Abstract P243: Greater Healthful Dietary Variety and Changes in Adiposity Indicators During a Weight-Loss Intervention: The POUNDS Lost Trial

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Maya Vadiveloo ◽  
Frank M Sacks ◽  
George A Bray ◽  
Catherine Champagne ◽  
Josiemer Mattei
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Energy Intake ◽  
Body Fat ◽  
Repeated Measures ◽  
Dietary Guidelines ◽  
Index Change ◽  
Dietary Variety ◽  
Stable Variety ◽  
The Us

Background: Adhering to a healthy lower energy diet is essential for sustained weight loss. Greater variety within energy-poor, nutrient-dense foods may improve adherence by making the diet less monotonous, and therefore more enjoyable. Greater healthful dietary variety has been inversely associated with adiposity in cross-sectional studies, but it is unclear if it predicts longitudinal changes in body weight. Objective: To examine the longitudinal associations between initial changes in healthful dietary variety (0-6 months) and long-term changes in adiposity over 24-months in a weight-loss trial. Methods: Participants in the POUNDS Lost trial were advised to follow energy-restricted diets. Data for participants with complete dietary assessments at baseline and 6-months were analyzed (n=367). Healthful dietary variety was quantified using the validated US Healthy Food Diversity (US HFD) index, which measures the number of foods consumed and consistency of dietary selections and amounts with recommendations from the 2010 Dietary Guidelines for Americans. Changes in the US HFD index between baseline and 6-months were divided into tertiles (T); adults in T1 had reductions in the US HFD index, T2 maintained stable index values, and T3 had increased index values. Body weight and waist circumference (WC) were measured at 6, 12, 18, and 24-months and percent body fat and trunk fat were measured at 6 and 24-months using DEXA. Repeated measures ANOVA was used to test whether US HFD index change tertiles were significantly associated with adiposity over 24-months. Models were adjusted for age, sex, race, smoking, education, income, diet arm, changes in physical activity and energy intake, baseline adiposity indicator, and the interaction between the US HFD index change tertile and time. Results: Reductions in energy intake were equivalent across US HFD index change tertiles in multivariable models (-425 vs.-265 kcal in T1 vs.T3, p=0.08). An improved variety (T3) as compared to stable variety (T2) was associated with greater weight loss at 24-months (-4.75 vs. -2.63kg, p=0.03; linear p-trend=0.04) and greater decrease in total body fat in T3 vs. T2 (-1.10% vs. -0.006%, p=0.03; p-trend=0.04) and trunk fat (-1.29% vs. 0.08%, p=0.03; p-trend=0.04). An improved variety (T3) as compared to stable variety (T2) or reduced variety (T1) was associated with greater reduction in WC (-6.48cm (T3) vs. -3.98cm (T2), p=0.01; and -4.14cm (T1), p=0.04; linear p-trend=0.01). Reducing variety (T1) did not reduce or increase other adiposity indicators compared to stable or increased variety. Conclusions: Increasing healthful dietary variety while restricting energy intake may improve sustained reductions in adiposity among adults trying to lose weight.

scholarly journals Ileal Transposition in Rats Reduces Energy Intake, Body Weight, and Body Fat Most Efficaciously When Ingesting a High-Protein Diet

2020 ◽  
Vol 30 (7) ◽  
pp. 2729-2742
Author(s):  
Edit Somogyi ◽  
David Sigalet ◽  
Thomas E. Adrian ◽  
Csaba Nyakas ◽  
Christiaan W. Hoornenborg ◽  
...  
Keyword(s):  
Energy Efficiency ◽  
Weight Loss ◽  
Body Weight ◽  
Energy Intake ◽  
Body Fat ◽  
High Protein Diet ◽  
Ileal Transposition ◽  
Cumulative Energy ◽  
Initial Weight Loss ◽  
Cumulative Energy Intake

