peripherally located arteries detected by ultrasound. In addition, we assessed changes in selected risk factors of atherosclerosis. During the mean follow-up of 56.0±7.62 months we did not find significant change in preclinical atherosclerosis defined as Belcaro score in either group (–3 % in the VTE group vs 0 % in non VTE group). Significant increase in body mass index (1.03±1.98 kg*m-2, resp. 1.21±1.67 kg*m-2, p<0.01) and non-significant increase in systolic blood pressure were detected in both groups. Waist circumference increased significantly only in patients without VTE (4.11±7.84 cm, p<0.05). No differences in changes of risk factors under study between both groups were detected. In summary, patients with thrombophilia and history of VTE showed no evidence of greater progression of atherosclerosis or increase in traditional risk factors of atherosclerosis than patients with thrombophilia without history of VTE. Unfavorable changes of body mass index, waist circumference and systolic blood pressure were detected in both groups during study period.


2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hussein H. Alhawari ◽  
Sameeha Al-Shelleh ◽  
Hussam H. Alhawari ◽  
Aseel Al-Saudi ◽  
Dina Aljbour Al-Majali ◽  
...  

Hypertension is one of the major risk factors associated with cardiovascular diseases. In this study, we will assess the frequency of hypertension among healthy university students and its association with gender, body mass index, smoking, and family history of both hypertension and cardiovascular diseases. We screened healthy university students ranging from 18 to 26 years of age. For each participant, we performed blood pressure measurements using a previously validated device and obtained demographic data, body mass index (BMI), smoking status, and family history of both hypertension and cardiovascular diseases. Out of the total number of 505 participants included in this study, 35.2% have blood pressure between 130/80 and 139/89, and 13.5% have blood pressure of more than 140/90. We found significant gender differences in both systolic pressure (p = 0.003) with mean difference = 18.08 mmHg (CI: 16.13 to 19.9) and diastolic pressure (p = 0.011) with mean difference = 3.6 mmHg (CI: 2.06 to 5.14), higher in males than in females. Upon comparing the mean difference in both systolic and diastolic blood pressure with BMI, we found significant differences in both systolic (p < 0.001) and diastolic (p = 0.002) blood pressure. We also found that smokers have significantly (p = 0.025) higher systolic blood pressure (mean difference = 4.2 mmHg, CI: 3.2 mmHg to 8.8 mmHg), but no significant difference for diastolic blood pressure (p = 0.386), compared to nonsmokers. First-degree family history of both hypertension and cardiovascular diseases affected systolic but not diastolic blood pressure. Taking into account the adverse short- and long-term effect of hypertension, we recommend adopting an awareness program highlighting the importance of screening blood pressure in young adolescent populations, keeping in mind that both high BMI and smoking are important modifiable factors.


2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Yudhaputra Setiadhi ◽  
Shirley E.S. Kawengian ◽  
Nelly Mayulu

Abstract: Hypertension is a condition where the systolic blood pressure is >140mmHg and the diastolic blood pressure is >90mmHg measured by a sphygmomanometer. The measurements were performed at least 2 times in a span of one week. Uncontrolled hypertension can cause damage to the arteries, damage to the heart, damage to the brain, kidneys and eyes, as well as accelerating the onset of chronic cardiovascular diseases. Hypertension in pregnancy could affect such things as reduced blood flow to the placenta, fetal growth restriction, premature birth, fetal death, and increased risk of cardiovascular disease. One of the factors that affect the risk of hypertension is a family history of hypertension.The study aimed to see whether there is a relationship between a family history of hypertension and hypertension in pregnancy. The data were collected using cross-sectional method. This cross-sectional study was conducted in September-November 2016, in Bahu Public Health Center, Ranotana Public Health Center, Tuminting Public Health Center, Kombos Public Health Center, and Paniki Public Health Center. The sample were taken with total sampling method, with the total number of respondents that are willing around 144 respondent. Based on the research, from 50 respondent with a family history of hypertension, 1 respondent (2%) belong to the category of stage 1 hypertension, 20 respondent (40%) belong to the category of pre-hypertension and 29 respondents (58%) were normal. Conclusion: Based on the results, it can be deduced that a family history of hypertension mostly did not affect the incidence of hypertension in pregnant woman.Keywords: hypertension, maternal hypertension, family history of hypertension  Abstrak: Hipertensi merupakan keadaan dimana tekanan darah sistolik >140mmHg dan tekanan darah diastolik >90mmHg yang diukur dengan sphygmomanometer. Pengukuran dilakukan minimal 2 kali dalam rentang waktu 1 minggu. Hipertensi yang tidak terkontrol dapat menyebabkan kerusakan pada pembuluh darah arteri, kerusakan pada jantung, kerusakan pada otak, ginjal dan mata, serta mempercepat terjadinya penyakit kardiovaskular yang kronis. Hipertensi pada wanita hamil dapat mempengaruhi beberapa hal seperti aliran darah ke plasenta berkurang, pertumbuhan janin terhambat, kelahiran prematur, bayi meninggal dalam kandungan, dan meningkatnya risiko terkena penyakit kardiovaskular. Salah satu faktor rikiko yang mempengaruhi hipertensi adalah riwayat hipertensi pada keluarga. Penelitian ini bertujuan untuk melihat apakah ada hubungan antara riwayat hipertensi pada keluarga dan hipertensi pada kehamilan. Pengambilan data dilakukan dengan menggunakan metode cross-sectional. Penelitian cross-sectional ini dilakukan pada bulan September-November 2016 di Puskesmas Bahu, Puskesmas Ranotana, Puskesmas Tuminting, Puskesmas Kombos dan Puskesmas Paniki. Pengambilan sampel dilakukan berdasarkan dengan metode total sampling dengan jumlah responden yang bersedia sebanyak 144 orang. Berdasarkan penelitian didapatkan dari 50 responden dengan riwayat hipertensi pada keluarga 1 responden (2%) masuk ke dalam kategori hipertensi stadium 1, 20 responden (40%) masuk ke dalam kategori pre-hipertensi dan 29 responden (58%) yang normal. Simpulan: Berdasarkan hasil tersebut, dapat ditarik kesimpulan bahwa riwayat hipertensi pada keluarga sebagian besar tidak mempengaruhi angka kejadian hipertensi pada ibu hamilKata kunci: hipertensi, hipertensi kehamilan, riwayat hipertensi pada keluarga


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