Abstract P111: Relationship of Vitamin D Status to Cardiac Arrhythmias in Veterans

2011 ◽  
Vol 4 (suppl_2) ◽  
Author(s):  
Tareq M Islam ◽  
Beth Bailey ◽  
Chowdhury Ferdous ◽  
Chris Finton ◽  
Todd Manning ◽  
...  
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Cardiac Arrhythmias ◽  
Odds Ratio ◽  
Ventricular Arrhythmias ◽  
Continuous Variable ◽  
P Value ◽  
Vitamin D Status ◽  
Relationship Of ◽  
Deficient Group

Relationship of Vitamin D status to cardiac arrhythmias in Veterans Islam T. MD MPH, Bailey B. PhD, Ferdous C. MD, Finton C. MD, Manning T. and Peiris A.N. MD PhD Introduction. Vitamin D deficiency is widespread and is associated with coronary artery disease. However, few studies have examined the link between Vitamin D status and cardiac arrhythmias. The present study was undertaken to explore this relationship. Method. We studied 34580 veterans in the southeastern USA and evaluated the relationship of Vitamin D status to both atrial and ventricular arrhythmias by retrospective chart review. Approximately 34.8 % (12030) patient were Vitamin D deficient (25(OH)D < 20 ng/ml). This group was more likely to be younger, have a significantly greater body mass index, more likely to be female and belong to a racial minority when compared to the Vitamin D replete group. The Vitamin D deficient group was also more likely to have hyperlipidemia, diabetes, hypertension and be tobacco users. Result. The presence of arrhythmias varied between 0.3 % (ventricular) to 25 % (Any arrhythmia plus heart block). Atrial and ventricular arrhythmias were significantly greater in the vitamin D deficient group. Vitamin D deficiency remained significantly associated with atrial and ventricular arrhythmias after adjusting for other variables through multivariate logistic regression analysis. Conclusion. To our knowledge, this is the first report indicating a significant link between vitamin D status and cardiac arrhythmias in Veterans. Vitamin D remained a significant predictor of this relationship even after adjusting for other variables. Emerging evidence suggest that Vitamin D replacement can improve cardiac ejection fraction. The potential for Vitamin D replacement to reduce an underlying arrythmogenic propensity is an exciting area for future research. Adjusted logistic regression model predicting atrial and ventricular arrhythmia by vitamin D level. Atrial Arrhythmia Present Absent p-value Vitamin D treated as Continuous variable, beta estimate -0.006 0 (ref.) 0.001 Categorical (low versus replete), odds ratio 1.18 1.00 (ref.) <0.001 Ventricular Arrhythmia Present Absent p-value Vitamin D treated as Continuous variable, beta estimate -0.020 0 (ref.) 0.042 Categorical (low versus replete), odds ratio 1.48 1.00 (ref.) 0.055

scholarly journals Vitamin D Status and Severe COVID-19 Disease Outcomes in Hospitalized Patients

2021 ◽  
Vol 12 ◽  
pp. 215013272110412
Author(s):  
Jennifer L. Pecina ◽  
Stephen P. Merry ◽  
John G. Park ◽  
Tom D. Thacher
Keyword(s):  
Vitamin D ◽  
Assisted Ventilation ◽  
Vitamin D Supplementation ◽  
Hospitalized Patients ◽  
Vitamin D Status ◽  
Icu Admission ◽  
Hydroxyvitamin D ◽  
Duration Of Hospitalization ◽  
D Values ◽  
Relationship Of

Background: Vitamin D deficiency may increase the risk of severe COVID-19 disease. Objectives: To determine if 25-hydroxyvitamin D [25(OH)D] levels in patients hospitalized for COVID-19 were associated with the clinical outcomes of days on oxygen, duration of hospitalization, ICU admission, need for assisted ventilation, or mortality. Methods: We conducted a retrospective study of 92 patients admitted to the hospital with SARS-CoV-2 infection between April 16, 2020 and October 17, 2020. Multivariable regression was performed to assess the independent relationship of 25(OH)D values on outcomes, adjusting for significant covariates and the hospitalization day the level was tested. Results: About 15 patients (16.3%) had 25(OH)D levels <20 ng/mL. Only 1 patient (3.4%) who had documented vitamin D supplementation prior to admission had 25(OH)D <20 ng/mL. Serum 25(OH)D concentrations were not significantly associated with any of our primary outcomes of days on oxygen, duration of hospitalization, intensive care unit (ICU) admission, need for mechanical ventilation, or mortality in any of the adjusted multivariable models. Adjusting for the hospital day of 25(OH)D sampling did not alter the relationship of 25(OH)D with any outcomes. Conclusion: Vitamin D status was not related to any of the primary outcomes reflecting severity of COVID-19 in hospitalized patients. However, our sample size may have lacked sufficient power to demonstrate a small effect of vitamin D status on these outcomes.