Abstract Purpose Ileal transposition (IT) allows exploration of hindgut effects of bariatric procedures in inducing weight loss and reducing adiposity. Here we investigated the role of dietary macronutrient content on IT effects in rats. Methods Male Lewis rats consuming one of three isocaloric liquid diets enriched with fat (HF), carbohydrates (HC), or protein (HP) underwent IT or sham surgery. Body weight, energy intake, energy efficiency, body composition, and (meal-induced) changes in plasma GIP, GLP-1, PYY, neurotensin, and insulin levels were measured. Results Following IT, HC intake remained highest leading to smallest weight loss among dietary groups. IT in HF rats caused high initial weight loss and profound hypophagia, but the rats caught up later, and finally had the highest body fat content among IT rats. HP diet most efficaciously supported IT-induced reduction in body weight and adiposity, but (as opposed to other diet groups) lean mass was also reduced. Energy efficiency decreased immediately after IT irrespective of diet, but normalized later. Energy intake alone explained variation in post-operative weight change by 80%. GLP-1, neurotensin, and PYY were upregulated by IT, particularly during (0–60 min) and following 17-h post-ingestive intake, with marginal diet effects. Thirty-day post-operative cumulative energy intake was negatively correlated to 17-h post-ingestive PYY levels, explaining 47% of its variation. Conclusion Reduction in energy intake underlies IT-induced weight loss, with highest efficacy of the HP diet. PYY, GLP-1, and neurotensin levels are upregulated by IT, of which PYY may be most specifically related to reduced intake and weight loss after IT.

scholarly journals Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study

2019 ◽  
Vol 8 ◽  
Author(s):  
Thea Toft Hansen ◽  
Bethan R. Mead ◽  
Jesús Francisco García-Gavilán ◽  
Sanne Kellebjerg Korndal ◽  
Joanne A. Harrold ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Weight Management ◽  
Energy Intake ◽  
Food Products ◽  
Weight Loss Maintenance ◽  
Overweight And Obesity ◽  
Dietary Guidelines ◽  
Double Blind ◽  
Effective Prevention

Abstract New dietary-based concepts are needed for treatment and effective prevention of overweight and obesity. The primary objective was to investigate if reduction in appetite is associated with improved weight loss maintenance. This cohort study was nested within the European Commission project Satiety Innovation (SATIN). Participants achieving ≥8% weight loss during an initial 8-week low-energy formula diet were included in a 12-week randomised double-blind parallel weight loss maintenance intervention. The intervention included food products designed to reduce appetite or matching controls along with instructions to follow national dietary guidelines. Appetite was assessed by ad libitum energy intake and self-reported appetite evaluations using visual analogue scales during standardised appetite probe days. These were evaluated at the first day of the maintenance period compared with baseline (acute effects after a single exposure of intervention products) and post-maintenance compared with baseline (sustained effects after repeated exposures of intervention products) regardless of randomisation. A total of 181 participants (forty-seven men and 134 women) completed the study. Sustained reduction in 24-h energy intake was associated with improved weight loss maintenance (R 0·37; P = 0·001), whereas the association was not found acutely (P = 0·91). Suppression in self-reported appetite was associated with improved weight loss maintenance both acutely (R −0·32; P = 0·033) and sustained (R −0·33; P = 0·042). Reduction in appetite seems to be associated with improved body weight management, making appetite-reducing food products an interesting strategy for dietary-based concepts.

scholarly journals The Twazon Arabic Weight Loss App: App-Based Intervention for Saudi Women With Obesity (Preprint)

2018 ◽  
Author(s):  
Aroub Alnasser ◽  
Janet Kyle ◽  
Najla Aloumi ◽  
Abdulrahman Al-Khalifa ◽  
Debbi Marais
Keyword(s):  
Weight Loss ◽  
Saudi Arabia ◽  
Body Weight ◽  
Energy Intake ◽  
Repeated Measures ◽  
Lifestyle Modification ◽  
Healthy Lifestyle ◽  
Attrition Rate ◽  
Saudi Women ◽  
Activity Measures

BACKGROUND By 2022, it is estimated that the rate of female obesity (78%) in Saudi Arabia will almost double that of males (41%). Despite being mainly attributed to poor diet, sedentary lifestyle, and a lack of health awareness, behavioral modification interventions are relatively new to the population; bariatric surgery continues to be the treatment of choice for comorbidities. However, neither pre nor postoperative diet and exercise are promoted. Evidence-informed mobile health (mHealth) weight loss apps and interventions may be an effective tool for delivering a culturally relevant intervention. OBJECTIVE This study aimed to determine the feasibility of a weight loss intervention that tests the effectiveness of Twazon, an originally designed Arabic weight-loss app that promotes lifestyle modification specific to Arab populations. METHODS A pre-post single‐arm pilot study was carried out among a sample of 240 overweight volunteer Saudi women residing in Riyadh, Saudi Arabia who used the Twazon app over a 4-month period. Anthropometric, diet, and physical activity measures were assessed 3 times: baseline, 2-months and 4-months; frequency of app use and system usability were evaluated during the 2 latter data collection periods. Repeated measures analysis of variance was used to identify changes over time. RESULTS A total of 40 participants completed the 4-month intervention with an attrition rate of 83%. An evaluation of the frequency of app use fostered 2 groups: engaged users (65%) and unengaged users (35%). At 4 months, the engaged users experienced more successful outcomes; body weight was lowered on average by 1.3 (SD 0.6) kg (P=.18), waist circumference (WC) was reduced by 4.9 (SD 1.1) cm (P<.001), and daily energy consumption was decreased by >600 calories (P=.002). Unengaged users experienced minor changes in body weight, WC, and reduced energy intake. CONCLUSIONS The findings have demonstrated that engagement with the Twazon app renders positive changes in body weight, WC, and energy intake. mHealth weight loss apps and interventions have the potential to be effective in promoting weight loss and healthy lifestyle modification in Saudi Arabia and similar populations.

