Abstract 13697: Prevalence and Disability Associated With Vitamin D Deficiency Amongst Patients With Cardiovascular and Cerebrovascular Disorders

Introduction: Previous studies had provided evidence that vitamin D deficiency is a strong negative predictor for survival and recovery after severe vascular events but national estimate on disability related burden is not clear. Hypothesis: We evaluate the prevalence of vitamin D deficiency (VDD) amongst patients with cardiovascular disease (CVD) and cerebrovascular disorders (CeVD) and to find out whether or not CVD and CeVD in the presence of VDD increases the disability. Methods: We performed a retrospective analysis of the Nationwide Inpatient Sample data (years 2016-2017) in adults (≥18 years) hospitalizations. We identified patients with secondary diagnosis of VDD and primary diagnosis of CVD (AFib, CHF, IHD, acute MI, and angina) and CeVD (AIS, TIA, ICeH and SAH) using ICD-10-CM codes. We performed a chi-square test and multivariable survey logistic regression to analyze disability of patients with CVD and CeVD in presence of VDD. Disability/loss of function was investigated by APRDRGs severity using 3M Health Information Systems software. (Score 1-4 indicates minor to extreme loss of function) Results: Among 58,259,589 US hospitalizations, 3.44%, 2.15%, 0.06%, 1.28%, 11.49%, 1.71%, 0.38%, 0.23% and 0.08% had primary admission of IHD, acute MI, angina, AFib, CHF, AIS, TIA, ICeH and SAH, respectively and 1.82% had VDD. Prevalence of hospitalizations due to CHF (14.66% vs 11.43%), AIS (1.87% vs 1.71%) and TIA (0.4% vs 0.38%) was higher; and IHD (2.62% vs 3.45%), acute MI (1.58% vs 2.16), angina (0.05% vs 0.06%), AFib (1.14% vs 1.28%), ICeH (0.17% vs 0.23%) and SAH (0.05% vs 0.08%) was lower among VDD patients in compare to non-VDD. (p<0.0001) In regression analysis, VDD was associated with higher odds of severe or extreme disability amongst patients hospitalized with AIS (OR:1.1; 95%CI:1.06-1.14), ICeH (1.22; 1.08-1.39), TIA (1.36; 1.25-1.47), IHD (1.37; 1.33-1.41), acute MI (1.44; 1.38-1.49), Afib (1.10; 1.06-1.15), and CHF (1.03; 1.02-1.05) in comparison to without VDD. Conclusions: CVD and CeVD in presence of VDD increase the disability amongst US hospitalizations. Future studies should be planned to evaluate the discharge outcomes as well as the effect of identification and in-hospital management of VDD on improvement of the outcomes.

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Abstract P652: Burden of Vascular Events Amongst TIA Patients - A Nationwide Estimate

Stroke ◽

10.1161/str.52.suppl_1.p652 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Aelia Akbar ◽

Benedict Francis ◽

Aran Deol ◽

Zeba Murtaza ◽

Lakshmi Saravanan ◽

...

Keyword(s):

Clinical Investigation ◽

Cerebrovascular Disorders ◽

Sampling Strategy ◽

Primary Diagnosis ◽

Vascular Events ◽

Cross Sectional ◽

Icd 10 ◽

Acute Mi ◽

Ischemic Attack

Introduction: Literature reported, 9-17% transient ischemic attack (TIA) patients have a vascular event within 90 days but there is limited data on long term risk involvement of vascular events following TIA. Aim: To identify prevalence and association of cardiovascular diseases (CVD) and cerebrovascular disorders (CeVD) amongst early and late TIA. Methods: We performed a retrospective cross-sectional analysis of Nationwide Inpatient Sample (2016-2017) in adults hospitalizations. Early TIA (primary diagnosis), late TIA (secondary diagnosis-within a year) and vascular events [CVD (AFib, IHD, acute MI angina) and CeVD (AIS, ICeH, SAH)] amongst TIA were identified using ICD 10 CM codes. Prevalence of vascular events were compared amongst patients with TIA and without TIA. Weighted analysis to account for sampling strategy using mix-effect multivariable survey logistic regression was performed to evaluate odds of having vascular events amongst TIA in comparison to non-TIA. Results: Amongst 58,259,589 US hospitalizations, 0.38% and 5.92% patients had early and late TIA, respectively. Patients with late TIA had higher prevalence of acute MI (4.9 vs 0.5 vs 3.4%), IHD (44 vs 28.6 vs 20.6%), angina (0.3 vs 0.2 vs 0.2%), AFib (22 vs 15.3 vs 10.9%), AIS (5.3 vs 0.6 vs 2%), SAH (0.2 vs 0.03 vs 0.1%) and ICeH (0.8 vs 0.04 vs 0.4%) compared to early TIA and no-TIA, respectively. (p<.0001) Patients with late TIA had 23% higher risk of having Afib [aOR 1.23; 95%CI 1.22-1.23] and higher odds of having IHD [1.52; 1.52-1.53], AIS [1.72; 1.70-1.74], and ICeH [1.29; 1.25-1.33]. (Table 1) Conclusion: We found a higher prevalence of late TIA amongst US hospitalizations. Additionally, late TIA patients had a higher risk of vascular events like Afib, IHD, and stroke. Hence, a thorough clinical investigation and long term followup of TIA patients may mitigate the risk of future vascular events and associated health care burden.