scholarly journals Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

2021 ◽  
Author(s):  
Yiyi Ding ◽  
Shuo Wang ◽  
Rui Guo ◽  
Aizhen Zhang ◽  
Yufang Zhu
Keyword(s):  
Logistic Regression ◽  
Blood Glucose ◽  
Odds Ratio ◽  
Exchange Transfusion ◽  
Binary Logistic Regression ◽  
P Value ◽  
Bilirubin Encephalopathy ◽  
Unbound Bilirubin ◽  
Independent Variable ◽  
The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

scholarly journals Assessment of risk factors associated with vitamin D status among children of an urban and a rural areas of Bangladesh

2020 ◽  
Vol 46 (2) ◽  
pp. 134-141
Author(s):  
Anamika Saha ◽  
Md Salim Shakur ◽  
Runa Laila ◽  
Salomee Shakur ◽  
Md Sohel Shomik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Urban Children ◽  
Outpatient Department ◽  
P Value ◽  
Rural Children ◽  
Vitamin D Status ◽  
Factors Associated

Background: Vitamin D deficiency is one of the most common micronutrient deficiency in children worldwide, even in Bangladesh. However, to date, the prevalence of vitamin D deficiency among children of different region of Bangladesh is less reported. Objective: This study was conducted to assess vitamin D status of urban and rural Bangladeshi children including the risk factors associated with vitamin D deficiency are also evaluated. Methods: A multi-centre (urban and rural based), cross sectional study was done from July 2016 to June 2017, using serum 25(OH) vitamin D3 as a marker of nutritional vitamin D status. Urban and rural children were taken from Paediatric Outpatient Department, United Hospital Limited. Dhaka and Medical Outpatient Department, Upazila Health Complex, Ghatail, Tangail respectively. Children of 1-10 years age attending OPD with mild undernutrition (<–1 SD z score) and/or clinical features suggestive of vitamin D deficiency were included in the study. Results: A total 150 children were studied with 102 (68.0%) urban and 48 (32.0%) rural children. Hypovitaminosis D (25-OHD <30ng/ml) was found in 75.0% of children. Hypovitaminosis D was found significantly more in urban children (81.0%) compared to rural (62.0%) children (OR=0.382, 95% CI: 0.177-0.822, p value <0.05). Inadequate exposure to sunlight was significantly associated with hypovitaminosis D compared to adequate sun exposure and it was about 2.5 times higher (OR=2.475, 95% CI: 1.139-5.380, p value <0.05). No significant associations of vitamin D deficiency were detected with skin color of children, covering clothes of mother, exclusive breast feeding, limb pain and anthropometric status. Children of higher educated mother (above Secondary School Certificate) (OR=0.412, 95% CI: 0.189-0.900) were more associated with vitamin D deficiency. Conclusion: Vitamin D deficiency (VDD) is prevalent among Bangladeshi children, urban children being more vulnerable to VDD. Adoption of a screening programme for children of all age group and implementation of preventive strategies for VDD through public health policies are strongly recommended. Bangladesh Med Res Counc Bull 2020; 46(2): 134-141

Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: A meta-analysis

Hepatology ◽  
2014 ◽  
Vol 60 (5) ◽  
pp. 1541-1550 ◽  
Author(s):  
Mónica García-Álvarez ◽  
Daniel Pineda-Tenor ◽  
María A. Jiménez-Sousa ◽  
Amanda Fernández-Rodríguez ◽  
María Guzmán-Fulgencio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Advanced Liver Fibrosis ◽  
Relationship Of

Association of statin use and risk for severe headache or migraine by serum vitamin D status: A cross-sectional population-based study

Cephalalgia ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. 757-766 ◽  
Author(s):  
Catherine Buettner ◽  
Rami Burstein
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Serum Vitamin ◽  
Severe Headache ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Adjusted Logistic Regression ◽  
Statin Use