Brown adipose tissue activation in a rat model of Parkinson’s disease

2017 ◽  
Vol 313 (6) ◽  
pp. E731-E736 ◽  
Author(s):  
Wenjuan Wang ◽  
Xiangzhi Meng ◽  
Chun Yang ◽  
Dongliang Fang ◽  
Xuemeng Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Energy Intake ◽  
Rat Model ◽  
Sympathetic Denervation ◽  
Brown Adipose

Loss of body weight and fat mass is one of the nonmotor symptoms of Parkinson’s disease (PD). Weight loss is due primarily to reduced energy intake and increased energy expenditure. Whereas inadequate energy intake in PD patients is caused mainly by appetite loss and impaired gastrointestinal absorption, the underlying mechanisms for increased energy expenditure remain largely unknown. Brown adipose tissue (BAT), a key thermogenic tissue in humans and other mammals, plays an important role in thermoregulation and energy metabolism; however, it has not been tested whether BAT is involved in the negative energy balance in PD. Here, using the 6-hydroxydopamine (6-OHDA) rat model of PD, we found that the activity of sympathetic nerve (SN), the expression of Ucp1 in BAT, and thermogenesis were increased in PD rats. BAT sympathetic denervation blocked sympathetic activity and decreased UCP1 expression in BAT and attenuated the loss of body weight in PD rats. Interestingly, sympathetic denervation of BAT was associated with decreased sympathetic tone and lipolysis in retroperitoneal and epididymal white adipose tissue. Our data suggeste that BAT-mediated thermogenesis may contribute to weight loss in PD.

Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women

1995 ◽  
Vol 79 (3) ◽  
pp. 818-823 ◽  
Author(s):  
A. S. Ryan ◽  
R. E. Pratley ◽  
D. Elahi ◽  
A. P. Goldberg
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Postmenopausal Women ◽  
Body Fat ◽  
Fat Mass ◽  
Management Program ◽  
Fat Free Mass ◽  
Percent Body Fat ◽  
Plasma Norepinephrine ◽  
Resistive Training

Percent body fat increases with age and is often accompanied by a loss in muscle mass, strength, and energy expenditure. The effects of 16 wk of resistive training (RT) alone or with weight loss (RTWL) on strength (isokinetic dynamometer), body composition (dual-energy X-ray absorptiometry), resting metabolic rate (RMR) (indirect calorimetry), and sympathetic nervous system activity (catecholamines) were examined in 15 postmenopausal women (50–69 yr). RT resulted in significant improvements in upper and lower body strength in both groups (P < 0.01). The nonobese women in the RT group (n = 8) did not change their body weight or fat mass with training. In the obese RTWL group (n = 7), body weight, fat mass, and percent body fat were significantly decreased (P < 0.001). Fat-free mass and RMR significantly increased with training in both groups combined (P < 0.05). There were no significant changes in resting arterialized plasma norepinephrine or epinephrine levels in either group with training. RT increases strength with and without weight loss. Furthermore, RT and RTWL increase fat-free mass and RMR and decrease percent fat in postmenopausal women. Thus, RT may be a valuable component of an integrated weight management program in postmenopausal women.