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Hypocalcemia and Vitamin D Deficiency amongst Migraine Patients: A Nationwide Retrospective Study

Medicina ◽

10.3390/medicina55080407 ◽

2019 ◽

Vol 55 (8) ◽

pp. 407 ◽

Cited By ~ 5

Author(s):

Patel ◽

Kodumuri ◽

Malik ◽

Kapoor ◽

Malhi ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Diagnosis Related Groups ◽

Multivariable Analysis ◽

Population Based ◽

Trend Test ◽

Loss Of Function ◽

Chi Square ◽

Cross Sectional ◽

Vitamin D Levels

Background and Objectives: Inadequate vitamin D and calcium intake have been linked to many health issues including chronic headaches. Some studies suggested an association between low vitamin D levels and increase the risk of frequent headaches in middle-aged and older men; however, no single study reported the role of these deficiencies in migraine patients. We aimed to investigate the association of hypocalcemia and vitamin D deficiency with migraine hospitalizations. Materials and Methods: A population-based retrospective cross-sectional analysis of the Nationwide Inpatient Sample (NIS) (years 2003–2014) in migraine hospitalizations was performed. The prevalence, demographic characteristics and All Patient Refined Diagnosis Related Groups severity/disability association were compared in patients with hypocalcemia and vitamin D deficiency to those without deficiencies, using ICD-9-CM codes. Weighted analyses using Chi-Square, paired Student’s t-test, and Cochran–Armitage trend test were performed. Survey logistic regression was performed to find an association between deficiencies and migraine hospitalizations and deficiency induced disability amongst migraineurs. Results: Between years 2003 and 2014, of the total 446,446 migraine hospitalizations, 1226 (0.27%) and 2582 (0.58%) presented with hypocalcemia and vitamin D deficiency, respectively. In multivariable analysis, hypocalcemia [Odds Ratio (OR): 6.19; Confidence Interval (CI): 4.40–8.70; p < 0.0001] and vitamin D deficiency (OR: 3.12; CI: 2.38–4.08; p < 0.0001) were associated with markedly elevated odds of major/extreme loss of function. There was higher prevalence (3.0% vs. 1.5% vs. 1.6%; p < 0.0001) and higher odds of migraine among vitamin D deficiency (OR: 1.97; CI: 1.89–2.05; p < 0.0001) patients in comparison to patients with hypocalcemia (OR: 1.11; CI: 1.03–1.20; p = 0.0061) and no-deficiency, respectively. Conclusions: In this study, we demonstrated a significant association between hypocalcemia and vitamin D deficiency with migraine attacks and deficiency induced loss of function among migraineurs. Early preventive measures may reduce the disability in migraineurs.

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OR-013 One Year Outdoor and Daytime Aerobic Dance Practice Increased Serum 25(OH)D3 and PTH, but Decreased FSH Level of Postmenopausal Women