Objective The objective of this article is to evaluate whether statin use and vitamin D status is associated with severe headache or migraine in a nationally representative sample. Methods We conducted a cross-sectional study of US individuals aged ≥40 years for whom information on statin use, serum 25-hydroxy vitamin D (25(OH)D), and self-reported severe headache or migraine had been collected. We calculated prevalence estimates of headache according to statin and 25(OH)D, and conducted adjusted logistic regression analyses stratified by the median 25(OH)D (≤57 and >57 nmol/l). Results Among 5938 participants, multivariable-adjusted logistic regression showed that statin use was significantly associated with a lower prevalence of severe headache or migraine (OR 0.67; 95% CI 0.46, 0.98, p = 0.04). We found a significant interaction between statin use and 25(OH)D with the prevalence of severe headache or migraine ( p for interaction = 0.005). Among participants who had serum 25(OH)D > 57 nmol/l, statin use was associated with a multivariable-adjusted odds ratio of 0.48 (95% CI 0.32, 0.71, p = 0.001) for having severe headache or migraine. Among those with 25(OH)D ≤ 57 nmol/l, no significant association was observed between statin use and severe headache or migraine. Conclusion Statin use in those with higher serum vitamin D levels is significantly associated with lower odds of having severe headache or migraine.

scholarly journals Peranan Ultraviolet B Sinar Matahari terhadap Status Vitamin D dan Tekanan Darah pada Wanita Usia Subur

2014 ◽  
pp. 256 ◽  
Author(s):  
Betty Yosephin ◽  
Ali Khomsan ◽  
Dodik Briawan ◽  
Rimbawan Rimbawan
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Ultraviolet B ◽  
P Value ◽  
Vitamin D Status ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Anthropometric Parameter

Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia subur yang bekerja di dalam ruangan mempunyai vitamin D yang rendah meskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevaluasi peranan paparan sinar matahari pada wanita usia subur terhadap status vitamin D dan tekanan darah. Desain penelitian yang digunakan adalah eksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian ini membandingkan status vitamin D dan tekanan darah sebelum dan setelah mendapat paparan sinar matahari pada wajah dan lengan tiga kali seminggu selama 12 minggu. Analisis data menggunakan uji t-berpasangan. Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)D meningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar matahari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (nilai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali seminggu selama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah.Ultraviolet B sunlight exposure is a primary source of vitamin D, but women of childbearing age who worked in room every day had low serum vitamin D despite Indonesia is a tropical country. The objective of this study was to evaluate the role of sun exposure in women of childbearing age on vitamin D status, and blood pressure. An intervention before-after study without group control was conducted on 21 healthy women. This study compared vitamin D status, and blood pressure before and after receiving ultraviolet B (UVB) from sun exposure on the face and both arms three times a week for 12 weeks. Anthropometric parameter and blood pressure were measured, were determined at baseline and after 12 weeks of sun exposure. The effect of sun exposure can improve vitamin D. Serum 25 (OH)D increase 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly reduced systolic blood pressure (p value = 0.004), and diastolic blood pressure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3 times a week for 12 weeks improves the vitamin D status, and blood pressure.

scholarly journals THE ANALYSIS OF FACTORS INFLUENCING GRADUATION ACHIEVEMENT IN NURSE COMPETENCE TEST OF NURSE PROFESSION PROGRAM

2018 ◽  
Vol 37 (2) ◽  
Author(s):  
Lukmanulhakim Lukmanulhakim ◽  
Lenny Stia Pusporini
Keyword(s):  
Logistic Regression ◽  
Odds Ratio ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Influencing ◽  
Nurse Competence ◽  
Competence Test ◽  
Chi Square Analysis ◽  
Simple Logistic