Nutritional Practices of Elite Female Surfers during Training and Competition

1998 ◽  
Vol 8 (1) ◽  
pp. 36-48 ◽  
Author(s):  
Jenni M. Felder ◽  
Louise M. Burke ◽  
Brian J. Lowdon ◽  
David Cameron-Smith ◽  
Gregory R. Collier
Keyword(s):  
Body Weight ◽  
Energy Intake ◽  
Body Fat ◽  
Protein Intake ◽  
Nutrient Intakes ◽  
Dietary Practices ◽  
Zinc Intake ◽  
Fat Stores ◽  
Food Diaries ◽  
And Training

The aim of this study was to assess the dietary practices of 10 elite female surfers. Four- and five-day food diaries completed over competition and training periods demonstrated energy intakes (mean ± SD) of 9,468 kJ (±2,007) and 8,397 kJ (±1,831), respectively. This level of energy intake was less than that estimated for the requirements of surfing. Female surfers' carbohydrate intakes failed to meet the recommendations, and suboptimal zinc intake was observed with 90% of subjects not meeting the Australian RDI. Comparisons between competition and training demonstrated that carbohydrate (g and g/kg body weight) and confectionary (g) intakes were significantly higher (p < .05) and protein intake was significantly lower (p < .05) during competition. These results show that although body fat stores were not compromised (mean 22%), self-reported energy, carbohydrate, and nutrient intakes were marginal in elite female surfers. Questionnaires revealed that 90% of surfers did not have good nutritional habits while traveling, which was compounded by a lack of knowledge of nutritional practices.

Lower limit of body fat in healthy active men

1994 ◽  
Vol 77 (2) ◽  
pp. 933-940 ◽  
Author(s):  
K. E. Friedl ◽  
R. J. Moore ◽  
L. E. Martinez-Lopez ◽  
J. A. Vogel ◽  
E. W. Askew ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Lower Limit ◽  
Body Fat ◽  
Fat Mass ◽  
Subcutaneous Fat ◽  
Fat Free Mass ◽  
Energy Deficit ◽  
Strenuous Exercise ◽  
Healthy Men

We examined body composition changes in 55 normal young men during an 8-wk Army combat leadership training course involving strenuous exercise and low energy intake, with an estimated energy deficit of 5.0 +/- 2.0 MJ/day and a resultant 15.7 +/- 3.1% weight loss. Percent body fat (BF) measured by dual-energy X-ray absorptiometry (DEXA) averaged 14.3% (range 6–26%) and 5.8 +/- 1.8% (range 4–11%) at the beginning and end of the course, respectively. Men who achieved a minimum percent BF (4–6%) by 6 wk demonstrated only small additional total and subcutaneous fat losses in the final 2 wk and sacrificed increasingly larger proportions of fat-free mass. Percent BF estimated from skinfold thicknesses reflected relative changes in fat mass, although actual percent BF was overestimated. Instead of reaching a plateau after fat stores were substantially depleted, abdominal, hip, and thigh girths continued to decline with body weight loss. Final percent BF for the leanest men was similar to that observed after a 25% body weight reduction in the 1950 Minnesota study (5.2% by underwater weighting), and height-corrected final fat mass was the same (1.0 +/- 0.2 vs. 0.9 +/- 0.7 kg fat/m2), suggesting that these values represent a minimal body fat content in healthy men and that weight loss subsequent to achieving this level is contributed from the fat-free mass. Our results suggest that 4–6% BF or approximately 2.5 kg fat represents the lower limit for healthy men, as assessed by DEXA or by underwater weighing.

Wheel running of kangaroo rats, Dipodomys merriami, as related to food deprivation and body composition

1978 ◽  
Vol 44 (1) ◽  
pp. 17-20 ◽  
Author(s):  
D. B. Dill ◽  
L. F. Soholt ◽  
J. D. Morris
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Body Weight ◽  
Food Deprivation ◽  
Body Fat ◽  
Wheel Running ◽  
Initial Amount ◽  
Kangaroo Rats ◽  
Dipodomys Merriami ◽  
Percentage Of Body Fat

Kangaroo rats deprived of food ran themselves to death in 48 h in wheel cages. Despite the loss of 14.5% of body weight the ratio of water to protein was the same after the run as it was in control rats. Metabolic measurements at rest and in the running wheel and weight loss in the 48-h run were used to estimate fuels used and water expended. Two-thirds of the initial amount of fat and 9% of the protein were metabolized. The terminal mean percentage of body fat was about twice that observed in rats trapped in the spring of 1967, when seed production was low: death in the 48-h run could not have been due to depletion of body fat alone. The powerful activity drive seen in hungary kangaroo rats presumably is intensified in dry years when food is scarce and may deplete their reserves enough to result in death from starvation.

scholarly journals Effects of Ad Libitum Low Carbohydrate Versus Low Fat Diets on Body Weight and Fat Mass