Exercise Biochemistry Review ◽

10.14428/ebr.v1i2.9133 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

QUN ZUO ◽

YANYAN ZHANG

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Chi Square ◽

Aerobic Dance ◽

Before And After ◽

Vitamin D3 Supplementation ◽

Chi Square Test ◽

One Year ◽

Serum Pth

Objective Vitamin D deficiency is widespread in postmenopausal women. It is verified that Vitamin D3 supplementation intake can improve the Vitamin D3 level of those Vitamin D deficiency patients. In addition to the exogenous intake, whether aerobic exercise plus sunshine could affect vitamin D level in postmenopausal women gained our attention. Methods 16 postmenopausal women in Shanghai attended this test. They voluntarily participated in a one year aerobics plan, practicing Chinese traditional dance outdoor under sunshine for one hour from 9:30-10:30 am each day. Before and after one year practice, serum 25(OH)D, 25(OH)D3 and estradiol E2, follicle stimulating hormone(FSH), luteinizing hormone(LH), parathyroid hormone(PTH) of all participants were analyzed. Results Before aerobics practice, serum 25(OH)D and 25(OH)D3 levels were 16.30±4.12(ng/ml) and 15.60±3.79(ng/ml). After one year practice, the data were significantly increased 19.50% (P=0.002) and 18.78% (P=0.002), separately. Before aerobics practice, the state of 25(OH)D level of 13 women was inadequacy (≤20.0ng/ml), 3 women was in lack status (20-30ng/ml). After one year practice, 9 women was inadequacy, 7 women in lack. The value of the chi square test was 4.747(P=0.029). After one year practice, serum PTH significantly increased, while FSH significantly decreased. E2 and LH had no significant variance before and after one year of aerobics practice.  Conclusions One year aerobics practice under sunshine could increase serum 25(OH)D level, and affected estrogen levels variably in postmenopausal women. 

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Vitamin D Status and its Association with Lipid Profile among Medical Undergraduates in a Medical College in Kerala

10.25259/gjmpbu_22_2020 ◽

2020 ◽

Vol 15 ◽

pp. 7

Author(s):

K. Annapurna ◽

P. K. Swarnalatha

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Vitamin D Deficiency ◽

Cross Sectional Study ◽

Vitamin D Status ◽

Medication History ◽

Chi Square ◽

Cross Sectional ◽

Medical Undergraduates ◽

Chi Square Test

Objectives: To assess the vitamin D status among the study population and to determine the association between Vitamin D deficiency and dyslipidemia. Materials and Methods: This cross sectional study included medical undergraduates aged between 18-20 years with no major illness or medication history. Complete fasting lipid profile was measured by photometry method and biochemical estimation of serum 25-hydroxy 25(OH)D was done using automated chemiluminescent immunoassay. Vitamin D status and lipid profile parameters were compared using Pearson Chi-square test. P < 0.05 was considered as statistically significant. Descriptive statistics such as mean, standard deviation, and inferential statistics like Chi-square test were used. Results: 96.6% were vitamin D deficient and 40% of the subjects were dyslipidemic. There was no significant association between Vitamin D status and Lipid profile. Conclusion: High prevalence of Vitamin D deficiency but no significant association between vitamin D deficiency and dyslipidemia.

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Prevalence and Outcomes Associated with Vitamin D Deficiency among Indexed Hospitalizations with Cardiovascular Disease and Cerebrovascular Disorder—A Nationwide Study

Medicines ◽

10.3390/medicines7110072 ◽

2020 ◽

Vol 7 (11) ◽

pp. 72

Author(s):

Urvish Patel ◽

Salma Yousuf ◽

Komal Lakhani ◽

Payu Raval ◽

Nirmaljot Kaur ◽

...

Keyword(s):