Abstract: Competence test is conducted to fulfil the graduates’ performance competence standards. Nurse competence is oriented to the performance quality in giving a comprehensive care. Study intends to identify factors influencing graduation achievement in UKNI of Nurse Profession Program students of STIKes Faletehan Serang. It is a quantitative study with analytical correlational design and cross sectional approach. Samples are 106 respondents who were selected by using total sampling technique. The statistical used are Chi Square and simple logistic regression prediction model. The Chi Square analysis result with α = 0.05 finds p value of the three variables are 0.804 (anxiety and family support), and 1.000 (peers support). Besides, the analysis result of other three variables obtains p value of 0.034 (GPA), p value of 0.000 (liveliness), and p value of 0.000 (try out result). The analysis result of simple logistic regression shows that Odds Ratio (OR) of liveliness variable is 156.734. The research results can be an evaluation material to increase graduation achievement in UKNI are the benchmark of improving the implementation of university quality assurance. Keywords: capaian kompetensi, kompetensi perawat, uji kompetensi Ners, progra profesi Ners ANALISIS FAKTOR YANG MEMPENGARUHI CAPAIAN KELULUSAN UJI KOMPETENSI NERS MAHASISWA PROGRAM PROFESI NERS  Abstrak: Uji kompetensi dilaksanakan untuk mencapai lulusan yang memenuhi standar kompetensi kinerja. Kompetensi perawat berorientasi terhadap kualitas kinerja dalam memberikan pelayanan keperawatan secara komprehensif.Penelitian bertujuan untuk mengetahaui faktor-faktor yang mempengaruhi capaian kelulusan UKNI mahasiswa Program Profesi Ners STIKes Faletehan Serang. Penelitian berjenis kuantitatif dengan rancangan korelasi analitik melalui pendekatan Cross Sectional.Sampel penelitian sebanyak 106 responden yang diambil dengan teknik total sampling. Data dikumpulkan lewat angket. Analisis data dilakukan dengan menggunakan Chi Square dan regresi logistik sederhana model prediksi.Hasil analisis uji Chi Square dengan α = 0.05, ketiga variabel diperoleh p value sebesar 0,804 (kecemasan dan dukungan keluarga), serta 1,00 (dukungan teman sebaya). Hasil analisis ketiga variabel lainnya diperoleh p value sebesar 0.034(IPK Akademik), 0.000 (keaktfikan), dan 0.000 (try out nasional). Hasil analisis regresi logistik, teridentifikasi Odds-Ratio (OR) dari variabel keaktifan adalah 156.734.Hasil ini dapat dijadikan evaluasi dalam peningkatan capaian kelulusan UKNI yang merupakan tolak ukur dalam penyelenggaraan penjaminan mutu perguruan tinggi. Kata kunci : capaian kompetensi, kompetensi perawat, uji kompetensi Ners, progra profesi Ners

Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis

Endocrine ◽  
2020 ◽  
Author(s):  
S. D’Andrea ◽  
A. Martorella ◽  
F. Coccia ◽  
C. Castellini ◽  
E. Minaldi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Testosterone Levels ◽  
Relationship Of

Association of vitamin D receptor gene polymorphisms with type 2 diabetes mellitus in Taif population: a case-control study

2024 ◽  
Vol 84 ◽  
Author(s):  
A. Q. Alkhedaide ◽  
A. Mergani ◽  
A. A. Aldhahrani ◽  
A. Sabry ◽  
M. M. Soliman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Relative Risk ◽  
Vitamin D Receptor ◽  
Odds Ratio ◽  
P Value ◽  
Diabetic Patients ◽  
Similar Data

Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the possible association of two identified mutations ApaI (rs7975232) and TaqI (rs731236). Eighty-nine healthy individuals and Fifty-six Type 2 Diabetic (T2D) patients were investigated using RFLP technique for genotyping and haplotyping as well. The distribution of Apal genotypes was not statistically significant among the control (P=0.65) as well as for diabetic patients (P=0.58). For Taql allele frequencies of T allele was 0.61 where of G allele was 0.39. The frequency distribution of Taql genotypes was not statistically significant among the control (P=0.26) as well as diabetic patients (P=0.17). Relative risk of the allele T of Apa1 gene is 1.28 and the odds ratio of the same allele is 1.53, while both estimates were < 1.0 of the allele G. Similarly, with the Taq1 gene the relative risk and the odds ratio values for the allele T are 1.09 and 1.27 respectively and both estimates of the allele C were 0.86 for the relative risk and 0.79 for the odds ratio. The pairwise linkage disequilibrium between the two SNPs Taq1/apa1 was statistically significant in control group (D = 0.218, D' = 0.925 and P value < 0.001) and similar data in diabetic groups (D = 0.2, D' = 0.875 and P value < 0.001). These data suggest that the T allele of both genes Apa1 and Taq1 is associated with the increased risk of type 2 diabetes. We think that we need a larger number of volunteers to reach a more accurate conclusion.

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