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 658-658
Author(s):  
Alex Schick ◽  
James Boring ◽  
Amber Courville ◽  
Isabelle Gallagher ◽  
Juen Guo ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Body Fat ◽  
Fat Mass ◽  
Kidney Diseases ◽  
Primary Study ◽  
Low Fat ◽  
Fat Loss ◽  
Low Carbohydrate ◽  
Ad Libitum

Abstract Objectives To describe the effects of ad libitum low-fat (LF) and low-carbohydrate (LC) diets on body weight and fat mass. Methods Sixteen adults without diabetes spent 29 continuous days residing at the Metabolic Clinical Research Unit of the NIH Clinical Center where they were fed ad libitum either an animal-based, LC diet (75% fat, 10% carbohydrates, 15% protein) or a plant-based, LF diet (75% carbohydrates, 10% fat, 15% protein). Participants were randomly assigned to one diet for the first phase of the study (14 days), after which they were switched to the other diet for the remainder of the study. Participants were given three meals daily and were provided with additional snacks amounting to 200% of their daily energy requirements as determined by their resting energy expenditure multiplied by 1.6. Subjects were told that this was not a weight loss study and were not informed about the primary study aim. They were instructed to eat as much or as little as they desired. Total body weight and fat mass were measured using a calibrated scale and dual-energy X-ray absorptiometry, respectively. Subjects were blinded to their data and wore loose-fitting scrubs to avoid any feedback regarding changes in the fit of their clothing. Results Subjects included 7 women and 9 men, with an age of (mean ± SE) 29 ± 1.7 years and BMI of 27.5 ± 1.5 at baseline. Participants lost weight on both diets, with the LC diet resulting in 1.34 ± 0.31 kg of weight loss (P = 0.0006) and the LF diet resulting in 1.09 ± 0.31 kg of weight loss (P = 0.003) which was not significantly different from the LC diet (P = 0.58). However, participants lost 0.6 ± 0.17 kg of body fat on the LF diet (P = 0.002) but the LC diet did not result in significant body fat loss (0.04 ± 0.17 kg; P = 0.8) and the difference in body fat loss between the diets was statistically significant (P = 0.03). Conclusions While participants lost similar amounts of weight on both diets, only the LF diet led to significant body fat loss. Early weight loss with a LC diet does not necessarily reflect a similar state of negative energy balance as compared with a LF diet. Funding Sources Intramural Research Program of the National Institutes of Diabetes and Digestive and Kidney Diseases.

scholarly journals Energy Expenditure and Physical Activity in Recovering Malnourished Infants

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Russell Rising ◽  
Gul Tiryaki Sonmez
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Energy Metabolism ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Body Fat ◽  
Respiratory Quotient ◽  
Lower Amount ◽  
Healthy Controls ◽  
Metabolic Data

Background. Malnourished infants are small for age and weight.Objectives. Determine profiles in 24-hour energy metabolism in recovering malnourished infants and compare to similarly aged healthy controls.Methods. 10 malnourished infants (58.1±5.9 cm,7.7±5.6months) were healthy prior to spending 22 hours in the Enhanced Metabolic Testing Activity Chamber for measurement of EE (kcal/min), sleeping metabolic rate (SMR; kcal/min), respiratory quotient (RQ;VCO2/VO2), and physical activity (PA; oscillations in wt/min/kg body weight). Metabolic data were extrapolated to 24 hours (kcal/kg/d). Energy intake (kcal/kg/d) and the proportions (%) of carbohydrate, protein, and fat were calculated. Anthropometrics for malnourished infants were obtained. Statistical differences (P<.05) between groups were determined (SPSS, version 13).Results. In comparison to controls, malnourished infants were lighter (4.1±1.2versus7.3±0.8 kg;P<.05), had less body fat % (10.3±7.6versus25.7±2.5), and lower BMI (12.0±1.7versus15.5±1.5;P<.05). In contrast, they had greater energy intake (142.7±14.6versus85.1±25.8;P<.05) with a greater percentage of carbohydrates (55.1±3.9versus47.2±5.2;P<.05). However, malnourished infants had greater 24-hour EE (101.3±20.1versus78.6±8.4;P<.05), SMR (92.6±17.1versus65.0±3.9;P<.05), and RQ (1.00±0.13versus0.86±0.08;P<.05) along with a lower amount of PA (2.3±0.94versus4.0±1.5;P<.05).Conclusions. Malnourished infants require more energy, possibly for growth.

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