Cardiovascular Disease ◽

Vitamin D ◽

Regression Analysis ◽

Vitamin D Deficiency ◽

Admission Diagnosis ◽

Cerebrovascular Disorder ◽

Vascular Events ◽

Mixed Effect ◽

Discharge Disposition ◽

Acute Mi

Background: According to past studies, recovery and survival following severe vascular events such as acute myocardial infarction and stroke are negatively impacted by vitamin D deficiency. However, the national estimate on disability-related burden is unclear. We intend to evaluate the prevalence and outcomes of vitamin D deficiency (VDD) among patients with cardiovascular disease (CVD) and cerebrovascular disorder (CeVD). Methods: We performed a cross-sectional study on the Nationwide Inpatient Sample data (2016–2017) of adult (≥18 years) hospitalizations. We identified patients with a secondary diagnosis of VDD and a primary diagnosis of CVD and CeVD using the 9th revision of the International Classification of Diseases, clinical modification code (ICD-10-CM) codes. A univariate and mixed-effect multivariable survey logistic regression analysis was performed to evaluate the prevalence, disability, and discharge disposition of patients with CVD and CeVD in the presence of VDD. Results: Among 58,259,589 USA hospitalizations, 3.44%, 2.15%, 0.06%, 1.28%, 11.49%, 1.71%, 0.38%, 0.23%, and 0.08% had primary admission of IHD, acute MI, angina, AFib, CHF, AIS, TIA, ICeH, and SAH, respectively and 1.82% had VDD. The prevalence of hospitalizations due to CHF (14.66% vs. 11.43%), AIS (1.87% vs. 1.71%), and TIA (0.4% vs. 0.38%) was higher among VDD patients as compared with non-VDD patients (p < 0.0001). In a regression analysis, as compare with non-VDD patients, the VDD patients were associated with higher odds of discharge to non-home facilities with an admission diagnosis of CHF (aOR 1.08, 95% CI 1.07–1.09), IHD (aOR 1.24, 95% CI 1.21–1.28), acute MI (aOR 1.23, 95% CI 1.19–1.28), AFib (aOR 1.21, 95% CI 1.16–1.27), and TIA (aOR 1.19, 95% CI 1.11–1.28). VDD was associated with higher odds of severe or extreme disability among patients hospitalized with AIS (aOR 1.1, 95% CI 1.06–1.14), ICeH (aOR 1.22, 95% CI 1.08–1.38), TIA (aOR 1.36, 95% CI 1.25–1.47), IHD (aOR 1.37, 95% CI 1.33–1.41), acute MI (aOR 1.44, 95% CI 1.38–1.49), AFib (aOR 1.10, 95% CI 1.06–1.15), and CHF (aOR 1.03, 95% CI 1.02–1.05) as compared with non-VDD. Conclusions: CVD and CeVD in the presence of VDD increase the disability and discharge to non-home facilities among USA hospitalizations. Future studies should be planned to evaluate the effect of VDD replacement for improving outcomes.

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350. Neurocysticercosis – Gender Differences in Clinical Presentations

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.545 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S244-S244

Author(s):

Bharath Pendyala ◽

Prasanth Lingamaneni ◽

Patricia DeMarais ◽

Lakshmi Warrior ◽

Gregory Huhn

Keyword(s):

Gender Differences ◽

Categorical Variables ◽

Public Health Issue ◽

Diagnostic Code ◽

Continuous Variables ◽

Chi Square ◽

Generalized Seizures ◽

Icd 10 ◽

Chi Square Test ◽

Reported Data

Abstract Background Neurocysticercosis is a Neglected Tropical Disease and an important public health issue. Our goal was to collect and analyze data regarding clinically significant gender differences among our Neurocysticercosis patients. Methods A retrospective chart search with ICD 9/ ICD 10 diagnostic code for Neurocysticercosis and neuroimaging suggestive of Neurocysticercosis was performed for clinical encounters in the hospital or affiliated clinics between years 2013–2018. After a careful chart review, patients who were clinically diagnosed with Neurocysticercosis were included in the study. T-test was used to compare means of continuous variables and chi-square test to compare proportions of categorical variables. Results Among 90 total patients included, male (49.4%) and female (50.6%) distribution were nearly identical. The mean age in females was found to be higher than males (52.5 vs 42.0, P < 0.0001). Almost an equal number of males and females presented with either seizures (63.6% vs 57.8%, P= 0.85), headaches (25.0% vs 28.9%, p= 0.85), or other symptoms (11.4% vs 13.3%, p= 0.85). Males had more generalized seizures compared to females (60% vs 38%, P= 0.37), although this result was not statistically significant. Females were more likely to present with > 1 lesion (82.2% vs 56.8%, P= 0.01). Males were more likely to have cystic lesions (64.7% vs 27.9%, P < 0.001) compared to females who had more calcified lesions on presentation (65.1% vs 20.6%, P < 0.001). Male patients were more likely to have contrast enhancement or edema surrounding the lesions (61.4% vs 33.3%, P= 0.01) and were more likely to require treatment with Albendazole/Praziquantel (75.8% vs 31.7%, P < 0.001). Conclusion Although previously reported data is limited, there is a suggestion that there are gender differences in host immune response and that inflammation surrounding parenchymal lesions is more intense in females. This study suggests that men either present early in the disease phase or have different immune responses than women and require anti-parasitic therapy more frequently. More research in this aspect is needed. Disclosures All Authors: No reported disclosures

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Assessment of vitamin D deficiency and COVID-19 diagnosis in patients with breast or prostate cancer using electronic medical records.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.6589 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 6589-6589

Author(s):

Aaron Galaznik ◽

Emelly Rusli ◽

Vicki Wing ◽

Rahul Jain ◽

Sheila Diamond ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Cancer Patients ◽

Electronic Medical Records ◽

Medical Records ◽

Research Database ◽

Breast Cancer Cohort ◽

Icd 10

6589 Background: While patients with cancer are known to be at increased risk of infection in part due to the immunocompromising nature of cancer treatments, recent data indicate a particularly high risk for COVID-19 infection and poor outcomes (Wang et al., 2020). A recent study (Meltzer et al., 2020) demonstrated Vitamin D deficiency may increase risk of COVID-19 infection, and a small randomized controlled trial in Spain reported significant improvement in mortality among hospitalized patients treated with calcifediol. Vitamin D deficiency has been reported in two leading causes of cancer deaths: breast and prostate. In this study, we performed a retrospective cohort analysis on nationally representative electronic medical records (EMR) to assess whether Vitamin D deficiency affects risk of COVID-19 among these patients. Methods: Patients with breast (female) or prostate (male) cancer were identified between 3/1/2018 and 3/1/2020 from EMR data provided pro-bono by the COVID-19 Research Database ( covid19researchdatabase.org ). Patients with an ICD-10 code for Vitamin D deficiency or < 20ng/mL 20(OH)D laboratory result within 12 months prior to 3/1/2020 were classified as Vitamin D deficient. COVID-19 diagnosis was defined using ICD-10 codes and laboratory results for COVID-19 at any time after 3/1/2020. Logistic regressions, adjusting for baseline demographic and clinical characteristics, were conducted to estimate the effect of Vitamin D deficiency on COVID-19 incidence in each cancer cohort. Results: A total of 16,287 breast cancer and 14,919 prostate cancer patients were included in the study. The average age was 68.9 years in the breast cancer cohort and 73.6 years in the prostate cancer cohort. The breast cancer cohort consisted of 85% Whites, 13% Black or African Americans, and less than 5% of other races. A similar race distribution was observed in the prostate cancer cohort. Unadjusted analysis showed the risk of COVID-19 was higher among Vitamin D deficient patients compared to non-deficient patients in both cohorts (breast: OR = 1.60 [95% C.I.: 1.15, 2.20]; prostate: OR = 1.59 [95% C.I.: 1.08, 2.33]). Similar findings were observed when assessed in subgroups of patients with newly diagnosed cancer in the dataset, as well as after adjusting for baseline characteristics. Conclusions: Our study suggests breast and prostate cancer patients may have an elevated risk of COVID-19 infection if Vitamin D deficient. These results support findings by Meltzer et al., 2020 demonstrating a relationship between Vitamin D deficiency and COVID-19 infection. While a randomized clinical trial is warranted to confirm the role for Vitamin D supplementation in preventing COVID-19, our study underscores the importance of monitoring Vitamin D levels across and within cancer populations, particularly in the midst of the global COVID-19 pandemic.

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Abstract 56: Acute Stroke Reperfusion Treatment Rates at NIH StrokeNET Hospitals

Stroke ◽

10.1161/str.46.suppl_1.56 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Opeolu Adeoye ◽

Dawn Kleindorfer

Keyword(s):

Clinical Trials ◽

High Volume ◽

The United States ◽

Primary Diagnosis ◽

Categorical Variables ◽

Phase 3 ◽

Chi Square ◽

Successful Recruitment ◽

Chi Square Test ◽

Reperfusion Phase

Background: In 2013, the NIH Stroke Trials Network (StrokeNET) was established to maximize efficiencies in stroke clinical trials. Successful recruitment in future trials was required for participating sites. A high volume of cases treated is a surrogate for the potential to recruit. Among Medicare-eligible acute ischemic stroke (AIS) cases, we estimated the IV rt-PA and endovascular embolectomy treatment rates at StrokeNET Regional Coordinating Centers and their partner hospitals compared with non-StrokeNET hospitals in the United States (US). Methods: We used demographics and IV rt-PA and embolectomy rates in the 2013 Medicare Provider and Analysis Review (MEDPAR) dataset. ICD-9 codes 433.xx, 434.xx and 436 identified AIS cases. ICD-9 code 99.10 defined rt-PA treatment and ICD-9 code 39.74 defined embolectomy. Demographics and treatment rates at StrokeNET and non-StrokeNET sites were compared using t-test for proportions and Chi-square test for categorical variables as appropriate. Results: Of 386,157 AIS primary diagnosis discharges, 5.1% received IV rt-PA and 0.8% had embolectomy (Table). By June 6, 2014, StrokeNET comprised 247 acute care hospitals that discharged 48,946 (13%) out of 386,157 AIS cases. rt-PA (7.4% vs 4.8%) and embolectomy (1.9% vs 0.6%) treatment rates were higher at StrokeNET hospitals. In 2013, 36% of StrokeNET hospitals treated more than 20 AIS cases with rt-PA or embolectomy compared with 6% of non-StrokeNET hospitals (P<0.0001).Conclusions StrokeNET hospitals treat more AIS cases with acute reperfusion therapies. Thus, StrokeNET could successfully recruit in acute reperfusion clinical trials depending on study size, capture of eligible patients and the number of competing trials. We likely underestimated treatment rates due to not accounting for drip-and-ship and non-Medicare cases. To further enhance enrollments in large acute reperfusion phase 3 trials, partnership with high volume non-StrokeNET hospitals may be warranted.

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Prevalence of vitamin D deficiency in Iran: A systematic review and meta-analysis

Nutrition and Health ◽

10.1177/0260106018802968 ◽

2018 ◽

Vol 24 (4) ◽

pp. 269-278 ◽

Cited By ~ 6

Author(s):

Salam Vatandost ◽

Marzieh Jahani ◽

Ali Afshari ◽

Mohammad Reza Amiri ◽

Rashid Heidarimoghadam ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Random Effect ◽

National Level ◽

Age Groups ◽

Design Strategies ◽

Chi Square ◽

And Gender

Background: The prevalence of vitamin D deficiency in the Iranian community is very high. Women and older people are at the higher risk of vitamin D deficiency. Aim: This study aimed to estimate the prevalence of vitamin D deficiency in Iran by combining the results of various studies. Methods: This was a systematic review and meta-analysis. Separate strategies were developed for search in national databases (Irandoc, Magiran, SID) and international databases (Web of Science, PubMed, and Scopus) using the keywords of “vitamin D deficiency,” “Iran,” and “prevalence.” The titles and abstracts of the articles were screened and related full texts were appraised. Those articles that met inclusion criteria were selected for meta-analysis. The heterogeneity of the articles was assessed via the Chi-square test. They were combined using the random-effect approach. In addition, the groups were categorized and analyzed in terms of age and gender. Results: Of 639 articles, 30 articles with a sample size of 26,042 people were included for data analysis. The overall prevalence of vitamin D deficiency was reported as 0.56. Subgroup analysis showed that 0.64 of women and 0.44 of men were suffering from vitamin D deficiency. The prevalence of vitamin D deficiency in the age groups under 20, 20–50, and over 50 years was 0.56.4, 0.72.4, and 0.59.8, respectively. Conclusions: The Iranian Ministry of Health is expected to design strategies to improve the status of vitamin D at the national level.

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Functional outcome and complications following surgery for Dupuytren’s disease: a multi-centre cross-sectional study

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193416660045 ◽

2016 ◽

Vol 42 (1) ◽

pp. 7-17 ◽

Cited By ~ 9

Author(s):

J. N. Rodrigues ◽

W. Zhang ◽

B. E. Scammell ◽

I. Chakrabarti ◽

P. G. Russell ◽

...

Keyword(s):

Monte Carlo Simulation ◽

Monte Carlo ◽

Functional Outcome ◽

Dupuytren’S Disease ◽

Complication Rates ◽

Loss Of Function ◽

Chi Square ◽

Level Of Evidence ◽

Dupuytren's Disease ◽

Chi Square Test

Variables associated with recurrent Dupuytren’s disease, or a ‘diathesis’, have been investigated, but those associated with functional outcome and complications are less well studied. Outcomes 1 or 5 years after an aponeurotomy, fasciectomy or dermofasciectomy were assessed by patient interview and examination at five UK centres. A total of 432 procedures were studied. The reoperation rate did not differ at 1 year ( p = 0.396, Chi-square test with Monte Carlo simulation), but was higher after aponeurotomy in the 5-year group (30%, versus 6% after fasciectomy and 0% after dermofasciectomy, p = 0.003, Chi square test with Monte Carlo simulation). Loss of function (DASH>15) did not differ between procedures at 5 years, even when reoperation and other variables were controlled. Diabetes, female gender and previous ipsilateral surgery were associated with poorer function in logistic regression analysis. The variables associated with poor function after treatments differ from diathesis variables. Aponeurotomy had lower complication rates than fasciectomy and dermofasciectomy. This may counterbalance the former’s higher recurrence rate and explain why aponeurotomy demonstrated similar long-term functional outcome compared with excisional surgery in this study. Level of evidence: III

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